公开(公告)号：US20100062045A1

公开(公告)日：2010-03-11

申请号：US12516998

申请日：2007-11-30

申请人： Sumiyo Nishi ,  Akinori Hanatani ,  Junichi Sekiya ,  Sachiko Terashi ,  Hitoshi Akemi ,  Satoko Washiro

发明人： Sumiyo Nishi ,  Akinori Hanatani ,  Junichi Sekiya ,  Sachiko Terashi ,  Hitoshi Akemi ,  Satoko Washiro

IPC分类号： A61K31/445 ,  A61K9/70 ,  A61P25/28

CPC分类号： A61K31/445 ,  A61K9/7061 ,  A61K31/375 ,  A61K33/04

摘要： [Object] By suppressing coloring of an adhesive preparation containing donepezil, a naturally colored appearance is realized.[Solution] In a method for suppressing coloring of an adhesive preparation having a support and a pressure-sensitive adhesive layer, which comprises a pressure-sensitive adhesive and donepezil in the pressure-sensitive adhesive layer, ascorbic acid, a metal salt or an ester thereof and metal metabisulfite salt are contained in the pressure-sensitive adhesive layer. This method preferably has: a step of preparing a mixture comprising the pressure-sensitive adhesive, the donepezil, the ascorbic acid, a metal salt or an ester thereof, and the metal metabisulfite salt; and a step of film-forming the pressure-sensitive adhesive layer by applying the mixture to the surface of the support.

摘要翻译： 通过抑制含有多奈哌齐的粘合剂的着色，实现了自然着色的外观。 [解决方案]在压敏粘合剂层中包含压敏粘合剂和多奈哌齐的粘合剂的制备方法中，具有支持体和粘合剂层的粘合剂的制备方法，抗坏血酸，金属盐或酯 并且在压敏粘合剂层中含有偏亚硫酸氢盐。 该方法优选具有：制备包含压敏粘合剂，多奈哌齐，抗坏血酸，金属盐或其酯和偏亚硫酸氢盐的混合物的步骤; 以及通过将所述混合物施加到所述载体的表面来成膜所述压敏粘合剂层的步骤。

公开(公告)号：US20100048628A1

公开(公告)日：2010-02-25

申请号：US12517004

申请日：2007-11-30

申请人： Sumiyo Nishi ,  Akinori Hanatani ,  Junichi Sekiya ,  Sachiko Terashi ,  Hitoshi Akemi ,  Satoko Washiro

发明人： Sumiyo Nishi ,  Akinori Hanatani ,  Junichi Sekiya ,  Sachiko Terashi ,  Hitoshi Akemi ,  Satoko Washiro

IPC分类号： A61K31/445 ,  A61P25/28

CPC分类号： A61K31/445 ,  A61K9/7061 ,  A61K31/375 ,  A61K33/04

摘要： [Object] Discoloration, over time, of a donepezil-containing adhesive preparation is suppressed.[Solution] At least one species of stabilizer selected from the group consisting of ascorbic acid, a metal salt or an ester thereof, isoascorbic acid or a metal salt thereof, ethylenediamine tetraacetic acid or a metal salt thereof, 2-mercaptobenzimidazole, 3(2)-t-butyl-4-hydroxyanisole, 2,6-di-t-butyl-4-methylphenol, tetrakis[3-(3′,5′-di-t-butyl-4′-hydroxyphenyl)propionic acid]pentaerythritol, (±)-α-tocopherol, (±)-α-tocopherol acetate, rutin, hypophosphorous acid, a metal metabisulfite salt and a metal salt of hydroxymethanesulfinic acid, is blended in a pressure-sensitive adhesive layer containing a pressure-sensitive adhesive and donepezil.

摘要翻译： [目的]抑制多奈哌齐胶粘剂的变色，随着时间的推移。 [溶液]选自抗坏血酸，金属盐或其酯，异抗坏血酸或其金属盐，乙二胺四乙酸或其金属盐，2-巯基苯并咪唑，3（2 ）叔丁基-4-羟基苯甲醚，2,6-二叔丁基-4-甲基苯酚，四[3-（3'，5'-二叔丁基-4'-羟基苯基）丙酸]季戊四醇 ，（±）-α-生育酚，（±）-α-生育酚乙酸酯，芦丁，次磷酸，偏亚硫酸氢盐金属盐和羟基甲烷亚磺酸的金属盐混合在含有压敏粘合剂 和多奈哌齐。

公开(公告)号：US20080131490A1

公开(公告)日：2008-06-05

申请号：US11987480

申请日：2007-11-30

申请人： Akinori Hanatani ,  Junichi Sekiya ,  Sachiko Terashi ,  Sumiyo Nishi ,  Satoko Washiro ,  Hitoshi Akemi

发明人： Akinori Hanatani ,  Junichi Sekiya ,  Sachiko Terashi ,  Sumiyo Nishi ,  Satoko Washiro ,  Hitoshi Akemi

