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1.发明申请公开(公告)号：US20080095782A1
公开(公告)日：2008-04-24
申请号：US11875271
申请日：2007-10-19
IPC分类号： A61K39/395 , A61K31/4439 , A61P3/00 , C12Q1/02 , G01N33/68
CPC分类号： C12Q1/6883 , A61K31/44 , A61K31/4439 , C07K14/47 , C12Q2600/136 , C12Q2600/158 , Y10S436/811
摘要： Methods and compositions for identifying and treating obesity and obesity-induced metabolic disorders are provided. One aspect provides a method for the evaluation of risk and progression of glucose tolerance, insulin resistance and Type 2 diabetes in mammalian subjects. The method includes measuring the concentration of circulating lipocalin-2 in a subject and comparing the measured level to lipocalin-2 to a reference level. Another aspect provides methods of treating insulin resistance, type 2 diabetes and other related complications by administering to a patient a composition that can reduce the circulating levels of lipocalin-2, for example a lipocalin-2 antagonist.
摘要翻译： 提供了用于鉴定和治疗肥胖和肥胖诱导的代谢紊乱的方法和组合物。 一方面提供了用于评估哺乳动物受试者中葡萄糖耐量，胰岛素抵抗和2型糖尿病的风险和进展的方法。 该方法包括测量受试者中循环脂质运载蛋白-2的浓度，并将测量的水平与脂笼蛋白-2比较至参考水平。 另一方面提供了通过向患者施用可以降低脂质运载蛋白-2（例如脂质运载蛋白-2拮抗剂）的循环水平的组合物来治疗胰岛素抵抗，2型糖尿病和其它相关并发症的方法。
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2.发明申请Method for decreasing blood glucose and improving glucose tolerance using angiopoietin-like protein 4 审中-公开使用血管生成素样蛋白降低血糖和改善葡萄糖耐量的方法4公开(公告)号：US20080019911A1
公开(公告)日：2008-01-24
申请号：US11375297
申请日：2006-03-14
CPC分类号： G01N33/6893 , A61K38/1891 , A61K48/00 , C07K14/515 , C07K2319/21 , C07K2319/43 , C12N2799/022 , G01N2333/515 , G01N2800/042
摘要： Angiopoietin like protein 4 is a novel circulating protein predominantly expressed in adipose tissue and liver. Several recent studies demonstrated that angiopoietin like protein 4 is the target gene of peroxisome proliferation activators, the agonists of which are widely used as the anti-diabetic and lipid-lowering drugs. The invention provides a method for decreasing blood glucose or improving insulin sensitivity in a mammal in need thereof, comprising administering to the patient an amount of angiopoietin like protein-4 (ANGPTL4) polypeptide effective to decrease blood glucose, to improve glucose tolerance, or to increase insulin sensitivity.
摘要翻译： 促血管生成素如蛋白质4是主要在脂肪组织和肝脏中表达的新型循环蛋白。 最近的几项研究表明，血管生成素如蛋白质4是过氧化物酶体增殖激活剂的靶基因，其激动剂被广泛用作抗糖尿病和降脂药物。 本发明提供了有需要的哺乳动物降低血糖或改善胰岛素敏感性的方法，包括向患者施用一定量的血管生成素，如有效降低血糖的蛋白-4（ANGPTL4）多肽，以改善葡萄糖耐量，或向 增加胰岛素敏感性。
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公开(公告)号：US20100016216A1
公开(公告)日：2010-01-21
申请号：US12077040
申请日：2008-03-14
申请人： Garth Cooper , Aimin Xu , Yu Wang
发明人： Garth Cooper , Aimin Xu , Yu Wang
IPC分类号： A61K38/16
CPC分类号： C07K14/5759 , A61K38/00 , Y02A50/463
摘要： The invention provides methods and reagents for regulation of metabolic events, such as those mediated by adiponectin and adiponectin agonists. The invention also provides screening assays for identification of biologically active agents, diagnostic and therapeutic agents, and other methods and reagents.
