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公开(公告)号：US20200222413A1
公开(公告)日：2020-07-16
申请号：US16415515
申请日：2019-05-17
Applicant: AbbVie Inc.
Inventor： Steven Elmore , Andrew Souers , Lichun Wang , Tariq Ghayur , Stuart J. Perper
IPC: A61K31/5377 , A61K31/496
Abstract: This invention pertains to methods of treating systemic lupus erythematosus and Sjogren's Syndrome with compounds that selectively inhibit the activity of Bcl-2 anti-apoptotic proteins. Specifically, the current invention is directed to treatment with compounds that selectively inhibit the activity of Bcl-2 proteins, with a lesser affinity for inhibiting the activity of other BCL-2 family proteins, including Bcl-XL.
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公开(公告)号：US20180369250A1
公开(公告)日：2018-12-27
申请号：US15838605
申请日：2017-12-12
Applicant: AbbVie Inc.
Inventor： Steven Elmore , Andrew Souers , Lichun Wang , Tariq Ghayur , Stuart J. Perper
IPC: A61K31/5377 , A61K31/496
Abstract: This invention pertains to methods of treating systemic lupus erythematosus and Sjogren's Syndrome with compounds that selectively inhibit the activity of Bcl-2 anti-apoptotic proteins. Specifically, the current invention is directed to treatment with compounds that selectively inhibit the activity of Bcl-2 proteins, with a lesser affinity for inhibiting the activity of other BCL-2 family proteins, including Bcl-XL.
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公开(公告)号：US09840554B2
公开(公告)日：2017-12-12
申请号：US15183725
申请日：2016-06-15
Applicant: ABBVIE INC.
Inventor： Jijie Gu , Diana Bowley , Lucia Eaton , Feng Dong , Lorenzo Benatuil , Tariq Ghayur , Ravi Chari , Matthew Rieser , Anca Clabbers
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/00 , C07K16/24 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/51 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Binding proteins that bind one or more of VEGF, PDGF and/or their receptors, including antibodies, CDR-grafted antibodies, humanized antibodies, binding fragments, fusion proteins, and bispecific or multispecific proteins thereof are disclosed. Also disclosed are methods of making and using the binding proteins.
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公开(公告)号：US20170096470A1
公开(公告)日：2017-04-06
申请号：US15266885
申请日：2016-09-15
Applicant: AbbVie, Inc.
Inventor： Tariq Ghayur , Philip Bardwell
IPC: C07K14/705 , G01N33/68 , A61K38/17 , C12P21/02
CPC classification number: C07K16/28 , A61K38/177 , A61K38/1774 , A61K39/3955 , A61K45/06 , A61K49/00 , A61K51/1027 , C07K14/70521 , C07K14/70578 , C07K14/7151 , C07K16/22 , C07K16/244 , C07K16/44 , C07K2317/31 , C07K2319/00 , C07K2319/30 , C07K2319/32 , C07K2319/60 , C12P21/02 , G01N33/56972 , G01N33/68 , Y02A50/401 , Y02A50/411
Abstract: Engineered multispecific binding proteins that bind at least one ligand for a receptor are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：US20160176958A1
公开(公告)日：2016-06-23
申请号：US14950761
申请日：2015-11-24
Applicant: AbbVie Inc.
Inventor： Lorenzo Benatuil , Tariq Ghayur , Carrie L. Goodreau , Peter C. Isakson , Jochen Salfeld
IPC: C07K16/24
CPC classification number: C07K16/241 , A61K47/6845 , A61K51/1021 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/7151 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
Abstract: Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
Abstract translation: 公开了与肿瘤坏死因子-α（TNF-α）结合的分离的结合蛋白，例如结合肿瘤坏死因子-α（TNF-α）的抗体或其抗原结合部分以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
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Patent Agency Ranking
公开(公告)号：US09120870B2
公开(公告)日：2015-09-01
申请号：US13729645
申请日：2012-12-28
Applicant: AbbVie Inc.
Inventor： Chung-Ming Hsieh , Tariq Ghayur , Carrie L. Goodreau
IPC: A61K39/395 , C07K16/46 , A61K45/06 , G01N33/68 , C07K16/24
CPC classification number: C07K16/468 , A61K39/3955 , A61K45/06 , C07K16/244 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/64 , C07K2317/76 , C07K2317/92 , G01N33/6854 , G01N33/6869 , G01N2333/54 , G01N2333/5437
Abstract: Engineered multivalent and multispecific binding proteins that bind IL-13 and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
Abstract translation: 提供结合IL-13和/或IL-17的工程化多价和多特异性结合蛋白，以及制备和用于预防，诊断和/或治疗疾病的方法。
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公开(公告)号：US20150232550A1
公开(公告)日：2015-08-20
申请号：US14689914
申请日：2015-04-17
Applicant: AbbVie Inc.
Inventor： Tariq Ghayur , Jochen G. Salfeld , Michael J. McPherson
IPC: C07K16/24 , G01N33/68 , C07K16/18 , A61K39/395 , A61K45/06
CPC classification number: C07K16/241 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/22 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/626 , C07K2317/64 , C07K2317/76 , C07K2317/92 , G01N33/53 , G01N33/6854 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/53 , Y02A50/58
Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
Abstract translation: 提供了工程化的多价和多特异性结合蛋白，制备方法及其在预防，诊断和/或治疗疾病中的用途。
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公开(公告)号：US20140205562A1
公开(公告)日：2014-07-24
申请号：US14133380
申请日：2013-12-18
Applicant: AbbVie, Inc.
Inventor： Chengbin WU , Dominic J. Ambrosi , Chung-ming Hsieh , Tariq Ghayur
IPC: C07K16/24 , A61K45/06 , A61K9/00 , A61K39/395
CPC classification number: C07K16/245 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0053 , A61K9/006 , A61K9/007 , A61K9/0085 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K47/6879 , C07K14/545 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/545 , G01N2800/00 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/412 , Y02A50/463 , Y02A50/478 , Y02A50/481
Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.
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公开(公告)号：US20170313786A1
公开(公告)日：2017-11-02
申请号：US15427851
申请日：2017-02-08
Applicant: AbbVie Inc.
Inventor： Chengbin WU , Tariq Ghayur , Richard W. DIXON , Jochen G. SALFELD
IPC: C07K16/46 , A61K45/06 , A61K47/42 , A61K51/10 , C07K16/22 , C07K16/24 , C07K16/40 , C07K16/28 , A61K39/395 , A61K39/00
CPC classification number: C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/42 , A61K47/6803 , A61K51/1093 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K16/46 , C07K16/467 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/522 , C07K2317/56 , C07K2317/64 , C07K2317/76 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
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公开(公告)号：US20170306010A1
公开(公告)日：2017-10-26
申请号：US15641508
申请日：2017-07-05
Applicant: AbbVie Inc.
Inventor： Boris Labkovsky , Tariq Ghayur , Georgeen Gaza-Bulseco , Pratibha Mishra , Subramanya Hegde , Sudha Krishnan
CPC classification number: C07K16/241 , A61K2039/505 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/30 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/77 , Y02A50/386
Abstract: Provided are glycoengineered populations of Fc domain-containing binding proteins with a reduced anti-drug immune response (ADA). Also provided are methods of treating disease using such compositions, and methods and host for making such compositions.
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