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公开(公告)号：US20240209422A1
公开(公告)日：2024-06-27
申请号：US18423678
申请日：2024-01-26
IPC分类号： C12Q1/6832 , C12Q1/6841 , C12Q1/6876
CPC分类号： C12Q1/6832 , C12Q1/6841 , C12Q1/6876
摘要： The invention provides methods and compositions for hybridizing at least one molecule to a target. The composition comprises at least one nucleic acid sequence, formamide, and a hybridization solution, wherein the concentration of formamide is less than or equal to 25%.
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公开(公告)号：US20220154263A1
公开(公告)日：2022-05-19
申请号：US17588023
申请日：2022-01-28
IPC分类号： C12Q1/6841 , C12Q1/6832
摘要： The invention provides methods and compositions for separately denaturing a probe and target in hybridization applications. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in hybridization applications. Compositions for use in the invention include an aqueous composition comprising at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
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公开(公告)号：US20200232018A1
公开(公告)日：2020-07-23
申请号：US16842466
申请日：2020-04-07
IPC分类号： C12Q1/6832 , C12Q1/6841 , C12Q1/6876
摘要： The invention provides methods and compositions for hybridizing at least one molecule to a target. The composition comprises at least one nucleic acid sequence, formamide, and a hybridization solution, wherein the concentration of formamide is less than or equal to 25%.
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公开(公告)号：US11795499B2
公开(公告)日：2023-10-24
申请号：US16240448
申请日：2019-01-04
IPC分类号： C12Q1/68 , C07H21/00 , C12Q1/6841 , C12Q1/6832
CPC分类号： C12Q1/6841 , C12Q1/6832 , C12Q2527/125 , C12Q2527/137 , C12Q1/6832 , C12Q2527/137 , C12Q2527/125 , C12Q1/6841 , C12Q2527/137 , C12Q2527/125
摘要： The invention provides methods and compositions for separately denaturing a probe and target in hybridization applications. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in hybridization applications. Compositions for use in the invention include an aqueous composition comprising at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
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公开(公告)号：US20230213417A1
公开(公告)日：2023-07-06
申请号：US17927347
申请日：2021-05-26
CPC分类号： G01N1/312 , G01N35/00029 , G01N35/00584 , G01N2035/00039 , G01N2035/00425 , G01N2035/0405
摘要： Method and apparatus are provided for processing a sample on a slide. A capillary processing module has a crank to raise and lower a slide, and/or a side inlet to apply a fluid to the slide. A capillary gap is formed between the slide and a chamber floor of the capillary processing module when the crank has lowered the slide. Capillary action causes the fluid to spread through the capillary space across a processing area and to contact the sample. When the crank raises the slide, the fluid is withdrawn from the processing area of the slide because the capillary gap is eliminated.
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公开(公告)号：US11834703B2
公开(公告)日：2023-12-05
申请号：US17473524
申请日：2021-09-13
IPC分类号： C12Q1/6832 , C12Q1/6841
CPC分类号： C12Q1/6832 , C12Q1/6841 , Y10T436/143333 , C12Q1/6832 , C12Q2527/125 , C12Q1/6841 , C12Q2527/125
摘要： The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
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公开(公告)号：US20220064716A1
公开(公告)日：2022-03-03
申请号：US17473524
申请日：2021-09-13
IPC分类号： C12Q1/6832 , C12Q1/6841
摘要： The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
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公开(公告)号：US10996145B2
公开(公告)日：2021-05-04
申请号：US16545922
申请日：2019-08-20
摘要： An apparatus (100) for processing a biological sample (101). The biological sample being arranged on a first planar surface (102) of a carrier (103). The apparatus comprises a second planar surface (104) arranged substantially parallel to said first planar surface and at a first distance from said first planar surface, said first planar surface and said second planar surface are arranged at an angle (A) greater than zero degree from the horizontal plane (HP); supply mean (126, 131, 220) for supplying an amount (105) of a liquid that is to be applied to said biological sample. The first planar surface and said second planar surface are configured to be arranged at a second distance from each other, said second distance being such that said supplied amount of liquid is distributed over said biological sample when said first planar surface and said second planar surface are brought to said second distance from each other.
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公开(公告)号：US20240124922A1
公开(公告)日：2024-04-18
申请号：US18494603
申请日：2023-10-25
IPC分类号： C12Q1/6832 , C12Q1/6841
CPC分类号： C12Q1/6832 , C12Q1/6841 , Y10T436/143333
摘要： The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an Camount effective to denature double-stranded nucleotide sequences.
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公开(公告)号：US20240018590A1
公开(公告)日：2024-01-18
申请号：US18453947
申请日：2023-08-22
IPC分类号： C12Q1/6881 , C12Q1/6841 , C12Q1/6832
CPC分类号： C12Q1/6881 , C12Q1/6841 , C12Q1/6832
摘要： The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, utilize a of cyclic and/or non-cyclic solvent that is non-toxic and may eliminate or reduce the amount of formamide in the hybridization composition.
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