-
公开(公告)号：US5945513A
公开(公告)日：1999-08-31
申请号：US690096
申请日：1996-07-30
IPC分类号： A61K38/00 , A61K39/395 , A61P37/04 , A61P43/00 , C07K14/00 , C07K14/47 , C07K14/52 , C07K14/705 , C07K14/725 , C07K16/28 , C07K19/00 , C12N5/06 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08
CPC分类号： C07K14/70575 , C07K14/70517 , C07K14/7056 , C07K16/2878 , A61K38/00 , C07K2317/73
摘要： The present invention relates to fusion proteins having gp39 protein sequences, which fusion proteins bind to the B cell antigen, CD40. More specifically, the invention relates to fusion proteins having gp39 protein sequences attached to a polypeptide having an amino terminal secretory signal sequence to allow export of the fusion protein out of the recombinant host cell in which it is produced. The fusion proteins of this invention may be useful for promoting B cell proliferation.
摘要翻译： 本发明涉及具有gp39蛋白序列的融合蛋白，其融合蛋白与B细胞抗原CD40结合。 更具体地，本发明涉及具有连接到具有氨基末端分泌信号序列的多肽的gp39蛋白序列的融合蛋白，以允许融合蛋白从其产生的重组宿主细胞出口。 本发明的融合蛋白可用于促进B细胞增殖。
-
公开(公告)号：US5540926A
公开(公告)日：1996-07-30
申请号：US940605
申请日：1992-09-04
IPC分类号： A61K38/00 , A61K39/395 , A61P37/04 , A61P43/00 , C07K14/00 , C07K14/47 , C07K14/52 , C07K14/705 , C07K14/725 , C07K16/28 , C07K19/00 , C12N5/06 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , A61K38/17
CPC分类号： C07K14/70575 , C07K14/70517 , C07K14/7056 , C07K16/2878 , A61K38/00 , C07K2317/73
摘要： The present invention relates to soluble ligands for the B-cell antigen, CD40, and, in particular, to human gp39 protein and soluble ligands derived therefrom which may be used in methods of promoting B-cell proliferation.
摘要翻译： 本发明涉及可用于促进B细胞增殖的方法中的B细胞抗原的可溶性配体，CD40，特别是涉及人gp39蛋白和由其衍生的可溶性配体。
-
3.发明申请Methods for inhibiting an immune response by blocking the GP39/CD40 and CTLA4/CD28/B7 pathways and compositions for use therewith 审中-公开通过阻断GP39 / CD40和CTLA4 / CD28 / B7途径以及使用它们的组合物来抑制免疫反应的方法公开(公告)号：US20050202011A1
公开(公告)日：2005-09-15
申请号：US11028793
申请日：2005-01-04
申请人： Christian Larsen , Alejandro Aruffo , Diane Hollenbaugh , Peter Linsley , Jeffrey Ledbetter , Thomas Pearson
发明人： Christian Larsen , Alejandro Aruffo , Diane Hollenbaugh , Peter Linsley , Jeffrey Ledbetter , Thomas Pearson
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61P37/06 , A61P43/00 , C07K14/705 , C07K16/28
CPC分类号： C07K16/2878 , A61K38/00 , A61K39/395 , C07K14/70521 , C07K14/70532 , C07K14/70575 , C07K14/70578 , C07K16/2818 , C07K16/2827 , C07K16/2875 , C07K2317/73 , A61K38/17 , A61K2300/00
摘要： The present invention provides a method for inhibiting an immune reponse and a method for inhibiting rejection of transplanted tissues. This method comprises preventing an endogenous molecule on a cell selected from the group consisting of gp39 and CD40 antigens from binding its endogenous ligand and preventing an endogenous molecule on a cell selected from the group consisting of CTLA4, CD28, and B7 antigens from binding its endogenous ligand. The prevention of such molecules from binding their ligand thereby blocks two independent signal pathways and inhibits the immune response resulting in transplanted tissue rejection.
