公开(公告)号：US20080004270A1

公开(公告)日：2008-01-03

申请号：US11571713

申请日：2005-07-05

申请人： Adrian Gill ,  Maria Carr ,  Michael O'Brien ,  Paul Wyatt ,  Valerio Berdini

发明人： Adrian Gill ,  Maria Carr ,  Michael O'Brien ,  Paul Wyatt ,  Valerio Berdini

IPC分类号： A61K31/5377 ,  A61K31/4188 ,  A61P25/28 ,  A61P35/00 ,  C07D235/02 ,  C07D471/02 ,  C07D265/34 ,  A61P37/00 ,  A61P31/12 ,  A61K31/47

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D495/04

摘要： The invention provides compounds of the formula (I); or salts or solvates or N-oxides thereof; wherein: Rq is selected from groups (a), (b) and (c); the asterisk denoting the point of attachment to the pyrazole ring; X is N or CR5; X″ is NR4; O, S or S(O); A is a bond or —(CH2)m—(B)n—; B is C═O, NRg(C═O) or O(C═O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; m is 0, 1 or 2; n is 0 or 1; R0 is hydrogen or, together with NRg when present, forms a group —(CH2)p— wherein p is 2 to 4; and R1 to R6b are as defined in the description. Compounds of the formula (I) have activity as inhibitors of CDK, aurora and GSK-3 kinases are useful in treating or preventing diseases such as cancers that are mediated by the said kinases.

摘要翻译： 本发明提供式（I）化合物; 或其盐或溶剂合物或N-氧化物; 其中：R q选自（a），（b）和（c）组; 星号表示与吡唑环的连接点; X是N或CR 5; X“是NR 4; O，S或S（O）; A是键或 - （CH 2）m - （B）n - B为CO，NR（CO）或O（CO），其中R为氢或任选被羟基取代的C 1-4烷基烃基 或C 1-4烷氧基; m为0,1或2; n为0或1; 当存在时，R 0是氢或与NR a一起形成基团 - （CH 2 CH 2）n - - 其中p为2至4; 和R 1至R 6b如说明书中所定义。 式（I）化合物具有作为CDK抑制剂的活性，极光和GSK-3激酶可用于治疗或预防诸如由所述激酶介导的癌症的疾病。

公开(公告)号：US20060194843A1

公开(公告)日：2006-08-31

申请号：US11336599

申请日：2006-01-20

申请人： Valerio Berdini ,  Michael O'Brien ,  Maria Carr ,  Theresa Early ,  Adrian Gill ,  Gary Trewartha ,  Alison Woolford ,  Andrew Woodhead ,  Paul Wyatt

发明人： Valerio Berdini ,  Michael O'Brien ,  Maria Carr ,  Theresa Early ,  Adrian Gill ,  Gary Trewartha ,  Alison Woolford ,  Andrew Woodhead ,  Paul Wyatt

IPC分类号： A61K31/454 ,  A61K31/416 ,  A61K31/4152 ,  C07D403/02

CPC分类号： C07D231/38 ,  A61K31/415 ,  A61K31/4152 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C04B35/632 ,  C07D231/14 ,  C07D231/40 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D453/02 ,  C07D471/04

摘要： The invention provides compounds of the formula (0) or salts or tautomers or N-oxides or solvates thereof for use in the prophylaxis or treatment of disease states and conditions such as cancers mediated by cyclin-dependent kinase and glycogen synthase kinase-3. In formula (0): X is a group R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C═O, NRg(C═O) or O(C═O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g. fluorine), hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy (e.g. methoxy); or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy); R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy).

公开(公告)号：US20070135477A1

公开(公告)日：2007-06-14

申请号：US10564166

申请日：2004-07-05

申请人： Valerio Berdini ,  Michael O'Brien ,  Maria Carr ,  Theresa Early ,  Eva Navarro ,  Adrian Gill ,  Steven Howard ,  Gary Trewartha ,  Alison Woolford ,  Andrew Woodhead ,  Paul Wyatt

发明人： Valerio Berdini ,  Michael O'Brien ,  Maria Carr ,  Theresa Early ,  Eva Navarro ,  Adrian Gill ,  Steven Howard ,  Gary Trewartha ,  Alison Woolford ,  Andrew Woodhead ,  Paul Wyatt

IPC分类号： A61K31/4745 ,  A61K31/4184 ,  C07D403/04

CPC分类号： A61K31/5377 ,  A61K31/00 ,  A61K31/4184 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04 ,  C07D513/04

摘要： The invention provides compounds of the formula (1): The compounds have activity against cyclin depdenent kinases, glycogen synthase kinase and Auroa kinases and are therefore useful to treat cancer and viral diseases.

