公开(公告)号：US20100063305A1

公开(公告)日：2010-03-11

申请号：US12312125

申请日：2007-10-25

申请人： Akifumi Iida ,  Youichi Kyuuko ,  Toshio Hidaka

发明人： Akifumi Iida ,  Youichi Kyuuko ,  Toshio Hidaka

IPC分类号： C07D311/04

CPC分类号： C07D311/66 ,  C07B53/00

摘要： The present invention provides an industrially available method for efficiently producing high-purity S-(−)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid excellent in solid-liquid separability from an S-(−)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid ester, and also provides products obtained by the method.Under a temperature condition of 50-80° C. in an aqueous solvent, (A) an S-(−)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid ester represented by the general formula (1) is hydrolyzed under a basic condition for 1-3 hours; then (B) the insoluble matters contained in the reaction solution resulting from the hydrolysis are removed; and (C) an acid is added to the resulting solution to effect crystallization; provided that R in the general formula (1) represents an alkyl or aryl group.

摘要翻译： 本发明提供了一种工业上可行的方法，用于有效地生产出具有优异的S - （ - ） - （ - ） - 羟基-2,4,5,6,7,8-四甲基苯并二氢吡喃-2-羧酸的高纯度S - （ - ） - ）-6-羟基-2,5,7,8-四氢苯并二氢吡喃-2-羧酸酯，并且还提供通过该方法获得的产物。 在水性溶剂中在50-80℃的温度条件下，（A）由通式（A）表示的S - （ - ） - 6-羟基-2,5,7,8-四氢苯并二氢吡喃-2-羧酸酯 （1）在碱性条件下水解1-3小时; 然后（B）去除由水解产生的反应溶液中所含的不溶物; 和（C）向所得溶液中加入酸以进行结晶; 条件是通式（1）中的R表示烷基或芳基。

公开(公告)号：US08080676B2

公开(公告)日：2011-12-20

申请号：US12312125

申请日：2007-10-25

申请人： Akifumi Iida ,  Youichi Kyuuko ,  Toshio Hidaka

发明人： Akifumi Iida ,  Youichi Kyuuko ,  Toshio Hidaka

IPC分类号： C07D311/66

CPC分类号： C07D311/66 ,  C07B53/00

摘要： The present invention provides an industrially available method for efficiently producing high-purity S-(−)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid excellent in solid-liquid separability from an S-(−)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid ester, and also provides products obtained by the method.Under a temperature condition of 50-80° C. in an aqueous solvent, (A) an S-(−)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid ester represented by the general formula (1) is hydrolyzed under a basic condition for 1-3 hours; then (B) the insoluble matters contained in the reaction solution resulting from the hydrolysis are removed; and (C) an acid is added to the resulting solution to effect crystallization; provided that R in the general formula (1) represents an alkyl or aryl group.

摘要翻译： 本发明提供了一种工业上可行的方法，用于有效地生产出S-（ - ） - （ - ） - 羟基-2,5,7,8-四甲基苯并二氢吡喃-2-羧酸的固 - 液分离性优异的高纯度S - （ - ） - ）-6-羟基-2,5,7,8-四氢苯并二氢吡喃-2-羧酸酯，并且还提供通过该方法获得的产物。 在水性溶剂中在50-80℃的温度条件下，（A）由通式（A）表示的S - （ - ） - 6-羟基-2,5,7,8-四氢苯并二氢吡喃-2-羧酸酯 （1）在碱性条件下水解1-3小时; 然后（B）去除由水解产生的反应溶液中所含的不溶物; 和（C）向所得溶液中加入酸以进行结晶; 条件是通式（1）中的R表示烷基或芳基。

公开(公告)号：US20100330625A1

公开(公告)日：2010-12-30

申请号：US12866006

申请日：2009-02-05

申请人： Akifumi Iida ,  Youichi Kyuuko

发明人： Akifumi Iida ,  Youichi Kyuuko

IPC分类号： C12P17/10

CPC分类号： C12P17/10 ,  C12P41/005

摘要： Disclosed is a process for producing an optically active indoline-2-cabroxylic acid or a derivative thereof, which is useful as a raw material for synthesis of pharmaceuticals or the like, from an indoline-2-cabroxylic acid in an industrially advantageous manner.An indoline-2-cabroxylic acid is converted into an N-substituted-indoline-2-carboxylic acid, and then is esterified using a biocatalyst having a stereoselectivity in an organic solvent containing an alcohol. Next, an alkali is used to obtain an optically active N-substituted-indoline-2-carboxylic acid ester and an optically active N-substituted-indoline-2-cabroxylic acid or a salt thereof, and then the two optically active substances are separated utilizing distribution properties thereof in an organic solvent/water system. Further, the two substances are hydrolyzed and deprotected, whereby the optically active indoline-2-cabroyxlic acid or a derivative thereof, which is useful as a raw material for synthesis of pharmaceuticals or the like, can be produced and provided economically.

