公开(公告)号：US20140336167A1

公开(公告)日：2014-11-13

申请号：US13891338

申请日：2013-05-10

Applicant: AbbVie Inc.

Inventor： Ramzi F. Sweis ,  Michael L. Curtin ,  Marina A. Pliushchev ,  Todd M. Hansen ,  Kenton Longenecker

IPC: C07D417/14 ,  C07D417/12

CPC classification number: A61K31/506 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/497 ,  C07D417/12 ,  C07D417/14

Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

Abstract translation: 公开了抑制NAMPT活性的化合物，含有该化合物的组合物和治疗其中NAMPT表达的疾病的方法。

公开(公告)号：US20170320880A1

公开(公告)日：2017-11-09

申请号：US15588398

申请日：2017-05-05

Applicant: AbbVie Inc.

Inventor： Michael R. Michaelides ,  Michael L. Curtin ,  Huan-Qiu Li ,  Marina A. Pliushchev ,  Ying Wang ,  Hongyu H. Zhao ,  Richard F. Clark ,  Alan S. Florjancic ,  Zhiqin Ji ,  Mariazel Torrent ,  Ramzi F. Sweis ,  Anil Vasudevan ,  Justin D. Dietrich

IPC: C07D487/04 ,  C07D417/14 ,  C07D413/10 ,  C07D405/04 ,  C07D403/14 ,  C07D403/12 ,  C07D403/10 ,  C07D403/04 ,  C07D401/14 ,  C07D401/12 ,  C07D401/04 ,  C07D471/04 ,  C07D207/14

CPC classification number: C07D487/04 ,  A61K31/40 ,  C07D207/14 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D413/10 ,  C07D417/14 ,  C07D471/04

Abstract: Compounds having a structure of Formula (I): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein A1, A2, A3, A4, A5, n, and m are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various EED-related conditions or diseases, including cancer, by administration of such compounds are also provided.

公开(公告)号：US09598381B2

公开(公告)日：2017-03-21

申请号：US14812726

申请日：2015-07-29

Applicant: AbbVie Inc.

Inventor： Gary G. Chiang ,  William N. Pappano ,  Ramzi F. Sweis ,  Zhi Wang

IPC: C07D209/40 ,  C07D265/36 ,  C07D295/13 ,  C07D487/04 ,  C07D401/12 ,  C07D471/04 ,  C07C255/58

CPC classification number: C07D265/36 ,  C07C255/58 ,  C07C2601/14 ,  C07D209/40 ,  C07D295/13 ,  C07D401/12 ,  C07D471/04 ,  C07D487/04

Abstract: The present disclosure generally relates to compounds having cellular anti-proliferative activities, and more particularly relates to compounds which inhibit the activity of human SMYD2, a SET and MYND domain-containing protein lysine methyltransferase.

公开(公告)号：US09187472B2

公开(公告)日：2015-11-17

申请号：US13891366

申请日：2013-05-10

Applicant: AbbVie Inc.

Inventor： Richard F. Clark ,  Bryan Sorensen ,  Augustine T. Osuma ,  Robin Frey ,  Kenton Longenecker ,  George Doherty ,  Michael L. Curtin ,  Michael R. Michaelides ,  Ramzi F. Sweis ,  Marina A. Pliushchev ,  Andy Judd ,  Todd M. Hansen ,  Howard R. Heyman

IPC: C07D471/04 ,  C07D487/04 ,  A61K31/437 ,  A61K31/4985 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/55 ,  A61K31/407

CPC classification number: A61K31/437 ,  A61K31/407 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04 ,  A61K2300/00

Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

公开(公告)号：US20160193209A1

公开(公告)日：2016-07-07

申请号：US15068131

申请日：2016-03-11

Applicant: AbbVie Inc.

