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公开(公告)号：US11061169B2
公开(公告)日：2021-07-13
申请号：US16683886
申请日：2019-11-14
申请人： Alcon Inc.
IPC分类号： G02B1/04 , C08F216/06 , C08F216/38 , C08F218/08 , C08F230/02 , G02B1/10 , G02C7/04
摘要： The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating thereon and to a method for producing the same. The hydrogel lens body is composed of a crosslinked polymeric material comprising repeating units of at least one arylborono-containing vinylic monomer having a boronic acid group, and the coating comprises a layer of a phosphorylcholine-containing polymer which comprises (a) repeating units of vinyl alcohol, and (b) repeating units of 6-membered acetal ring substituted with a phosphorylcholine-containing group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one of the boronic acid groups of the crosslinked polymeric material and one of the 1,2-diol and 1,3-diol moieties of the phosphorylcholine-containing polymer.
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公开(公告)号：US11999908B2
公开(公告)日：2024-06-04
申请号：US17335628
申请日：2021-06-01
申请人： Alcon Inc.
发明人： Feng Jing , Frank Chang , Houliang Tang
IPC分类号： B29D11/00 , C08F230/08 , C09K9/02 , G02B1/04 , B29K83/00 , B29K105/00
CPC分类号： C09K9/02 , B29D11/00134 , C08F230/085 , G02B1/043 , B29K2083/00 , B29K2105/0061 , C09K2211/14
摘要： Described herein is a cost-effective and time-efficient method for producing photochromic contact lenses, in particular, preferably photochromic silicone hydrogel contact lenses, from a polymerizable composition comprising an unique selection and combination of main polymerizable components, a photochromic compound and a visible-light photoinitiator, based on the Lightstream Technology™. This invention also provides photochromic contact lenses or more preferably photochromic silicone hydrogel contact lenses made according to a method of the invention. A photochromic contact lens of the invention is capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light (HEVL) (with wavelengths from 380 nm to 440 nm).
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公开(公告)号：US20220251302A1
公开(公告)日：2022-08-11
申请号：US17666601
申请日：2022-02-08
申请人： Alcon Inc.
摘要： The invention provides a class of hydrophilized polydiorganosiloxane vinylic crosslinkers. Each of the hydrophilized polydiorganosiloxane vinylic crosslinkers of the invention comprise (1) a polydiorganosiloxane segment comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one organic substituent having a phosphorylcholine moiety; (2) ethylenically-unsaturated groups. The invention also provides a silicone hydrogel contact lens, which comprises a crosslinked polymeric material comprising repeating units of at least one of such a class of hydrophilized polydiorganosiloxane vinylic crosslinkers. The invention further provides a method of producing a hydrophilized contact lens from a polymerizable composition comprising at least one of such a class of hydrophilized polydiorganosiloxane vinylic crosslinkers.
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公开(公告)号：US20230374225A1
公开(公告)日：2023-11-23
申请号：US18321416
申请日：2023-05-22
申请人： Alcon Inc.
IPC分类号： C08G77/452
CPC分类号： C08G77/452
摘要： Described herein is a method for producing HEVL-filtering contact lenses in a relatively efficient and consistent manner from a polymerizable composition under a controlled thermal curing scheme. The polymerizable composition comprises at least one N-vinyl amide monomer and at least one Cu(II)-meso-aryl-substituted porphyrin free of any ethylenically unsaturated group. The resultant HEVL-filtering contact lenses each comprise a polymer matrix to which the Cu(II)-meso-aryl-substituted porphyrin is grafted or covalently attached.
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公开(公告)号：US20200158913A1
公开(公告)日：2020-05-21
申请号：US16683886
申请日：2019-11-14
申请人： Alcon Inc.
IPC分类号： G02B1/04 , G02C7/04 , C08F218/08 , C08F216/06 , C08F230/02 , C08F216/38 , G02B1/10
摘要： The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating thereon and to a method for producing the same. The hydrogel lens body is composed of a crosslinked polymeric material comprising repeating units of at least one arylborono-containing vinylic monomer having a boronic acid group, and the coating comprises a layer of a phosphorylcholine-containing polymer which comprises (a) repeating units of vinyl alcohol, and (b) repeating units of 6-membered acetal ring substituted with a phosphorylcholine-containing group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one of the boronic acid groups of the crosslinked polymeric material and one of the 1,2-diol and 1,3-diol moieties of the phosphorylcholine-containing polymer.