摘要翻译： 本发明提供式（1）化合物：该化合物对细胞周期蛋白依赖性激酶，糖原合酶激酶和Auroa激酶具有活性，因此可用于治疗癌症和病毒性疾病。

公开(公告)号：US20070105900A1

公开(公告)日：2007-05-10

申请号：US10563350

申请日：2004-07-04

申请人： Valerio Berdini ,  Andrew Woodhead ,  Paul Wyatt ,  Michael O'Brien ,  Eva Navarro

发明人： Valerio Berdini ,  Andrew Woodhead ,  Paul Wyatt ,  Michael O'Brien ,  Eva Navarro

IPC分类号： A61K31/4709 ,  A61K31/4745 ,  A61K31/422 ,  A61K31/42 ,  A61K31/4439 ,  A61K31/4178 ,  A61K31/416 ,  C07D403/14 ,  C07D471/02

CPC分类号： C07D401/14 ,  A61K31/00 ,  A61K31/4184 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

摘要： The invention provides compounds of the formula (I): The compounds have activity against cyclin dependent kinases, glycogen synthase kinase and Auroa kinases and are therefore useful to treat cancer and viral diseases.

摘要翻译： 本发明提供式（I）化合物：该化合物具有抗细胞周期蛋白依赖性激酶，糖原合成酶激酶和Auroa激酶的活性，因此可用于治疗癌症和病毒性疾病。

公开(公告)号：US20070259886A1

公开(公告)日：2007-11-08

申请号：US11680818

申请日：2007-03-01

申请人： Gianni Chessari ,  Maria Carr ,  Miles Congreve ,  Robert Downham ,  Martyn Frederickson ,  Christopher Murray ,  Eva Navarro ,  Michael O'Brien ,  Theresa Phillips ,  Andrew Woodhead

发明人： Gianni Chessari ,  Maria Carr ,  Miles Congreve ,  Robert Downham ,  Martyn Frederickson ,  Christopher Murray ,  Eva Navarro ,  Michael O'Brien ,  Theresa Phillips ,  Andrew Woodhead

IPC分类号： A61K31/497 ,  A61P35/00 ,  C07D403/00

CPC分类号： C07D209/44 ,  C07D401/04 ,  C07D401/12

摘要： Compounds having the formula (I): and in particular, those of subgenus VIIa are disclosed as inhibits or modulators of the activity of the heat shock protein Hsp90. As such they are useful for treating cancer, particularly hematopoietic tumors of lymphoid or myeloid lineage, prostate cancer, lung cancer, gastrointestinal stromal tumor, breast cancer and melanoma.

摘要翻译： 公开了具有式（I）：特别是亚属VIIa的化合物作为热休克蛋白Hsp90的活性的抑制剂或调节剂。 因此，它们可用于治疗癌症，特别是淋巴或骨髓谱系的造血肿瘤，前列腺癌，肺癌，胃肠道间质瘤，乳腺癌和黑素瘤。

公开(公告)号：US20070259871A1

公开(公告)日：2007-11-08

申请号：US11680830

申请日：2007-03-01

申请人： Gianni Chessari ,  Maria Carr ,  Miles Congreve ,  Robert Downham ,  Martyn Frederickson ,  Christopher Murray ,  Eva Navarro ,  Michael O'Brien ,  Theresa Phillips ,  Andrew Woodhead ,  Alison Woolford

发明人： Gianni Chessari ,  Maria Carr ,  Miles Congreve ,  Robert Downham ,  Martyn Frederickson ,  Christopher Murray ,  Eva Navarro ,  Michael O'Brien ,  Theresa Phillips ,  Andrew Woodhead ,  Alison Woolford

