公开(公告)号：US08017610B2

公开(公告)日：2011-09-13

申请号：US12843348

申请日：2010-07-26

申请人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

发明人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

IPC分类号： A61K31/501 ,  A61K31/497 ,  A61K31/443 ,  A61K31/421 ,  C07D403/14 ,  C07D413/14 ,  C07D265/08

CPC分类号： C07D413/14 ,  C07D207/333 ,  C07D207/335 ,  C07D207/337 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

摘要翻译： 本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，并且是通式（I）表示的化合物或其药理学上可接受的盐：[其中，A表示例如氧原子或 硫原子，R1表示例如C1-C6烷基，C1-C6烷氧基或C1-C6卤代烷基，A和R1与与其结合的碳原子一起形成可以被 1至3个独立地选自取代基组α的基团，R 2表示可以被独立地选自取代基组α的1至5个基团取代的苯基或可被1至3个基团取代的杂环基 独立地选自取代基组α，R3表示羟基或C1-C6烷氧基，取代基组α由例如卤素原子，C1-C6烷基，C1-C6烷基组成 取代 具有1或2个羟基，C1-C6烷基磺酰基和由式-V-NR5R6表示的基团（其中，V表示羰基或磺酰基，R5和R6可以相同） 或不同，分别表示氢原子或C1-C6烷基，或R5和R6与键合的氮原子一起形成可以被1或2个基团独立地取代的4至6元饱和杂环 选自C 1 -C 6烷基和羟基，并且4至6元饱和杂环可以进一步含有一个氧原子或氮原子）]。

公开(公告)号：US20110003787A1

公开(公告)日：2011-01-06

申请号：US12843348

申请日：2010-07-26

申请人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

发明人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

IPC分类号： A61K31/427 ,  C07D417/04 ,  C07D413/14 ,  C07D413/12 ,  A61P3/10 ,  A61K31/501 ,  A61K31/4439 ,  A61K31/428 ,  C07D403/04 ,  A61K31/497 ,  C07D207/34 ,  A61K31/40 ,  C07D413/04 ,  A61K31/422 ,  A61K31/5355 ,  C07D417/14 ,  A61K31/5377

CPC分类号： C07D413/14 ,  C07D207/333 ,  C07D207/335 ,  C07D207/337 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

摘要翻译： 本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，并且是通式（I）表示的化合物或其药理学上可接受的盐：[其中，A表示例如氧原子或 硫原子，R1表示例如C1-C6烷基，C1-C6烷氧基或C1-C6卤代烷基，A和R1与与其结合的碳原子一起形成可以被 1至3个独立地选自取代基组α的基团，R 2表示可以被独立地选自取代基组α的1至5个基团取代的苯基或可被1至3个基团取代的杂环基 独立地选自取代基组α，R3表示羟基或C1-C6烷氧基，取代基组α由例如卤素原子，C1-C6烷基，C1-C6烷基组成 取代 具有1或2个羟基，C1-C6烷基磺酰基和由式-V-NR5R6表示的基团（其中，V表示羰基或磺酰基，R5和R6可以相同） 或不同，分别表示氢原子或C1-C6烷基，或R5和R6与键合的氮原子一起形成可以被1或2个基团独立地取代的4至6元饱和杂环 选自C 1 -C 6烷基和羟基，并且4至6元饱和杂环可以进一步含有一个氧原子或氮原子）]。

公开(公告)号：US08415359B2

公开(公告)日：2013-04-09

申请号：US13198819

申请日：2011-08-05

申请人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

发明人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

IPC分类号： A61K31/497 ,  A61K31/4439 ,  A61K31/443 ,  A61K31/428 ,  A61K31/427 ,  A61K31/421 ,  A61K31/4155 ,  A61K31/4025 ,  A61K31/40 ,  C07D401/14 ,  C07D401/12 ,  C07D413/04 ,  C07D413/14 ,  C07D277/62 ,  C07D277/20 ,  C07D263/08 ,  C07D263/30 ,  C07D403/04 ,  C07D403/14 ,  C07D207/323