摘要翻译： 本发明提供抑制免疫应答的方法和抑制移植组织排斥的方法。 该方法包括防止选自gp39和CD40抗原的细胞上的内源性分子与其内源性配体结合并防止选自CTLA4，CD28和B7抗原的细胞上的内源性分子结合其内源性 配体。 阻止这些分子结合其配体从而阻断两个独立的信号通路并抑制免疫应答导致移植组织排斥反应。
-
4.发明授权Method of treating graft-versus-host disease with anti-GP39 antibodies and bone marrow cells 失效用抗GP39抗体和骨髓细胞治疗移植物抗宿主病的方法公开(公告)号：US06312692B1
公开(公告)日：2001-11-06
申请号：US09069871
申请日：1998-04-30
IPC分类号： A61K39395
CPC分类号： C07K14/70578 , A61K38/00 , A61K2039/505 , A61K2039/57 , C07K16/2875 , C07K19/00 , C07K2317/24 , C07K2317/73 , C07K2319/00 , G01N33/6854
摘要： A method of treating graft-vs-host diseases by administration of bone marrow and an anti-gp39 antibody specific to human gp39 is provided.
摘要翻译： 提供了一种通过施用骨髓治疗移植物抗宿主病的方法和针对人gp39特异的抗gp39抗体。
-
5.发明授权Methods of inducing T cell non-responsiveness to transplanted tissues and of treating graft-versus-host-disease with anti-gp39 antibodies 失效诱导T细胞对移植组织无反应性和用抗gp39抗体治疗移植物抗宿主病的方法
公开(公告)号：US5876718A
公开(公告)日：1999-03-02
申请号：US49043
申请日：1998-03-27
IPC分类号： A61K39/395 , A61K31/00 , A61K35/14 , A61K35/28 , A61K38/00 , A61K38/17 , A61K39/00 , A61P37/00 , A61P37/06 , C07K14/705 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/68 , C12N5/12
CPC分类号： C07K14/70578 , C07K16/2875 , C07K19/00 , G01N33/6854 , A61K2039/505 , A61K2039/57 , A61K38/00 , C07K2317/24 , C07K2317/73 , C07K2319/00
摘要： Antibodies that bind a protein gp39 (also referred to as CD40 ligand) are disclosed. Preferably, the antibodies are monoclonal antibodies of an IgG1 isotype and bind human gp39. In a preferred embodiment, an antibody of the invention binds an epitope recognized by a monoclonal antibody 24-31, produced by a hybridoma 24-31 (ATTC Accession No. HB11712) or binds an epitope recognized by a monoclonal antibody 89-76, produced by a hybridoma 89-76 (ATCC Accession No. HB 11713). Pharmaceutical compositions comprising the antibodies of the invention are also disclosed. The antibodies of the invention are useful for inhibiting B cell proliferation and differentiation, T cell responses and for inducing T cell tolerance. Nucleic acid molecules encoding anti-gp39 antibodies, or portions thereof, as well as expression vectors and host cells incorporating said nucleic acid molecules, are also encompassed by the invention.