IPC分类号： A61K31/4035 ,  A61K31/47 ,  A61K31/496 ,  A61K31/5377 ,  A61P35/00 ,  C07D209/04 ,  C07D215/00 ,  C07D217/00 ,  C07D227/00 ,  C07D241/00 ,  C07D265/30 ,  C07D401/02 ,  C07D471/00

CPC分类号： C07D401/12 ,  C07C65/21 ,  C07D209/08 ,  C07D209/44 ,  C07D215/08 ,  C07D217/06 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D471/10 ,  C07D491/08 ,  C07D491/10

摘要： The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors.

摘要翻译： 本发明提供式（I）的化合物：或其盐，互变异构体，溶剂合物和N-氧化物; 其中R 1是羟基或氢; R 2是羟基; 甲氧基或氢; 条件是R 1和R 2中的至少一个是羟基; R 3选自氢; 卤素; 氰基; 任选取代的C 1-5烃基和任选取代的C 1-5 - 烃氧基; R 4选自氢; 其中n为0或1且R 7为任选取代的无环C 1 - （O）N - ， - -5个烃基或具有3〜7个环成员的单环碳环或杂环基; 卤素; 氰基; 羟基; 氨基; 和任选取代的单或二-C 1-5烃基 - 氨基; 或R 3和R 4一起形成5至7个环成员的单环碳环或杂环; 并且NR 5 R 6形成具有8至12个环成员的任选取代的双环杂环基，其中多达5个环成员是选自氧，氮和硫的杂原子。 该化合物具有作为Hsp90抑制剂的活性。

公开(公告)号：US09628256B2

公开(公告)日：2017-04-18

申请号：US13885221

申请日：2011-11-15

申请人： Conor O'Keeffe ,  Michael O'Brien

发明人： Conor O'Keeffe ,  Michael O'Brien

IPC分类号： H04B17/00 ,  H04L7/00 ,  H01Q3/26 ,  H04B7/10 ,  H04B17/12 ,  H04B17/21

CPC分类号： H04L7/0016 ,  H01Q3/267 ,  H04B7/10 ,  H04B17/12 ,  H04B17/21

摘要： A multiple input multiple output (MIMO) calibration device (360) for calibrating a phase relationship between at least two signals present on at least two radio frequency (RF) paths coupling a wireless communication unit and the MIMO calibration device (360) is described. The MIMO calibration device (360) is operably coupleable via at least two RF paths between a wireless communication unit and an antenna arrangement (219). The calibration device (360) comprises a processing module (490) configured to: process a coupled amount of at least one first signal from a first path operably coupleable to a first polarization of the antenna arrangement (219) to determine at least one pilot signal from said at least one first signal; process a coupled amount of at least one second signal from a second path operably coupleable to at least one second polarization feed of antenna arrangement (219), different to the first polarization, to determine the at least one pilot signal from said at least one second signal; and determine a first phase relationship of the same pilot signal between the at least two RF paths.

公开(公告)号：US20160124901A9

公开(公告)日：2016-05-05

申请号：US13845007

申请日：2013-03-17

申请人： Matthew Banet ,  Larkin Lowrey ,  Paul Washicko ,  Michael O'Brien

发明人： Matthew Banet ,  Larkin Lowrey ,  Paul Washicko ,  Michael O'Brien

IPC分类号： G06F17/00

CPC分类号： G07C5/00 ,  G06F17/00 ,  G07C5/008 ,  G08G1/00 ,  G08G1/20

摘要： Embodiments of the present invention provide a wireless appliance for monitoring a vehicle. The wireless appliance includes a microprocessor configured to select a vehicle-communication protocol of a host vehicle, and then communicate with the host vehicle through the vehicle-communication protocol. The appliance also includes a vehicle-communication circuit, in electrical communication with the microprocessor, which collects diagnostic data from the host vehicle using the vehicle-communication protocol. A GPS module, also in electrical communication with the microprocessor, generates location-based data. For transmitting these data, the appliance includes a first wireless transmitter operating on a terrestrial network and a second wireless transmitter operating on a satellite network. The microprocessor selects the first or second wireless transmitter for transmitting the diagnostic and location-based data.

