公开(公告)号：US20160016986A1

公开(公告)日：2016-01-21

申请号：US14805421

申请日：2015-07-21

Applicant: Milind Deshpande ,  Jason Allan Wiles ,  Akihiro Hashimoto ,  Avinash Phadke

Inventor： Milind Deshpande ,  Jason Allan Wiles ,  Akihiro Hashimoto ,  Avinash Phadke

IPC: C07H19/10 ,  C07H19/056 ,  A61K31/7056 ,  A61K31/7072

CPC classification number: C07H19/10 ,  A61K31/7056 ,  A61K31/7072 ,  C07B59/005 ,  C07H19/056 ,  C07H19/11

Abstract: 5′-Deuterated nucleosides and nucleotides and modifications thereof are provided for use in medical therapies, including as antiviral, anti-tumor and anti-neoplastic agents. In one embodiment, compounds, methods and uses are provided for the treatment of hepatitis C, RSV, HSV and other viral diseases in a host, including a human.

Abstract translation: 5'-脱唾液酸核苷及其核苷酸及其修饰被提供用于医学疗法，包括抗病毒，抗肿瘤和抗肿瘤剂。 在一个实施方案中，提供化合物，方法和用途用于在宿主（包括人）中治疗丙型肝炎，RSV，HSV和其它病毒性疾病。

公开(公告)号：US08285442B2

公开(公告)日：2012-10-09

申请号：US11994103

申请日：2006-06-26

Applicant: Hiroji Kohsaka ,  Keiko Kohsaka, legal representative ,  Masatomo Ishikura ,  Akihiro Hashimoto

Inventor： Hiroji Kohsaka ,  Masatomo Ishikura ,  Akihiro Hashimoto

IPC: G06F7/00

CPC classification number: G07C5/085 ,  G07C5/008 ,  G07C5/0891

Abstract: This invention intends to provide a vehicle-mounted driving recorder that can obtain necessary situation data only surely and accurately and that can contribute to effective use of a memory and to facilitation of an after-the-fact analysis of the situation data. The vehicle-mounted driving recorder comprises a situation data receiving section that receives situation data as being data indicating behavior, a surrounding situation and an operation situation of a vehicle and that temporarily stores the situation data in a temporary data storage section specified in a predetermined area of a memory, and a data administration section, in case that a plurality of contents indicated by the received situation data satisfy a previously specified given condition, that transfers a part or all of the situation data during a certain period before and after a time when the condition is satisfied from the temporary data storage section to the situation data storage section specified in a predetermined area of the memory.

Abstract translation: 本发明旨在提供一种车载驾驶记录仪，其可以准确且准确地获得必要的情况数据，并且有助于有效地使用存储器并且促进对情况数据的事后分析。 车载驾驶记录仪包括状况数据接收部分，其接收情况数据作为指示车辆的行为，周围情况和操作情况的数据，并且将情况数据临时存储在在预定区域中指定的临时数据存储部分中 存储器和数据管理部分，在由接收到的情况数据指示的多个内容满足先前指定的给定条件的情况下，在一段时间之前和之后的某个时间段内传送部分或全部情况数据， 从临时数据存储部分到在存储器的预定区域中指定的情况数据存储部分满足条件。

公开(公告)号：US20100323164A1

公开(公告)日：2010-12-23

申请号：US12801720

申请日：2010-06-22

Applicant: Mitsuhiko Ogihara ,  Tomohiko Sagimori ,  Masaaki Sakuta ,  Akihiro Hashimoto ,  Satoru Tanaka

Inventor： Mitsuhiko Ogihara ,  Tomohiko Sagimori ,  Masaaki Sakuta ,  Akihiro Hashimoto ,  Satoru Tanaka

IPC: B32B3/26 ,  C01B31/04 ,  B32B38/10

CPC classification number: H01L21/2007 ,  H01L21/02378 ,  H01L21/02527 ,  H01L21/02664

Abstract: A method is used for releasing a graphene layer from a substrate. A graphene layer is first formed on a surface of a first substrate. A metal layer is then formed on a surface of the graphene layer. A pulling force is then applied to the metal layer to detach the graphene layer from the first substrate. The released graphene layer is bonded by intermolecular force onto a surface of a second substrate separate from the first substrate or onto a surface of a bonding layer formed on the surface of the second substrate. The metal layer is then removed, by for example, etching.

