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    Process for preparing crystalline salts of acetoacetamide-N-sulfofluoride
    6.
    发明授权
    Process for preparing crystalline salts of acetoacetamide-N-sulfofluoride 失效
    制备乙酰乙酰胺-N-磺酰氟的结晶盐的方法

    公开(公告)号：US4618455A

    公开(公告)日：1986-10-21

    申请号：US713466

    申请日：1985-03-19

    申请人： Adolf Linkies ,  Dieter Reuschling

    发明人： Adolf Linkies ,  Dieter Reuschling

    IPC分类号： A23L27/30 ,  B01J27/00 ,  B01J27/232 ,  C07B61/00 ,  C07C67/00 ,  C07C301/00 ,  C07C303/36 ,  C07C307/00 ,  C07C307/02 ,  C07C311/00 ,  C07D291/06 ,  C07C143/70

    CPC分类号： C07D291/06

    摘要： Crystalline salts of acetoacetamide-N-sulfofluoride are prepared by reacting amidosulfofluoride H.sub.2 NSO.sub.2 F with diketene in the presence of inorganic bases, preferably alkali metal carbonates and/or hydrogencarbonates, in particular potassium carbonate, in an inert organic solvent.The salts can be further processed with further base, for example with methanolic KOH, into salts of 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one-2,2-dioxide; the potassium salt, in particular, is important for use as a sweetener ("Acesulfame").

    摘要翻译： 在惰性有机溶剂中，在无机碱，优选碱金属碳酸盐和/或碳酸氢盐，特别是碳酸钾的存在下，使酰胺二氟化物H 2 NSO 2 F与双烯酮反应，制备乙酰乙酰胺-N-氟磺酸盐的结晶盐。 盐可以进一步用另外的碱例如与甲醇KOH一起加工成6-甲基-3,4-二氢-1,2,3-氧杂噻嗪-4-酮-2,2-二氧化物的盐; 特别地，钾盐对于用作甜味剂（“Acesulfame”）是重要的。

    Process for the preparation of 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide and its non-toxic salts
    7.
    发明授权
    Process for the preparation of 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide and its non-toxic salts 失效
    制备6-甲基-3,4-二氢-1,2,3-氧杂噻嗪-4-酮2,2-二氧化物及其无毒盐的方法

    公开(公告)号：US4607100A

    公开(公告)日：1986-08-19

    申请号：US714177

    申请日：1985-03-20

    申请人： Karl Clauss ,  Adolf Linkies ,  Dieter Reuschling

    发明人： Karl Clauss ,  Adolf Linkies ,  Dieter Reuschling

    IPC分类号： A23L27/30 ,  B01J31/00 ,  B01J31/02 ,  B01J31/24 ,  C07B61/00 ,  C07C303/34 ,  C07C307/02 ,  C07C311/46 ,  C07D291/06

    CPC分类号： C07D291/06

    摘要： 6-Methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide is prepared by(a) reacting, in an inert organic solvent, a salt of sulfamic acid, which is at least partially soluble therein, with at least approximately the equimolar amount of an acetoacetylating agent, in the presence of an amine or phosphine catalyst, and by cyclizing the acetoacetamide-N-sulfonate which is formed in this reaction, or the free sulfonic acid,(b) by the action of at least approximately the equimolar amount of SO.sub.3, where appropriate in an inert inorganic or organic solvent, to give 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide, which is produced in the form of the acid in this reaction;it is possible, if desired, to obtain from the acid form(c) the appropriate salts by neutralization with bases.The non-toxic salts--in particular the potassium salt--are valuable synthetic sweeteners.

    摘要翻译： 6-甲基-3,4-二氢-1,2,3-氧杂噻嗪-4-酮2,2-二氧化物通过以下步骤制备：（a）在惰性有机溶剂中使氨基磺酸盐至少 至少约等摩尔量的乙酰乙酰化剂，在胺或膦催化剂的存在下，通过使在该反应中形成的乙酰乙酰胺-N-磺酸盐或游离磺酸（b ）通过至少近似等摩尔量的SO 3的作用，在适当的惰性无机或有机溶剂中，得到6-甲基-3,4-二氢-1,2,3-氧杂噻嗪-4-酮2,2 在该反应中以酸的形式产生的二氧化物; 如果需要，可以通过用碱中和从酸形式（c）获得适当的盐。 无毒盐 - 特别是钾盐 - 是有价值的合成甜味剂。