公开(公告)号：US08017610B2

公开(公告)日：2011-09-13

申请号：US12843348

申请日：2010-07-26

申请人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

发明人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

IPC分类号： A61K31/501 ,  A61K31/497 ,  A61K31/443 ,  A61K31/421 ,  C07D403/14 ,  C07D413/14 ,  C07D265/08

CPC分类号： C07D413/14 ,  C07D207/333 ,  C07D207/335 ,  C07D207/337 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

摘要翻译： 本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，并且是通式（I）表示的化合物或其药理学上可接受的盐：[其中，A表示例如氧原子或 硫原子，R1表示例如C1-C6烷基，C1-C6烷氧基或C1-C6卤代烷基，A和R1与与其结合的碳原子一起形成可以被 1至3个独立地选自取代基组α的基团，R 2表示可以被独立地选自取代基组α的1至5个基团取代的苯基或可被1至3个基团取代的杂环基 独立地选自取代基组α，R3表示羟基或C1-C6烷氧基，取代基组α由例如卤素原子，C1-C6烷基，C1-C6烷基组成 取代 具有1或2个羟基，C1-C6烷基磺酰基和由式-V-NR5R6表示的基团（其中，V表示羰基或磺酰基，R5和R6可以相同） 或不同，分别表示氢原子或C1-C6烷基，或R5和R6与键合的氮原子一起形成可以被1或2个基团独立地取代的4至6元饱和杂环 选自C 1 -C 6烷基和羟基，并且4至6元饱和杂环可以进一步含有一个氧原子或氮原子）]。

公开(公告)号：US20110003787A1

公开(公告)日：2011-01-06

申请号：US12843348

申请日：2010-07-26

申请人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

发明人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

IPC分类号： A61K31/427 ,  C07D417/04 ,  C07D413/14 ,  C07D413/12 ,  A61P3/10 ,  A61K31/501 ,  A61K31/4439 ,  A61K31/428 ,  C07D403/04 ,  A61K31/497 ,  C07D207/34 ,  A61K31/40 ,  C07D413/04 ,  A61K31/422 ,  A61K31/5355 ,  C07D417/14 ,  A61K31/5377

CPC分类号： C07D413/14 ,  C07D207/333 ,  C07D207/335 ,  C07D207/337 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

摘要翻译： 本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，并且是通式（I）表示的化合物或其药理学上可接受的盐：[其中，A表示例如氧原子或 硫原子，R1表示例如C1-C6烷基，C1-C6烷氧基或C1-C6卤代烷基，A和R1与与其结合的碳原子一起形成可以被 1至3个独立地选自取代基组α的基团，R 2表示可以被独立地选自取代基组α的1至5个基团取代的苯基或可被1至3个基团取代的杂环基 独立地选自取代基组α，R3表示羟基或C1-C6烷氧基，取代基组α由例如卤素原子，C1-C6烷基，C1-C6烷基组成 取代 具有1或2个羟基，C1-C6烷基磺酰基和由式-V-NR5R6表示的基团（其中，V表示羰基或磺酰基，R5和R6可以相同） 或不同，分别表示氢原子或C1-C6烷基，或R5和R6与键合的氮原子一起形成可以被1或2个基团独立地取代的4至6元饱和杂环 选自C 1 -C 6烷基和羟基，并且4至6元饱和杂环可以进一步含有一个氧原子或氮原子）]。

公开(公告)号：US08415359B2

公开(公告)日：2013-04-09

申请号：US13198819

申请日：2011-08-05

申请人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

发明人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

IPC分类号： A61K31/497 ,  A61K31/4439 ,  A61K31/443 ,  A61K31/428 ,  A61K31/427 ,  A61K31/421 ,  A61K31/4155 ,  A61K31/4025 ,  A61K31/40 ,  C07D401/14 ,  C07D401/12 ,  C07D413/04 ,  C07D413/14 ,  C07D277/62 ,  C07D277/20 ,  C07D263/08 ,  C07D263/30 ,  C07D403/04 ,  C07D403/14 ,  C07D207/323

CPC分类号： C07D413/14 ,  C07D207/333 ,  C07D207/335 ,  C07D207/337 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

