公开(公告)号：US20210278421A1

公开(公告)日：2021-09-09

申请号：US17212195

申请日：2021-03-25

Applicant: AJINOMOTO CO., INC.

Inventor： Takeshi IKEUCHI ,  Yuki YANO ,  Hiroko KONDO ,  Wataru SATO ,  Naoko ARASHIDA ,  Satoko UENO ,  Rumi NISHIMOTO ,  Masashi HARADA

IPC: G01N33/68 ,  G16H50/30

Abstract: An evaluating method includes an evaluating step of evaluating a state of mild cognitive impairment for a subject to be evaluated, using (i) at least one value of concentration values of Put, α-ABA, Ala, Arg, Asn, Cit, Glu, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, Val, Taurine, 1-MeHis, 3-MeHis, aAAA, aAiBA, ADMA, Allyl Cys, bABA, bAiBA, Cystathionine, Cysteic acid, EtGly, GABA, hArg, Hypotaurine, Hypro, Kyn, Pyrazole-1-Ala, MCSO, MeCys, N6-AcLys, N8-AcSpd, Opthalmic acid, PEA, Pipecolic acid, Sar, SDMA, Spd, Spm, and Thioproline and test values of Alb, Folate, WBC, RBC, Hb, Ht, and PLT in blood of the subject, or (ii) a value of a formula including an explanatory variable to be substituted with the at least one value, calculated using the at least one value and the formula.

公开(公告)号：US20250020656A1

公开(公告)日：2025-01-16

申请号：US18784141

申请日：2024-07-25

Applicant: AJINOMOTO CO., INC.

Inventor： Naoko ARASHIDA ,  Rumi NISHIMOTO ,  Kazutaka SHIMBO ,  Hidehiro NAKAMURA ,  Natsumi NISHIKATA ,  Akira IMAIZUMI

IPC: G01N33/68 ,  G01N33/574 ,  G16H50/20

Abstract: An evaluating method includes an evaluating step of evaluating a state of lung cancer for a subject to be evaluated using a concentration value of at least one of Homoarginine, GABA, 3-Me-His, ADMA, Spermine, Spermidine, Cystathionine, Sarcosine, aAiBA, bAiBA, Putrescine, N-Acetyl-L-lys, Hypotaurine, bABA, and Ethylglycine in blood of the subject.

公开(公告)号：US20180017570A1

公开(公告)日：2018-01-18

申请号：US15715389

申请日：2017-09-26

Applicant: AJINOMOTO CO., INC.

Inventor： Naoko ARASHIDA ,  Rumi NISHIMOTO ,  Kazutaka SHIMBO ,  Hidehiro NAKAMURA ,  Natsumi NISHIKATA ,  Akira IMAIZUMI

IPC: G01N33/68 ,  G01N33/574 ,  G06F19/00

CPC classification number: G01N33/6812 ,  G01N33/57423 ,  G01N2800/56 ,  G06F19/3418 ,  G16H50/20

Abstract: An evaluating method includes an evaluating step of evaluating a state of lung cancer for a subject to be evaluated using a concentration value of at least one of Homoarginine, GABA, 3-Me-His, ADMA, Spermine, Spermidine, Cystathionine, Sarcosine, aAiBA, bAiBA, Putrescine, N-Acetyl-L-lys, Hypotaurine, bABA, and Ethylglycine in blood of the subject.

公开(公告)号：US20240115719A1

公开(公告)日：2024-04-11

申请号：US18463903

申请日：2023-09-08

Applicant: Ajinomoto Co., Inc.

Inventor： Tomohiro FUJII ,  Kei YAMADA ,  Yutaka MATSUDA ,  Ryusuke HIRAMA ,  Noriko HATADA ,  Naoko ARASHIDA

IPC: A61K47/68 ,  C07K16/28

CPC classification number: A61K47/68031 ,  C07K16/2803

Abstract: Compounds or salts thereof represented by formula (I):






wherein
X indicates a leaving group,
Y indicates an affinity peptide having a binding region in a CH2 domain in an immunoglobulin unit comprising two heavy chains and two light chains,
M indicates a trivalent group linking the carbon atom in C═O adjacent to M and the carbon atom in C═W via a main chain portion consisting of 3 to 5 carbon atoms,
O indicates an oxygen atom,
S indicates a sulfur atom,
W indicates an oxygen atom or a sulfur atom,
N3 indicates an azide group,
La indicates a bond or a divalent group, and
Lb indicates a bond or a divalent group; and antibodies or salts thereof which can be prepared using such a compound or salt thereof, are useful for controlling the bonding ratio of an antibody and a modifying group within a desired range.