Inventor： Ramzi F. Sweis ,  Michael L. Curtin ,  Marina A. Pliushchev ,  Todd M. Hansen ,  Kenton Longenecker

IPC: A61K31/506 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/427

CPC classification number: A61K31/506 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/497 ,  C07D417/12 ,  C07D417/14

Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

公开(公告)号：US20150274660A1

公开(公告)日：2015-10-01

申请号：US14229021

申请日：2014-03-28

Applicant: AbbVie Inc.

Inventor： Marina A. Pliushchev ,  Gary G. Chiang ,  William N. Pappano ,  Michael R. Michaelides ,  Ramzi F. Sweis

IPC: C07D209/40 ,  C07D403/12 ,  C07D209/96

CPC classification number: C07D209/40 ,  C07D209/96 ,  C07D403/12

Abstract: Described herein are compounds, pharmaceutical compositions and methods for treating cancer, inflammation, or autoimmune disease in a subject, or for inhibiting histone methyltransferase G9a.

Abstract translation: 本文描述了用于治疗受试者中的癌症，炎症或自身免疫性疾病或用于抑制组蛋白甲基转移酶G9a的化合物，药物组合物和方法。

公开(公告)号：US09334264B2

公开(公告)日：2016-05-10

申请号：US13891338

申请日：2013-05-10

Applicant: AbbVie Inc.

Inventor： Ramzi F. Sweis ,  Michael L. Curtin ,  Marina A. Pliushchev ,  Todd M. Hansen ,  Kenton Longenecker

IPC: C07D417/14 ,  C07D417/12

CPC classification number: A61K31/506 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/497 ,  C07D417/12 ,  C07D417/14

Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

公开(公告)号：US20130303511A1

公开(公告)日：2013-11-14

申请号：US13891366

申请日：2013-05-10

Applicant: AbbVie Inc.

Inventor： Richard F. Clark ,  Bryan Sorensen ,  Augustine T. Osuma ,  Robin Frey ,  Kenton Longenecker ,  George Doherty ,  Michael L. Curtin ,  Michael R. Michaelides ,  Ramzi F. Sweis ,  Marina A. Pliushchev ,  Andy Judd ,  Todd M. Hansen ,  Howard R. Heyman

IPC: C07D471/04 ,  A61K45/06 ,  C07D487/04 ,  A61K31/4985 ,  A61K31/437 ,  A61K31/5377

CPC classification number: A61K31/437 ,  A61K31/407 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04 ,  A61K2300/00

Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

公开(公告)号：US20130303508A1

公开(公告)日：2013-11-14

申请号：US13891349

申请日：2013-05-10

Applicant: AbbVie Inc.

Inventor： Richard F. Clark ,  Bryan Sorensen ,  Augustine T. Osuma ,  Robin Frey ,  Kenton Longenecker ,  George Doherty ,  Michael L. Curtin ,  Michael R. Michaelides ,  Ramzi F. Sweis ,  Marina A. Pliushchev ,  Andy Judd ,  Todd M. Hansen ,  Howard R. Heyman

IPC: C07D471/04 ,  A61K31/5377 ,  A61K45/06 ,  A61K31/496 ,  A61K31/55 ,  A61K31/4725 ,  A61K31/437 ,  A61K31/4545

CPC classification number: A61K31/437 ,  A61K31/407 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04 ,  A61K2300/00

Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

公开(公告)号：US20240383886A1

公开(公告)日：2024-11-21

申请号：US17787828

申请日：2020-12-18

Applicant: CALICO LIFE SCIENCES LLC ,  ABBVIE INC.

Inventor： Gesine Kerstin Veits ,  Mark E. Fitzgerald ,  Alexander W. Hird ,  James A. Henderson ,  Harit U. Vora ,  Ramzi F. Sweis ,  Michael E. Kort ,  Christopher G. Nasveschuk ,  Martin Duplessis

IPC: C07D417/14 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  C07D471/04

Abstract: Provided herein are compounds, compositions, and methods useful for degrading protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer 5 or a metabolic disease.