公开(公告)号：US20080045796A1

公开(公告)日：2008-02-21

申请号：US11758688

申请日：2007-06-06

申请人： Akira YAMAMOTO ,  Yusuke IIMORI ,  Mizue SAZE ,  Mariko ISHIGURO ,  Pilryon LEE ,  Hiroyuki SASAKI

发明人： Akira YAMAMOTO ,  Yusuke IIMORI ,  Mizue SAZE ,  Mariko ISHIGURO ,  Pilryon LEE ,  Hiroyuki SASAKI

IPC分类号： A61B1/00 ,  A61K49/00

CPC分类号： A61K49/0023

摘要： A fluorescent stain which has a function of clarifying the shape of the surface of the gastrointestinal lumen in the visible light wavelength region, and simultaneously, emitting fluorescence by being excited by light of a specific wavelength, and which is also biologically safe and is suitable for endoscopic observation, is provided. A histofluorescent stain composition for endoscopy, containing a compound represented by the following Formula (1): wherein R1 represents a hydrogen atom or a hydroxyl group; R3 represents a phenyl group or methyl group, to which R2c is bound; one to three of R2a, R2b and R2c represent —SO3M (wherein M represents an alkali metal atom or an alkaline earth metal atom), or —SO3NH4, and when one represents —SO3−, the others represent hydrogen atoms is provided.

摘要翻译： 具有澄清可见光波长区域的胃肠腔表面形状的荧光染料，同时通过被特定波长的光激发而发出荧光，并且也具有生物学安全性，适用于 提供内窥镜观察。 用于内窥镜检查的组织荧光染色组合物，其含有由下式（1）表示的化合物：其中R 1表示氢原子或羟基; R 3表示R 2c结合的苯基或甲基; R 2a，R 2b和R 2c中的一个至三个表示-SO 3 M（其中M表示 碱金属原子或碱土金属原子）或-SO 3 NH 4，当一个表示-SO 3 - ，其他代表氢原子。

公开(公告)号：US20080008656A1

公开(公告)日：2008-01-10

申请号：US11762961

申请日：2007-06-14

申请人： Akira YAMAMOTO ,  Yusuke IIMORI ,  Mizue SAZE ,  Mariko ISHIGURO ,  Pilryon LEE

发明人： Akira YAMAMOTO ,  Yusuke IIMORI ,  Mizue SAZE ,  Mariko ISHIGURO ,  Pilryon LEE

IPC分类号： A61K49/00 ,  A61P43/00

CPC分类号： A61K49/0043 ,  A61K49/0071

摘要： It is intended to provide means for more clearly showing an image of fluorescent staining of a lumen of the digestive tract. The present invention provides an agent for enhancing a contrast of an image of fluorescent staining of a lumen of the digestive tract with an intravenously administered fluorescent dye, wherein the agent for enhancing a contrast is an agent for a lumen of the digestive tract containing an aqueous solution having a buffer capacity and having a pH of 6 to 10.

摘要翻译： 旨在提供用于更清楚地显示消化道的内腔的荧光染色的图像的装置。 本发明提供了一种用于增强消化道腔的荧光染色的图像与静脉内施用的荧光染料的对比度的试剂，其中用于增强对比度的药剂是含有水性的消化道的内腔的药剂 具有缓冲能力并且pH为6至10的溶液。

公开(公告)号：US20080069776A1

公开(公告)日：2008-03-20

申请号：US11855254

申请日：2007-09-14

申请人： Akira YAMAMOTO ,  Yusuke IIMORI ,  Mizue SAZE ,  Mariko ISHIGURO ,  Yae KUROSAWA ,  Hiroyuki SASAKI

发明人： Akira YAMAMOTO ,  Yusuke IIMORI ,  Mizue SAZE ,  Mariko ISHIGURO ,  Yae KUROSAWA ,  Hiroyuki SASAKI

IPC分类号： A61B1/06 ,  A61K49/00

CPC分类号： A61K49/0023

摘要： A histofluorescent stain for endoscopy having good fluorescent stainability for the inner part of tissues is provided.A histofluorescent stain composition for endoscopy, containing a compound represented by the following Formula (1) wherein R1 and R2, which may be identical or different, each represent an alkyl group having 1 to 5 carbon atoms; and X− represents an anion residue.

