摘要:
The present invention provides a pharmaceutical composition or crystalline composition with a specific dissolution profile, which comprises suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof as an active ingredient. The present invention provides a process of producing said crystalline composition or pharmaceutical composition. The present invention also provides compositions with a specific particle size distribution.
摘要:
The present invention provides a pharmaceutical composition or crystalline composition with a specific dissolution profile, which comprises suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof as an active ingredient. The present invention provides a process of producing said crystalline composition or pharmaceutical composition. The present invention also provides compositions with a specific particle size distribution.
摘要:
The present invention provides a pharmaceutical composition or crystalline composition with a specific dissolution profile, which comprises suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof as an active ingredient. The present invention provides a process of producing said crystalline composition or pharmaceutical composition. The present invention also provides compositions with a specific particle size distribution.
摘要:
A ground support apparatus for a material moving implement configured for moving a material from a surface. The material moving implement has a front surface and a rear surface. The ground support apparatus includes an actuating system that has at least one skid shoe actuator attached to the rear surface of the material moving implement, and at least one skid shoe operably coupled to the at least one skid shoe actuator. The skid shoe includes a first end configured for coupling to the at least one skid shoe actuator and a second end configured for contacting the surface. The ground support apparatus also includes manually-operated skid shoe controls operably connected to the actuating system and operable to actuate the at least one skid shoe actuator.
摘要:
The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, and R4 are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
摘要:
A wireless charging system includes a charging pad including a base having a coil. The charging pad includes an electrical connector connected to the coil for supplying power to the coil. The charging pad can be connected by an AC cord to a household AC outlet via the electrical connector. The charging pad can also be connected to a vehicle connector for connecting the charging pad to a vehicle electrical supply. In this manner, the wireless charging pad can be used for both home and vehicle charging.
摘要:
The present invention relates to a novel class of histone deacetylase inhibitors with aryl-pyrazolyl motifs. The compounds of this invention can be used to treat cancer. The compounds of this invention are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The present invention further provides pharmaceutical compositions comprising the compounds of this invention and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the compounds of this invention in vivo.
摘要:
The present invention relates to a tray comprising: a) a base panel having two opposite edges adapted for sliding within grooves of a structure; b) a pair of electrical contacts located on the two opposite edges of the base adapted to conduct electricity; c) a battery recharging system adapted to provide one or more electromagnetic fields capable of transferring an electrical charge to a properly equipped electrical device having a rechargeable battery or a connection for a portable electronic device adapted to connect the portable electronic device to the power system of a host and/or other electronic systems of the host; d) means for connecting the pair of electrical contacts to the battery recharging system or to the connection to the portable electronic device; e) one or more display panels providing a surface for resting one or more rechargeable portable electric devices upon, such panels adapted to allow one or more users of portable electronic device to view one or more displays of the portable electronic devices; f) panels for connecting the base panel and one or more display panels and for enclosing the tray. The tray is adapted for use in a host system which supplies power to the tray. In a preferred embodiment, the host system is or is utilized in a vehicle.
摘要:
The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof a first amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or hydrate thereof, in a first treatment procedure, and a second amount of an anti-cancer agent in a second treatment procedure. The first and second amounts together comprise a therapeutically effective amount. The effect of the HDAC inhibitor and the anti-cancer agent may be additive or synergistic.
摘要:
The present invention relates to a novel class of hydroxamic acid derivatives having a diamine or iminodiacetic acid backbone. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively including terminal differentiation, arresting cell growth and/or apoptosis of neo-plastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compound of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives, and safe, dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.