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公开(公告)号：US07403017B2
公开(公告)日：2008-07-22
申请号：US10541812
申请日：2004-01-16
IPC分类号： G01N27/02
CPC分类号： G01N27/44 , G01N33/4905 , G01N33/491 , G01N33/5438 , G01N33/80
摘要： There is disclosed a method of measuring formation of a barrier to restrict or reduce movement of an electroactive species. The method comprises providing an electrochemical cell having a working electrode and a counter electrode spaced from the working electrode, providing a subject component, a testing component and at least one electroactive species within the cell, the subject and testing components being intended to cause the formation of a barrier to restrict or reduce movement of an electroactive species, applying a potential between the working electrode and the counter electrode sufficient to produce a current proportional to the concentration of the electroactive species being measured, and measuring the current at the working electrode to obtain a measure of the formation of the barrier to restrict or reduce movement of the electroactive species.
摘要翻译： 公开了一种测量阻挡层的形成以限制或减少电活性物质的运动的方法。 该方法包括提供电化学电池，其具有与工作电极间隔开的工作电极和对电极，提供主体部件，测试部件和电池内的至少一个电活性物质，受试者和测试部件旨在引起形成 限制或减少电活性物质的运动的障碍物，在工作电极和对电极之间施加足以产生与所测量的电活性物质的浓度成正比的电流，并测量工作电极处的电流以获得 形成屏障以限制或减少电活性物质的运动的量度。
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公开(公告)号：US08974658B2
公开(公告)日：2015-03-10
申请号：US12374276
申请日：2007-07-13
CPC分类号： G01N33/4905 , G01N2011/0086 , G01N2011/147 , G01N2015/1075
摘要： An exemplary embodiment of the invention may include a method for electrochemically monitoring the mobility of particles in a fluid in response to an external field, the method may include monitoring an electrical characteristic of the fluid in an electrochemical cell, the fluid comprising particles that can be moved under the influence of an externally applied field; observing changes in the electrical characteristic caused by particle movement induced by the external field; and inferring a change in the physical state of the fluid from a change in the magnitude of the electrical characteristic observed.
摘要翻译： 本发明的示例性实施例可以包括用于电化学地监测响应于外部场的流体中颗粒的迁移率的方法，所述方法可以包括监测电化学电池中的流体的电特性，所述流体包括可以是 受外部应用场的影响; 观察由外场引起的粒子运动引起的电特性变化; 并且从观察到的电特性的大小的变化推断流体的物理状态的变化。
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公开(公告)号：US20080223732A1
公开(公告)日：2008-09-18
申请号：US12153411
申请日：2008-05-19
IPC分类号： G01N27/26
CPC分类号： G01N27/44 , G01N33/4905 , G01N33/491 , G01N33/5438 , G01N33/80
摘要： There is disclosed a method of measuring formation of a barrier to restrict or reduce movement of an electroactive species. The method comprises providing an electrochemical cell having a working electrode and a counter electrode spaced from the working electrode, providing a subject component, a testing component and at least one electroactive species within the cell, the subject and testing components being intended to cause the formation of a barrier to restrict or reduce movement of an electroactive species, applying a potential between the working electrode and the counter electrode sufficient to produce a current proportional to the concentration of the electroactive species being measured, and measuring the current at the working electrode to obtain a measure of the formation of the barrier to restrict or reduce movement of the electroactive species.
摘要翻译： 公开了一种测量阻挡层的形成以限制或减少电活性物质的运动的方法。 该方法包括提供电化学电池，其具有与工作电极间隔开的工作电极和对电极，提供主体部件，测试部件和电池内的至少一个电活性物质，受试者和测试部件旨在引起形成 限制或减少电活性物质的运动的障碍物，在工作电极和对电极之间施加足以产生与所测量的电活性物质的浓度成正比的电流，并测量工作电极处的电流以获得 形成屏障以限制或减少电活性物质的运动的量度。
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公开(公告)号：US06193865B1
公开(公告)日：2001-02-27
申请号：US09268250
申请日：1999-03-15
申请人： Alastair McIndoe Hodges , Oddvar Johansen , Ronald Christopher Chatelier , Ian Andrew Maxwell , Thomas William Beck
发明人： Alastair McIndoe Hodges , Oddvar Johansen , Ronald Christopher Chatelier , Ian Andrew Maxwell , Thomas William Beck
IPC分类号： G01N27401
CPC分类号： G01N27/401 , G01N27/4035
摘要： Electrochemical cell having a porous substrate and a first and a second electrodes separated by an ion diffusion inhibiting partition is disclosed. The ion diffusion inhibiting partition between the two electrodes is defined by compressing the substrate and/or blocking pores of the substrate so as to inhibit but not entirely block ion diffusion between the two electrodes.