摘要翻译： 提供了对于内部部分具有良好荧光染色性的内镜检查的组织荧光染色剂。 用于内窥镜检查的组织荧光染色组合物，其含有下式（1）表示的化合物，其中R 1和R 2可以相同或不同，各自表示烷基 具有1至5个碳原子的基团; 而X - 代表阴离子残基。

公开(公告)号：US20070138206A1

公开(公告)日：2007-06-21

申请号：US11611245

申请日：2006-12-15

申请人： Akira YAMAMOTO ,  Tetsuya NAKAMURA ,  Yae KUROSAWA ,  Yusuke IIMORI ,  Pilryon LEE

发明人： Akira YAMAMOTO ,  Tetsuya NAKAMURA ,  Yae KUROSAWA ,  Yusuke IIMORI ,  Pilryon LEE

IPC分类号： B67D5/38 ,  B65D37/00

CPC分类号： A61B1/012 ,  A61B5/4839

摘要： A liquid spray tool for an endoscope includes a flexible tube to be inserted into and extracted from a treatment tool insertion channel of the endoscope, a liquid storage pouch configured to pool solution to be conveyed into the flexible tube therein, a liquid measuring pouch for measuring an amount of the solution which is arranged between a rear end of the flexible tube and a distal end of the liquid storage pouch, and a first one-way valve arranged between the liquid storage pouch and the liquid measuring pouch, the first one-way valve being configured to allow the solution to pass theretrough from an inside of the liquid storage pouch to an inside of the liquid measuring pouch, and to prevent the solution from passing theretrough from the inside of the liquid measuring pouch to the inside of the liquid storage pouch.

摘要翻译： 一种用于内窥镜的液体喷射工具，包括：插入到内窥镜的治疗工具插入通道中并从其中取出的柔性管;液体储存袋，其构造成将要输送到其中的柔性管的溶液集中;用于测量的液体测量袋 布置在柔性管的后端和液体储存袋的远端之间的溶液的量和布置在液体储存袋和液体测量袋之间的第一单向阀，第一单向 阀构造成允许溶液从液体储存袋的内部通过液体测量袋的内部，并且防止溶液从液体测量袋的内部通过液体储存器的内部 袋。

公开(公告)号：US20070149851A1

公开(公告)日：2007-06-28

申请号：US11567315

申请日：2006-12-06

申请人： Tetsuya NAKAMURA ,  Akira YAMAMOTO ,  Yae KUROSAWA ,  Yusuke IIMORI ,  Pilryon LEE

发明人： Tetsuya NAKAMURA ,  Akira YAMAMOTO ,  Yae KUROSAWA ,  Yusuke IIMORI ,  Pilryon LEE

IPC分类号： A61B1/00 ,  A61B1/12

CPC分类号： A61B1/012 ,  A61B1/0008 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/00181 ,  A61B1/00188 ,  A61B1/04 ,  G02B23/2423

摘要： An endoscope for magnified image observation configured to observe a magnified image of in vivo tissue comprises an insertion part configured to be inserted into a body, a magnified image observation port configured to take in the magnified image of the in vivo tissue in one of a state where the magnified image observation port is in contact with the in vivo tissue and a state where the magnified image observation port is in proximity to the in vivo tissue, the observation port being provided at a distal end of the insertion part, and a marking unit configured to mark the in vivo tissue in one of the state where the magnified image observation port is in contact with the in vivo tissue and the state where the magnified image observation port is in proximity to the in vivo tissue.

摘要翻译： 用于观察体内组织的放大图像的放大图像观察用内窥镜包括被配置为插入到体内的插入部，被配置为以一种状态摄取体内组织的放大图像的放大图像观察端口 其中放大图像观察端口与体内组织接触，放大图像观察端口接近体内组织的状态，观察端口设置在插入部分的远端，标记单元 被配置为在放大图像观察端口与体内组织接触的状态和放大图像观察端口接近体内组织的状态之一标记体内组织。

公开(公告)号：US20070135776A1

公开(公告)日：2007-06-14

申请号：US11610081

申请日：2006-12-13

申请人： Akira YAMAMOTO ,  Tetsuya NAKAMURA ,  Yae KUROSAWA ,  Yusuke IIMORI ,  Pilryon LEE

发明人： Akira YAMAMOTO ,  Tetsuya NAKAMURA ,  Yae KUROSAWA ,  Yusuke IIMORI ,  Pilryon LEE

IPC分类号： A61M35/00

CPC分类号： A61M31/00

摘要： A liquid applicator for an endoscope configured to apply liquid to in vivo tissue includes a flexible tube to be inserted into and extracted from a treatment tool insertion channel of the endoscope, a brush member provided at a distal end of the flexible tube, and a fluid channel formed in the flexible tube to supply the liquid to the brush member.

