公开(公告)号：US08017610B2

公开(公告)日：2011-09-13

申请号：US12843348

申请日：2010-07-26

申请人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

发明人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

IPC分类号： A61K31/501 ,  A61K31/497 ,  A61K31/443 ,  A61K31/421 ,  C07D403/14 ,  C07D413/14 ,  C07D265/08

CPC分类号： C07D413/14 ,  C07D207/333 ,  C07D207/335 ,  C07D207/337 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

摘要翻译： 本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，并且是通式（I）表示的化合物或其药理学上可接受的盐：[其中，A表示例如氧原子或 硫原子，R1表示例如C1-C6烷基，C1-C6烷氧基或C1-C6卤代烷基，A和R1与与其结合的碳原子一起形成可以被 1至3个独立地选自取代基组α的基团，R 2表示可以被独立地选自取代基组α的1至5个基团取代的苯基或可被1至3个基团取代的杂环基 独立地选自取代基组α，R3表示羟基或C1-C6烷氧基，取代基组α由例如卤素原子，C1-C6烷基，C1-C6烷基组成 取代 具有1或2个羟基，C1-C6烷基磺酰基和由式-V-NR5R6表示的基团（其中，V表示羰基或磺酰基，R5和R6可以相同） 或不同，分别表示氢原子或C1-C6烷基，或R5和R6与键合的氮原子一起形成可以被1或2个基团独立地取代的4至6元饱和杂环 选自C 1 -C 6烷基和羟基，并且4至6元饱和杂环可以进一步含有一个氧原子或氮原子）]。

公开(公告)号：US20110003787A1

公开(公告)日：2011-01-06

申请号：US12843348

申请日：2010-07-26

申请人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

发明人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

IPC分类号： A61K31/427 ,  C07D417/04 ,  C07D413/14 ,  C07D413/12 ,  A61P3/10 ,  A61K31/501 ,  A61K31/4439 ,  A61K31/428 ,  C07D403/04 ,  A61K31/497 ,  C07D207/34 ,  A61K31/40 ,  C07D413/04 ,  A61K31/422 ,  A61K31/5355 ,  C07D417/14 ,  A61K31/5377

CPC分类号： C07D413/14 ,  C07D207/333 ,  C07D207/335 ,  C07D207/337 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

摘要翻译： 本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，并且是通式（I）表示的化合物或其药理学上可接受的盐：[其中，A表示例如氧原子或 硫原子，R1表示例如C1-C6烷基，C1-C6烷氧基或C1-C6卤代烷基，A和R1与与其结合的碳原子一起形成可以被 1至3个独立地选自取代基组α的基团，R 2表示可以被独立地选自取代基组α的1至5个基团取代的苯基或可被1至3个基团取代的杂环基 独立地选自取代基组α，R3表示羟基或C1-C6烷氧基，取代基组α由例如卤素原子，C1-C6烷基，C1-C6烷基组成 取代 具有1或2个羟基，C1-C6烷基磺酰基和由式-V-NR5R6表示的基团（其中，V表示羰基或磺酰基，R5和R6可以相同） 或不同，分别表示氢原子或C1-C6烷基，或R5和R6与键合的氮原子一起形成可以被1或2个基团独立地取代的4至6元饱和杂环 选自C 1 -C 6烷基和羟基，并且4至6元饱和杂环可以进一步含有一个氧原子或氮原子）]。

公开(公告)号：US08415359B2

公开(公告)日：2013-04-09

申请号：US13198819

申请日：2011-08-05

申请人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

发明人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

IPC分类号： A61K31/497 ,  A61K31/4439 ,  A61K31/443 ,  A61K31/428 ,  A61K31/427 ,  A61K31/421 ,  A61K31/4155 ,  A61K31/4025 ,  A61K31/40 ,  C07D401/14 ,  C07D401/12 ,  C07D413/04 ,  C07D413/14 ,  C07D277/62 ,  C07D277/20 ,  C07D263/08 ,  C07D263/30 ,  C07D403/04 ,  C07D403/14 ,  C07D207/323

CPC分类号： C07D413/14 ,  C07D207/333 ,  C07D207/335 ,  C07D207/337 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

摘要翻译： 本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，并且是通式（I）表示的化合物或其药理学上可接受的盐：[其中，A表示例如氧原子或 硫原子，R1表示例如C1-C6烷基，C1-C6烷氧基或C1-C6卤代烷基，A和R1与与其结合的碳原子一起形成可以被 1至3个独立地选自取代基组α的基团，R 2表示可以被独立地选自取代基组α的1至5个基团取代的苯基或可被1至3个基团取代的杂环基 独立地选自取代基组α，R3表示羟基或C1-C6烷氧基，取代基组α由例如卤素原子，C1-C6烷基，C1-C6烷基组成 取代 具有1或2个羟基，C1-C6烷基磺酰基和由式-V-NR5R6表示的基团（其中，V表示羰基或磺酰基，R5和R6可以相同） 或不同，分别表示氢原子或C1-C6烷基，或R5和R6与键合的氮原子一起形成可以被1或2个基团独立地取代的4至6元饱和杂环 选自C 1 -C 6烷基和羟基，并且4至6元饱和杂环可以进一步含有一个氧原子或氮原子）]。

公开(公告)号：US20090036492A1

公开(公告)日：2009-02-05

申请号：US11990289

申请日：2006-08-08

申请人： Akihiro Furukawa ,  Jun Ohsumi ,  Tsuyoshi Arita ,  Takehiro Fukuzaki ,  Kazushi Araki ,  Makoto Mori ,  Takayuki Momose ,  Takeshi Honda ,  Masanori Kuroha ,  Ryo Okuyama ,  Susumu Satoh