Abstract translation: 一种用于从基底释放石墨烯层的方法。 首先在第一基板的表面上形成石墨烯层。 然后在石墨烯层的表面上形成金属层。 然后将拉力施加到金属层以将石墨烯层与第一基板分离。 释放的石墨烯层通过分子间力粘合到与第一基板分离的第二基板的表面上或者形成在第二基板的表面上的接合层的表面上。 然后通过例如蚀刻去除金属层。

公开(公告)号：US07486479B2

公开(公告)日：2009-02-03

申请号：US10826505

申请日：2004-04-19

Applicant: Toru Nakao ,  Takahisa Izumida ,  Akihiro Hashimoto

Inventor： Toru Nakao ,  Takahisa Izumida ,  Akihiro Hashimoto

IPC: G11B15/60 ,  G11B5/187

CPC classification number: G11B5/1871 ,  G11B5/584

Abstract: A magnetic head assembly to record servo signals, that serves for positioning of data recording magnetic heads and data reproducing magnetic heads, on magnetic tapes includes a servo signal recording head of which sliding surface has a magnetic gap embedded thereon in order to record the servo signals onto a magnetic tape and guide blocks which are set adjacent to at least one of the up-stream position or the down-stream position of a line of magnetic tape passing the servo signal recording head and are slightly set back from the sliding surface of the recording head so that said magnetic tape slides an edge of the servo signal recording head and an edge of the guide block.

Abstract translation: 用于记录伺服信号的磁头组件，用于将数据记录磁头和数据再现磁头定位在磁带上，包括伺服信号记录头，滑动表面上嵌有磁隙，以便记录伺服信号 设置在与通过伺服信号记录头的磁带系列的上游位置或下游位置中的至少一个相邻设置的磁带和导向块上，并且稍微从背面流动的 记录头，使得所述磁带滑动伺服信号记录头的边缘和引导块的边缘。

公开(公告)号：US20080071086A1

公开(公告)日：2008-03-20

申请号：US11840006

申请日：2007-08-16

Applicant: Barton Bradbury ,  Jason Wiles ,  Akihiro Hashimoto ,  Qiuping Wang ,  Edlaine Lucien ,  Godwin Pais ,  Ha Young Kim

Inventor： Barton Bradbury ,  Jason Wiles ,  Akihiro Hashimoto ,  Qiuping Wang ,  Edlaine Lucien ,  Godwin Pais ,  Ha Young Kim

IPC: C07D491/00

CPC classification number: C07D215/28 ,  C07D401/04 ,  C07D513/04

Abstract: The present invention provides process for synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones of the Formula A. The substituents R, R5, R6, R7, R8 and R9 are defined herein. The invention also provides novel synthetic intermediates useful in the synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones.

Abstract translation: 本发明提供8-甲氧基-9H-异噻唑并[5,4-b]喹啉-3,4-二酮和8A,9-二氢-4a-异噻唑并[5,4-b]喹啉-3的合成方法， 取代基R 1，R 5，R 6，R 7，R 8，R 8， >和R 9'在本文中定义。 本发明还提供了用于合成8-甲氧基-9H-异噻唑并[5,4-b]喹啉-3,4-二酮和8A,9-二氢-4a-异噻唑并[5,4-b] 喹啉-3,4-二酮。

公开(公告)号：US07199128B2

公开(公告)日：2007-04-03

申请号：US11345201

申请日：2006-02-01

Applicant: Barton J. Bradbury ,  Jason Allan Wiles ,  Milind Deshpande ,  Qiuping Wang ,  Akihiro Hashimoto ,  Edlaine Lucien

Inventor： Barton J. Bradbury ,  Jason Allan Wiles ,  Milind Deshpande ,  Qiuping Wang ,  Akihiro Hashimoto ,  Edlaine Lucien