摘要翻译： 构造成将液体施加到体内组织的内窥镜用液体涂布器包括：插入到内窥镜的治疗工具插入通道中的柔性管，以及设置在柔性管的远端的刷部件，以及流体 通道形成在柔性管中以将液体供应到刷构件。

公开(公告)号：US20070004839A1

公开(公告)日：2007-01-04

申请号：US11428418

申请日：2006-07-03

申请人： Akira YAMAMOTO ,  Yusuke IIMORI ,  Mae KOYAMA

发明人： Akira YAMAMOTO ,  Yusuke IIMORI ,  Mae KOYAMA

IPC分类号： C08K3/32

CPC分类号： C08K3/32 ,  C08K3/08 ,  C08L79/02

摘要： Highly dispersible inorganic compound nanoparticles include a high molecular nitrogen compound having at least two amino groups selected from primary amino groups, secondary amino groups and tertiary amino groups; and inorganic compound nanoparticles bonded to at least one amino group of the at least two amino groups. The inorganic compound nanoparticles are covered with the high molecular nitrogen compound.

摘要翻译： 高分散性无机化合物纳米颗粒包括具有至少两个选自伯氨基，仲氨基和叔氨基的氨基的高分子氮化合物; 和与至少两个氨基的至少一个氨基键合的无机化合物纳米颗粒。 无机化合物纳米颗粒被高分子氮化合物覆盖。

公开(公告)号：US20100311902A1

公开(公告)日：2010-12-09

申请号：US11531909

申请日：2006-09-14

申请人： Akira YAMAMOTO ,  Yusuke IIMORI ,  Mae KOYAMA

发明人： Akira YAMAMOTO ,  Yusuke IIMORI ,  Mae KOYAMA

IPC分类号： C08F8/40

CPC分类号： B82Y5/00 ,  C01B25/32 ,  Y10S977/773

摘要： Highly dispersible inorganic compound nanoparticles modified by functional molecules include the functional molecules; a high molecular nitrogen compound having at least two amino groups selected from primary amino groups, secondary amino groups and tertiary amino groups; and inorganic compound nanoparticles bonded to at least one amino group of the at least two amino groups. The high molecular nitrogen compound is modified by the functional molecules, and the inorganic compound nanoparticles are covered with the high molecular nitrogen compound modified by the functional molecules.

摘要翻译： 通过功能分子改性的高分散性无机化合物纳米粒子包括功能分子; 具有至少两个选自伯氨基，仲氨基和叔氨基的氨基的高分子氮化合物; 和与至少两个氨基的至少一个氨基键合的无机化合物纳米颗粒。 高分子氮化合物被功能分子改性，无机化合物纳米粒子被功能分子改性的高分子氮化合物覆盖。

公开(公告)号：US20070190650A1

公开(公告)日：2007-08-16

申请号：US11673793

申请日：2007-02-12

申请人： Akira YAMAMOTO ,  Yusuke IIMORI ,  Mae KOYAMA

发明人： Akira YAMAMOTO ,  Yusuke IIMORI ,  Mae KOYAMA

IPC分类号： C12N5/06

CPC分类号： A61L27/3847 ,  A61K35/12 ,  A61L27/12 ,  A61L27/34 ,  A61L27/3895 ,  C12N5/0654 ,  C12N2533/10 ,  C12N2533/18 ,  C12N2533/30

摘要： A composite body of an inorganic compound and cells includes animal cells filled with fine particles of the inorganic compound, and the fine particles of the inorganic compound adhered to an outer portion of the animal cells. A method of producing a composite body of an inorganic compound and cells is also provided, including cultivating animal cells in a culture medium containing fine particles of the inorganic compound, and separating a solid component from the cultivated product.

摘要翻译： 无机化合物和细胞的复合体包括填充有无机化合物的细颗粒的动物细胞和附着于动物细胞外部的无机化合物的微粒。 还提供了生产无机化合物和细胞的复合体的方法，包括在含有无机化合物的微粒的培养基中培养动物细胞，并从培养物中分离出固体成分。