公开(公告)号：US20240337668A1

公开(公告)日：2024-10-10

申请号：US18632426

申请日：2024-04-11

申请人： Abbott Laboratories

发明人： Beth McQuiston ,  Saul Datwyler ,  Raj Chandran ,  Jaime Marino

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  G01N2333/435 ,  G01N2333/948 ,  G01N2800/28

摘要： Disclosed herein are methods that aid in the determination of whether a subject has or may have sustained an acquired brain injury, such as a traumatic brain injury (TBI), by detecting levels of at least one biomarker, glial fibrillary acidic protein (GFAP), in one or more samples taken from a subject, such as a human subject.

公开(公告)号：US20240110928A1

公开(公告)日：2024-04-04

申请号：US18474826

申请日：2023-09-26

申请人： Abbott Laboratories

发明人： Beth McQuiston ,  Saul Datwyler ,  Raj Chandran

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N2333/916 ,  G01N2800/28 ,  G01N2800/56

摘要： Disclosed herein are methods for aiding in the diagnosis and evaluation of a subject (e.g., a human subject) that has sustained or may have sustained an injury to the head, such as to determine whether the subject is suffering from a mild or a supermild traumatic brain injury.

公开(公告)号：US20230213536A1

公开(公告)日：2023-07-06

申请号：US18147094

申请日：2022-12-28

申请人： Abbott Laboratories

发明人： Beth McQuiston ,  Saul Datwyler ,  Raj Chandran

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  G01N2800/56 ,  G01N2800/28

摘要： Disclosed herein are methods that aid in the determination of whether a subject has a traumatic brain injury (TBI) by detecting levels of at least one biomarker, glial fibrillary acidic protein (GFAP), in samples taken from a subject, such as a human subject, where the subject has received a head CT scan that is negative for a TBI.

公开(公告)号：US20210072243A1

公开(公告)日：2021-03-11

申请号：US17095695

申请日：2020-11-11

申请人： Abbott Laboratories

发明人： Beth McQuiston ,  Justin Rogers ,  Saul Datwyler ,  Jaime Marino

IPC分类号： G01N33/573 ,  G01N33/68 ,  A61B6/03 ,  A61B6/00

摘要： Disclosed herein are methods that aid in the hyperacute diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild, moderate, severe, or moderate to severe traumatic brain injury (TBI), using an early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof. Also disclosed here are methods that aid in the hyperacute determination of whether a human subject that has sustained an injury or may have sustained to the head would benefit from and thus receive a head computerized tomography (CT) scan based on the levels of UCH-L1. These methods involve detecting changes of levels of an early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof, in samples taken from a human subject at a time point within about 2 hours, such as about 10, 12, or 20 minutes, after the subject has sustained or may have sustained an injury to the head and a second time point about 3 hours to about 6 hours after the first sample is taken.

公开(公告)号：US20210059594A1

公开(公告)日：2021-03-04

申请号：US17084568

申请日：2020-10-29

申请人： Abbott Laboratories

发明人： Beth McQuiston ,  Frederick Korley ,  Agim Beshiri ,  Jaime Marino ,  Saul Datwyler

IPC分类号： A61B5/00 ,  G01N33/68 ,  G01N33/543 ,  G01N33/577

摘要： Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or a moderate, severe, or moderate to severe traumatic brain injury (TBI), by detecting levels of cardiac troponin I (cTnI) and one or more early biomarkers which are not cTnI, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof, in biological samples taken from a human subject at time points within about 24 hours of injury after the subject has sustained or may have sustained the injury to the head.