IPC: A61K31/429 ,  A61K31/424 ,  C07D498/14 ,  C07D498/20 ,  C07D513/14 ,  C07D513/20 ,  A61P31/04 ,  C07D455/02

CPC classification number: C07D513/14 ,  C07D498/14 ,  C07D513/22 ,  C07D519/00

Abstract: The invention provides compounds and salts of Formula I and Formula II: which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables A1, A8, R2, R3, R5, R6, R7, and R9 are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of compounds of Formula I and/or Formula II and one or more other active agents. The invention also provides methods for treating microbial and protozoal infections in animals.

Abstract translation: 本发明提供式I和式II的化合物和盐：

公开(公告)号：US20060100215A1

公开(公告)日：2006-05-11

申请号：US11271556

申请日：2005-11-10

Applicant: Barton Bradbury ,  Milind Deshpande ,  Michael Pucci ,  Qiuping Wang ,  Jason Wiles ,  Yongsheng Song ,  Akihiro Hashimoto ,  Edlaine Lucien

Inventor： Barton Bradbury ,  Milind Deshpande ,  Michael Pucci ,  Qiuping Wang ,  Jason Wiles ,  Yongsheng Song ,  Akihiro Hashimoto ,  Edlaine Lucien

IPC: A61K31/496 ,  A61K31/4745 ,  C07D498/02

CPC classification number: C07D513/04 ,  C07D513/14

Abstract: The invention provides compounds and salts of Formula I and Formula II: which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables n, m, p, RA, RB, A1, R2, R3, R5, R6, R7, A8 and R9 are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and/or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in eukaryotes.

Abstract translation: 本发明提供具有抗微生物活性的式I和式II化合物和盐。 本发明还提供了可用于制备式I和式II化合物的新型合成中间体。 变量n，m，p，R a，R B，A 1，R 2，R 2， R 3，R 5，R 6，R 7，A 8和R 8， 本文定义了SUB> 9 。 本文公开的某些式I和式II化合物是细菌DNA合成和细菌复制的有效和/或选择性抑制剂。 本发明还提供包含一种或多种式I或式II化合物和一种或多种载体，赋形剂或稀释剂的抗微生物组合物，包括药物组合物。 这样的组合物可以含有式I或式II的化合物作为唯一的活性剂或可以含有式I或式II的化合物与一种或多种其它活性剂的组合。 本发明还提供了用于治疗真核生物中的微生物感染的方法。

公开(公告)号：US20060008258A1

公开(公告)日：2006-01-12

申请号：US11138316

申请日：2005-05-27

Applicant: Kazushige Kawana ,  Akihiro Hashimoto ,  Kazuhiko Oogami ,  Hideyasu Iwano ,  Hiroyuki Enomoto ,  Shinichiro Abe ,  Hiroyuki Akama ,  Masakazu Takahashi

Inventor： Kazushige Kawana ,  Akihiro Hashimoto ,  Kazuhiko Oogami ,  Hideyasu Iwano ,  Hiroyuki Enomoto ,  Shinichiro Abe ,  Hiroyuki Akama ,  Masakazu Takahashi

IPC: H04N5/781

CPC classification number: G11B27/34 ,  G11B27/3027 ,  H04N5/7805 ,  H04N9/8205

Abstract: An information reproducing device includes a setting unit that sets priority for displaying appended data appended to compressed data in a compressed data file, such as an MP3 file. The appended data is appended at various positions to the compressed data. A reading unit reads a compressed data file, an extracting unit extracts appended data from the compressed data file based on the priority set, and a display unit displays the extracted appended data. A reproducing unit reproduces the compressed data.