摘要翻译： 公开了结合蛋白质gp39（也称为CD40配体）的抗体。 优选地，抗体是IgG1同种型的单克隆抗体并结合人gp39。 在优选的实施方案中，本发明的抗体结合由杂交瘤24-31（ATTC登录号HB11712）产生的单克隆抗体24-31识别的表位或结合由单克隆抗体89-76识别的表位，产生 通过杂交瘤89-76（ATCC登录号HB 11713）。 还公开了包含本发明抗体的药物组合物。 本发明的抗体可用于抑制B细胞增殖和分化，T细胞应答和诱导T细胞耐受。 编码抗gp39抗体或其部分的核酸分子以及掺入所述核酸分子的表达载体和宿主细胞也包括在本发明中。
-
公开(公告)号：US5747037A
公开(公告)日：1998-05-05
申请号：US475847
申请日：1995-06-07
IPC分类号： A61K39/395 , A61K31/00 , A61K35/14 , A61K35/28 , A61K38/00 , A61K38/17 , A61K39/00 , A61P37/00 , A61P37/06 , C07K14/705 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/68 , C12N5/12
CPC分类号： C07K14/70578 , C07K16/2875 , C07K19/00 , G01N33/6854 , A61K2039/505 , A61K2039/57 , A61K38/00 , C07K2317/24 , C07K2317/73 , C07K2319/00
摘要： Antibodies that bind a protein gp39 (also referred to as CD40 ligand) are disclosed. Preferably, the antibodies are monoclonal antibodies of an IgG1 isotype and bind human gp39. In a preferred embodiment, an antibody of the invention binds an epitope recognized by a monoclonal antibody 24-31, produced by a hybridoma 24-31 (ATTC Accession No. HB11712) or binds an epitope recognized by a monoclonal antibody 89-76, produced by a hybridoma 89-76 (ATCC Accession No.HB11713). Pharmaceutical compositions comprising the antibodies of the invention are also disclosed. The antibodies of the invention are useful for inhibiting B cell proliferation and differentiation, T cell responses and for inducing T cell tolerance. Nucleic acid molecules encoding anti-gp39 antibodies, or portions thereof, as well as expression vectors and host cells incorporating said nucleic acid molecules, are also encompassed by the invention.
摘要翻译： 公开了结合蛋白质gp39（也称为CD40配体）的抗体。 优选地，抗体是IgG1同种型的单克隆抗体并结合人gp39。 在优选的实施方案中，本发明的抗体结合由杂交瘤24-31（ATTC登录号HB11712）产生的单克隆抗体24-31识别的表位或结合由单克隆抗体89-76识别的表位，产生 通过杂交瘤89-76（ATCC登录号HB11713）。 还公开了包含本发明抗体的药物组合物。 本发明的抗体可用于抑制B细胞增殖和分化，T细胞应答和诱导T细胞耐受。 编码抗gp39抗体或其部分的核酸分子以及掺入所述核酸分子的表达载体和宿主细胞也包括在本发明中。
-
公开(公告)号：US5968768A
公开(公告)日：1999-10-19
申请号：US432016
申请日：1995-05-01
IPC分类号： G01N33/53 , A61K38/00 , A61P37/06 , C07K14/705 , C07K14/725 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/00 , C12R1/91
CPC分类号： C07K14/70503 , C07K16/2803 , A61K38/00 , C07K2319/30
摘要： The present invention relates to an isolated nucleic acid molecule having a sequence that encodes a CD6 ligand present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cell types. The invention further relates to a construct containing the nucleic acid molecule and to a host cell comprising same. Further, the invention relates to a method of producing a CD6 ligand.
摘要翻译： 本发明涉及具有编码存在于胸腺上皮细胞，单核细胞，活化的T细胞和多种其他细胞类型的表面上的CD6配体的序列的分离的核酸分子。 本发明还涉及包含核酸分子的构建体和包含该核酸分子的宿主细胞。 此外，本发明涉及一种制备CD6配体的方法。
-
公开(公告)号：US5998172A
公开(公告)日：1999-12-07
申请号：US684594
申请日：1996-07-18
申请人： Barton F. Haynes , Alejandro Aruffo , Dhavalkumar D. Patel , Michael A. Bowen , Hans Marquardt , Anthony W. Siadak
发明人： Barton F. Haynes , Alejandro Aruffo , Dhavalkumar D. Patel , Michael A. Bowen , Hans Marquardt , Anthony W. Siadak
IPC分类号： G01N33/53 , A61K31/00 , A61K38/00 , A61K39/395 , A61K45/00 , A61P37/00 , A61P37/02 , C07K14/47 , C07K14/705 , C07K16/28 , C12N5/00 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/566 , G01N33/577 , G01N33/68 , C12N5/12
CPC分类号： C07K14/705 , C07K14/70503 , C07K14/70596 , C07K16/2803 , C07K16/2896 , G01N33/68 , A61K38/00 , C07K2319/00 , C07K2319/30 , G01N2333/70503
摘要： The present invention relates, in general, to CD6 and, in particular, to a CD6 ligand present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cell types. The invention further relates to methods of inhibiting the interaction of CD6 and the CD6 ligand, and to methods of screening compounds for their ability to inhibit that interaction. The invention also relates to antibodies, and binding fragments thereof, specific for CD6 ligand.
