公开(公告)号：US20060223849A1

公开(公告)日：2006-10-05

申请号：US11374723

申请日：2006-03-14

申请人： Adnan Mjalli ,  David Jones ,  Devi Gohimukkula ,  Guoxiang Huang ,  Jeff Zhu ,  Mohan Rao ,  Robert Andrews ,  Tan Ren

发明人： Adnan Mjalli ,  David Jones ,  Devi Gohimukkula ,  Guoxiang Huang ,  Jeff Zhu ,  Mohan Rao ,  Robert Andrews ,  Tan Ren

IPC分类号： A61K31/4709 ,  C07D417/02 ,  C07D413/02 ,  C07D403/02 ,  A61K31/4439

CPC分类号： C07D401/14 ,  A61K31/4725 ,  C07D235/30 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.

公开(公告)号：US20110065713A1

公开(公告)日：2011-03-17

申请号：US12950718

申请日：2010-11-19

申请人： Adnan M.M. Mjalli ,  David Jones ,  Devi Reddy Gohimmukkula ,  Guoxiang Huang ,  Jeff Zhu ,  Mohan Rao ,  Robert C. Andrews ,  Tan Ren

发明人： Adnan M.M. Mjalli ,  David Jones ,  Devi Reddy Gohimmukkula ,  Guoxiang Huang ,  Jeff Zhu ,  Mohan Rao ,  Robert C. Andrews ,  Tan Ren

IPC分类号： A61K31/4725 ,  C07D401/14 ,  A61K31/4439 ,  C07D401/12 ,  C07D417/14 ,  C07D403/12 ,  A61K31/4184 ,  C07D409/14 ,  C07D405/14 ,  C07D491/056 ,  A61K31/4741 ,  C07D471/04 ,  A61K31/4375 ,  A61K31/437 ,  A61K31/498 ,  C07D403/14 ,  A61K31/502 ,  C07D513/04 ,  A61K31/4365 ,  A61P25/28

CPC分类号： C07D401/14 ,  A61K31/4725 ,  C07D235/30 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.

摘要翻译： 本发明涉及抑制β-淀粉样蛋白前体蛋白切割酶（BACE）的苯扎唑化合物，其可用于治疗或预防BACE所涉及的疾病如阿尔茨海默氏病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及BACE的疾病中的用途。

公开(公告)号：US20090326006A1

公开(公告)日：2009-12-31

申请号：US11885096

申请日：2006-03-14

申请人： Adnan M.M. Mjalli ,  David Jones ,  Devi Reddy Gohmmukkula ,  Guoxiang Huang ,  Jeff Zhu ,  Mohan Rao ,  Robert C. Andrews ,  Tan Ren

发明人： Adnan M.M. Mjalli ,  David Jones ,  Devi Reddy Gohmmukkula ,  Guoxiang Huang ,  Jeff Zhu ,  Mohan Rao ,  Robert C. Andrews ,  Tan Ren

IPC分类号： A61K31/4725 ,  C07D401/14 ,  A61P25/28

CPC分类号： C07D401/14 ,  A61K31/4725 ,  C07D235/30 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.

摘要翻译： 本发明涉及抑制β-位淀粉样蛋白前体蛋白切割酶（BACE）的苯并唑化合物，其可用于治疗或预防BACE所涉及的疾病如阿尔茨海默氏病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及BACE的疾病中的用途。

公开(公告)号：US07893267B2

公开(公告)日：2011-02-22

申请号：US11885096

申请日：2006-03-14

申请人： Adnan M. M. Mjalli ,  David Jones ,  Devi Reddy Gohimmukkula ,  Guoxiang Huang ,  Jeff Zhu ,  Mohan Rao ,  Robert C. Andrews ,  Tan Ren

发明人： Adnan M. M. Mjalli ,  David Jones ,  Devi Reddy Gohimmukkula ,  Guoxiang Huang ,  Jeff Zhu ,  Mohan Rao ,  Robert C. Andrews ,  Tan Ren

IPC分类号： C07D217/12 ,  A61K31/47

CPC分类号： C07D401/14 ,  A61K31/4725 ,  C07D235/30 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.

摘要翻译： 本发明涉及抑制β-淀粉样蛋白前体蛋白切割酶（BACE）的苯扎唑化合物，其可用于治疗或预防BACE所涉及的疾病如阿尔茨海默氏病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及BACE的疾病中的用途。

公开(公告)号：US20070021386A1

公开(公告)日：2007-01-25

申请号：US11511163

申请日：2006-08-28

申请人： Adnan Mjalli ,  Robert Andrews ,  Ramesh Gopalaswamy ,  Anitha Hari ,  Kwasi Avor ,  Ghassan Qabaja ,  Xiao-Chuan Guo ,  Suparna Gupta ,  David Jones ,  Xin Chen

发明人： Adnan Mjalli ,  Robert Andrews ,  Ramesh Gopalaswamy ,  Anitha Hari ,  Kwasi Avor ,  Ghassan Qabaja ,  Xiao-Chuan Guo ,  Suparna Gupta ,  David Jones ,  Xin Chen

IPC分类号： A61K31/695 ,  A61K31/4172

CPC分类号： C07D233/64 ,  C07D235/08 ,  C07D235/12 ,  C07D235/14 ,  C07D235/18 ,  C07D235/30 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/12 ,  C07D413/12 ,  C07D453/02

摘要： This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, β-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.

