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    Polypeptides capable of interacting with the human topoisomerase III&agr;
    1.
    发明授权
    Polypeptides capable of interacting with the human topoisomerase III&agr; 失效
    能够与人拓扑异构酶IIIal相互作用的多肽

    公开(公告)号：US06706514B1

    公开(公告)日：2004-03-16

    申请号：US09856930

    申请日：2001-06-25

    申请人： Alain Fournier ,  Hélène Goulaouic ,  Jean-Francois Riou

    发明人： Alain Fournier ,  Hélène Goulaouic ,  Jean-Francois Riou

    IPC分类号： C12N990

    CPC分类号： C12N9/90 ,  A61K38/00

    摘要： The invention concerns novel polypeptides capable of interacting with the human topoisomerase III&agr; and the nucleic acid sequences coding for said polypeptides. The invention also concerns a method for identifying compounds capable of interacting with said polypeptides and a method for identifying molecules capable of modulating the interaction of the topoisomerase III&agr; with said polypeptides.

    摘要翻译： 本发明涉及能够与人拓扑异构酶IIIa相互作用的新型多肽和编码所述多肽的核酸序列。 本发明还涉及鉴定能够与所述多肽相互作用的化合物的方法，以及鉴定能够调节拓扑异构酶IIIal与所述多肽的相互作用的分子的方法。

    Labelled adrenomedullin derivatives and their use for imaging and therapy
    3.
    发明申请
    Labelled adrenomedullin derivatives and their use for imaging and therapy 有权
    标记的肾上腺髓质素衍生物及其用于成像和治疗

    公开(公告)号：US20090028790A1

    公开(公告)日：2009-01-29

    申请号：US12149989

    申请日：2008-05-12

    申请人： Jocelyn Dupuis ,  Alain Fournier

    发明人： Jocelyn Dupuis ,  Alain Fournier

    IPC分类号： A61K51/00 ,  C07K14/00 ,  A61K49/00

    CPC分类号： A61K51/088 ,  C07K14/575

    摘要： The present invention relates to an adrenomedullin derivative including an adrenomedullin peptide, or a fragment thereof chelated or otherwise bound to at least one active agent. Examples of active agents include a paramagnetic element, a radioactive element and a fibrinolytic agent, among others. Paramagnetic agents have a distribution that is relatively easily shown through Magnetic Resonance Imaging (MRI). Radioactive agents have applications in imaging and delivery of radiations, depending on the specific element included in the active agent. Delivery of fibrinolytic agents mainly to a specific organ, such as for example to the lungs, allows to substantially improve the specificity and efficacy of thrombolytic therapy by allowing local delivery of the fibrinolytic agent, thereby reducing the risks of major bleeding in the therapy of the organ. If the organ is the lungs, a non-limiting example of pathology treatable with the fibrinolytic agent is pulmonary embolus.

    摘要翻译： 本发明涉及包含与至少一种活性剂螯合或以其它方式结合的肾上腺髓质素肽或其片段的肾上腺髓质素衍生物。 活性剂的实例包括顺磁元件，放射性元素和纤维蛋白溶解剂等。 顺磁剂具有通过磁共振成像（MRI）相对容易地显示的分布。 取决于活性剂中包含的特定元素，放射性剂可用于成像和辐射辐射。 纤维蛋白溶解剂主要递送到特定器官，例如肺，允许通过允许局部输送纤维蛋白溶解剂来大大改善溶栓治疗的特异性和功效，从而降低治疗中的大出血的风险 器官。 如果器官是肺，则可用纤维蛋白溶解剂治疗的病理学的非限制性实例是肺栓塞。

    Process for the protection of flexible silicone membranes, particularly in the case of molding by resin transfer
    6.
    发明授权
    Process for the protection of flexible silicone membranes, particularly in the case of molding by resin transfer 有权
    用于保护柔性硅氧烷膜的方法，特别是在通过树脂转移成型的情况下

    公开(公告)号：US06790531B2

    公开(公告)日：2004-09-14

    申请号：US10095082

    申请日：2002-03-12

    申请人： Alain Fournier

    发明人： Alain Fournier

    IPC分类号： B32B2520

    CPC分类号： C08J7/047 ,  B29C33/64 ,  B29C43/3642 ,  B29K2083/00 ,  B29K2995/0067 ,  B29K2995/0069 ,  B32B25/20 ,  C08J2383/04 ,  C08J2483/00 ,  Y10S528/901 ,  Y10T428/31663

    摘要： Process for treating a flexible bi-constituent self-demolding silicone membrane used as a counterform particularly for resin transfer molding. The membrane is coated with a thin layer of at least one monoconstituent silicone which is a polysiloxane cross-linkable at ambient temperature in the presence of the moisture in air. The polysiloxane corresponds to the formula (I): in which: the substituents R3, R4, and R5 are selected from alkyl or aryl radicals, R6 represents an alkyloxy group, an alkenyloxy group, an alcanoyloxy group, an amino group, a ketiminoxy group, an amido group, an aminoxy group.

