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1.发明申请公开(公告)号：US20130030006A1
公开(公告)日：2013-01-31
申请号：US13640824
申请日：2011-04-27
IPC分类号： A61K31/496 , A61P29/00 , C07D413/14 , A61P13/08 , A61K31/4545 , C07D401/14 , C07D401/12 , A61P13/10
CPC分类号： C07D401/12 , A61K31/4545 , A61K31/496 , C07D213/65 , C07D213/80 , C07D401/14 , C07D413/14
摘要： [Problem] Provided is an agent for preventing or treating diseases accompanied by urinary pain.[Means for Solution] A pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound or a salt thereof was confirmed to have not only an action of increasing effective bladder capacity but also an analgesic action against bladder pain and testis pain, based on FAAH inhibitory action. Accordingly, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound or a salt thereof can be used for preventing or treating interstitial cystitis/bladder pain syndrome and/or chronic nonbacterial prostatitis/chronic pelvic pain syndrome.
摘要翻译： [问题]提供用于预防或治疗伴有尿痛的疾病的药剂。 [解决方案]确认吡啶基非芳香族含氮杂环-1-羧酸酯化合物或其盐不仅具有增加膀胱有效能力的作用，而且还具有针对膀胱疼痛和睾丸疼痛的镇痛作用，基于 FAAH抑制作用。 因此，吡啶基非芳香族含氮杂环-1-羧酸酯化合物或其盐可用于预防或治疗间质性膀胱炎/膀胱疼痛综合征和/或慢性非细菌性前列腺炎/慢性盆腔疼痛综合征。
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公开(公告)号：US08426673B2
公开(公告)日：2013-04-23
申请号：US12811338
申请日：2009-01-09
IPC分类号： C12N15/00
CPC分类号： A61K49/0008 , A01K2207/20 , A01K2227/10 , A01K2227/105 , A01K2267/03 , G01N33/5082 , G01N2500/00
摘要： A pathologic animal model characterized in that a pain or discomfort behavior and urinary frequency are induced by administering a stimulative substance into the testes of a small-sized mammal, and a screening method for a therapeutic agent for pelvic pain syndrome, particularly non-bacterial chronic prostatitis, which comprises administering a test substance to the pathologic animal model and measuring pain or discomfort behaviors and/or urinary frequency.
摘要翻译： 一种病理动物模型，其特征在于通过向小型哺乳动物的睾丸施用刺激性物质诱导疼痛或不适行为和尿频，以及用于骨盆疼痛综合征，特别是非细菌性慢性疾病的治疗剂的筛选方法 前列腺炎，其包括向病理动物模型施用测试物质并测量疼痛或不适行为和/或尿频。
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3.发明申请PATHOLOGICAL ANIMAL MODEL SIMULTANEOUSLY DEVELOPING TESTICULAR PAIN OR DISCOMFORT BEHAVIORS AND URINARY FREQUENCY 失效病理动物模型同时发展特征性疼痛或不良反应行为和尿频公开(公告)号：US20100313282A1
公开(公告)日：2010-12-09
申请号：US12811338
申请日：2009-01-09
CPC分类号： A61K49/0008 , A01K2207/20 , A01K2227/10 , A01K2227/105 , A01K2267/03 , G01N33/5082 , G01N2500/00
摘要： A pathologic animal model characterized in that a pain or discomfort behavior and urinary frequency are induced by administering a stimulative substance into the testes of a small-sized mammal, and a screening method for a therapeutic agent for pelvic pain syndrome, particularly non-bacterial chronic prostatitis, which comprises administering a test substance to the pathologic animal model and measuring pain or discomfort behaviors and/or urinary frequency.