摘要翻译： 本发明提供某些化合物，其制备方法，包含该化合物的药物组合物及其在治疗人或动物疾病中的用途。 本发明的化合物可用作晚期糖基化终产物（RAGE）的受体与其配体如晚期糖基化终产物（AGE），S100 /钙粒蛋白/ EN-RAGE，β-淀粉样蛋白和两性蛋白之间相互作用的调节剂 ，以及由RAGE引起的人类疾病的管理，治疗，控制或辅助治疗。 这些疾病或疾病状态包括急性和慢性炎症，糖尿病晚期并发症的发展，例如血管通透性增加，肾病，动脉粥样硬化和视网膜病变，阿尔茨海默病的发展，勃起功能障碍和肿瘤侵袭和转移。

公开(公告)号：US20070213347A1

公开(公告)日：2007-09-13

申请号：US11800085

申请日：2007-05-03

申请人： Adnan Mjalli ,  Robert Andrews ,  Ramesh Gopalaswamy ,  Anitha Hari ,  Kwasi Avor ,  Ghassan Qabaja ,  Xiao-Chuan Guo ,  Supama Gupta ,  David Jones ,  Xin Chen

发明人： Adnan Mjalli ,  Robert Andrews ,  Ramesh Gopalaswamy ,  Anitha Hari ,  Kwasi Avor ,  Ghassan Qabaja ,  Xiao-Chuan Guo ,  Supama Gupta ,  David Jones ,  Xin Chen

IPC分类号： A61K31/4184 ,  A61K31/4164 ,  A61K31/496 ,  C07D233/61 ,  C07D235/18 ,  C07D403/12

CPC分类号： C07D233/64 ,  C07D235/08 ,  C07D235/12 ,  C07D235/14 ,  C07D235/18 ,  C07D235/30 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/12 ,  C07D413/12 ,  C07D453/02

摘要： This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, β-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.

公开(公告)号：US20110230458A1

公开(公告)日：2011-09-22

申请号：US13028036

申请日：2011-02-15

申请人： Devi R. Gohimukkula ,  David Jones ,  Ghassan Qabaja ,  Jeff J. Zhu ,  Jeremy T. Cooper ,  William K. Banner ,  Kurt Sundermann ,  Muralidhar Bondlela ,  Mohan Rao ,  Pingzhen Wang ,  Raju B. Gowda ,  Robert C. Andrews ,  Suparna Gupta ,  Anitha Hari

发明人： Devi R. Gohimukkula ,  David Jones ,  Ghassan Qabaja ,  Jeff J. Zhu ,  Jeremy T. Cooper ,  William K. Banner ,  Kurt Sundermann ,  Muralidhar Bondlela ,  Mohan Rao ,  Pingzhen Wang ,  Raju B. Gowda ,  Robert C. Andrews ,  Suparna Gupta ,  Anitha Hari

IPC分类号： A61K31/397 ,  C07D401/12 ,  A61K31/501 ,  C07D413/12 ,  A61K31/5377 ,  C07D401/14 ,  C07D413/14 ,  A61P29/00 ,  A61P17/00 ,  A61P11/00 ,  A61P3/10 ,  A61P13/12 ,  A61P9/00 ,  A61P25/00 ,  A61P15/10 ,  A61P19/10 ,  A61P35/04

CPC分类号： C07D401/12 ,  A61K31/497 ,  C07D237/14 ,  C07D237/24 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D451/06 ,  C07D453/02 ,  C07D471/04

摘要： The present invention provides phenyl-heteroaryl derivatives of Formula (I) and pharmaceutically acceptable salts thereof These compounds are useful in the treatment of RAGE-mediated diseases such as Alzheimer's Disease.The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating RAGE-mediated diseases.