    摘要翻译： 用于处理柔性双组分自脱模硅酮膜的方法，其特别用于树脂传递模塑。 膜上涂有薄层的至少一种单成分硅酮，它是在空气中存在湿气的情况下可在环境温度下交联的聚硅氧烷。 聚硅氧烷对应于式（I）：其中：取代基R 3，R 4和R 5选自烷基或芳基，R 6表示烷氧基，链烯氧基 氨基酰氧基，氨基，酮亚氨氧基，酰氨基，氨氧基。

    FEBP1 Protein: vector, host cells and method for making FEBP1 protein
    7.
    发明授权
    FEBP1 Protein: vector, host cells and method for making FEBP1 protein 失效
    FEBP1蛋白：载体，宿主细胞和制备FEBP1蛋白的方法

    公开(公告)号：US06696273B2

    公开(公告)日：2004-02-24

    申请号：US09780996

    申请日：2001-02-09

    申请人： Isabelle Maury ,  Luc Mercken ,  Alain Fournier

    发明人： Isabelle Maury ,  Luc Mercken ,  Alain Fournier

    IPC分类号： C12N1511

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention relates to novel compounds and their pharmaceutical or diagnostic use, or use as a pharmacological target. More particularly, the present invention describes the identification of partners of the FE65 protein and the use of these partners, or of any compound which is capable of modulating, at least partially, their interaction with FE65, for regulating the activity of FE65, and in particular the phenomenon of intracellular transport or of endocytosis of the APP.

    摘要翻译： 本发明涉及新化合物及其药物或诊断用途，或用作药理学靶标。 更具体地，本发明描述了鉴定FE65蛋白的配偶体以及这些配偶体或任何能够至少部分调节其与FE65的相互作用以调节FE65活性的化合物的使用，以及 特别是APP的细胞内运输或内吞现象。

    Protection device for tubular conduits of a sap collecting system
    8.
    发明授权
    Protection device for tubular conduits of a sap collecting system 失效
    液体收集系统管状导管的保护装置

    公开(公告)号：US06370818B1

    公开(公告)日：2002-04-16

    申请号：US09593247

    申请日：2000-06-13

    申请人： Jean-Marie Chabot ,  Alain Fournier

    发明人： Jean-Marie Chabot ,  Alain Fournier

    IPC分类号： A01G2310

    CPC分类号： A01G23/10

    摘要： A device for protecting the connection of a tubular conduit to a main tube of a maple sap collecting system wherein sap collected from maple trees are directed under vacuum to a pumping station of a sap processing center. The device comprises a band having a first end adapted to be mounted to the main tube and an opposite end adapted to be mounted externally onto the tubular conduit at a given distance from the main tube. This distance is greater than the distance between the first and opposite ends of the band so that accidental impact on the tubular conduit resulting from falling objects and tension applied to the attachment of the conduit to the main tube are taken by the band to thereby protect the connection of the tubular conduit to the adapter.

    摘要翻译： 一种用于保护管状管道连接到枫树汁收集系统的主管的装置，其中从枫树收集的树汁被真空地引导到树汁处理中心的泵站。 该装置包括具有适于安装到主管的第一端的带，以及适于以与主管相距给定距离外部安装在管状导管上的相对端。 该距离大于带的第一和相对端之间的距离，使得由于物体下落导致的管状导管的意外撞击和施加到导管与主管的附接的张力被带束带，从而保护 管状导管与适配器的连接。

    Backblast gas structure equipped with thrust reverser with two rear doors and planar exhaust area
    10.
    发明授权
    Backblast gas structure equipped with thrust reverser with two rear doors and planar exhaust area 有权
    反气体结构配有推力反向器，带有两个后门和平面排气区

    公开(公告)号：US06256979B1

    公开(公告)日：2001-07-10

    申请号：US09445073

    申请日：1999-12-02

    申请人： Alain Fournier ,  Robert Standish

    发明人： Alain Fournier ,  Robert Standish

    IPC分类号： F02K302

    CPC分类号： F02K1/60 ,  Y02T50/671

    摘要： The invention concerns a backblast gas structure for jet engine comprising a thrust reversal system with two downstream doors. The invention is characterized in that the two tilt-up doors articulated about axes (6, 7) are mounted on two side beams (2, 3) with free downstream edges (16, 17) comprising protuberances (18, 19). The door downstream edges (13, 14) having median zones (13b, 14b) forming an angle (A) with the lateral parts (13a, 14a), such that when the doors are in retracted position in direct jet, the beam (13b, 14b) edges (16, 17) of the doors are found in the same plane (P2), thereby constituting a gas exhaust outlet which is planar and substantially circular. The invention aims at improving the power package performance in direct jet.

    摘要翻译： 本发明涉及用于喷气发动机的反气体结构，其包括具有两个下游门的推力反转系统。 本发明的特征在于，围绕轴线（6,7）铰接的两个倾斜的门安装在具有包括突起（18,19）的自由下游边缘（16,17）的两个侧梁（2,3）上。 具有与侧面部分（13a，14a）形成角度（A）的中间区域（13b，14b）的门下游边缘（13,14），使得当门在直接喷射中处于缩回位置时，梁（13b ，14b）门的边缘（16,17）位于同一平面（P2）中，从而构成平面且基本上为圆形的排气出口。 本发明旨在提高直喷式动力封装性能。