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公开(公告)号:US06193865B1
公开(公告)日:2001-02-27
申请号:US09268250
申请日:1999-03-15
申请人: Alastair McIndoe Hodges , Oddvar Johansen , Ronald Christopher Chatelier , Ian Andrew Maxwell , Thomas William Beck
发明人: Alastair McIndoe Hodges , Oddvar Johansen , Ronald Christopher Chatelier , Ian Andrew Maxwell , Thomas William Beck
IPC分类号: G01N27401
CPC分类号: G01N27/401 , G01N27/4035
摘要: Electrochemical cell having a porous substrate and a first and a second electrodes separated by an ion diffusion inhibiting partition is disclosed. The ion diffusion inhibiting partition between the two electrodes is defined by compressing the substrate and/or blocking pores of the substrate so as to inhibit but not entirely block ion diffusion between the two electrodes.
摘要翻译: 公开了具有多孔基底的电化学电池和由离子扩散抑制分隔物隔开的第一和第二电极。 通过压缩衬底和/或阻挡衬底的孔来限定两个电极之间的离子扩散抑制分隔,以便抑制但不完全阻止两个电极之间的离子扩散。
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公开(公告)号:US06521110B1
公开(公告)日:2003-02-18
申请号:US09709968
申请日:2000-11-10
IPC分类号: G01N27327
CPC分类号: C12Q1/004 , C12Q1/006 , G01N27/3272
摘要: A method of manufacture of a thin layer electrochemical cell (FIGS. 12, 14) comprising the steps of: forming an aperture (11) extending through a sheet (1) of electrically resistive material, said aperture defining a side wall of the cell, mounting a first thin electrode layer (13) to one side of the sheet and extending over aperture (11) whereby to define a cell first end wall, mounting a second thin electrode layer (13) to the other side of the sheet and extending over aperture (11) whereby to define a second cell end wall in substantial overlying registration with the first electrode, and providing means (16) for admission of a liquid into the cell.
摘要翻译: 一种制造薄层电化学电池(图12,14)的方法,包括以下步骤:形成延伸穿过电阻材料片材(1)的孔(11),所述孔限定电池的侧壁, 将第一薄电极层(13)安装到片材的一侧并延伸到孔(11)上,从而限定电池第一端壁,将第二薄电极层(13)安装到片材的另一侧并延伸 孔(11),从而限定与第一电极基本重叠的第二电池端壁,以及用于将液体进入电池的提供装置(16)。
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公开(公告)号:US06179979B2
公开(公告)日:2001-01-30
申请号:US09068828
申请日:1999-03-15
IPC分类号: G01N2726
CPC分类号: C12Q1/006 , C12Q1/004 , G01N27/3272
摘要: A method of manufacture of a thin layer electrochemical cell (FIGS. 12, 14) comprising the steps of: forming an aperture (11) extending through a sheet (1) of electrically resistive material, said aperture defining a side wall of the cell; mounting a first thin electrode layer (13) to one side of the sheet and extending over aperture (11) whereby to define a cell first end wall; mounting a second thin electrode layer (13) to the other side of the sheet and extending over aperture (11) whereby to define a second cell end wall in substantial overlying registration with the first electrode; and providing means (16) for admission of a liquid into the cell.
摘要翻译: 一种制造薄层电化学电池(图12,14)的方法,包括以下步骤:形成延伸通过电阻材料片材(1)的孔(11),所述孔限定电池的侧壁; 将第一薄电极层(13)安装到所述片材的一侧并延伸到孔(11)上,从而限定电池第一端壁; 将第二薄电极层(13)安装到片材的另一侧并且延伸到孔(11)上,从而限定与第一电极基本上重叠的第二电池端壁; 以及用于将液体进入电池的装置(16)。
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公开(公告)号:US06174420B1
公开(公告)日:2001-01-16
申请号:US09314251
申请日:1999-05-18
IPC分类号: G01N2726
CPC分类号: G01N27/3272
摘要: A method of manufacture of a thin layer electrochemical cell (FIGS. 12, 14) comprising the steps of: forming an aperture (11) extending through a sheet (1) of electrically resistive material, said aperture defining a side wall of the cell, mounting a first thin electrode layer (13) to one side of the sheet and extending over aperture (11) whereby to define a cell first end wall, mounting a second thin electrode layer (13) to the other side of the sheet and extending over aperture (11) whereby to define a second cell end wall in substantial overlying registration with the first electrode, and providing means (16) for admission of a liquid into the cell.
