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    Probe Unit, Apparatus for Identifying Nucleotide Region and Method of Identifying Nucleotide Region
    1.
    发明申请
    Probe Unit, Apparatus for Identifying Nucleotide Region and Method of Identifying Nucleotide Region 审中-公开
    探针单元，识别核苷酸区域的装置和识别核苷酸区域的方法

    公开(公告)号：US20080302674A1

    公开(公告)日：2008-12-11

    申请号：US11667980

    申请日：2005-12-21

    申请人： Akimitsu Okamoto ,  Taku Kamei ,  Isao Saito

    发明人： Akimitsu Okamoto ,  Taku Kamei ,  Isao Saito

    IPC分类号： G01N33/487

    CPC分类号： G01N33/5438 ,  C12Q1/6825 ,  C12Q2565/519 ,  C12Q2563/113

    摘要： A probe unit for identifying a target nucleotide region in a target nucleic acid, the unit being provided with an electrode, a probe bound to the electrode and recognizes the target nucleic acid, and a hole-transfer-inducing agent bound to the probe, wherein a nucleotide region corresponding to the target nucleotide region is located between the hole-transfer-inducing-agent-binding site and the electrode-binding end of the probe. A state of the target nucleotide region in the target nucleic acid can be identified by comparing electrochemical signal levels by energy-induced hole transfers before and after the hybridization of such a probe unit with the target nucleic acid.

    摘要翻译： 用于鉴定目标核酸中的靶核苷酸区域的探针单元，所述单元设置有电极，与电极结合并识别靶核酸的探针和与探针结合的空穴传递诱导剂，其中 与靶核苷酸区域对应的核苷酸区域位于探针的空穴传递诱导剂结合位点和电极结合末端之间。 可以通过在这种探针单元与靶核酸的杂交之前和之后通过能量诱导的空穴转移比较电化学信号水平来鉴定靶核酸中靶核苷酸区的状态。

    Nitrogen-containing heterocyclic compound and use of same
    4.
    发明授权
    Nitrogen-containing heterocyclic compound and use of same 有权
    含氮杂环化合物及其用途

    公开(公告)号：US08592454B2

    公开(公告)日：2013-11-26

    申请号：US13119743

    申请日：2009-09-18

    申请人： Junya Shirai ,  Hideyuki Sugiyama ,  Taku Kamei ,  Hironobu Maezaki

    发明人： Junya Shirai ,  Hideyuki Sugiyama ,  Taku Kamei ,  Hironobu Maezaki

    IPC分类号： A61K31/445 ,  A61K31/40 ,  A61K31/535 ,  A61K31/00 ,  C07D211/58 ,  C07D295/03

    CPC分类号： C07D401/04 ,  C07D207/14 ,  C07D211/58 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D405/12 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D413/04 ,  C07D413/06 ,  C07D413/08 ,  C07D413/14 ,  C07D417/08

    摘要： The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle; ring B is an aromatic ring optionally having substituent(s); ring D is an aromatic ring optionally having substituent(s); L is a group represented by the formula R2, R3, R4a and R4b are each independently a hydrogen atom, an optionally halogenated C1-6 alkyl group or an optionally halogenated C3-6 cycloalkyl group, or R2 and R3 are optionally bonded via an alkylene chain or an alkenylene chain, or R4a and R4b are optionally bonded via an alkylene chain or an alkenylene chain; R1 is a hydrogen atom or a substituent; m and n are each independently an integer of 0 to 5; m+n is an integer of 2 to 5; and is a single bond or double bond, or a salt thereof; and the like. The compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, digestive tract diseases, central neurological disease and the like.

    摘要翻译： 本发明涉及由下式表示的化合物：其中环A是含氮杂环; 环B是任选具有取代基的芳香环; 环D是任选具有取代基的芳香环; L是由式R2表示的基团，R3，R4a和R4b各自独立地为氢原子，任选卤代的C 1-6烷基或任选卤代的C 3-6环烷基，或者R 2和R 3经由亚烷基 链或亚链烯基，或者R4a和R4b任选地通过亚烷基链或亚烯基链键合; R1是氢原子或取代基; m和n各自独立地为0〜5的整数; m + n为2〜5的整数。 并且是单键或双键，或其盐; 等等。 该化合物具有优异的速激肽受体拮抗作用，可用作预防或治疗诸如下尿路疾病，消化道疾病，中枢神经疾病等各种疾病的药剂。