摘要翻译： 公开了以工业上有利的方式从二氢吲哚-2-羧酸生产用作合成药物等的原料的光学活性二氢吲哚-2-羧酸或其衍生物的方法。 将二氢吲哚-2-羧酸转化为N-取代 - 二氢吲哚-2-羧酸，然后使用在含有醇的有机溶剂中具有立体选择性的生物催化剂进行酯化。 接着，使用碱来得到光学活性的N-取代 - 二氢吲哚-2-羧酸酯和光学活性的N-取代 - 二氢吲哚-2-羧酸或其盐，然后分离出两种光学活性物质 利用其在有机溶剂/水体系中的分布特性。 此外，两种物质被水解和脱保护，从而可以经济地制备和提供可用作药物等的合成原料的光学活性二氢吲哚-2-壳核酸或其衍生物。

公开(公告)号：US20060141591A1

公开(公告)日：2006-06-29

申请号：US10559577

申请日：2004-05-31

申请人： Youichi Kyuuko ,  Sachiko Koshiishi ,  Toshio Hidaka

发明人： Youichi Kyuuko ,  Sachiko Koshiishi ,  Toshio Hidaka

IPC分类号： C12P17/06 ,  C07D311/04

CPC分类号： C12P17/06 ,  C12P41/004

摘要： In the method for producing an optically active chromancarboxylate of the present invention, one of the enantiomers of racemic chromancarboxylic acid is esterified in a solvent containing an alcohol in the presence of a biocatalyst. After the esterification, the other enantiomer, i.e., the non-reacted chromancarboxylic acid is separated out of the reaction mixture to obtain the aimed optically active ester. The optically active chromancarboxylate is useful as the material for medicines, agricultural chemicals, etc. The invention provides an efficient production method thereof which is industrially applicable.

摘要翻译： 在本发明的光学活性色淀羧酸盐的制造方法中，在生物催化剂存在下，将含有醇的溶剂中的外消旋二羧酸的对映异构体酯化。 酯化后，从反应混合物中分离出另一种对映异构体，即未反应的色原羧酸，得到目标光学活性酯。 光学活性色淀羧酸盐可用作药物，农药等的材料。本发明提供了其在工业上可应用的有效的制备方法。

公开(公告)号：US07615650B2

公开(公告)日：2009-11-10

申请号：US10587545

申请日：2005-01-28

申请人： Kazuo Tanaka ,  Youichi Kyuuko ,  Toshio Hidaka

发明人： Kazuo Tanaka ,  Youichi Kyuuko ,  Toshio Hidaka

IPC分类号： C07D311/66

CPC分类号： C07D311/66 ,  C07D311/62

摘要： The invention provides a process for producing a chroman compound represented by formula (1), characterized in that the process includes allowing a phenol, an unsaturated compound, and a formaldehyde to react in the absence of catalyst and in the presence of water in an amount by mole 1 to 10 times that of the phenol.According to the present invention, a high-purity chroman compound can be produced in the absence of catalyst and under mild conditions. In addition, the invention provides an industrial means for producing the compound, without using a large amount of an acid or a base serving as a reaction promoter or a catalyst, which would otherwise cause side reactions, apparatus corrosion, etc.

摘要翻译： 本发明提供一种制备由式（1）表示的苯并二氢吡喃化合物的方法，其特征在于该方法包括使苯酚，不饱和化合物和甲醛在不存在催化剂的情况下和在水存在下反应， 为摩尔比的1〜10倍。 根据本发明，可以在不存在催化剂的条件下，在温和的条件下生产高纯度色满化合物。 此外，本发明提供了一种用于生产化合物的工业方法，而不使用大量的酸或作为反应促进剂或催化剂的碱，否则会引起副反应，装置腐蚀等。

公开(公告)号：US20070179304A1

公开(公告)日：2007-08-02

申请号：US10587545

申请日：2005-01-28

申请人： Kazuo Tanaka ,  Youichi Kyuuko ,  Toshio Hidaka

发明人： Kazuo Tanaka ,  Youichi Kyuuko ,  Toshio Hidaka

IPC分类号： C07D311/04

CPC分类号： C07D311/66 ,  C07D311/62

摘要： The invention provides a process for producing a chroman compound represented by formula (1), characterized in that the process includes allowing a phenol, an unsaturated compound, and a formaldehyde to react in the absence of catalyst and in the presence of water in an amount by mole 1 to 10 times that of the phenol. According to the present invention, a high-purity chroman compound can be produced in the absence of catalyst and under mild conditions. In addition, the invention provides an industrial means for producing the compound, without using a large amount of an acid or a base serving as a reaction promoter or a catalyst, which would otherwise cause side reactions, apparatus corrosion, etc.