摘要翻译： 本发明提供了用于调节代谢事件的方法和试剂，例如由脂连蛋白和脂联素激动剂介导的那些。 本发明还提供用于鉴定生物活性剂，诊断和治疗剂以及其它方法和试剂的筛选试验。
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4.发明申请公开(公告)号：US20100310578A1
公开(公告)日：2010-12-09
申请号：US12637097
申请日：2009-12-14
申请人： Aimin Xu , Yu Wang , Karen Siu Ling Lam
发明人： Aimin Xu , Yu Wang , Karen Siu Ling Lam
IPC分类号： A61K39/395 , A61K31/4439 , A61P3/04 , A61P3/00 , A61P3/10 , A61P3/06
CPC分类号： C12Q1/6883 , A61K31/44 , A61K31/4439 , C07K14/47 , C12Q2600/136 , C12Q2600/158 , Y10S436/811
摘要： Methods and compositions for identifying and treating obesity and obesity-induced metabolic disorders are provided. One aspect provides a method for the evaluation of risk and progression of glucose tolerance, insulin resistance and Type 2 diabetes in mammalian subjects. The method includes measuring the concentration of circulating lipocalin-2 in a subject and comparing the measured level to lipocalin-2 to a reference level. Another aspect provides methods of treating insulin resistance, type 2 diabetes and other related complications by administering to a patient a composition that can reduce the circulating levels of lipocalin-2, for example a lipocalin-2 antagonist.
摘要翻译： 提供了用于鉴定和治疗肥胖和肥胖诱导的代谢紊乱的方法和组合物。 一方面提供了用于评估哺乳动物受试者中葡萄糖耐量，胰岛素抵抗和2型糖尿病的风险和进展的方法。 该方法包括测量受试者中循环脂质运载蛋白-2的浓度，并将测量的水平与脂笼蛋白-2比较至参考水平。 另一方面提供了通过向患者施用可以降低脂质运载蛋白-2（例如脂质运载蛋白-2拮抗剂）的循环水平的组合物来治疗胰岛素抵抗，2型糖尿病和其它相关并发症的方法。
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公开(公告)号：US08044182B2
公开(公告)日：2011-10-25
申请号：US12077040
申请日：2008-03-14
申请人： Garth Cooper , Aimin Xu , Yu Wang
发明人： Garth Cooper , Aimin Xu , Yu Wang
CPC分类号： C07K14/5759 , A61K38/00 , Y02A50/463
摘要： The invention provides methods and reagents for regulation of metabolic events, such as those mediated by adiponectin and adiponectin agonists. The invention also provides screening assays for identification of biologically active agents, diagnostic and therapeutic agents, and other methods and reagents.
摘要翻译： 本发明提供了用于调节代谢事件的方法和试剂，例如由脂连蛋白和脂联素激动剂介导的那些。 本发明还提供用于鉴定生物活性剂，诊断和治疗剂以及其它方法和试剂的筛选试验。
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6.发明授权Lipocalin-2 as a prognostic and diagnostic marker for heart and stroke risks 有权Lipocalin-2作为心脏和卒中风险的预后和诊断标记公开(公告)号：US08030097B2
公开(公告)日：2011-10-04
申请号：US12113056
申请日：2008-04-30
申请人： Aimin Xu , Yu Wang , Reinhard Renneberg , George William Hunter Cautherley , Cangel Pui Yee Chan , Matthias Lehmann
发明人： Aimin Xu , Yu Wang , Reinhard Renneberg , George William Hunter Cautherley , Cangel Pui Yee Chan , Matthias Lehmann
IPC分类号： G01N33/53
CPC分类号： C07K14/47 , A61K38/00 , C07K16/18 , G01N33/6872 , G01N2800/32 , Y10S436/811
摘要： Methods and apparatus are disclosed for the measurement of lipocalin-2 in body fluids (including but not limited to blood, serum, plasma, urine, saliva, tear, etc.) by an assay such as an immunoassay or an immunotest for (1) the prediction of risk of future cardiovascular diseases; and (2) the determination of the likelihood that certain individuals will benefit to a greater or lesser extent from the use of certain treatments designed to prevent and/or treat cardiovascular diseases.