摘要翻译: 一种制造薄层电化学电池(图12,14)的方法,包括以下步骤:形成延伸穿过电阻材料片材(1)的孔(11),所述孔限定电池的侧壁, 将第一薄电极层(13)安装到片材的一侧并延伸到孔(11)上,从而限定电池第一端壁,将第二薄电极层(13)安装到片材的另一侧并延伸 孔(11),从而限定与第一电极基本重叠的第二电池端壁,以及用于将液体进入电池的提供装置(16)。
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公开(公告)号:US5942102A
公开(公告)日:1999-08-24
申请号:US852804
申请日:1997-05-07
IPC分类号: G01N27/28 , C12Q1/00 , C12Q1/54 , G01N20060101 , G01N27/30 , G01N27/327 , G01N27/403 , G01N27/416 , G01N27/42 , G01N27/49 , G01N33/487 , G01N27/26
CPC分类号: C12Q1/006 , C12Q1/004 , G01N27/3272
摘要: A method for determining the concentration of a reduced or oxidized form of a redox species in an electrochemical cell (FIG. 10) of the kind comprising a working electrode (2) and a counter electrode (16) spaced from the working electrode such that reaction products from the counter electrode arrive at the working electrode, the method comprising the steps (FIG. 5) of applying (21) an electric potential between the electrodes, such that the electro-oxidation of the redox species is diffusion controlled, determining the current as a function of time, estimating the magnitude of the steady state current (23), reversing the potential, again determining current as a function of time and estimating the reverse potential steady state (25).
摘要翻译: 一种用于确定电化学电池(图10)中还原或氧化形式的还原或氧化形式的浓度的方法,其包括与工作电极间隔开的工作电极(2)和对电极(16),使得反应 来自对电极的产品到达工作电极,该方法包括在电极之间施加(21)电位的步骤(图5),使得氧化还原物质的电氧化被扩散控制,确定电流 作为时间的函数,估计稳态电流(23)的大小,反转电位,再次确定电流作为时间的函数,并估计反向电位稳态(25)。
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公开(公告)号:US06863801B2
公开(公告)日:2005-03-08
申请号:US09840624
申请日:2001-04-23
IPC分类号: C12Q1/00 , G01N27/30 , G01N27/403 , G01N27/49 , G01N33/487 , G01N27/327
CPC分类号: C12Q1/004 , C12Q1/006 , G01N27/3272
摘要: A biosensor for use in determining a concentration of a component in an aqueous liquid sample is provided including: an electrochemical cell having a first electrically resistive substrate having a thin layer of electrically conductive material, a second electrically resistive substrate having a thin layer of electrically conductive material, the substrates being disposed with the electrically conductive materials facing each other and being separated by a sheet including an aperture, the wall of which aperture defines a cell wall and a sample introduction aperture whereby the aqueous liquid sample may be introduced into the cell; and a measuring circuit.