公开(公告)号：US20180313837A1

公开(公告)日：2018-11-01

申请号：US15934541

申请日：2018-03-23

申请人： Abbott Laboratories

发明人： Beth McQuiston ,  Justin Rogers ,  Saul Datwyler ,  Jaime Marino

IPC分类号： G01N33/573 ,  A61B6/03 ,  A61B6/00

CPC分类号： G01N33/6896

摘要： Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or moderate to severe traumatic brain injury (TBI), using an early biomarker, ubiquitin carboxy-terminal hydrolase L1 (UCH-L1). Also disclosed here are methods that aid in determining whether a human subject that has sustained an injury or may have sustained to the head would benefit from and thus receive a head computerized tomography (CT) scan based on the levels of UCH-L1. These methods involve detecting levels and changes in levels of UCH-L1 in one or more samples taken from a human subject at time points within 24 hours after the subject has sustained or may have sustained an injury to the head.

公开(公告)号：US20230295684A1

公开(公告)日：2023-09-21

申请号：US18147360

申请日：2022-12-28

申请人： Abbott Laboratories

发明人： Beth McQuiston ,  Saul Datwyler ,  Raj Chandran

IPC分类号： C12Q1/44 ,  G01N33/68 ,  A61B5/00

CPC分类号： C12Q1/44 ,  A61B5/4064 ,  G01N33/68 ,  G01N2800/40

摘要： Disclosed herein are methods and systems of determining whether a subject’s levels of GFAP, UCH-L1, or GFAP and UCH-L1 are elevated in a sample collected from the subject. The methods comprise determining whether the levels of GFAP, UCH-L1, or GFAP and UCH-L1 are elevated in the sample, and communicating the determination on or from an instrument. The methods may be used to aid in the diagnosis and evaluation of a subject (e.g., a human subject) that has sustained or may have sustained an injury to the head, such as to determine whether the subject is suffering from a mild, moderate, severe, or moderate to severe traumatic brain injury (TBI).

公开(公告)号：US20220003786A1

公开(公告)日：2022-01-06

申请号：US17143345

申请日：2021-01-07

申请人： Abbott Laboratories

发明人： Saul A. Datwyler ,  Beth McQuiston ,  Elaine Brate ,  John Ramp ,  David Pacenti

IPC分类号： G01N33/68

摘要： Disclosed herein are methods of aiding in a diagnosis of a traumatic brain injury (TBI) in a subject suspected of having sustained or known to have sustained an injury to the head, by detecting at least one biomarker, wherein the at least one biomarker is glial fibrillary acidic protein (GFAP).

公开(公告)号：US20210389334A1

公开(公告)日：2021-12-16

申请号：US17316257

申请日：2021-05-10

申请人： Abbott Laboratories

发明人： Beth McQuiston ,  Saul Datwyler ,  Raj Chandran ,  Jaime Marino

IPC分类号： G01N33/68

摘要： Disclosed herein are methods of aiding in the diagnosis and evaluation of a subject that has sustained or may have sustained an injury to the head. For example, the present disclosure provides methods for aiding in the diagnosis and evaluation of a subject to determine whether the subject has sustained a traumatic brain injury (TBI) by detecting or measuring a combination of the levels of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) in samples taken at various time points within 48 hours after the subject has sustained or may have sustained an injury to the head.

公开(公告)号：US20210356477A1

公开(公告)日：2021-11-18

申请号：US17316267

申请日：2021-05-10

申请人： Abbott Laboratories

发明人： Beth McQuiston ,  Saul A. Datwyler ,  Raj Chandran

IPC分类号： G01N33/68

摘要： Disclosed herein are methods, and kits for use in said methods, that aid in the diagnosis and evaluation of a subject that has sustained an orthopedic injury and sustained or may have sustained an injury to the head, such as mild traumatic brain injury (TBI), using ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof. Also disclosed herein are methods, and kits for use in said methods, that aid in determining whether a subject that has sustained an orthopedic injury and sustained or may have sustained an injury to the head would benefit from and thus receive an imaging procedure, such as MRI or head computerized tomography (CT) scan based on the levels of GFAP and/or UCH-L1. These methods involve detecting levels and changes in levels of GFAP and/or UCH-L1 in biological samples taken from a subject at time points within 48 hours after the subject has sustained or may have sustained an injury to the head.