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公开(公告)号：US12055512B2
公开(公告)日：2024-08-06
申请号：US17151296
申请日：2021-01-18
发明人： John V. LaTour , Jonathan D. McCanless , Stephen Oja , Tianmei Ouyang , Kevin Paul Wallis , Benjamin J. Feldman , Udo Hoss , Suyue Qian
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , G01N27/3277
摘要： Methods and analyte sensors including a sensor tail comprising at least a first working electrode and a second working electrode that are spaced apart from one another along a length of the sensor tail. A first active area is disposed upon a surface of the first working electrode and a second active area is disposed upon a surface of the second working electrode, the first active area and the second active area being responsive to different analytes. A mass transport limiting membrane is deposited upon the first active area and the second active area by sequential dip coating operations, and the mass transport limiting membrane comprises a bilayer membrane portion overcoating the first active area and a homogeneous membrane portion overcoating the second active area.
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公开(公告)号：US12044648B2
公开(公告)日：2024-07-23
申请号：US17132360
申请日：2020-12-23
发明人： John V. LaTour , Jonathan D. McCanless , Stephen Oja , Tianmei Ouyang , Kevin Paul Wallis , Benjamin J. Feldman , Udo Hoss , Suyue Qian
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , G01N27/3277
摘要： Analyte sensors responsive at low working electrode potentials may comprise an active area upon a surface of a working electrode, wherein the active area comprises a polymer, a redox mediator covalently bonded to the polymer, and at least one analyte-responsive enzyme covalently bonded to the polymer. A specific redox mediator responsive at low potential may have a structure of
wherein G is a linking group covalently bonding the redox mediator to the polymer. A mass transport limiting membrane permeable to the analyte may overcoat the active area. In some sensor configurations, the mass transport limiting membrane may comprise a membrane polymer crosslinked with a branched crosslinker comprising three or more crosslinkable groups, such as polyethylene glycol tetraglycidyl ether.-
公开(公告)号：US20220386910A1
公开(公告)日：2022-12-08
申请号：US17819099
申请日：2022-08-11
发明人： Stephen OJA , Tianmei Ouyang , Hyun Cho , Lam N. Tran , Benjamin J. Feldman , Mark K. Sloan , AShwin Kumar , Namvar Kiaie , Michael R. Love
IPC分类号： A61B5/1486 , A61B5/145 , C12Q1/00
摘要： Methods and analyte sensors including at least a first working electrode having a first active area thereon, and performing a dip coating operation to deposit a bilayer membrane upon the first working electrode and the first active area. The bilayer may include an inner layer having a first membrane polymer and an outer layer having a second membrane polymer, the first membrane polymer and the second membrane polymer differing from one another. The dip coating operation may comprise one or more first dips in a first membrane formulation to form the inner layer of the bilayer membrane and one or more second dips in a second membrane formulation to form the outer layer of the bilayer membrane upon the inner layer.
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公开(公告)号：US20220186278A1
公开(公告)日：2022-06-16
申请号：US17548487
申请日：2021-12-10
发明人： Zenghe Liu , Stephen Oja , Tianmei Ouyang , Benjamin J. Feldman
摘要： The present disclosure provides an analyte sensor for use in detecting ketones. In certain embodiments, a ketones-responsive active site of a presently disclosed analyte sensor includes an enzyme system comprising β-hydroxybutyrate dehydrogenase and NADH oxidase disposed on a surface of a platinum working electrode. The present disclosure further provides methods for detecting ketones using the disclosed analyte sensors.