CPC分类号： C07D413/14 ,  C07D207/333 ,  C07D207/335 ,  C07D207/337 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

摘要翻译： 本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，并且是通式（I）表示的化合物或其药理学上可接受的盐：[其中，A表示例如氧原子或 硫原子，R1表示例如C1-C6烷基，C1-C6烷氧基或C1-C6卤代烷基，A和R1与与其结合的碳原子一起形成可以被 1至3个独立地选自取代基组α的基团，R 2表示可以被独立地选自取代基组α的1至5个基团取代的苯基或可被1至3个基团取代的杂环基 独立地选自取代基组α，R3表示羟基或C1-C6烷氧基，取代基组α由例如卤素原子，C1-C6烷基，C1-C6烷基组成 取代 具有1或2个羟基，C1-C6烷基磺酰基和由式-V-NR5R6表示的基团（其中，V表示羰基或磺酰基，R5和R6可以相同） 或不同，分别表示氢原子或C1-C6烷基，或R5和R6与键合的氮原子一起形成可以被1或2个基团独立地取代的4至6元饱和杂环 选自C 1 -C 6烷基和羟基，并且4至6元饱和杂环可以进一步含有一个氧原子或氮原子）]。

公开(公告)号：US5002884A

公开(公告)日：1991-03-26

申请号：US297793

申请日：1989-01-17

申请人： Hideki Kobayashi ,  Tadashi Matsunaga ,  Hideki Kobayashi

发明人： Hideki Kobayashi ,  Tadashi Matsunaga ,  Hideki Kobayashi

IPC分类号： A61K39/00 ,  A61K39/44 ,  C07F7/18 ,  C12N11/14 ,  G01N33/543 ,  G01N33/551

CPC分类号： C12N11/14 ,  G01N33/54353 ,  G01N33/551 ,  Y10S530/811

摘要： Physiologically active substances are immobilized on an inorganic support, by treating the inorganic support with an aminoalkylakoxysilane having the general formula(RO).sub.3 SiCH.sub.2 CH.sub.2 CH.sub.2 NH(CH.sub.2).sub.n NH.sub.2wherein, R is an alkyl group having 1 to 4 carbon atoms, and n is an integer having a value of 5 to 12, and chemically bonding a physiologically active substance by means of an amino group to the support.

公开(公告)号：US09073467B2

公开(公告)日：2015-07-07

申请号：US13816033

申请日：2011-07-29

申请人： Shinji Awata ,  Hideki Kobayashi ,  Hisaya Mori

发明人： Shinji Awata ,  Hideki Kobayashi ,  Hisaya Mori

IPC分类号： B60N2/42 ,  B60N2/64 ,  B60N2/58 ,  B60N2/66 ,  B60N2/68 ,  B60N2/70 ,  B60N2/72 ,  B60N2/427

CPC分类号： B60N2/427 ,  B60N2/5825 ,  B60N2/64 ,  B60N2/66 ,  B60N2/68 ,  B60N2/7094 ,  B60N2/72

摘要： A vehicle seat includes a seat back frame that has a pair of side frames, and that forms a skeleton member of a seat back, a back board portion that is formed by a resin plate, and that is disposed at a back side of the seat back frame, and a back spring section that is at least partially formed of resin, and that is integral with the back board portion, and that spans between the pair of side frames so as to be directly supported, and that is formed so as to be able to flexurally deform in a load application direction due to load toward a seat back rear side being applied.