    Nitrogen-containing heterocyclic compound and use thereof
    6.
    发明授权
    Nitrogen-containing heterocyclic compound and use thereof 有权
    含氮杂环化合物及其用途

    公开(公告)号：US08470816B2

    公开(公告)日：2013-06-25

    申请号：US12314015

    申请日：2008-12-02

    申请人： Yoshinori Ikeura ,  Junya Shirai ,  Hideyuki Sugiyama ,  Yuji Nishikimi ,  Taku Kamei ,  Nobuki Sakauchi

    发明人： Yoshinori Ikeura ,  Junya Shirai ,  Hideyuki Sugiyama ,  Yuji Nishikimi ,  Taku Kamei ,  Nobuki Sakauchi

    IPC分类号： A61K31/5355 ,  A61K31/445 ,  A61K31/444 ,  A61K31/40 ,  C07D413/04 ,  C07D401/04 ,  C07D211/56 ,  C07D207/14

    CPC分类号： C07D211/58 ,  C07D401/12 ,  C07D401/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/14

    摘要： The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle optionally further having substituent(s), ring B is an aromatic ring optionally having substituent(s), ring C is a cyclic group optionally having substituent(s), R1 is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group, a heterocyclic group optionally having substituent(s) or an amino group optionally having substituent(s), R2 is an optionally halogenated C1-6 alkyl group, m and n are each an integer of 0 to 5, m+n is an integer of 2 to 5, and is a single bond or a double bond, or a salt thereof and the like. Since the compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, gastrointestinal diseases, central nervous system diseases and the like.

    摘要翻译： 本发明涉及一种由下式表示的化合物：其中环A为任选具有取代基的含氮杂环，环B为任选具有取代基的芳环，环C为任选具有取代基的环状基团 R 1为氢原子，任选具有取代基的烃基，酰基，任选具有取代基的杂环基或任选具有取代基的氨基，R2为任选卤代的C1 -6烷基，m和n分别为0〜5的整数，m + n为2〜5的整数，为单键或双键，或其盐等。 由于该化合物具有优异的速激肽受体拮抗作用，并且可用作预防或治疗诸如下尿路疾病，胃肠道疾病，中枢神经系统疾病等各种疾病的药剂。

    Nitrogen-containing heterocyclic compound and use thereof
    8.
    发明申请
    Nitrogen-containing heterocyclic compound and use thereof 有权
    含氮杂环化合物及其用途

    公开(公告)号：US20090156572A1

    公开(公告)日：2009-06-18

    申请号：US12314015

    申请日：2008-12-02

    申请人： Yoshinori Ikeura ,  Junya Shirai ,  Hideyuki Sugiyama ,  Yuji Nishikimi ,  Taku Kamei ,  Nobuki Sakauchi

    发明人： Yoshinori Ikeura ,  Junya Shirai ,  Hideyuki Sugiyama ,  Yuji Nishikimi ,  Taku Kamei ,  Nobuki Sakauchi

    IPC分类号： A61K31/397 ,  C07D413/12 ,  A61K31/5377 ,  C07D401/12 ,  A61K31/4545 ,  C07D417/14 ,  A61K31/541 ,  C07D401/14 ,  A61K31/497 ,  C07D487/04 ,  A61K31/4985

    CPC分类号： C07D211/58 ,  C07D401/12 ,  C07D401/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/14

    摘要： The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle optionally further having substituent(s), ring B is an aromatic ring optionally having substituent(s), ring C is a cyclic group optionally having substituent(s), R1 is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group, a heterocyclic group optionally having substituent(s) or an amino group optionally having substituent(s), R2 is an optionally halogenated C1-6 alkyl group, m and n are each an integer of 0 to 5, m+n is an integer of 2 to 5, and is a single bond or a double bond, or a salt thereof and the like. Since the compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, gastrointestinal diseases, central nervous system diseases and the like.

    摘要翻译： 本发明涉及一种由下式表示的化合物：其中环A为任选具有取代基的含氮杂环，环B为任选具有取代基的芳环，环C为任选具有取代基的环状基团 R 1为氢原子，任选具有取代基的烃基，酰基，任选具有取代基的杂环基或任选具有取代基的氨基，R2为任选卤代的C1 -6烷基，m和n各自为0至5的整数，m + n为2至5的整数，并且是单键或双键，或其盐等。 由于该化合物具有优异的速激肽受体拮抗作用，并且可用作预防或治疗诸如下尿路疾病，胃肠道疾病，中枢神经系统疾病等各种疾病的药剂。