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公开(公告)号：US20200241015A1
公开(公告)日：2020-07-30
申请号：US16582583
申请日：2019-09-25
发明人： Tianmei Ouyang , Benjamin J. Feldman , Hyun Cho
IPC分类号： G01N33/70 , C12Q1/34 , C12Q1/00 , C12Q1/26 , G01N27/327
摘要： Creatinine levels may be monitored as a measure of kidney function. Conventionally, blood and/or urine tests are used for this purpose. Analyte sensors capable of monitoring creatinine in vivo may comprise: a sensor tail comprising at least a first working electrode, a creatinine-responsive active area disposed upon a surface of the first working electrode, a first membrane that is permeable to creatinine and overcoats the creatinine-responsive active area, and an oxygen scavenger located upon the sensor tail in proximity to the creatinine-responsive active area. The creatinine-responsive active area comprises a first electron transfer agent, a first polymer, and an enzyme system comprising multiple enzymes, particularly creatinine amidohydrolase, creatine amidohydrolase, and sarcosine oxidase, that are capable of acting in concert to facilitate detection of creatinine. An oxidase enzyme may serve as the oxygen scavenger, particularly glucose oxidase when detecting creatinine in fluids also containing glucose.
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公开(公告)号：US10219728B2
公开(公告)日：2019-03-05
申请号：US14445750
申请日：2014-07-29
发明人： Tianmei Ouyang , Zenghe Liu , Hyun Cho , Benjamin J. Feldman
IPC分类号： A61B5/1486 , A61B5/145 , A61B5/1473 , A61B5/1477 , A61B5/00
摘要： An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.
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公开(公告)号：US09914952B2
公开(公告)日：2018-03-13
申请号：US15183488
申请日：2016-06-15
IPC分类号： C12Q1/00 , G01N27/327 , C12N9/08 , C12N9/96 , C12N9/02
CPC分类号： C12Q1/005 , C12N9/0065 , C12N9/0069 , C12N9/96 , C12Y111/01006 , C12Y113/12004 , G01N2333/904 , G01N2333/908
摘要： Embodiments of the present disclosure relate to stabilized lactate oxidase compositions, and electrodes, sensors and systems that include the same. Also provided are methods for making the compositions and for detecting and/or measuring lactate in vivo with stable lactate enzyme compositions.
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公开(公告)号：US20170188904A1
公开(公告)日：2017-07-06
申请号：US15351162
申请日：2016-11-14
发明人： Benjamin J. Feldman , Zenghe Liu , Tianmei Ouyang
IPC分类号： A61B5/1486 , C12Q1/00 , A61B5/145 , G01N27/327 , A61B5/00 , A61B90/98
CPC分类号： A61B5/1486 , A61B5/0004 , A61B5/14532 , A61B5/6849 , A61B90/98 , C12Q1/005 , C12Q1/006 , G01N27/3273 , G01N27/3274 , G01N27/4035
摘要： Generally, embodiments of the invention relate to self-powered analyte determining devices (e.g., electrochemical analyte monitoring systems) that include a working electrode, a counter electrode, and an optional resistance value, where the working electrode includes analyte sensing components and the self-powered analyte determining device spontaneously passes a current directly proportional to analyte concentration in the absence of an external power source. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
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公开(公告)号：US20170138886A1
公开(公告)日：2017-05-18
申请号：US15360120
申请日：2016-11-23
发明人： Benjamin J. Feldman , Zenghe Liu , Tianmei Ouyang , Suyue Qian
IPC分类号： G01N27/327 , C12Q1/00
CPC分类号： G01N27/3272 , C12Q1/004 , C12Q1/006 , G01N27/327
摘要： Provided are sensors for determining the concentration of an analyte in a sample fluid. In certain embodiments, the sensors include conductive particles and exhibit improved uniformity of distribution of one or more sensing chemistry components, increased effective working electrode surface area, and/or reduced entry of interfering components into a sample chamber of the sensor. Methods of using and manufacturing the sensors are also provided.
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10.发明申请公开(公告)号：US20160045147A1
公开(公告)日：2016-02-18
申请号：US14737082
申请日：2015-06-11
发明人： Tianmei Ouyang , Benjamin J. Feldman , Udo Hoss , Balasubrahmanya S. Bommakanti , Gurinder Sandhu
IPC分类号： A61B5/1486
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/686
摘要： Disclosed herein are membrane structures for use in analyte sensors, where the membrane structures exhibit low temperature sensitivity.
摘要翻译： 本文公开了用于分析物传感器的膜结构，其中膜结构显示低温敏感性。
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