摘要翻译： 本发明提供一种制备由式（1）表示的苯并二氢吡喃化合物的方法，其特征在于该方法包括使苯酚，不饱和化合物和甲醛在不存在催化剂的情况下和在水存在下反应， 为摩尔比的1〜10倍。 根据本发明，可以在不存在催化剂的条件下，在温和的条件下生产高纯度色满化合物。 此外，本发明提供了一种用于生产化合物的工业方法，而不使用大量的酸或作为反应促进剂或催化剂的碱，否则会引起副反应，装置腐蚀等。

公开(公告)号：US20110251407A1

公开(公告)日：2011-10-13

申请号：US13126281

申请日：2009-10-28

申请人： Youichi Kyuuko

发明人： Youichi Kyuuko

IPC分类号： C07D311/66 ,  C07B57/00

CPC分类号： C07D311/66 ,  C07B57/00 ,  C07B2200/07 ,  C07C51/487 ,  C07C53/134

摘要： The present invention is a simple method, in which a specific amount of alkali is added to an enantiomeric mixture of an optically active organic carboxylic acid where enantiomers are present in a non-equimolar ratio, or in which the enantiomeric mixture of an optically active organic carboxylic acid is neutralized with an alkali, and then a specific amount of acid is added thereto, thereby separating an organic carboxylic acid salt in the mother liquor and a crystallized organic carboxylic acid from each other. The method makes it possible to obtain an optically active organic carboxylic acid with improved enantiomeric excess. The present invention provides a simple production method for obtaining an optically active organic carboxylic acid with improved enantiomeric excess from an enantiomeric mixture of an optically active organic carboxylic acid where enantiomers are present in a non-equimolar ratio.

摘要翻译： 本发明是一种简单的方法，其中将特定量的碱加入到对映异构体以非等摩尔比存在的光学活性有机羧酸的对映体混合物中，或其中光学活性有机物的对映体混合物 羧酸用碱中和，然后加入特定量的酸，从而将母液中的有机羧酸盐和结晶的有机羧酸彼此分离。 该方法可以获得具有改善的对映体过量的光学活性有机羧酸。 本发明提供了一种简单的制备方法，用于从对映异构体以非等摩尔比存在的光学活性有机羧酸的对映体混合物中获得具有改进的对映异构体过量的光学活性有机羧酸。

公开(公告)号：US06504069B1

公开(公告)日：2003-01-07

申请号：US09504042

申请日：2000-02-14

申请人： Youichi Kyuuko ,  Norio Fushimi ,  Makoto Takagawa

发明人： Youichi Kyuuko ,  Norio Fushimi ,  Makoto Takagawa

IPC分类号： C07C1328

CPC分类号： C07C5/31 ,  C07C2521/04 ,  C07C2521/06 ,  C07C2521/08 ,  C07C2521/12 ,  C07C2527/054 ,  C07C2527/173 ,  C07C2529/04 ,  C07C13/48

摘要： 5-Tolyl-pent-2-ene is cyclized in liquid phase in the present of an aliphatic hydrocarbon to produce the corresponding dimethyltetralin. The use of the aliphatic hydrocarbon effectively prevents a side reaction such as dimerization of 5-tolyl-pent-2-ene to provide dimethyltetralin in a high yield. Also, 5-tolyl-pent-2-ene is cyclized in liquid phase or vapor phase in the presence of a catalyst comprising a carrier supporting sulfate ions to produce the corresponding dimethyltetralin. The catalyst supporting sulfate ions shows a high catalytic activity event at low temperatures. Therefore, the cyclization of 5-tolyl-pent-2-ene is conducted in a wide temperature range from low temperatures to high temperatures.

摘要翻译： 在脂肪族烃的存在下，5-甲苯基戊-2-烯在液相中环化，生成相应的二甲基儿茶素。 脂肪烃的使用有效地防止了5-甲苯基戊-2-烯的二聚反应，从而提供高产率的二甲基儿茶素。 此外，5-甲苯基戊-2-烯在含有支持硫酸根离子的载体的催化剂存在下在液相或气相中环化，生成相应的二甲基四氢化萘。 支持硫酸根离子的催化剂在低温下显示出高催化活性。 因此，5-甲苯基戊-2-烯的环化在从低温到高温的宽温度范围内进行。

公开(公告)号：US20120149933A1

公开(公告)日：2012-06-14

申请号：US13377626

申请日：2010-06-10

申请人： Kazunari Yamamoto ,  Youichi Kyuuko ,  Atsushi Okamoto

发明人： Kazunari Yamamoto ,  Youichi Kyuuko ,  Atsushi Okamoto

IPC分类号： C07C253/28 ,  B01J27/228 ,  B01J29/04 ,  B01J21/18

CPC分类号： B01J23/002 ,  B01J21/063 ,  B01J23/22 ,  B01J23/26 ,  B01J23/28 ,  B01J23/34 ,  B01J27/198 ,  B01J35/023 ,  B01J37/0009 ,  B01J37/0221 ,  B01J2523/00 ,  C07C253/28 ,  B01J2523/305 ,  B01J2523/47 ,  B01J2523/51 ,  B01J2523/55 ,  B01J2523/68 ,  B01J2523/67 ,  B01J2523/72 ,  C07C255/51

摘要： The present invention provides an ammoxidation catalyst containing vanadium oxide, titanium oxide and diamond.

摘要翻译： 本发明提供含有氧化钒，氧化钛和金刚石的氨氧化催化剂。