摘要翻译: 提供了一种用于确定含水液体样品中组分浓度的生物传感器,包括:电化学电池,其具有具有导电材料薄层的第一电阻衬底,具有导电薄层的第二电阻衬底 材料,所述基板被布置成导电材料相互面对并由包括孔的片分隔开,所述片的壁的孔限定细胞壁和样品引入孔,由此可将水性液体样品引入细胞中; 和测量电路。
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公开(公告)号:US20120145539A1
公开(公告)日:2012-06-14
申请号:US13357318
申请日:2012-01-24
IPC分类号: C25B9/00
CPC分类号: G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要: Devices and methods are provided for determining the concentration of a reduced form of a redox species. For example, a device can include a working electrode and a counter electrode spaced by a predetermined distance so that reaction produces from the counter electrode arrive at the working electrode. An electric potential difference can be applied between the electrodes, and the potential of the working electrode can be selected such that the rate of electro-oxidation of the reduced form of the species is diffusion controlled. Current as a function of time can be determined, the magnitude of the steady state current can be estimated, and a value indicative of the diffusion coefficient and/or of the concentration of the reduced form of the species can be obtained from the change in current with time and the magnitude of the steady state current. Other embodiments of apparatuses, devices, and methods are also provided.
摘要翻译: 提供了用于确定还原形式的氧化还原物质的浓度的装置和方法。 例如,器件可以包括隔开预定距离的工作电极和对电极,使得从反电极产生的反应到达工作电极。 可以在电极之间施加电位差,并且可以选择工作电极的电位,使得物种的还原形式的电氧化速率被扩散控制。 可以确定作为时间的函数的电流,可以估计稳态电流的大小,并且可以从电流的变化获得指示物种的还原形式的扩散系数和/或浓度的值 随着时间和稳态电流的大小。 还提供了装置,装置和方法的其他实施例。
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公开(公告)号:US07604722B2
公开(公告)日:2009-10-20
申请号:US10624823
申请日:2003-07-22
IPC分类号: G01N27/327
CPC分类号: G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要: This invention relates to a biosensor and more particularly to an electrochemical biosensor for determining the concentration of an analyte in a carrier. The invention is particularly useful for determining the concentration of glucose in blood and is described herein with reference to that use but it should be understood that the invention is applicable to other analytic determinations.
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公开(公告)号:US06413410B1
公开(公告)日:2002-07-02
申请号:US09618515
申请日:2000-07-18
IPC分类号: G01N2726
CPC分类号: G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要: This invention relates to a biosensor and more particularly to an electrochemical biosensor for determining the concentration of an analyte in a carrier. The invention is particularly useful for determining the concentration of glucose in blood and is described herein with reference to that use but it should be understood that the invention is applicable to other analytic determinations.
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公开(公告)号:US08101056B2
公开(公告)日:2012-01-24
申请号:US12567433
申请日:2009-09-25
IPC分类号: G01N27/403 , G01N27/327
CPC分类号: G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要: A hollow electrochemical cell is provided. In one exemplary embodiment, a hollow electrochemical cell includes two sets of electrodes and an opening for admitting an analyte to the cell. At least one of the two sets of electrodes can be in fluid communication with the opening. Further, a first set of electrodes can include a working electrode spaced from a counter or counter/reference electrode by less than 500 μm one embodiment the working and counter or counter/reference electrodes are not co-planer. In another embodiment the working and counter or counter/reference electrodes are of substantially corresponding area. In yet another embodiment the working and counter or counter/reference electrodes are spaced from 100 to 200 μm apart. The first set of electrodes and the second set of electrodes can be spaced apart by greater than about 500 μm. Other embodiments of a hollow electrochemical cell are also provided, as are several embodiments of a glucose sensor.
摘要翻译: 提供了一种中空的电化学电池。 在一个示例性实施例中,中空电化学电池包括两组电极和用于允许分析物进入细胞的开口。 两组电极中的至少一个可以与开口流体连通。 此外,第一组电极可以包括与计数器或对准/参考电极间隔小于500μm的工作电极。 在一个实施例中,工作和计数器或计数器/参考电极不是共平面的。 在另一个实施例中,工作和计数器或计数器/参考电极具有基本对应的区域。 在又一个实施例中,工作和计数器或对准/参考电极间隔开100至200微米。 第一组电极和第二组电极可间隔开大于约500μm。 还提供了中空电化学电池的其它实施方案,葡萄糖传感器的几个实施方案也是如此。
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