Abstract translation: 信息再现装置包括设置单元，该设置单元设置在压缩数据文件（例如MP3文件）中显示附加到压缩数据的附加数据的优先级。 附加数据被附加到压缩数据的各个位置。 读取单元读取压缩数据文件，提取单元基于优先级设置从压缩数据文件中提取附加数据，并且显示单元显示所提取的附加数据。 再现单元再现压缩数据。

公开(公告)号：US06522233B1

公开(公告)日：2003-02-18

申请号：US09971597

申请日：2001-10-09

Applicant: Yasuo Kyoso ,  Akihiro Hashimoto ,  Torao Misono

Inventor： Yasuo Kyoso ,  Akihiro Hashimoto ,  Torao Misono

IPC: H01F500

CPC classification number: H01F27/306 ,  H01F27/324

Abstract: A coil apparatus capable of insulating a one-turn coil from an adjacent member while requiring a small number of members. In the coil apparatus according to the present invention, a retaining piece is formed at one end and a pair of coil terminals are formed at another end of a round coil constituted of a metal plate. A fitting wall at which the coil main body is fitted and first and second retaining portions formed by notching two portions of the fitting wall facing opposite each other are formed in the insulating case. The coil main body is fitted at the fitting wall of the insulating case, the coil terminals at one end of the coil are retained at the first retaining portion as the coil is turned and the coil is insulated from the core by retaining the retaining piece at the second retaining portion and thus preventing the coil from becoming lifted. The center of the coil constituted of a metal plate is aligned on a line extending from the central line passing the center of one of the pair of coil terminals along the widthwise direction.

Abstract translation: 一种线圈装置，其能够在需要少量构件的同时将一匝线圈与相邻构件绝缘。 在根据本发明的线圈装置中，在一端形成保持片，在由金属板构成的圆形线圈的另一端形成一对线圈端子。 在绝缘壳体中形成有线圈主体嵌合的嵌合壁和在嵌合壁的两个相互相对的两个部分上形成的第一和第二保持部。 线圈主体装配在绝缘壳体的配合壁上，线圈一端的线圈端子在线圈转动时保持在第一保持部分，并且线圈通过将保持件保持在 第二保持部，从而防止线圈抬起。 由金属板构成的线圈的中心沿着沿着宽度方向从一对线圈端子的中心线的中心线延伸的线对准。

公开(公告)号：US06459494B1

公开(公告)日：2002-10-01

申请号：US09506805

申请日：2000-02-18

Applicant: Koshu Kurokawa ,  Youichi Hayata ,  Akihiro Hashimoto

Inventor： Koshu Kurokawa ,  Youichi Hayata ,  Akihiro Hashimoto

IPC: G01B1104

CPC classification number: G01B11/046

Abstract: The width measuring apparatus according to this invention includes a light emitting element, a pair of light receiving elements, a measurement support table for fixing them and calculating device, where a pair of partial laser beams of the laser beam from the light emitting element which are not projected over a traveling elongated object to be measured are received by the light receiving elements, and a width of the elongated object calculated from the received light quantities of the pair of partial laser beams. The width measuring apparatus according to this invention further includes a single light emitting element, pairs of light receiving elements, a measurement support table for fixing and calculating devise, where pairs of partial laser beams of the laser beams from the light emitting element which are not projected over traveling elongated objects are received by the light receiving elements, and widths of the elongated objects are calculated from light quantities of the received partial laser beams. Based on the apparatus, it can continuously and optically measure the width of the object in a non-contact fashion with a less amount of measuring error, and measure the widths of the objects at a less expensive cost, securing a working space.

Abstract translation: 根据本发明的宽度测量装置包括发光元件，一对光接收元件，用于固定它们和计算装置的测量支撑台，其中来自发光元件的激光束的一对局部激光束是 没有投影在被测量的行进细长物体上，由光接收元件接收，并且由该对部分激光束的接收光量计算的细长物体的宽度。 根据本发明的宽度测量装置还包括单个发光元件，一对光接收元件，用于固定和计算设备的测量支撑台，其中来自发光元件的不是激光束的激光束的一对部分激光束 投影在行进的细长物体上被光接收元件接收，并且从所接收的部分激光束的光量计算细长物体的宽度。 基于该装置，其可以以较少量的测量误差以非接触的方式连续且光学地测量物体的宽度，并且以较便宜的成本测量物体的宽度，确保工作空间。