摘要翻译： 本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，并且是通式（I）表示的化合物或其药理学上可接受的盐：[其中，A表示例如氧原子或 硫原子，R1表示例如C1-C6烷基，C1-C6烷氧基或C1-C6卤代烷基，A和R1与与其结合的碳原子一起形成可以被 1至3个独立地选自取代基组α的基团，R 2表示可以被独立地选自取代基组α的1至5个基团取代的苯基或可被1至3个基团取代的杂环基 独立地选自取代基组α，R3表示羟基或C1-C6烷氧基，取代基组α由例如卤素原子，C1-C6烷基，C1-C6烷基组成 取代 具有1或2个羟基，C1-C6烷基磺酰基和由式-V-NR5R6表示的基团（其中，V表示羰基或磺酰基，R5和R6可以相同） 或不同，分别表示氢原子或C1-C6烷基，或R5和R6与键合的氮原子一起形成可以被1或2个基团独立地取代的4至6元饱和杂环 选自C 1 -C 6烷基和羟基，并且4至6元饱和杂环可以进一步含有一个氧原子或氮原子）]。

公开(公告)号：US20090036492A1

公开(公告)日：2009-02-05

申请号：US11990289

申请日：2006-08-08

申请人： Akihiro Furukawa ,  Jun Ohsumi ,  Tsuyoshi Arita ,  Takehiro Fukuzaki ,  Kazushi Araki ,  Makoto Mori ,  Takayuki Momose ,  Takeshi Honda ,  Masanori Kuroha ,  Ryo Okuyama ,  Susumu Satoh

发明人： Akihiro Furukawa ,  Jun Ohsumi ,  Tsuyoshi Arita ,  Takehiro Fukuzaki ,  Kazushi Araki ,  Makoto Mori ,  Takayuki Momose ,  Takeshi Honda ,  Masanori Kuroha ,  Ryo Okuyama ,  Susumu Satoh

IPC分类号： A61K31/443 ,  C07D307/91 ,  C07D405/12 ,  A61K31/343

CPC分类号： C07D307/91 ,  C07D405/12 ,  C07D407/12

摘要： The present invention relates to a novel cercosporamide derivative, a pharmacologically acceptable salt thereof or an ester thereof which has an excellent hypoglycemic effect and is useful as a therapeutic and/or prophylactic agent for diabetes.A cercosporamide derivative having the general formula (I): [wherein X represents an oxygen atom or the like, R1 represents a hydrogen atom or a C1-C6 alkyl group, R2 represents a hydrogen atom, a C1-C6 alkyl group or a C1-C6 halogenated alkyl group, R3 represents a hydrogen atom or a C1-C6 alkyl group, R4 represents a C6-C10 aryl group which may be substituted with one to five group(s) independently selected from Substituent Group a, or the like, n represents 1, 2 or 3, and Substituent Group a represents a halogen atom, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group, a C1-C6 alkoxy group, a C1-C6 halogenated alkoxy group, a C2-C6 alkenyloxy group, a C2-C6 alkynyloxy group and the like], a pharmacologically acceptable salt thereof or an ester thereof.

摘要翻译： 本发明涉及一种具有优异的降血糖作用，可用作糖尿病治疗和/或预防剂的新颖的孢子虫素衍生物，其药理学上可接受的盐或其酯。 具有通式（I）的孢孢酰胺衍生物：[其中X表示氧原子等，R 1表示氢原子或C 1 -C 6烷基，R 2表示氢原子，C 1 -C 6烷基或C 1 -C 6卤代烷基，R 3表示氢原子或C 1 -C 6烷基，R 4表示可以被一至五个独立地选自取代基组a的基团取代的C 6 -C 10芳基等， n表示1,2或3，取代基组a表示卤素原子，C1-C6烷基，C1-C6卤代烷基，C2-C6烯基，C2-C6炔基，C1-C6 烷氧基，C1-C6卤代烷氧基，C2-C6链烯氧基，C2-C6炔氧基等]，其药理学上可接受的盐或其酯。

公开(公告)号：US20090216888A1

公开(公告)日：2009-08-27

申请号：US12389797

申请日：2009-02-20

申请人： Akihiro Furukawa ,  Takanobu Suzuki

发明人： Akihiro Furukawa ,  Takanobu Suzuki

IPC分类号： G06F15/173

CPC分类号： H04L67/06 ,  H04L67/12

摘要： A data transmission device to transmit a data file to an external device is provided. The data transmission device includes a data file storing unit to store a data file to be transmitted, a communication session establishing unit, which is capable of establishing a plurality of communication sessions between the data transmission device and the external device, a data transmitting unit to transmit data included in the data file and divided in portions concurrently through the plurality of communication sessions to the external device.