摘要翻译： 本发明提供式（I）的苯基 - 杂芳基衍生物及其药学上可接受的盐。这些化合物可用于治疗RAGE介导的疾病如阿尔茨海默氏病。 本发明还涉及制备式（I）的化合物及其药学上可接受的盐，包含这些化合物的药物组合物的方法，以及这些化合物和/或药物组合物在治疗RAGE介导的疾病中的用途。

公开(公告)号：US08940387B2

公开(公告)日：2015-01-27

申请号：US13262581

申请日：2010-04-01

申请人： Caroline OLeary ,  Marcello Venturelli ,  John OSullivan ,  David Jones

发明人： Caroline OLeary ,  Marcello Venturelli ,  John OSullivan ,  David Jones

IPC分类号： B41M5/00 ,  B44C1/17 ,  G03G7/00 ,  D06Q1/10 ,  B32B27/08 ,  B41M5/52 ,  B41M5/50 ,  B32B15/08 ,  D06P5/24 ,  D06Q1/12 ,  D06Q1/14

CPC分类号： D06P5/003 ,  B32B15/08 ,  B32B27/08 ,  B41M5/506 ,  B41M5/508 ,  B41M5/52 ,  B41M5/5218 ,  D06Q1/10 ,  D06Q1/12 ,  D06Q1/14 ,  Y10S428/9133 ,  Y10T156/10 ,  Y10T428/1476 ,  Y10T428/24802 ,  Y10T428/24851

摘要： An appliqué of the invention comprises a disposable carrier film onto which a release layer and PU inks are printed using layering techniques. The ink layers can be multicoloured and each color is applied sequentially using a conventional screen-printing method. A back-up, a lacquer layer, and an adhesive layer are printed in sequence over the ink layers. The ink includes reflective particles providing the optical effect of a 3-dimensional appliqué. The artwork is created by overlapping design layers to controlled specification sequences. The ink, because of the additives, creates a desired color tone, and this may be enhanced by layering of the ink in an overlapping region. Thus, there are three main regions, namely a central region with reflective ink, a “shoulder” region with overlapping matt and reflective inks and an outer region with only matt ink.

摘要翻译： 本发明的贴花包括一次性载体膜，使用分层技术在其上印刷释放层和PU油墨。 油墨层可以是多色的，并且使用常规的丝网印刷方法依次应用各种颜色。 备份，漆层和粘合剂层依次印刷在油墨层上。 油墨包括提供三维贴花的光学效果的反射颗粒。 艺术品是通过将设计层重叠到受控的规格序列而创建的。 由于添加剂，油墨产生所需的色调，并且可以通过在重叠区域中分层油墨来增强油墨。 因此，存在三个主要区域，即具有反射墨水的中心区域，具有重叠的亚光和反射墨水的“肩部”区域和仅具有无光墨水的外部区域。

公开(公告)号：USPP24868P2

公开(公告)日：2014-09-09

申请号：US13573615

申请日：2012-09-27

申请人： Jimmy Jones ,  David Jones

发明人： Jimmy Jones ,  David Jones

IPC分类号： A01H5/00

CPC分类号： A01H5/02

摘要： A new and distinct cultivar of Diascia plant named ‘Sunjodiblupi’, characterized by its semi-upright and mounding plant habit; long and strong flowering stems; early and long flowering period; numerous large red purple-colored flowers; and good garden performance.

摘要翻译： 一种新的和独特的Diascia植物品种“Sunjodiblupi”，其特征是其半直立和堆肥植物习性; 长而强壮的开花茎; 早开花期; 许多大红色紫色花朵; 和良好的花园表演。

公开(公告)号：US08801065B1

公开(公告)日：2014-08-12

申请号：US14090054

申请日：2013-11-26

申请人： David Jones

发明人： David Jones

IPC分类号： A45F5/00 ,  H05K5/02 ,  A45F5/10

CPC分类号： A45F5/10 ,  A45F2005/1006 ,  A45F2200/0525 ,  G06F1/1613 ,  Y10T16/476

摘要： A carrying device for an electronic device including a unitary body having a handle and a base, the handle having a centrally disposed aperture and a concave opening in each of the right and left sides of the handle to receive a user's fingers therethrough is provided. A pivotable first flange and an identical second flange are disposed on a base, each flange having a folding score line to allow the device to pivot from a first position to a second position when in use with a laptop. Each flange has an adhesive inner wall to attach the carrying device to an electronic device. A channel, configured to receive an outer edge of an electronic device, is disposed between the first and second flanges to permit a user to transport an electronic device without the need for a satchel or carrying case.

摘要翻译： 提供了一种电子装置的携带装置，其包括具有手柄和基座的整体，手柄具有居中设置的孔和在手柄的左右两侧的凹入开口，用于接收使用者的手指。 可枢转的第一凸缘和相同的第二凸缘设置在基座上，每个凸缘具有折叠刻痕线，以在与笔记本电脑一起使用时允许装置从第一位置枢转到第二位置。 每个凸缘都具有粘合剂内壁，用于将承载装置附接到电子装置。 配置成接收电子设备的外边缘的通道设置在第一和第二凸缘之间，以允许用户运输电子设备而不需要手提包或手提箱。