摘要翻译： 一种病理动物模型，其特征在于通过向小型哺乳动物的睾丸施用刺激性物质诱导疼痛或不适行为和尿频，以及用于骨盆疼痛综合征，特别是非细菌性慢性疾病的治疗剂的筛选方法 前列腺炎，其包括向病理动物模型施用测试物质并测量疼痛或不适行为和/或尿频。
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公开(公告)号：US08163746B2
公开(公告)日：2012-04-24
申请号：US12297275
申请日：2007-04-19
申请人： Keizo Sugasawa , Kenichi Kawaguchi , Takaho Matsuzawa , Ryushi Seo , Hironori Harada , Akira Suga , Tomoaki Abe , Hidenori Azami , Shunichiro Matsumoto , Takashi Shin , Masayuki Tanahashi , Toru Watanabe
发明人： Keizo Sugasawa , Kenichi Kawaguchi , Takaho Matsuzawa , Ryushi Seo , Hironori Harada , Akira Suga , Tomoaki Abe , Hidenori Azami , Shunichiro Matsumoto , Takashi Shin , Masayuki Tanahashi , Toru Watanabe
IPC分类号： A61K31/5355 , A61K31/496 , A61K31/451 , A61K31/4535 , A61K31/426 , C07D413/14 , C07D211/32 , C07D211/46 , C07D277/24
CPC分类号： C07D277/56 , C07D263/34 , C07D263/48 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/08
摘要： Provided is an agent for treating or preventing urinary frequency, urinary urgency and urinary, incontinence which are associated with overactive bladder, a lower urinary tract disease such as interstitial cystitis and chronic prostatitis accompanied by lower urinary tract pain, and various diseases accompanied by pain. A novel azolecarboxamide derivative in which an azole ring such as thioazole or oxazole is bonded to a benzene ring, pyridine ring or pyrimidine ring through carboxamide was confirmed to have a potent trkA receptor-inhibitory activity and found to be an agent for treating or preventing lower urinary tract disease and various diseases accompanied by pain, which is excellent in efficacy and safety, and thus the present invention was accomplished.
摘要翻译： 提供治疗或预防与膀胱过度活动相关的尿频，尿急和尿失禁的药物，诸如间质性膀胱炎的下尿路疾病和伴有下尿路疼痛的慢性前列腺炎以及伴有疼痛的各种疾病。 通过甲酰胺将唑环或吡唑环或吡啶环或吡啶环与吡唑或恶唑等唑类结合的新型偶氮甲酰胺衍生物被证实具有强的trkA受体抑制活性，被发现是用于治疗或预防较低 泌尿道疾病，伴有疼痛的各种疾病，其功效和安全性优异，从而完成了本发明。
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公开(公告)号：US20090286766A1
公开(公告)日：2009-11-19
申请号：US12297275
申请日：2007-04-19
申请人： Keizo Sugasawa , Kenichi Kawaguchi , Takaho Matsuzawa , Ryushi Seo , Hironori Harada , Akira Suga , Tomoaki Abe , Hidenori Azami , Shunichiro Matsumoto , Takashi Shin , Masayuki Tanahashi , Toru Watanabe
发明人： Keizo Sugasawa , Kenichi Kawaguchi , Takaho Matsuzawa , Ryushi Seo , Hironori Harada , Akira Suga , Tomoaki Abe , Hidenori Azami , Shunichiro Matsumoto , Takashi Shin , Masayuki Tanahashi , Toru Watanabe
IPC分类号： A61K31/496 , C07D417/12 , C07D487/04 , C07D417/14 , C07D413/12 , C07D413/14 , A61K31/454 , A61K31/5377 , A61K31/551 , A61K31/55 , A61K31/541 , A61P13/00
CPC分类号： C07D277/56 , C07D263/34 , C07D263/48 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/08
摘要： Provided is an agent for treating or preventing urinary frequency, urinary urgency and urinary, incontinence which are associated with overactive bladder, a lower urinary tract disease such as interstitial cystitis and chronic prostatitis accompanied by lower urinary tract pain, and various diseases accompanied by pain. A novel azolecarboxamide derivative in which an azole ring such as thioazole or oxazole is bonded to a benzene ring, pyridine ring or pyrimidine ring through carboxamide was confirmed to have a potent trkA receptor-inhibitory activity and found to be an agent for treating or preventing lower urinary tract disease and various diseases accompanied by pain, which is excellent in efficacy and safety, and thus the present invention was accomplished.
