公开(公告)号：US20210084957A1

公开(公告)日：2021-03-25

申请号：US16971055

申请日：2019-02-19

申请人： ABBOTT LABORATORIES

发明人： Stephen J. Demichele ,  Mustafa Vurma ,  Megan Terp

IPC分类号： A23L33/00 ,  A23L33/12 ,  A23L33/155

摘要： Aqueous lipid emulsions for providing enteral nutrition are provided. The aqueous lipid emulsions include at least 33% of lipids, lipid soluble nutrients, or a combination thereof, based upon the total weight of the emulsion, and are essentially free of carbohydrate and protein. The aqueous lipid emulsions are shelf-stable for at least 7 months. The aqueous lipid emulsions are a source of supplemental enteral nutrition for any patient in need thereof, including preterm infants.

公开(公告)号：US12096785B2

公开(公告)日：2024-09-24

申请号：US16971055

申请日：2019-02-19

申请人： ABBOTT LABORATORIES

发明人： Stephen J. Demichele ,  Mustafa Vurma ,  Megan Terp

IPC分类号： A23L33/115 ,  A23L33/00 ,  A23L33/12 ,  A23L33/155 ,  A23L35/00

CPC分类号： A23L33/40 ,  A23L33/115 ,  A23L33/12 ,  A23L33/155 ,  A23L35/10

摘要： Aqueous lipid emulsions for providing enteral nutrition are provided. The aqueous lipid emulsions include at least 33% of lipids, lipid soluble nutrients, or a combination thereof, based upon the total weight of the emulsion, and are essentially free of carbohydrate and protein. The aqueous lipid emulsions are shelf-stable for at least 7 months. The aqueous lipid emulsions are a source of supplemental enteral nutrition for any patient in need thereof, including preterm infants.

公开(公告)号：US20230114071A1

公开(公告)日：2023-04-13

申请号：US17964609

申请日：2022-10-12

申请人： Abbott Laboratories

发明人： Paul Johns ,  Mustafa Vurma ,  Daniel Albrecht ,  Stephen DeMichele ,  Gary Katz ,  Todime Reddy

IPC分类号： A23L33/115 ,  A23L33/00 ,  A23L33/15 ,  A23C9/152 ,  A23L33/17 ,  A23L33/155 ,  A23L33/19

摘要： Disclosed herein is a nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising at least one assembly comprising at least one hydrophobic protein, monoglycerides and diglycerides (“MDG”) and at least one lipophilic compound, wherein at least 1% of the total MDG in the nutritional composition remains in the aqueous phase after centrifugation at 100,000×g for 1 hour at 20° C.

公开(公告)号：US11129404B2

公开(公告)日：2021-09-28

申请号：US16066585

申请日：2016-12-27

申请人： ABBOTT LABORATORIES

发明人： Tapas Das ,  Mustafa Vurma ,  Chron-Si Lai ,  Paul Johns

IPC分类号： A23L33/00 ,  A61K38/01 ,  A23L33/12 ,  A23L33/19 ,  A23L33/18 ,  A23L33/115 ,  A61K45/06 ,  A23L29/00 ,  A61P25/28 ,  A23L33/125 ,  A61K31/575 ,  A61K31/685

摘要： Disclosed embodiments provide nutritional compositions and methods of enhancing maturation of an infant's brain. The methods include the step of administering to the infant a nutritional composition comprising a protein with a degree of hydrolysis of 10% to 75% in combination with at least one of a monoglyceride, a free fatty acid, a salt of a free fatty acid, a phospholipid, and cholesterol.

公开(公告)号：US20160219913A1

公开(公告)日：2016-08-04

申请号：US14915552

申请日：2014-08-28

申请人： Abbott Laboratories

发明人： Paul Johns ,  Mustafa Vurma ,  Daniel Albrecht ,  Stephen DeMichele ,  Gary Katz ,  Todime Reddy

IPC分类号： A23L1/302 ,  A23D7/005 ,  A23L1/303

摘要： Disclosed herein is a nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising at least one assembly comprising at least one hydrophobic protein, monoglycerides and diglycerides (“MDG”) and at least one lipophilic compound, wherein at least 1% of the total MDG in the nutritional composition remains in the aqueous phase after centrifugation at 100,000×g for 1 hour at 20° C.

摘要翻译： 本文公开了具有至少一种蛋白质，至少一种脂肪和至少一种亲脂性化合物的营养组合物，所述组合物包含至少一种包含至少一种疏水性蛋白质，甘油单酯和甘油二酯（“MDG”）的组合物和至少一种 亲脂性化合物，其中营养组合物中总MDG的至少1％在20℃下以100,000×g离心1小时后残留在水相中。

公开(公告)号：US20160213041A1

公开(公告)日：2016-07-28

申请号：US14915548

申请日：2014-08-28

申请人： ABBOTT LABORATORIES

发明人： Paul Johns ,  Mustafa Vurma ,  Daniel Albrecht ,  Stephen DeMichele ,  Gary Katz ,  Todime Reddy

IPC分类号： A23D7/005 ,  A23L1/305

摘要： Disclosed herein is a nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising at least one assembly comprising at least one hydrophobic protein, monoglycerides and diglycerides (“MDG”) and at least one lipophilic compound, wherein at least 1% of the total MDG in the nutritional composition remains in the aqueous phase after centrifugation at 100,000×g for 1 hour at 20° C.