公开(公告)号：US20190228844A1

公开(公告)日：2019-07-25

申请号：US16373427

申请日：2019-04-02

Applicant: AJINOMOTO CO., INC.

Inventor： Hidehiro NAKAMURA ,  Natsumi NISHIKATA ,  Akira IMAIZUMI ,  Kazutaka SHIMBO ,  Naoko ARASHIDA ,  Rumi NISHIMOTO

IPC: G16C20/70

Abstract: An evaluating method includes an evaluating step of evaluating a state of colorectal cancer for a subject to be evaluated using (i) a concentration value of at least one metabolite of bABA, N-Me-bABA, 1-Me-His, aABA, Aminoadipic acid, bAiBA, Cadaverine, Ethylglycine, GABA, Homoarginine, Hypotaurine, Kinurenine, N6-Acetyl-L-Lys, Putrescine, Serotonin, Spermidine, Spermine, ADMA, Homocitrulline, 3-Me-His, Hydroxyproline, Phosphoethanolamine, SDMA, Acylcarnitine (13:1), and EPA in blood of the subject or (ii) a value of a formula calculated using the concentration value of the metabolite and the formula including an explanatory variable to be substituted with the concentration value of the metabolite.

公开(公告)号：US20220088111A1

公开(公告)日：2022-03-24

申请号：US17548044

申请日：2021-12-10

Applicant: AJINOMOTO CO., INC.

Inventor： Yoshiro KITAHARA ,  Yoriko OKAMATSU ,  Kazutaka SHIMBO ,  Naoko ARASHIDA ,  Ayaka SHIRASAWA

IPC: A61K38/01

Abstract: Peptides consisting of the amino acid sequence of any of LIVTQTMKGL (SEQ ID NO: 1), LIVTQTMKG (SEQ ID NO: 2), LIVTQTMK (SEQ ID NO: 3), IVTQTMKGL (SEQ ID NO: 4), IVTQTMKG (SEQ ID NO: 5), and VTQTMKGL (SEQ ID NO: 6) are useful for improving intestinal barrier function, for suppressing blood glucose elevation, for improving insulin sensitivity, for promoting FGF21 secretion, for suppressing stress or protecting nerves, or for reducing fatigue.

公开(公告)号：US20190277862A1

公开(公告)日：2019-09-12

申请号：US16239817

申请日：2019-01-04

Applicant: AJINOMOTO CO., INC.

Inventor： Takeshi IKEUCHI ,  Nobuhiro KAWAI ,  Yuki YANO ,  Naoko ARASHIDA ,  Rumi NISHIMOTO ,  Kazutaka SHIMBO

IPC: G01N33/68

Abstract: An evaluating method includes an evaluating step of evaluating a state of mild cognitive impairment or Alzheimer's disease for a subject to be evaluated using a concentration value of at least one of α-ABA, Ala, Arg, Asn, Cit, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, Val, Cysteine, Taurine, GABA, Hypotaurine, S-Adenosyl homocysteine, Sarcosine, Serotonin, Spermidine, hCit, 3-hKyn, aAiBA, N8-Acetylspermidine, Phosphoserine, bABA, ADMA, and Thioproline in blood of the subject.

公开(公告)号：US20190227071A1

公开(公告)日：2019-07-25

申请号：US16373193

申请日：2019-04-02

Applicant: AJINOMOTO CO., INC.

Inventor： Hidehiro NAKAMURA ,  Natsumi NISHIKATA ,  Akira IMAIZUMI ,  Kazutaka SHIMBO ,  Naoko ARASHIDA ,  Rumi NISHIMOTO

IPC: G01N33/574 ,  G01N33/49 ,  G01N33/487

Abstract: An evaluating method includes an evaluating step of evaluating a state of pancreatic cancer for a subject to be evaluated using (i) a concentration value of at least one metabolite of N-Me-bABA, bABA, GABA, N6-Acetyl-L-Lys, 1-Me-His, aABA, Aminoadipic acid, bAiBA, Cadaverine, Ethylglycine, Homoarginine, Hypotaurine, Kinurenine, Putrescine, Serotonin, Spermidine, Spermine, ADMA, Homocitrulline, 3-Me-His, Hydroxyproline, Phosphoethanolamine, Acylcarnitine (13:1), and EPA in blood of the subject or (ii) a value of a formula calculated using the concentration value of the metabolite and the formula including an explanatory variable to be substituted with the concentration value of the metabolite.