摘要翻译： 本发明提供一种治疗或预防尿频，尿急，尿失禁，与膀胱过度活动，下尿路疾病如间质性膀胱炎和伴有下尿路疼痛的慢性前列腺炎以及伴有疼痛的各种疾病相关的尿失禁。 通过甲酰胺将唑环或吡唑环或吡啶环或吡啶环与吡唑或恶唑等唑类结合的新型偶氮甲酰胺衍生物被证实具有强的trkA受体抑制活性，被发现是用于治疗或预防较低 泌尿道疾病，伴有疼痛的各种疾病，其功效和安全性优异，从而完成了本发明。
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公开(公告)号：US08304547B2
公开(公告)日：2012-11-06
申请号：US12739433
申请日：2008-10-23
申请人： Keizo Sugasawa , Kenichi Kawaguchi , Takaho Nomura , Shunichiro Matsumoto , Takashi Shin , Hidenori Azami , Tomoaki Abe , Akira Suga , Ryushi Seo , Masayuki Tanahashi , Toru Watanabe
发明人： Keizo Sugasawa , Kenichi Kawaguchi , Takaho Nomura , Shunichiro Matsumoto , Takashi Shin , Hidenori Azami , Tomoaki Abe , Akira Suga , Ryushi Seo , Masayuki Tanahashi , Toru Watanabe
IPC分类号： C07D211/68 , C07D221/20 , C07D491/20 , C07D413/14 , C07D239/09 , A61K31/535 , A61K31/505 , A61K31/44 , A61K31/445
CPC分类号： C07D263/34 , C07D263/48 , C07D277/20 , C07D277/56 , C07D401/14 , C07D403/12 , C07D407/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D491/08 , C07D491/107 , C07D491/113 , C07D491/20 , C07D495/04 , C07D498/10
摘要： [Object] To provide a therapeutic and/or prophylactic agent for urinary frequency, urinary urgency, and urinary incontinence associated with various lower urinary tract diseases including overactive bladder, various lower urinary tract diseases accompanied by lower urinary tract pain, such as interstitial cystitis, chronic prostatitis, and the like, and various diseases accompanied by pain, based on an excellent trkA receptor inhibitory action.[Means for Solution] A novel azolecarboxamide compound in which a thiazole ring or an oxazole ring is bonded to a benzene ring, a pyridine ring, a pyridazine ring, a thiophene ring, a pyrazole ring or a pyrrole ring through carboxamide, or a salt thereof is confirmed to have a potent trkA receptor inhibitory activity, and found to be capable of being used as a therapeutic and/or prophylactic agent which is excellent in efficacy and safety for urinary frequency, urinary urgency, and urinary incontinence associated with various lower urinary tract diseases including overactive bladder, various lower urinary tract diseases accompanied by lower urinary tract pain, such as interstitial cystitis, chronic prostatitis, and the like, and various diseases accompanied by pain, thereby completing the present invention.
摘要翻译： 本发明提供一种用于与各种下尿路疾病（包括膀胱过度活动症，伴有下尿路疼痛，诸如间质性膀胱炎等）的各种下尿路疾病相关的尿频，尿急和尿失禁的治疗和/或预防剂， 慢性前列腺炎等，以及伴有疼痛的各种疾病，基于优异的trkA受体抑制作用。 [解决方案]通过甲酰胺或其盐将噻唑环或恶唑环与苯环，吡啶环，哒嗪环，噻吩环，吡唑环或吡咯环结合的新型偶氮甲酰胺化合物 被证实具有强的trkA受体抑制活性，发现能够用作治疗和/或预防剂，其对于尿频，尿急和与各种下尿路相关的尿失禁的功效和安全性优异 包括膀胱活动过度，伴有尿路下下尿路疼痛的下尿路疾病，如间质性膀胱炎，慢性前列腺炎等多种疾病，伴有疼痛的各种疾病，从而完成本发明。
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公开(公告)号：US20100249088A1
公开(公告)日：2010-09-30
申请号：US12739433
申请日：2008-10-23
申请人： Keizo Sugasawa , Kenichi Kawaguchi , Takaho Nomura , Shunichiro Matsumoto , Takashi Shin , Hidenori Azami , Tomoaki Abe , Akira Suga , Ryushi Seo , Masayuki Tanahashi , Toru Watanabe
发明人： Keizo Sugasawa , Kenichi Kawaguchi , Takaho Nomura , Shunichiro Matsumoto , Takashi Shin , Hidenori Azami , Tomoaki Abe , Akira Suga , Ryushi Seo , Masayuki Tanahashi , Toru Watanabe
IPC分类号： A61K31/4545 , C07D413/14 , C07D417/14 , A61P13/02 , A61P13/10 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/397 , A61P13/00 , A61P13/08
CPC分类号： C07D263/34 , C07D263/48 , C07D277/20 , C07D277/56 , C07D401/14 , C07D403/12 , C07D407/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D491/08 , C07D491/107 , C07D491/113 , C07D491/20 , C07D495/04 , C07D498/10
摘要： [Object] To provide a therapeutic and/or prophylactic agent for urinary frequency, urinary urgency, and urinary incontinence associated with various lower urinary tract diseases including overactive bladder, various lower urinary tract diseases accompanied by lower urinary tract pain, such as interstitial cystitis, chronic prostatitis, and the like, and various diseases accompanied by pain, based on an excellent trkA receptor inhibitory action.[Means for Solution] A novel azolecarboxamide compound in which a thiazole ring or an oxazole ring is bonded to a benzene ring, a pyridine ring, a pyridazine ring, a thiophene ring, a pyrazole ring or a pyrrole ring through carboxamide, or a salt thereof is confirmed to have a potent trkA receptor inhibitory activity, and found to be capable of being used as a therapeutic and/or prophylactic agent which is excellent in efficacy and safety for urinary frequency, urinary urgency, and urinary incontinence associated with various lower urinary tract diseases including overactive bladder, various lower urinary tract diseases accompanied by lower urinary tract pain, such as interstitial cystitis, chronic prostatitis, and the like, and various diseases accompanied by pain, thereby completing the present invention.