发明人： Akihiro Furukawa ,  Jun Ohsumi ,  Tsuyoshi Arita ,  Takehiro Fukuzaki ,  Kazushi Araki ,  Makoto Mori ,  Takayuki Momose ,  Takeshi Honda ,  Masanori Kuroha ,  Ryo Okuyama ,  Susumu Satoh

IPC分类号： A61K31/443 ,  C07D307/91 ,  C07D405/12 ,  A61K31/343

CPC分类号： C07D307/91 ,  C07D405/12 ,  C07D407/12

摘要： The present invention relates to a novel cercosporamide derivative, a pharmacologically acceptable salt thereof or an ester thereof which has an excellent hypoglycemic effect and is useful as a therapeutic and/or prophylactic agent for diabetes.A cercosporamide derivative having the general formula (I): [wherein X represents an oxygen atom or the like, R1 represents a hydrogen atom or a C1-C6 alkyl group, R2 represents a hydrogen atom, a C1-C6 alkyl group or a C1-C6 halogenated alkyl group, R3 represents a hydrogen atom or a C1-C6 alkyl group, R4 represents a C6-C10 aryl group which may be substituted with one to five group(s) independently selected from Substituent Group a, or the like, n represents 1, 2 or 3, and Substituent Group a represents a halogen atom, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group, a C1-C6 alkoxy group, a C1-C6 halogenated alkoxy group, a C2-C6 alkenyloxy group, a C2-C6 alkynyloxy group and the like], a pharmacologically acceptable salt thereof or an ester thereof.

摘要翻译： 本发明涉及一种具有优异的降血糖作用，可用作糖尿病治疗和/或预防剂的新颖的孢子虫素衍生物，其药理学上可接受的盐或其酯。 具有通式（I）的孢孢酰胺衍生物：[其中X表示氧原子等，R 1表示氢原子或C 1 -C 6烷基，R 2表示氢原子，C 1 -C 6烷基或C 1 -C 6卤代烷基，R 3表示氢原子或C 1 -C 6烷基，R 4表示可以被一至五个独立地选自取代基组a的基团取代的C 6 -C 10芳基等， n表示1,2或3，取代基组a表示卤素原子，C1-C6烷基，C1-C6卤代烷基，C2-C6烯基，C2-C6炔基，C1-C6 烷氧基，C1-C6卤代烷氧基，C2-C6链烯氧基，C2-C6炔氧基等]，其药理学上可接受的盐或其酯。

公开(公告)号：US08235934B2

公开(公告)日：2012-08-07

申请号：US12527765

申请日：2008-02-20

申请人： Kazuyoshi Tsuchiya ,  Akifumi Morishima ,  Yasutomo Uetsuji ,  Takehiro Fukuzaki

发明人： Kazuyoshi Tsuchiya ,  Akifumi Morishima ,  Yasutomo Uetsuji ,  Takehiro Fukuzaki

IPC分类号： A61B17/20

CPC分类号： F04B19/006 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150229 ,  A61B5/150282 ,  A61B5/150396 ,  A61B5/150503 ,  F04B43/095 ,  F04D33/00 ,  F04F7/00

摘要： The object of the invention is to provide a functional thin tube device in which a pump and a liquid drawing device are constituted to be not separate without a sophisticated channel design and to correspond to various applications. A functional thin tube device includes a hollow tubular body, a plurality of vibrating ring bodies mounted as being kept in contact with the tubular body spaced an interval along an axial direction on an outer circumference of the tubular body, and an energy supply means of energy for vibrating the vibrating ring bodies. The energy supply means is constituted to supply energy such that the displacement caused by vibrations is mutually different among the vibrating ring bodies.

摘要翻译： 本发明的目的是提供一种功能性薄管装置，其中泵和液体拉伸装置构成为不分离而不需要复杂的通道设计并且与各种应用相对应。 功能性薄管装置包括中空管状体，多个振动环体，其安装成与管状体保持接触，所述管状体在管状体的外周上沿着轴向方向隔开间隔，并且能量供应装置的能量 用于振动振动环体。 能量供给装置构成为提供能量，使得由振动引起的位移在振动环体之间相互不同。

公开(公告)号：US20100094223A1

公开(公告)日：2010-04-15

申请号：US12527765

申请日：2008-02-20

申请人： Kazuyoshi Tsuchiya ,  Akifumi Morishima ,  Yasutomo Uetsuji ,  Takehiro Fukuzaki

发明人： Kazuyoshi Tsuchiya ,  Akifumi Morishima ,  Yasutomo Uetsuji ,  Takehiro Fukuzaki

IPC分类号： A61M1/00 ,  F04B19/00

CPC分类号： F04B19/006 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150229 ,  A61B5/150282 ,  A61B5/150396 ,  A61B5/150503 ,  F04B43/095 ,  F04D33/00 ,  F04F7/00

摘要： The object of the invention is to provide a functional thin tube device in which a pump and a liquid drawing device are constituted to be not separate without a sophisticated channel design and to correspond to various applications. A functional thin tube device includes a hollow tubular body, a plurality of vibrating ring bodies mounted as being kept in contact with the tubular body spaced an interval along an axial direction on an outer circumference of the tubular body, and an energy supply means of energy for vibrating the vibrating ring bodies. The energy supply means is constituted to supply energy such that the displacement caused by vibrations is mutually different among the vibrating ring bodies.

摘要翻译： 本发明的目的是提供一种功能性薄管装置，其中泵和液体拉伸装置构成为不分离而不需要复杂的通道设计并且与各种应用相对应。 功能性薄管装置包括中空管状体，多个振动环体，其安装成与管状体保持接触，所述管状体在管状体的外周上沿着轴向方向隔开间隔，并且能量供应装置的能量 用于振动振动环体。 能量供给装置构成为提供能量，使得由振动引起的位移在振动环体之间相互不同。