公开(公告)号：US20160022658A1

公开(公告)日：2016-01-28

申请号：US14877783

申请日：2015-10-07

Applicant: AbbVie Inc.

Inventor： Murali Gopalakrishnan ,  Marie P. Honore ,  Chih-Hung Lee ,  John Malysz ,  Jianguo Ji ,  Tao Li ,  Michael R. Schrimpf ,  Kevin B. Sippy ,  David J. Anderson

IPC: A61K31/4439 ,  A61K31/444 ,  G01N33/94 ,  C07D413/04 ,  C07D413/14 ,  A61K45/06 ,  A61K31/4427 ,  A61K31/4709

CPC classification number: A61K31/4439 ,  A61K31/4245 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4709 ,  A61K45/06 ,  C07D413/04 ,  C07D413/14 ,  G01N33/944 ,  G01N2333/70571 ,  A61K2300/00

Abstract: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.

Abstract translation: 本发明涉及包含神经元烟碱性受体配体和α4和bgr2阳性变构调节剂，其使用方法和相关制品的组合物。

公开(公告)号：US20150353550A1

公开(公告)日：2015-12-10

申请号：US14715330

申请日：2015-05-18

Applicant: AbbVie Inc.

Inventor： Michael R. Schrimpf ,  Chih-Hung Lee ,  Tao Li ,  Gregory A. Gfesser ,  Kathleen H. Mortell ,  Ramin Faghih ,  Diana L. Nersesian ,  Kevin B. Sippy ,  William H. Bunnelle ,  Marc Scanio ,  Lei Shi ,  Murali Gopalakrishnan ,  Diana L. Donnelly-Roberts ,  Min Hu

IPC: C07D471/18

CPC classification number: G01N33/5058 ,  C07D471/18 ,  C07D487/10 ,  C07D487/18 ,  G01N33/6896 ,  G01N2800/28 ,  G01N2800/30

Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Abstract translation: 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

公开(公告)号：US20180024144A1

公开(公告)日：2018-01-25

申请号：US15454313

申请日：2017-03-09

Applicant: AbbVie Inc.

Inventor： Michael R. Schrimpf ,  Chih-hung Lee ,  Tao Li ,  Gregory Gfesser ,  Kathleen Mortell ,  Ramin Faghih ,  Diana L. Schmidt ,  Kevin Sippy ,  William H. Bunnelle ,  Marc Scanio ,  Lei Shi ,  Murali Gopalakrishnan ,  Diana L. Donnelly-Roberts ,  Min Hu

IPC: G01N33/68 ,  G01N33/50 ,  C07D471/18 ,  C07D487/10

CPC classification number: G01N33/6896 ,  C07D471/18 ,  C07D487/10 ,  G01N33/5058 ,  G01N2800/2814 ,  G01N2800/30

Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

公开(公告)号：US09983218B2

公开(公告)日：2018-05-29

申请号：US15454313

申请日：2017-03-09

Applicant: AbbVie Inc.

Inventor： Michael R. Schrimpf ,  Chih-hung Lee ,  Tao Li ,  Gregory Gfesser ,  Kathleen Mortell ,  Ramin Faghih ,  Diana L. Schmidt ,  Kevin Sippy ,  William H. Bunnelle ,  Marc Scanio ,  Lei Shi ,  Murali Gopalakrishnan ,  Diana L. Donnelly-Roberts ,  Min Hu

IPC: C07D471/18 ,  G01N33/68 ,  C07D487/10 ,  G01N33/50

CPC classification number: G01N33/6896 ,  C07D471/18 ,  C07D487/10 ,  G01N33/5058 ,  G01N2800/2814 ,  G01N2800/30

Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.