摘要翻译： 提供了将数据文件发送到外部设备的数据传输设备。 数据传输装置包括：数据文件存储单元，用于存储要发送的数据文件;通信会话建立单元，能够在数据传输装置和外部装置之间建立多个通信会话;数据发送单元， 发送包括在数据文件中的数据，并通过多个通信会话同时分割到外部设备。

公开(公告)号：US5175850A

公开(公告)日：1992-12-29

申请号：US323288

申请日：1989-03-14

申请人： Keiichi Hirata ,  Yasushi Kawakami ,  Atsuko Kawasumi ,  Miyuki Sato ,  Yoshinari Morimoto ,  Akihiro Furukawa

发明人： Keiichi Hirata ,  Yasushi Kawakami ,  Atsuko Kawasumi ,  Miyuki Sato ,  Yoshinari Morimoto ,  Akihiro Furukawa

IPC分类号： G06F3/02 ,  G06F17/21 ,  G06F17/30 ,  G06F17/40

CPC分类号： G06F17/30595 ,  G06F17/21 ,  G06F17/30017 ,  G06Q10/109 ,  Y10S707/954

摘要： A data processing device wherein messages are inputted for a plurality of recipients. The recipients' names are displayed along with the number of messages. When a message is inputted for a new recipient, the recipient's name as well as the message are automatically stored. In the event the recipient's name has already been stored only the message is stored.

摘要翻译： 一种数据处理装置，其中为多个接收者输入消息。 收件人姓名与邮件数量一起显示。 当为新收件人输入消息时，会自动存储收件人的姓名以及邮件。 如果收件人的姓名已经存储，则只存储该邮件。

公开(公告)号：US4689673A

公开(公告)日：1987-08-25

申请号：US872780

申请日：1986-06-10

申请人： Junichi Ohki ,  Akihiro Furukawa

发明人： Junichi Ohki ,  Akihiro Furukawa

IPC分类号： G06T7/20 ,  H04N7/26 ,  H04N7/36 ,  H04N7/137

CPC分类号： G06T7/2013 ,  H04N19/142 ,  H04N19/179 ,  H04N19/503 ,  H04N19/51 ,  H04N19/87 ,  G06T2207/10016

摘要： In a movement compensation predictive encoder, a vector detector (19) is supplied with a moving picture signal and produces a movement vector signal representative of at least one movement vector for each region of each frame. A picture analyzer (16) serves as a variation detector for detecting a variation in each region to produce a variation signal when the variation exceeds a predetermined threshold in one of the regions. The variation signal is used in giving a predetermined value, such as zero, to the above-mentioned at least one movement vector for that one of the regions. In place of the variation detector, a scene change detector can likewise be used to produce a scene change signal for giving a predetermined value to the movement vectors for a frame for which a scene change is detected. The scene change detector is preferably operable on a summation for each frame of results of evaluation for movement compensated prediction errors rather than, as in prior art, for differences between picture elements of two consecutive frames.

摘要翻译： 在运动补偿预测编码器中，矢量检测器（19）被提供有运动图像信号，并产生代表每帧的每个区域的至少一个运动矢量的运动矢量信号。 图像分析器（16）用作变化检测器，用于当区域中的一个区域中的变化超过预定阈值时，检测每个区域的变化以产生变化信号。 变化信号用于向上述至少一个区域的一个运动矢量给出诸如零的预定值。 同样可以使用场景改变检测器来产生场景改变信号，以便为检测到场景变化的帧的运动矢量给出预定值。 优选地，对于运动补偿预测误差的评估结果的结果，场景变化检测器可操作，而不是像现有技术中那样用于两个连续帧的像素之间的差异。

公开(公告)号：US4575756A

公开(公告)日：1986-03-11

申请号：US634126

申请日：1984-07-25

申请人： Akihiro Furukawa

发明人： Akihiro Furukawa

IPC分类号： G06T9/00 ,  H04N7/26 ,  H04N7/46 ,  H04N7/12

CPC分类号： H04N19/527 ,  H04N19/577

摘要： In order to interpolate each instantaneous picture skipped between a preceding and a succeeding picture in a moving picture signal comprising a movement vector signal, a decoder comprises a movement region detector responsive to the moving picture signal for detecting a movement region for a moving or movable body in each of the preceding and the succeeding pictures, a vector selector for selecting a representative movement vector for each movement region from individual movement vectors reproduced from the movement vector signal, and an interpolator responsive to the movement region and the representative movement vector for interpolating the skipped picture between the preceding and the succeeding pictures. Preferably, the decoder is a predictive decoder for a moving picture signal of the above-mentioned type and including a prediction error signal for the movement vector signal. The vector selector selects the representative movement vector in consideration of that significance of each reproduced movement vector which is evaluated by the prediction errors represented by the prediction error signal. In either event, the representative movement vector may be the individual movement vector which is most frequent in each movement region. Alternatively, the representative movement vector may be an average of the individual movement vectors in each movement region.

