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公开(公告)号：US20220112492A1
公开(公告)日：2022-04-14
申请号：US17177747
申请日：2021-02-17
发明人： Michael D. West , Karen Chapman , Hal Sternberg
IPC分类号： C12N15/113 , A61K31/00 , A61K31/715 , C07K16/18
摘要： Aspects of the present invention include methods and compositions related to the modulation of molecules regulating the regenerative potential of cells and tissues in the embryonic state and the loss thereof in later fetal and adult stages of development. Said methods and compositions have uses in research in stern cell biology and in increasing regenerative potential in fetal and adult tissues otherwise incapable of regeneration.
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公开(公告)号：US20220090078A1
公开(公告)日：2022-03-24
申请号：US17543018
申请日：2021-12-06
发明人： Michael D. West , Karen Chapman , Hal Sternberg
IPC分类号： C12N15/113 , A61K31/00 , A61K31/715 , C07K16/18
摘要： Aspects of the present invention include methods and compositions related to the modulation of molecules regulating the regenerative potential of cells and tissues in the embryonic state and the loss thereof in later fetal and adult stages of development. Said methods and compositions have uses in research in stem cell biology and in increasing regenerative potential in fetal and adult tissues otherwise incapable of regeneration.
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公开(公告)号：US20220088137A1
公开(公告)日：2022-03-24
申请号：US17542997
申请日：2021-12-06
发明人： Michael D. West , Dana Larocca
IPC分类号： A61K38/18 , A61K38/22 , A61K9/06 , A61K31/19 , A61K31/7105 , A61K31/715 , A61K31/713 , A61K45/06 , A61K9/00 , A61K47/36
摘要： Aspects of the present invention include algorithms, methods and compositions related to the modulation of molecules regulating the mammalian transition from embryonic to fetal development. Methods and compositions for the use of such modulations to increase the regenerative potential in fetal and adult tissues otherwise incapable of scarless regeneration are also presented.
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公开(公告)号：US20240066070A1
公开(公告)日：2024-02-29
申请号：US18272044
申请日：2022-01-11
发明人： Michael D. West
CPC分类号： A61K35/42 , A61K35/36 , A61L27/38 , A61L27/52 , C12N5/0625 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2510/00
摘要： Methods are provided for the ex vivo reprogramming of microbiopsies of tissue such as from the skin, wherein the cells from the tissue are reverted to a state capable of extensive expansion in volume and when transplanted in vivo, of promoting scarless tissue regeneration at the site of administration.
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5.发明申请公开(公告)号：US20220316013A1
公开(公告)日：2022-10-06
申请号：US17251145
申请日：2020-08-25
发明人： Michael D. West , Karen B. Chapman
IPC分类号： C12Q1/6886 , C12Q1/6806
摘要： The present invention relates to compositions and methods for the assay, diagnosis, prognosis or monitoring of the embryonic, fetal, and adult epigenetic states of a human genome. The disclosed methods are useful in monitoring the progress of in vitro and in vivo cellular reprogramming and the diagnosis, prognosis or monitoring of cancer in an individual. Specifically, the invention provides methods for the detection and interpretation of observed differential DNA methylation patterns and associated epigenetic modifications to core histones in determining the developmental status of human cells for the detection and characterization of cancer cells and determining optimum therapeutic modalities.
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公开(公告)号：US20210180013A1
公开(公告)日：2021-06-17
申请号：US17050354
申请日：2019-04-23
发明人： Michael D. West , Hal Stemberg
IPC分类号： C12N5/071
摘要： Aspects of the present invention include compositions and methods for discovering novel compositions and applying said compositions in treating medical conditions including aging, degenerative disease, wound treatment, and cancer through the modulation of molecular pathways regulating regeneration and senolysis by means of altering the embryonic-fetal and prenatal/postnatal transitional states of mammalian cells.
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公开(公告)号：US10961531B2
公开(公告)日：2021-03-30
申请号：US14896664
申请日：2014-06-03
发明人： Michael D. West , Karen Chapman , Hal Sternberg
IPC分类号： C12N15/113 , A61K31/00 , A61K31/715 , C07K16/18
摘要： Aspects of the present invention include methods and compositions related to the modulation of molecules regulating the regenerative potential of cells and tissues in the embryonic state and the loss thereof in later fetal and adult stages of development. Said methods and compositions have uses in research in stem cell biology and in increasing regenerative potential in fetal and adult tissues otherwise incapable of regeneration.
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公开(公告)号：US20240350553A1
公开(公告)日：2024-10-24
申请号：US18701109
申请日：2022-10-14
发明人： Michael D. West , Hal Sternberg
IPC分类号： A61K35/33 , C12N5/077 , C12N15/113 , C12N15/86
CPC分类号： A61K35/33 , C12N5/0656 , C12N15/1137 , C12N15/86 , C12Y207/11001 , C12N2310/14 , C12N2501/727 , C12N2750/14143
摘要： Aspects of the present invention include compositions and methods for discovering novel compositions and applying said compositions in treating medical conditions including aging, degenerative disease, and cancer through the modulation of molecular pathways regulating regeneration and senolysis by means of altering the embryonic-fetal and prenatal/postnatal transitional states of mammalian cells.
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9.发明公开公开(公告)号：US20240158788A1
公开(公告)日：2024-05-16
申请号：US18279963
申请日：2022-03-02
发明人： Michael D. West
IPC分类号： C12N15/113 , A61K35/545 , A61K45/06 , A61P35/00
CPC分类号： C12N15/113 , A61K35/545 , A61K45/06 , A61P35/00 , C12N2310/14
摘要： Compositions and methods are disclosed for modifying the chromatin structure of cells for therapeutic effect. More specifically, compositions and methods are disclosed to modify the relative expression of the nuclear lamins LMNA and LMNB1 to modify the regenerative potential of cells and to modify the heterogeneous states of cancer cells to improve therapeutic outcomes and thereby reduce tumor burden in diverse cancer types. The methods have application in veterinary and human medicine.
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10.发明申请公开(公告)号：US20220160833A1
公开(公告)日：2022-05-26
申请号：US17542992
申请日：2021-12-06
发明人： Michael D. West , Dana Larocca
IPC分类号： A61K38/18 , A61K38/22 , A61K9/06 , A61K31/19 , A61K31/7105 , A61K31/715 , A61K31/713 , A61K45/06 , A61K9/00 , A61K47/36
摘要： Aspects of the present invention include algorithms, methods and compositions related to the modulation of molecules regulating the mammalian transition from embryonic to fetal development. Methods and compositions for the use of such modulations to increase the regenerative potential in fetal and adult tissues otherwise incapable of scarless regeneration are also presented.
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