摘要翻译： 车辆座椅包括座椅靠背框架，该座椅靠背框架具有一对侧框架，并且形成座椅靠背的骨架构件，由树脂板形成的背板部分，并且设置在座椅的后侧 后框架，以及至少部分地由树脂形成并且与背板部分成一体的后弹簧部分，并且跨过一对侧框架直接支撑，并且形成为 能够在施加朝向座椅靠背后侧的负载下在负载施加方向上弯曲变形。

公开(公告)号：US20150145309A1

公开(公告)日：2015-05-28

申请号：US14406358

申请日：2013-07-01

申请人： Gen Takahashi ,  Hideyuki Kato ,  Hideki Kobayashi

发明人： Gen Takahashi ,  Hideyuki Kato ,  Hideki Kobayashi

IPC分类号： B60N2/48

CPC分类号： B60N2/838 ,  B60N2/809 ,  B60N2/897 ,  B60N2205/20

摘要： Two headrest stays-are supported such that, when the tilting amount in the seat front-rear direction of the headrest stays-relative to a seatback frame is within a specified range, the support stiffness of a headrest relative to the seat front-rear direction is reduced in comparison to when the tilt amount is outside the range. The two headrest stays are secured to be swingable in the seat front-rear direction in the headrest.

摘要翻译： 两个头枕支撑件被支撑成使得当头枕的座椅前后方向上的倾斜量相对于座椅靠背架在一定范围内时，头枕相对于座椅前后方向的支撑刚度 与倾斜量在该范围之外的情况相比减少。 两个头枕支架被固定在头枕的座椅前后方向上可摆动。

公开(公告)号：US08979204B2

公开(公告)日：2015-03-17

申请号：US13806967

申请日：2011-06-16

申请人： Shinji Awata ,  Hideki Kobayashi ,  Hisaya Mori

发明人： Shinji Awata ,  Hideki Kobayashi ,  Hisaya Mori

IPC分类号： A47C7/00 ,  B60N2/58 ,  B60N2/68 ,  B60N2/70 ,  B60N2/72

CPC分类号： B60N2/5816 ,  B60N2/5825 ,  B60N2/68 ,  B60N2/686 ,  B60N2/7094 ,  B60N2/72

摘要： In a seat backboard, a backboard section is formed with a size that enables it to pass through between left and right side frames of a seatback frame. Coupling fixing sections are also provided at the two seat width direction sides of the backboard section, the coupling fixing sections engaging with the front side of the side frames and supported by the side frames. The seat backboard can thereby be attached to the seatback frame from the seat front side, and the degrees of freedom for design can be increased. The seat backboard is also provided with a cover anchor section to which outer periphery anchor portions provided to a seat cover are anchored.

摘要翻译： 在座椅背板中，背板部分形成有使其能够穿过座椅靠背框架的左侧框架和右侧框架之间的尺寸。 耦合固定部分还设置在背板部分的两个座椅宽度方向侧上，联接固定部分与侧框架的前侧接合并由侧框架支撑。 因此，座椅背板可以从座椅前侧附接到座椅靠背框架，并且可以增加设计的自由度。 座椅背板还设置有盖锚固部分，其中设置到座椅盖的外周锚固部分被锚定到该锚固部分。

公开(公告)号：US08888189B2

公开(公告)日：2014-11-18

申请号：US13643274

申请日：2010-04-26

申请人： Hiroshi Tamura ,  Hideki Kobayashi ,  Shinji Fujita

发明人： Hiroshi Tamura ,  Hideki Kobayashi ,  Shinji Fujita

IPC分类号： A47C13/00 ,  A47C7/62 ,  A47C7/50 ,  B60N3/06 ,  B60N2/44 ,  B60N2/02 ,  B60N2/20 ,  B60N2/06

CPC分类号： B60N3/06 ,  B60N2/01 ,  B60N2/0232 ,  B60N2/067 ,  B60N2/20 ,  B60N2/22 ,  B60N2/5685 ,  B60N2/6009 ,  B60N2/976 ,  B60N2/995

摘要： A vehicle footrest system allows an occupant seated in a rear seat to brace their feet and that is capable of inhibiting load from concentrating at the heels of an occupant. A footrest system is provided with: a reclining device that rotates an upper end part side of a seatback in the direction of arrow A and holds it at a predetermined angle of rotation; and a slide device that slides a front seat in the direction of arrow B with respect to a vehicle body floor. When an occupant seated in a rear seat uses a footrest portion of the seatback, the reclining device is operated and the upper end part side of the seatback is inclined toward the vehicle front side. Further, the slide device is operated and a slide portion of a seat cushion is moved in a vehicle front-rear direction along a rail portion.