IPC分类号： A61K9/70 ,  A61K31/445 ,  A61P25/28

CPC分类号： A61K31/445 ,  A61K9/7061 ,  A61K31/375 ,  A61K33/04

摘要： A donepezil-containing patch preparation is provided whereby production of donepezil-related substances in the pressure-sensitive adhesive layer is suppressed. A stabilizer comprising at least one or more species selected from the group consisting of ascorbic acid, metal salts or esters thereof, isoascorbic acid or metal salts thereof, ethylenediamine tetraacetic acid or metal salts thereof, cysteine, acetylcysteine, 2-mercaptobenzimidazole, 3(2)-t-butyl-4-hydroxyanisole, 2,6-di-t-butyl-4-methylphenol, tetrakis[3-(3′,5′-di-t-butyl-4′-hydroxyphenyl)propionic acid]pentaerythritol, 3-mercapto-1,2-propanediol, tocopherol acetate, rutin, quercetin, hydroquinone, metal salts of hydroxymethanesulfinic acid, metal metabisulfite salts, metal sulfite salts and metal thiosulfate salts is blended in a donepezil-containing pressure-sensitive adhesive layer provided on at least one side of a support.

摘要翻译： 提供了含多奈哌齐的贴剂，抑制了压敏粘合剂层中多奈哌齐相关物质的产生。 包含至少一种或多种选自抗坏血酸，金属盐或其酯，异抗坏血酸或其金属盐，乙二胺四乙酸或其金属盐，半胱氨酸，乙酰半胱氨酸，2-巯基苯并咪唑，3（2 ）叔丁基-4-羟基苯甲醚，2,6-二叔丁基-4-甲基苯酚，四[3-（3'，5'-二叔丁基-4'-羟基苯基）丙酸]季戊四醇 ，3-巯基-1,2-丙二醇，生育酚乙酸酯，芦丁，槲皮素，氢醌，羟基甲烷亚磺酸的金属盐，偏亚硫酸氢盐，金属亚硫酸盐和金属硫代硫酸盐，配制在含有多奈哌齐的压敏粘合剂层中 在支架的至少一侧。

公开(公告)号：US20080131491A1

公开(公告)日：2008-06-05

申请号：US11987481

申请日：2007-11-30

申请人： Akinori Hanatani ,  Satoko Washiro ,  Hitoshi Akemi

发明人： Akinori Hanatani ,  Satoko Washiro ,  Hitoshi Akemi

IPC分类号： A61F13/02

CPC分类号： A61K9/7061 ,  A61F2013/00646 ,  A61K31/445

摘要： The present invention provides a percutaneously absorbable preparation for percutaneous absorption of donepezil or its hydrochloride which is stable and resistant to loss of cohesiveness of the pressure-sensitive adhesive layer while attached and resistant to adhesive transfer due to cohesive failure during removal by peeling. The percutaneously absorbable preparation comprises 2-[(1-benzyl-4-piperidinyl)methyl]-5,6-dimethoxyindan-1-on and/or its hydrochloride and a metal chloride in a pressure-sensitive adhesive layer which has been crosslinked.

摘要翻译： 本发明提供一种用于经皮吸收多奈哌齐或其盐酸盐的经皮吸收制剂，其在附着时耐压粘合剂层的稳定性和耐粘附性，并且由于通过剥离去除期间的内聚力破坏而抵抗粘合剂转移。 经皮吸收制剂包含2 - [（1-苄基-4-哌啶基）甲基] -5,6-二甲氧基茚满-1-酮和/或其盐酸盐和已经交联的压敏粘合剂层中的金属氯化物。

公开(公告)号：US20070134311A1

公开(公告)日：2007-06-14

申请号：US11634104

申请日：2006-12-06

申请人： Satoko Washiro ,  Akinori Hanatani

发明人： Satoko Washiro ,  Akinori Hanatani

IPC分类号： A61K31/4164 ,  A61K31/44 ,  A61K31/40 ,  A61K9/70

CPC分类号： A61K9/0014 ,  A61K9/7038

摘要： An external preparation having excellent percutaneous absorption ability for ionic drugs is provided. An external preparation which comprises the following components (a) and (b); component (a): an ionic drug, component (b): an ionic liquid containing a cation and an anion. By this construction, the ionic liquid functions as a solubilizing agent for the ionic drug and thereby the solubility of the drug in the external preparation increases, so that percutaneous absorption ability of the ionic drug is accelerated.

摘要翻译： 提供了具有优异的离子药物经皮吸收能力的外用制剂。 包含以下组分（a）和（b）的外用制剂; 组分（a）：离子药物，组分（b）：含有阳离子和阴离子的离子液体。 通过这种结构，离子液体用作离子药物的增溶剂，由此使药物在外用制剂中的溶解度增加，从而加速离子药物的经皮吸收能力。