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公开(公告)号：US20220281193A1
公开(公告)日：2022-09-08
申请号：US17688022
申请日：2022-03-07
申请人： Alcon Inc.
发明人： Houliang Tang , Frank Chang
摘要： Described herein is a method for producing a contact lens comprising a central zone that has a diameter of about 13 mm or less, is concentric with the central axis of the contact lens, and possesses at least one photo functionality. The method comprises: applying a first polymerizable fluid composition containing at least one photochemically functional compound on a central portion of the molding surface of a female mold half to form a circular layer; partially curing, in situ, the circular layer in the female mold half; dispensing a second polymerizable fluid composition over the partially-cured circular layer on the molding surface of the female mold half; and a step of curing the second polymerizable fluid composition and the partially-cured circular layer immersed therein in the mold cavity formed between the the molding surfaces of the female mold half and a male mold half.
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公开(公告)号：US20210371731A1
公开(公告)日：2021-12-02
申请号：US17335628
申请日：2021-06-01
申请人： Alcon Inc.
发明人： Feng Jing , Frank Chang , Houliang Tang
IPC分类号： C09K9/02 , C08F230/08 , B29D11/00
摘要： Described herein is a cost-effective and time-efficient method for producing photochromic contact lenses, in particular, preferably photochromic silicone hydrogel contact lenses, from a polymerizable composition comprising an unique selection and combination of main polymerizable components, a photochromic compound and a visible-light photoinitiator, based on the Lightstream Technology™. This invention also provides photochromic contact lenses or more preferably photochromic silicone hydrogel contact lenses made according to a method of the invention. A photochromic contact lens of the invention is capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light (HEVL) (with wavelengths from 380 nm to 440 nm).
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公开(公告)号：US20240287379A1
公开(公告)日：2024-08-29
申请号：US18645497
申请日：2024-04-25
申请人： Alcon Inc.
发明人： Feng Jing , Frank Chang , Houliang Tang
IPC分类号： C09K9/02 , B29D11/00 , B29K83/00 , B29K105/00 , C08F230/08 , G02B1/04
CPC分类号： C09K9/02 , B29D11/00134 , C08F230/085 , G02B1/043 , B29K2083/00 , B29K2105/0061 , C09K2211/14
摘要： Described herein is a cost-effective and time-efficient method for producing photochromic contact lenses, in particular, preferably photochromic silicone hydrogel contact lenses, from a polymerizable composition comprising an unique selection and combination of main polymerizable components, a photochromic compound and a visible-light photoinitiator, based on the Lightstream Technology™. This invention also provides photochromic contact lenses or more preferably photochromic silicone hydrogel contact lenses made according to a method of the invention. A photochromic contact lens of the invention is capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light (HEVL) (with wavelengths from 380 nm to 440 nm).
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公开(公告)号：US20230374306A1
公开(公告)日：2023-11-23
申请号：US18321435
申请日：2023-05-22
申请人： Alcon Inc.
CPC分类号： C08L83/04 , C08J3/075 , C08J2383/04 , C08J2471/02
摘要： Described herein is UV/HEVL-absorbing contact lens of the invention comprises a bulk hydrogel material that comprises repeating units of at least one UV-absorbing vinylic monomer, repeating units of at least one UV/HEVL-absorbing vinylic monomer, and derivatives of a reactive Cu(II)-porphyrin present in selected amounts and at a selected ratio. A UV/HEVL-filtering contact lens of the invention not only can provide Class I UV protection against UVA and UVB rays (i.e., filtering more than 90% of UVA and 99% of UVB rays) but also can mimics the natural crystalline lens of a human eye in providing HEVL protection.
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公开(公告)号：US20230364832A1
公开(公告)日：2023-11-16
申请号：US18308210
申请日：2023-04-27
申请人： Alcon Inc.
CPC分类号： B29C39/026 , B29C39/006 , B29C39/26 , B29C39/36 , B29D11/00038 , G02B1/043 , B29K2101/10
摘要： Described herein is a cost-effective and time-efficient method for producing UV- and HEVL-absorbing silicone hydrogel contact lenses capable of blocking ultra-violet (“UV”) radiation and high-energy-violet light (HEVL) with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV and HEVL radiation. This invention also provides UV- and HEVL-absorbing absorbing contact lenses made according to a method of the invention.
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