摘要翻译： 本发明提供一种用于与各种下尿路疾病（包括膀胱过度活动症，伴有下尿路疼痛，诸如间质性膀胱炎等）的各种下尿路疾病相关的尿频，尿急和尿失禁的治疗和/或预防剂， 慢性前列腺炎等，以及伴有疼痛的各种疾病，基于优异的trkA受体抑制作用。 [解决方案]通过甲酰胺或其盐将噻唑环或恶唑环与苯环，吡啶环，哒嗪环，噻吩环，吡唑环或吡咯环结合的新型偶氮甲酰胺化合物 被证实具有强的trkA受体抑制活性，发现能够用作治疗和/或预防剂，其对于尿频，尿急和与各种下尿路相关的尿失禁的功效和安全性优异 包括膀胱活动过度，伴有尿路下下尿路疼痛的下尿路疾病，如间质性膀胱炎，慢性前列腺炎等多种疾病，伴有疼痛的各种疾病，从而完成本发明。
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8.发明申请Ceramic green sheet, laminated ceramic article, and process for producing the same 审中-公开陶瓷生片，层压陶瓷制品及其制造方法公开(公告)号：US20060014049A1
公开(公告)日：2006-01-19
申请号：US10530586
申请日：2004-05-17
IPC分类号： B32B15/04
CPC分类号： B32B18/00 , C04B35/6342 , C04B2237/346 , C04B2237/68 , C04B2237/704 , C08K3/34 , C08L29/14 , C08L2205/02 , C09D129/14 , H01G4/1209 , C08L2666/04
摘要： A ceramic green sheet is obtained by forming a ceramic coating containing at least a ceramic raw material powder, a binder, and an organic solvent in a sheet shape, followed by drying. The binder contains two or more kinds of polyvinyl acetal with different average degrees of polymerization, and polyvinyl acetal with a higher average degree of polymerization contains a relatively large amount of hydroxyl group, and polyvinyl acetal with a lower average degree of polymerization contains a relatively small amount of hydroxyl group. This green sheet is subjected to binder-removal and firing, thereby obtaining a ceramic capacitor in which inner electrode layers 2 and dielectric layers 1 are laminated alternately and external electrodes 3 are sintered at both ends of the laminate. Consequently, a decrease in the sheet strength caused by a reduction in the thickness of the dielectric layers is suppressed, and there are provided a high-strength green sheet, a laminated ceramic article, and a method for manufacturing the same.
摘要翻译： 通过形成至少含有陶瓷原料粉末，粘合剂和有机溶剂的陶瓷涂层，形成片状，然后干燥，得到陶瓷生片。 粘合剂含有两种以上聚合度不同的聚乙烯醇缩醛，聚合度较低的聚乙烯醇缩醛具有较高的平均聚合度，而具有较低的平均聚合度的聚乙烯醇缩醛含有较小的聚合度 羟基量。 对该生片进行粘合剂除去和烧结，得到交替层叠内电极层2和电介质层1的陶瓷电容器，在层叠体的两端烧结外部电极3。 因此，抑制了由电介质层的厚度减小引起的片材强度的降低，并且提供了高强度生片，层压陶瓷制品及其制造方法。
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