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    Analyte sensors employing multiple enzymes and methods associated therewith
    1.
    发明授权
    Analyte sensors employing multiple enzymes and methods associated therewith 有权

    公开(公告)号：US12048539B2

    公开(公告)日：2024-07-30

    申请号：US16774841

    申请日：2020-01-28

    申请人： Abbott Diabetes Care Inc.

    发明人： Stephen Oja ,  Tianmei Ouyang ,  Hyun Cho ,  Benjamin J. Feldman ,  Namvar Kiaie

    IPC分类号： A61B5/1486 ,  A61B5/145 ,  C12Q1/00

    CPC分类号： A61B5/14865 ,  A61B5/14532 ,  C12Q1/002 ,  C12Q1/005 ,  G01N2333/9029 ,  G01N2333/904 ,  G01N2333/908

    摘要： Multiple enzymes may be present in the active area(s) of an electrochemical sensor to facilitate analysis of one or more analytes. The multiple enzymes may function independently to detect several analytes or in concert to detect a single analyte. One sensor configuration includes a first active area and a second active area, where the first active area has an oxidation-reduction potential that is sufficiently separated from the oxidation-reduction potential of the second active area to allow independent signal production. Some sensor configurations may have an active area overcoated with a multi-component membrane containing two or more different membrane polymers. Sensor configurations having multiple enzymes capable of interacting in concert include those in which a first enzyme converts an analyte into a first product and a second enzyme converts the first product into a second product, thereby generating a signal at a working electrode that is proportional to the analyte concentration.

    SYSTEMS, DEVICES, AND METHODS RELATED TO KETONE SENSORS
    8.
    发明申请
    SYSTEMS, DEVICES, AND METHODS RELATED TO KETONE SENSORS 有权

    公开(公告)号：US20220233116A1

    公开(公告)日：2022-07-28

    申请号：US17585499

    申请日：2022-01-26

    申请人： ABBOTT DIABETES CARE INC.

    发明人： Shridhara A. Karinka ,  Stephen Oja

    IPC分类号： A61B5/1486 ,  A61B5/145 ,  A61B5/00 ,  A61B5/265 ,  A61B5/1473

    摘要： Systems are provided for an in vivo ketone sensor having a distal portion configured for placement in contact with an interstitial fluid of a user and a proximal portion including a working electrode, a sensing layer with β-hydroxybutyrate dehydrogenase, and a membrane layer configured to limit transport of one or more biomolecules. The in vivo ketone sensor is configured to generate signals at the working electrode corresponding to an amount of ketone in the interstitial fluid. Further, the systems includes a sensor control unit having at least one contact in electrical communication with the proximal portion of the sensor, which is configured to receive the generated signals, and convert the generated signals to ketone concentration data using a sensitivity associated with the in vivo ketone sensor. Also included is a transmitter configured to communicate ketone concentration data to a remote device.

    ANALYTE SENSORS AND SENSING METHODS FEATURING LOW-POTENTIAL DETECTION
    10.
    发明申请
    ANALYTE SENSORS AND SENSING METHODS FEATURING LOW-POTENTIAL DETECTION 有权

    公开(公告)号：US20210190719A1

    公开(公告)日：2021-06-24

    申请号：US17151296

    申请日：2021-01-18

    申请人： Abbott Diabetes Care Inc.

    发明人： John V. LaTour ,  Jonathan D. McCanless ,  Stephen Oja ,  Tianmei Ouyang ,  Kevin Paul Wallis ,  Benjamin J. Feldman ,  Udo Hoss ,  Suyue Qian

    IPC分类号： G01N27/327

    摘要： Methods and analyte sensors including a sensor tail comprising at least a first working electrode and a second working electrode that are spaced apart from one another along a length of the sensor tail. A first active area is disposed upon a surface of the first working electrode and a second active area is disposed upon a surface of the second working electrode, the first active area and the second active area being responsive to different analytes. A mass transport limiting membrane is deposited upon the first active area and the second active area by sequential dip coating operations, and the mass transport limiting membrane comprises a bilayer membrane portion overcoating the first active area and a homogeneous membrane portion overcoating the second active area.