摘要翻译： 车辆脚踏系统允许坐在后座的乘员支撑他们的脚，并且能够阻止负载集中在乘员的后跟。 脚踏系统设置有：倾斜装置，其使座椅靠背的上端部侧沿箭头A的方向旋转并将其保持在预定的旋转角度; 以及滑动装置，其相对于车身底板沿箭头B的方向滑动前排座椅。 当坐在后排座椅上的乘客使用座椅靠背的脚踏板时，操作倾斜装置，并且座椅靠背的上端部侧朝向车辆前侧倾斜。 此外，滑动装置被操作，并且座垫的滑动部分沿着轨道部分沿车辆前后方向移动。

公开(公告)号：US08864224B2

公开(公告)日：2014-10-21

申请号：US13519614

申请日：2010-12-22

申请人： Hideki Kobayashi

发明人： Hideki Kobayashi

IPC分类号： A47C13/00 ,  B60N2/46 ,  B60N2/36 ,  B60N2/30 ,  B60N2/44

CPC分类号： B60N2/4613 ,  B60N2/3011 ,  B60N2/36 ,  B60N2/366 ,  B60N2/757 ,  B60N2002/948 ,  B60N2205/30 ,  B60N2205/35 ,  B60N2205/40

摘要： Provided is a vehicle seat capable of reliably moving a seat cushion or a seat back to a folded position by remote control without deformation or the like of an armrest. A vehicle seat has a seat cushion, a seat back, and an armrest movable between a use position and a stowed position, in which at least one of the seat cushion and the seat back is movable from a seated position to a folded position, and a remote control restraint element for restraining movement of the movable seat cushion or the movable seat back in the direction of the folded position when the armrest is at the use position is provided.

摘要翻译： 提供一种车座，其能够通过遥控器可靠地将座垫或座椅靠背移动到折叠位置而不会发生扶手的变形等。 车辆座椅具有座垫，座椅靠背和可在使用位置和收起位置之间移动的扶手，其中座垫和座椅靠背中的至少一个可从就座位置移动到折叠位置，并且 提供了一种遥控限制元件，用于当扶手处于使用位置时，限制可动座垫或可动座椅靠背在折叠位置的方向上的移动。

公开(公告)号：US08845026B2

公开(公告)日：2014-09-30

申请号：US13382091

申请日：2010-06-30

申请人： Hideki Kobayashi ,  Tetsuya Ishikawa ,  Kazuhisa Nishimura

发明人： Hideki Kobayashi ,  Tetsuya Ishikawa ,  Kazuhisa Nishimura

IPC分类号： B60N2/36 ,  B60N2/30 ,  B60N2/48

CPC分类号： B60N2/3065 ,  B60N2/3013 ,  B60N2/3088 ,  B60N2/36 ,  B60N2/859 ,  B60N2/874 ,  B60N2205/40

摘要： In a vehicle seat including a first seat portion movable between a use position in which the first seat portion is ready for use and a retracted position in which the first seat portion not in use is located, and a second seat portion movable between a use position in which the second seat portion is ready for use and a retracted position in which the second seat portion not in use is located, an actuator mechanism is configured to cause the second seat portion to start moving toward its retracted position at a time when the first seat portion passes a predetermined intermediate position that is on a way from the use position toward the retracted position.

摘要翻译： 一种车辆座椅，包括第一座椅部分，其可在第一座椅部分准备使用的使用位置与不使用第一座椅部分的缩回位置之间移动，以及可在使用位置之间移动的第二座椅部分 其中第二座椅部分准备使用，并且其中不使用第二座椅部分的缩回位置，致动器机构构造成使得第二座椅部分在第一座椅部分的第一 座部分经过从使用位置朝向缩回位置的途中的预定中间位置。