摘要翻译： 本发明的实施例提供了一种用于监控车辆的无线设备。 无线设备包括被配置为选择主车辆的车辆通信协议，然后通过车辆通信协议与主车辆通信的微处理器。 该设备还包括与微处理器电通信的车辆通信电路，其使用车辆通信协议从主车辆收集诊断数据。 还与微处理器进行电气通信的GPS模块生成基于位置的数据。 为了发送这些数据，该设备包括在陆地网络上操作的第一无线发射机和在卫星网络上操作的第二无线发射机。 微处理器选择用于发送诊断和基于位置的数据的第一或第二无线发射机。

公开(公告)号：US09035828B2

公开(公告)日：2015-05-19

申请号：US13201566

申请日：2010-02-10

申请人： Conor O'Keeffe ,  Michael O'Brien

发明人： Conor O'Keeffe ,  Michael O'Brien

IPC分类号： H01Q3/26 ,  H04B17/00 ,  H01Q1/24 ,  H04B7/10

CPC分类号： H01Q3/267 ,  H01Q1/246 ,  H04B7/10 ,  H04B17/0085 ,  H04B17/12 ,  H04B17/20 ,  H04B17/21

摘要： A method for calibrating (700) an antenna array comprises a plurality of antenna elements coupled to a plurality of respective receive paths in a wireless communication system. The method comprises, in receive mode, applying a test signal to an individual single receive path (715) of the plurality of receive paths; and feeding back the test signal via a switched coupler network. The method further comprises running a receive calibration measurement routine to determine at least one measurement value used to calibrate the individual signal receive path and waiting for at least one converged measurement value; and extracting (720) the converged measurement value for at least one individual receive path. The steps of applying, running, extracting for a next individual single receive path are repeated until the calibration routine has completed (725). The method further comprises selecting a converged measurement value of at least one individual receive path from a plurality of receive paths (730) to form a reference receiver calibration result (730); normalizing a plurality of at least one measurement values of the plurality of receive paths using the reference receiver calibration result (730); and applying a normalized value to at least one of the plurality of receive paths.

摘要翻译： 用于校准（700）天线阵列的方法包括耦合到无线通信系统中的多个相应接收路径的多个天线元件。 该方法包括在接收模式下，将测试信号施加到多个接收路径中的单个单个接收路径（715）; 并通过交换耦合器网络反馈测试信号。 该方法还包括运行接收校准测量程序以确定用于校准各个信号接收路径和等待至少一个会聚测量值的至少一个测量值; 以及提取（720）用于至少一个个体接收路径的收敛测量值。 重复下一个单个接收路径的应用，运行，提取步骤，直到校准程序完成（725）。 该方法还包括从多个接收路径（730）中选择至少一个单独接收路径的会聚测量值以形成参考接收机校准结果（730）; 使用参考接收机校准结果对所述多个接收路径的多个至少一个测量值进行归一化（730）; 以及将归一化值应用于所述多个接收路径中的至少一个。

公开(公告)号：US08675685B2

公开(公告)日：2014-03-18

申请号：US13061626

申请日：2008-09-05

申请人： Paul Kelleher ,  Michael O'Brien ,  Conor O'Keeffe

发明人： Paul Kelleher ,  Michael O'Brien ,  Conor O'Keeffe

IPC分类号： H04J3/24

CPC分类号： H04W56/0045 ,  H04B1/40 ,  H04B15/02 ,  H04B2215/067

摘要： A semiconductor device comprising interface logic for transmitting data bursts across an interface. The interface logic is arranged to transmit bursts of data across the interface such that the start of a burst of data is substantially aligned with a symbol interval (SI) boundary. The interface logic is further arranged to apply an offset to the SI boundary at the start of the burst of data.

摘要翻译： 一种半导体器件，包括用于通过接口传输数据脉冲串的接口逻辑。 接口逻辑被布置成通过接口传输数据脉冲串，使得数据突发的开始基本上与符号间隔（SI）边界对齐。 接口逻辑还被布置为在数据突发的开始处向SI边界应用偏移。