公开(公告)号：US09957274B2

公开(公告)日：2018-05-01

申请号：US15588398

申请日：2017-05-05

Applicant: AbbVie Inc.

Inventor： Michael R. Michaelides ,  Michael L. Curtin ,  Huan-Qiu Li ,  Marina A Pliushchev ,  Ying Wang ,  Hongyu H. Zhao ,  Richard F. Clark ,  Alan S. Florjancic ,  Zhiqin Ji ,  Mariazel Torrent ,  Ramzi F. Sweis ,  Anil Vasudevan ,  Justin D. Dietrich

IPC: C07D207/14 ,  A61K31/40 ,  C07D487/04 ,  C07D403/10 ,  C07D405/04 ,  C07D413/10 ,  C07D403/12 ,  C07D401/12 ,  C07D403/04 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04 ,  C07D401/04 ,  C07D401/14

CPC classification number: C07D487/04 ,  A61K31/40 ,  C07D207/14 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D413/10 ,  C07D417/14 ,  C07D471/04

Abstract: Compounds having a structure of Formula (I): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein A1, A2, A3, A4, A5, n, and m are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various EED-related conditions or diseases, including cancer, by administration of such compounds are also provided.