摘要翻译： 为了内插在包括运动矢量信号的运动图像信号中在前一帧和后一帧之间跳过的每个瞬时图像，解码器包括响应于运动图像信号的运动区域检测器，用于检测运动或移动体的运动区域 在前面和后面的每个图像中，矢量选择器用于从根据运动矢量信号再现的各个运动矢量中选择每个运动区域的代表运动矢量，以及内插器，其响应于运动区域和代表运动矢量，用于内插 在上一张照片和下一张照片之间跳过图片。 优选地，解码器是用于上述类型的运动图像信号的预测解码器，并且包括用于运动矢量信号的预测误差信号。 考虑到由预测误差信号表示的预测误差来评估的每个再现移动矢量的有效性，向量选择器选择代表运动矢量。 在任一情况下，代表运动矢量可以是在每个移动区域中最常见的个体运动矢量。 或者，代表运动矢量可以是每个运动区域中的各运动矢量的平均值。

公开(公告)号：US20140009097A1

公开(公告)日：2014-01-09

申请号：US14004650

申请日：2012-02-03

申请人： Tomohiro Kawati ,  Akihiro Furukawa

发明人： Tomohiro Kawati ,  Akihiro Furukawa

IPC分类号： H02P25/18

CPC分类号： H02P25/188 ,  B60L7/14 ,  B60L11/1803 ,  B60L15/007 ,  B60L15/2009 ,  B60L2240/421 ,  B60L2240/429 ,  Y02T10/642 ,  Y02T10/645 ,  Y02T10/7005 ,  Y02T10/72 ,  Y02T10/7275

摘要： If a running range is selected, a current conduction mode of a motor is set to a low speed mode in which a current is conducted through a first and second windings, when a rotation speed of the motor is less than a threshold value, and is set to a high speed mode in which a current is conducted through only the first winding, when the rotation speed is equal to or greater than the threshold value. If a neutral range is selected, control of the inverter is stopped, and, a regeneration suppression control is executed to switch the current conduction mode to the high speed mode, not only in a higher-side speed range where the rotation speed is equal to or greater than the threshold value, but also in at least a part of a lower-side speed range where the rotation speed is less than the threshold value.

摘要翻译： 如果选择运行范围，则当马达的转速小于阈值时，马达的电流传导模式被设定为通过第一和第二绕组传导电流的低速模式，并且是 当转速等于或大于阈值时，设定为仅通过第一绕组电流的高速模式。 如果选择了中立范围，则停止对变频器的控制，并且执行再生抑制控制以将电流传导模式切换到高速模式，不仅在转速等于 或大于阈值，而且在旋转速度小于阈值的下侧速度范围的至少一部分中。

公开(公告)号：US20090238364A1

公开(公告)日：2009-09-24

申请号：US12365764

申请日：2009-02-04

申请人： Akihiro Furukawa ,  Satoko Ando

发明人： Akihiro Furukawa ,  Satoko Ando

IPC分类号： H04N1/44 ,  H04N1/04 ,  G06F21/00

CPC分类号： H04N1/00222 ,  H04N1/00225 ,  H04N1/4406 ,  H04N1/444 ,  H04N1/4486 ,  H04N2201/3208

摘要： A scanner includes a scanning unit which scans an object to generate scan data, a scan data storage, a location information transmitting unit configured to transmit location information indicative of a location where the scan data is stored to an external device, a device-location storage stores device-location information including device identifying information used for identifying a device to which the scan data generated by the scanning unit is transmitted and the location identifying information in a associated manner, a reception unit receives combination information representing a combination of the device identifying information and the location identifying information, and a scan data transmitting unit configured to transmit the scan data stored at a location identified by the location identifying information to the device identified by the device identifying information on condition that the combination represented by the combination information received by the reception unit is stored in the device-location storage.

摘要翻译： 扫描仪包括扫描对象以产生扫描数据的扫描单元，扫描数据存储器，位置信息发送单元，被配置为将指示扫描数据存储的位置的位置信息发送到外部设备，设备位置存储 存储包括用于识别由扫描单元生成的扫描数据发送到的设备的设备识别信息和相关联的位置识别信息的设备位置信息，接收单元接收表示设备识别信息的组合的组合信息 以及扫描数据发送单元，被配置为将由所述位置识别信息识别的位置存储的扫描数据发送到由所述设备识别信息识别的设备，条件是由由所述设备识别信息接收到的组合信息表示的组合 接待单位 存储在设备位置存储器中。