摘要翻译： 公开了具有多孔基底的电化学电池和由离子扩散抑制分隔物隔开的第一和第二电极。 通过压缩衬底和/或阻挡衬底的孔来限定两个电极之间的离子扩散抑制分隔，以便抑制但不完全阻止两个电极之间的离子扩散。
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公开(公告)号：US08182765B2
公开(公告)日：2012-05-22
申请号：US12280317
申请日：2007-02-15
CPC分类号： F16K99/0017 , B01L3/502738 , B01L2200/143 , B01L2300/0645 , B01L2300/0816 , B01L2300/0825 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , F16K99/0001 , F16K99/0025 , F16K2099/008 , F16K2099/0086 , Y10T436/25 , Y10T436/2575
摘要： A microfluidic device for transferring liquid from a first chamber to a second chamber is provided. The device has a first chamber; a second chamber; and a barrier between the first chamber and the second chamber, the barrier having least one opening fluidly connecting the first chamber to the second chamber, the at least one opening being sized such that a retention force, such as surface tension, keeps the liquid in the first chamber. The fluid is transferred from the first chamber to the second chamber when an initiation input such as fluid pressure is introduced to the liquid that is sufficient to overcome the retention force. The device may be a sensor strip.
摘要翻译： 提供了用于将液体从第一室转移到第二室的微流体装置。 该装置具有第一室; 第二个房间 和所述第一腔室和所述第二腔室之间的阻挡件，所述阻挡件具有至少一个开口，其将所述第一腔室与所述第二腔室流体连接，所述至少一个开口的尺寸设定为使得诸如表面张力的保持力将所述液体保持在 第一个房间 当诸如流体压力的起始输入被引入到足以克服保持力的液体时，流体从第一室转移到第二室。 该装置可以是传感器条。
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公开(公告)号：US20090305431A1
公开(公告)日：2009-12-10
申请号：US12280317
申请日：2007-02-15
CPC分类号： F16K99/0017 , B01L3/502738 , B01L2200/143 , B01L2300/0645 , B01L2300/0816 , B01L2300/0825 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , F16K99/0001 , F16K99/0025 , F16K2099/008 , F16K2099/0086 , Y10T436/25 , Y10T436/2575
摘要： A microfluidic device for transferring liquid from a first chamber to a second chamber is provided. The device has a first chamber; a second chamber; and a barrier between the first chamber and the second chamber, the barrier having least one opening fluidly connecting the first chamber to the second chamber, the at least one opening being sized such that a retention force, such as surface tension, keeps the liquid in the first chamber. The fluid is transferred from the first chamber to the second chamber when an initiation input such as fluid pressure is introduced to the liquid that is sufficient to overcome the retention force. The device may be a sensor strip.
摘要翻译： 提供了用于将液体从第一室转移到第二室的微流体装置。 该装置具有第一室; 第二个房间 和所述第一腔室和所述第二腔室之间的阻挡件，所述阻挡件具有至少一个开口，其将所述第一腔室与所述第二腔室流体连接，所述至少一个开口的尺寸设定为使得诸如表面张力的保持力将所述液体保持在 第一个房间 当诸如流体压力的起始输入被引入到足以克服保持力的液体时，流体从第一室转移到第二室。 该装置可以是传感器条。
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公开(公告)号：US20100270178A1
公开(公告)日：2010-10-28
申请号：US12829599
申请日：2010-07-02
CPC分类号： A61B5/14532 , A61B5/1486 , A61B2562/0295 , G01N27/3273
摘要： Methods and apparatus for electrochemically determining an analyte concentration value in a physiological sample are disclosed. The methods include using a test strip in which two time-current transients are measured by a meter electrically connected to an electrochemical test strip. Integrative current values are derived from the time-current transients and used in the calculation of analyte concentration.
