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公开(公告)号：US09951121B2
公开(公告)日：2018-04-24
申请号：US15064036
申请日：2016-03-08
Applicant: Academia Sinica
Inventor： An-Suei Yang , Yu-Ching Lee , Ing-Chien Chen , Chung-Ming Yu , Hung-Ju Hsu , Yi-Jen Huang , Hung-Ju Chang , Keng-Chang Tsai , Hung-Pin Peng
CPC classification number: C07K16/005 , C07K16/1018 , C07K16/22 , C07K2317/622 , C07K2317/624 , C07K2319/02 , C12N15/1037 , C12N15/1051 , C12N15/73 , C12N2795/00022 , C40B40/08 , C40B50/06
Abstract: Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.
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公开(公告)号：US09309522B2
公开(公告)日：2016-04-12
申请号：US13897850
申请日：2013-05-20
Applicant: Academia Sinica
Inventor： An-Suei Yang , Yu-Ching Lee , Ing-Chien Chen , Chung-Ming Yu , Hung-Ju Hsu , Yi-Jen Huang , Hung-Ju Chang , Keng-Chang Tsai , Hung-Pin Peng
CPC classification number: C07K16/005 , C07K16/1018 , C07K16/22 , C07K2317/622 , C07K2317/624 , C07K2319/02 , C12N15/1037 , C12N15/1051 , C12N15/73 , C12N2795/00022 , C40B40/08 , C40B50/06
Abstract: Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.
Abstract translation: 公开了用于鉴定促进二硫键稳定的单链抗体的产生并促进二硫键稳定的单链抗体的产生的信号肽的核酸文库。 还公开了宿主细胞文库和包括核酸文库的噬菌体文库。 进一步公开了用于鉴定促进二硫键稳定的单链抗体的产生的信号肽的方法，以及用于制备二硫键稳定的单链抗体及其非融合形式的方法。
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公开(公告)号：US20160176952A1
公开(公告)日：2016-06-23
申请号：US15064036
申请日：2016-03-08
Applicant: Academia Sinica
Inventor： An-Suei Yang , Yu-Ching Lee , Ing-Chien Chen , Chung-Ming Yu , Hung-Ju Hsu , Yi-Jen Huang , Hung-Ju Chang , Keng-Chang Tsai , Hung-Pin Peng
CPC classification number: C07K16/005 , C07K16/1018 , C07K16/22 , C07K2317/622 , C07K2317/624 , C07K2319/02 , C12N15/1037 , C12N15/1051 , C12N15/73 , C12N2795/00022 , C40B40/08 , C40B50/06
Abstract: Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.
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公开(公告)号：US20130323787A1
公开(公告)日：2013-12-05
申请号：US13897850
申请日：2013-05-20
Applicant: Academia Sinica
Inventor： An-Suei Yang , Yu-Ching Lee , Ing-Chien Chen , Chung-Ming Yu , Hung-Ju Hsu , Yi-Jen Huang , Hung-Ju Chang , Keng-Chang Tsai , Hung-Pin Peng
IPC: C12N15/73
CPC classification number: C07K16/005 , C07K16/1018 , C07K16/22 , C07K2317/622 , C07K2317/624 , C07K2319/02 , C12N15/1037 , C12N15/1051 , C12N15/73 , C12N2795/00022 , C40B40/08 , C40B50/06
Abstract: Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.
Abstract translation: 公开了用于鉴定促进二硫键稳定的单链抗体的产生并促进二硫键稳定的单链抗体的产生的信号肽的核酸文库。 还公开了宿主细胞文库和包括核酸文库的噬菌体文库。 进一步公开了用于鉴定促进二硫键稳定的单链抗体的产生的信号肽的方法，以及用于制备二硫键稳定的单链抗体及其非融合形式的方法。
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