公开(公告)号：US20230270151A1

公开(公告)日：2023-08-31

申请号：US18056768

申请日：2022-11-18

申请人： Abbott Laboratories

发明人： Paul Johns ,  Mustafa Vurma ,  Daniel Albrecht ,  Stephen DeMichele ,  Gary Katz ,  Todime Reddy

IPC分类号： A23L33/115 ,  A23L33/00 ,  A23L33/15 ,  A23C9/152 ,  A23L33/17 ,  A23L33/155 ,  A23L33/19

CPC分类号： A23L33/115 ,  A23L33/40 ,  A23L33/15 ,  A23C9/1528 ,  A23L33/17 ,  A23L33/155 ,  A23L33/19 ,  A23C9/1526 ,  A23V2002/00

摘要： Disclosed herein is a nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising at least one assembly comprising at least one hydrophobic protein, monoglycerides and diglycerides (“MDG”) and at least one lipophilic compound, wherein at least 1% of the total MDG in the nutritional composition remains in the aqueous phase after centrifugation at 100,000×g for 1 hour at 20° C.

公开(公告)号：US09844227B2

公开(公告)日：2017-12-19

申请号：US14362532

申请日：2012-12-03

申请人： ABBOTT LABORATORIES

发明人： Mustafa Vurma ,  Gul Konuklar

IPC分类号： A23L29/212 ,  A23L2/52 ,  A23L29/10 ,  A23L29/30 ,  A23L33/00 ,  A23L33/10

CPC分类号： A23L29/212 ,  A23L2/52 ,  A23L5/00 ,  A23L21/00 ,  A23L29/10 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A23L33/40 ,  A23V2002/00

摘要： Disclosed are stabilized nutritional compositions having a stabilizer system including starch, or a combination of starch and maltotriose, and methods for manufacturing the compositions. The retrogradation effect commonly seen with starch stabilizers is substantially reduced or even eliminated in the disclosed nutritional compositions.

公开(公告)号：US20140335258A1

公开(公告)日：2014-11-13

申请号：US14362532

申请日：2012-12-03

申请人： ABBOTT LABORATORIES

发明人： Mustafa Vurma ,  Gul Konuklar

IPC分类号： A23L1/29 ,  A23L1/035

CPC分类号： A23L29/212 ,  A23L2/52 ,  A23L5/00 ,  A23L21/00 ,  A23L29/10 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A23L33/40 ,  A23V2002/00

摘要： Disclosed are stabilized nutritional compositions having a stabilizer system including starch, or a combination of starch and maltotriose, and methods for manufacturing the compositions. The retrogradation effect commonly seen with starch stabilizers is substantially reduced or even eliminated in the disclosed nutritional compositions.

摘要翻译： 公开了具有包括淀粉或淀粉和麦芽三糖的组合的稳定剂体系的稳定的营养组合物以及制备组合物的方法。 在所公开的营养组合物中，淀粉稳定剂常见的退化效应显着降低甚至消除。

公开(公告)号：US20160037817A1

公开(公告)日：2016-02-11

申请号：US14774526

申请日：2014-02-28

申请人： ABBOTT LABORATORIES

发明人： Paul Johns ,  Steven Dimler ,  Mustafa Vurma

IPC分类号： A23L1/304 ,  A23L1/29 ,  A23L1/305

CPC分类号： A23L33/40 ,  A23L33/16 ,  A23L33/17 ,  A23V2002/00 ,  A23V2200/244 ,  A23V2250/1578 ,  A23V2250/1618 ,  A23V2250/54

摘要： A nutritional composition comprising at least one protein, at least one macronutrient other than the at least one protein, and micronized calcium phosphate. The micronized calcium phosphate has a median particle size from about 0.20 to about 1.20 micrometers and may modify the viscosity of the nutritional composition. The micronization of the calcium phosphate may provide for increased bioavailability of calcium and phosphate and protein stability in the nutritional composition.

摘要翻译： 包含至少一种蛋白质，至少一种除了至少一种蛋白质以外的大量营养素和微粉化磷酸钙的营养组合物。 微粉化磷酸钙具有约0.20至约1.20微米的中值粒度，并可改变营养组合物的粘度。 磷酸钙的微粉化可提供营养组合物中钙和磷酸盐的增加的生物利用度和蛋白质的稳定性。