摘要翻译： 公开了用于电化学测定生理样品中分析物浓度值的方法和装置。 这些方法包括使用测试条，其中通过电连接到电化学测试条的仪表测量两个时间电流瞬变。 积分电流值来自时间 - 电流瞬变，并用于计算分析物浓度。
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公开(公告)号：US20090301901A1
公开(公告)日：2009-12-10
申请号：US12374276
申请日：2007-07-13
IPC分类号： G01N15/05
CPC分类号： G01N33/4905 , G01N2011/0086 , G01N2011/147 , G01N2015/1075
摘要： An exemplary embodiment of the invention may include a method for electrochemically monitoring the mobility of particles in a fluid in response to an external field, the method may include monitoring an electrical characteristic of the fluid in an electrochemical cell, the fluid comprising particles that can be moved under the influence of an externally applied field; observing changes in the electrical characteristic caused by particle movement induced by the external field; and inferring a change in the physical state of the fluid from a change in the magnitude of the electrical characteristic observed.
摘要翻译： 本发明的示例性实施例可以包括用于电化学地监测响应于外部场的流体中颗粒的迁移率的方法，所述方法可以包括监测电化学电池中的流体的电特性，所述流体包括可以是 受外部应用场的影响; 观察由外场引起的粒子运动引起的电特性变化; 并且从观察到的电特性的大小的变化推断流体的物理状态的变化。
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公开(公告)号：US06923978B2
公开(公告)日：2005-08-02
申请号：US10368693
申请日：2003-02-19
申请人： Ronald Christopher Chatelier , Liming Dai , Hans Jörg Griesser , Sheng Li , Paul Zientek , Dieter Lohmann , Peter Chabrecek
发明人： Ronald Christopher Chatelier , Liming Dai , Hans Jörg Griesser , Sheng Li , Paul Zientek , Dieter Lohmann , Peter Chabrecek
摘要： The invention is directed to a composite material, especially a biomedical device, e.g. an ophthalmic device, preferably a contact lens, with one or more wettable surfaces capable of holding a continuous layer of aqueous fluid thereon which composite material comprises a bulk material and a hydrophilic coating characterized in that the hydrophilic coating consists of a carbohydrate attached covalently to reactive groups at the surface of the bulk material, either directly or via functional groups of an oligofunctional compound, said oligofunctional compound in turn having functional groups being capable of reacting with said reactive groups at the surface of the bulk material and with the carbohydrate, wherein said reactive groups are either inherently (a priori) present in the bulk material or wherein said reactive groups have been attached to the surface of the bulk material by a plasma surface preparation, as well as to a process of manufacture of such a composite material.
摘要翻译： 本发明涉及复合材料，特别是生物医学装置，例如， 眼科装置，优选隐形眼镜，具有能够在其上容纳水性流体的连续层的一个或多个可润湿表面，所述复合材料包括本体材料和亲水涂层，其特征在于，所述亲水性涂层由共价连接到反应性的碳水化合物 在本体材料表面的基团，直接地或通过低官能化合物的官能团，所述低官能化合物又具有能够与本体材料的表面与碳水化合物的所述反应性基团反应的官能团，其中所述 反应性基团本质上（先验地）存在于本体材料中，或者其中所述反应性基团已经通过等离子体表面制备被附着到散装材料的表面，以及制造这种复合材料的方法。
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公开(公告)号：US06623747B1
公开(公告)日：2003-09-23
申请号：US08601420
申请日：1996-02-14
申请人： Ronald Christopher Chatelier , Liming Dai , Hans Jörg Griesser , Sheng Li , Paul Zientek , Dieter Lohmann , Peter Chabrecek
发明人： Ronald Christopher Chatelier , Liming Dai , Hans Jörg Griesser , Sheng Li , Paul Zientek , Dieter Lohmann , Peter Chabrecek
IPC分类号： A61F200
摘要： The invention is directed to a composite material, especially a biomedical device, e.g. an ophthalmic device, preferably a contact lens, with one or more wettable surfaces capable of holding a continous layer of aqueous fluid thereon which composite material comprises a bulk material and a hydrophilic coating characterized in that the hydrophilic coating consists of a carbohydrate attached covalently to reactive groups at the surface of the bulk material, either directly or via functional groups of an oligofunctional compound, said oligofunctional compound in turn having functional groups being capable of reacting with said reactive groups at the surface of the bulk material and with the carbohydrate, wherein said reactive groups are either inherently (a priori) present in the bulk material or wherein said reactive groups have been attached to the surface of the bulk material by a plasma surface preparation, as well as to a process of manufacture of such a composite material.
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