摘要翻译： 公开了通过诸如免疫测定法或免疫测定法（1）的体液（包括但不限于血液，血清，血浆，尿液，唾液，泪液等）中脂质运载蛋白-2的测量的方法和装置， 预测未来心血管疾病的风险; 和（2）确定某些个体可能或多或少地受益于使用旨在预防和/或治疗心血管疾病的某些治疗的可能性。
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公开(公告)号：US20050074756A1
公开(公告)日：2005-04-07
申请号：US10378544
申请日：2003-03-03
申请人： Garth Cooper , Aimin Xu , Yu Wang
发明人： Garth Cooper , Aimin Xu , Yu Wang
IPC分类号： A61K38/00 , A61P3/04 , A61P3/06 , A61P9/12 , C07K14/47 , C12N1/21 , C12N5/20 , C12Q1/68 , C07H21/04 , C12N9/00 , C12N15/74 , C12P21/02
CPC分类号： C07K14/4713 , A61K38/00 , A61K2039/505 , C07K14/47
摘要： Novel fat tissue low molecular weight proteins (FALPs) that show response to insulin are described.
摘要翻译： 描述了显示对胰岛素反应的新型脂肪组织低分子量蛋白（FALP）。
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公开(公告)号：US20050047998A1
公开(公告)日：2005-03-03
申请号：US10964870
申请日：2004-10-14
申请人： Garth Cooper , Aimin Xu , Yu Wang
发明人： Garth Cooper , Aimin Xu , Yu Wang
IPC分类号： G01N33/50 , A61K45/00 , A61P3/00 , A61P3/10 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/68 , G01N33/74 , G01N33/53 , A61K49/00
CPC分类号： G01N33/6893 , G01N33/74 , G01N2500/02 , G01N2500/10 , G01N2800/042
摘要： This invention provides methods for diagnosing and treating individuals with insulin resistance.
摘要翻译： 本发明提供用于诊断和治疗具有胰岛素抵抗的个体的方法。
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公开(公告)号：US08481032B2
公开(公告)日：2013-07-09
申请号：US12637097
申请日：2009-12-14
申请人： Aimin Xu , Yu Wang , Karen S. L. Lam
发明人： Aimin Xu , Yu Wang , Karen S. L. Lam
CPC分类号： C12Q1/6883 , A61K31/44 , A61K31/4439 , C07K14/47 , C12Q2600/136 , C12Q2600/158 , Y10S436/811
摘要： Methods and compositions for identifying and treating obesity and obesity-induced metabolic disorders are provided. One aspect provides a method for the evaluation of risk and progression of glucose tolerance, insulin resistance and Type 2 diabetes in mammalian subjects. The method includes measuring the concentration of circulating lipocalin-2 in a subject and comparing the measured level to lipocalin-2 to a reference level. Another aspect provides methods of treating insulin resistance, type 2 diabetes and other related complications by administering to a patient a composition that can reduce the circulating levels of lipocalin-2, for example a lipocalin-2 antagonist.
摘要翻译： 提供了用于鉴定和治疗肥胖和肥胖诱导的代谢紊乱的方法和组合物。 一方面提供了用于评估哺乳动物受试者中葡萄糖耐量，胰岛素抵抗和2型糖尿病的风险和进展的方法。 该方法包括测量受试者中循环脂质运载蛋白-2的浓度，并将测量的水平与脂笼蛋白-2比较至参考水平。 另一方面提供了通过向患者施用可以降低脂质运载蛋白-2（例如脂质运载蛋白-2拮抗剂）的循环水平的组合物来治疗胰岛素抵抗，2型糖尿病和其它相关并发症的方法。
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公开(公告)号：US07365170B2
公开(公告)日：2008-04-29
申请号：US10349326
申请日：2003-01-21
申请人： Garth Cooper , Aimin Xu , Yu Wang
发明人： Garth Cooper , Aimin Xu , Yu Wang
CPC分类号： C07K14/5759 , A61K38/00 , Y02A50/463
摘要： The invention provides methods and reagents for regulation of metabolic events, such as those mediated by adiponectin and adiponectin agonists. The invention also provides screening assays for identification of biologically active agents, diagnostic and therapeutic agents, and other methods and reagents.
摘要翻译： 本发明提供了用于调节代谢事件的方法和试剂，例如由脂连蛋白和脂联素激动剂介导的那些。 本发明还提供用于鉴定生物活性剂，诊断和治疗剂以及其它方法和试剂的筛选试验。
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