公开(公告)号：US20180280487A1

公开(公告)日：2018-10-04

申请号：US15767625

申请日：2016-10-14

申请人： ADVAXIS, INC.

发明人： Robert Petit ,  Kyle Perry

IPC分类号： A61K39/00 ,  A61K39/02 ,  A61K39/39 ,  A61K39/245 ,  A61P35/00 ,  A61K35/74

摘要： The present invention provides methods of treating, protecting against, and inducing an immune response against a human papillomavirus-associated tumor or cancer, comprising the step of administering to a subject a recombinant Listeria strain expressing a construct comprising at least one human papillomavirus antigen.

公开(公告)号：US20180305702A1

公开(公告)日：2018-10-25

申请号：US15563447

申请日：2016-09-14

申请人： Advaxis, Inc.

发明人： Robert Petit ,  Michael F. Princiotta ,  Kyle Perry

IPC分类号： C12N15/74 ,  C07K14/195 ,  C12N9/64 ,  C07K14/47 ,  C12N9/90 ,  C12N9/10

CPC分类号： C12N15/74 ,  A61K39/00 ,  A61K39/0011 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/585 ,  C07K14/195 ,  C07K14/4747 ,  C07K14/4748 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/03 ,  C12N9/1096 ,  C12N9/6424 ,  C12N9/6445 ,  C12N9/90 ,  C12Y206/01021 ,  C12Y304/21077 ,  C12Y304/21106 ,  C12Y501/01001

摘要： Disclosed herein are recombinant Listeria strains comprising nucleotides encoding two or more heterologous antigens each fused to a truncated LLO, an N-terminal ActA or a PEST-sequence, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering same.