摘要翻译： 本发明一般涉及CD6，特别是涉及存在于胸腺上皮细胞，单核细胞，活化的T细胞和多种其他细胞类型的表面上的CD6配体。 本发明还涉及抑制CD6和CD6配体相互作用的方法，以及筛选化合物抑制该相互作用的能力的方法。 本发明还涉及对CD6配体特异性的抗体及其结合片段。
-
公开(公告)号：US5830731A
公开(公告)日：1998-11-03
申请号：US861205
申请日：1997-05-21
申请人： Brian Seed , Alejandro Aruffo
发明人： Brian Seed , Alejandro Aruffo
IPC分类号： A61K38/00 , C07K14/705 , C12N15/10 , C12N15/12 , C12N15/85 , G01N33/569 , C12N15/66
CPC分类号： C07K14/705 , C07K14/70578 , C12N15/1034 , C12N15/85 , G01N33/56972 , A61K38/00 , C12N2800/108 , C12N2830/00 , C12N2830/15 , C12N2830/38 , C12N2830/60 , C12N2840/44
摘要： A simple and highly efficient method for cloning cDNAs from mammalian expression libraries based on transient expression in mammalian host cells has been discovered. Novel expression vectors allowing highly efficient construction of mammalian cDNA libraries are disclosed. The cloning method of the invention which has been used to clone genes for cell surface antigens of human lymphocytes, has general application in gene cloning. Cell surface antigens cloned according to the present invention have been purified, and the nucleotide and amino acid sequences determined. These antigens have diagnostic and therapeutic utility in immune-mediated infections in mammals, including humans.
摘要翻译： 已经发现了一种用于从哺乳动物宿主细胞中的瞬时表达克隆来自哺乳动物表达文库的cDNA的简单且高效的方法。 公开了能够高效构建哺乳动物cDNA文库的新型表达载体。 用于克隆人淋巴细胞表面抗原基因的本发明的克隆方法在基因克隆中具有一般应用。 已经纯化了根据本发明克隆的细胞表面抗原，并确定了核苷酸和氨基酸序列。 这些抗原在哺乳动物（包括人）的免疫介导感染中具有诊断和治疗效用。
-
公开(公告)号：US07119183B2
公开(公告)日：2006-10-10
申请号：US09836544
申请日：2001-04-17
申请人： Brian Seed , Alejandro Aruffo , David Camerini
发明人： Brian Seed , Alejandro Aruffo , David Camerini
IPC分类号： C07H21/04
CPC分类号： C07K14/705 , A61K38/00 , C07K14/70578 , C12N15/1034 , C12N15/85 , C12N2800/108 , C12N2830/00 , C12N2830/15 , C12N2830/38 , C12N2830/60 , C12N2840/44 , G01N33/56972
摘要： A simple and highly efficient method for cloning cDNAs including CD27 (SEQ ID NO:28) from mammalian expression libraries based on transient expression in mammalian host cells has been discovered. Novel expression vectors allowing highly efficient construction of mammalian cDNA libraries are disclosed. The cloning method of the invention which has been used to clone genes for cell surface antigens of human lymphocytes, has general application in gene cloning. Cell surface antigens cloned according to the present invention have been purified, and the nucleotide and amino acid sequences determined. These antigens have diagnostic and therapeutic utility in immune-mediated infections in mammals, including humans.
摘要翻译： 已经发现了一种基于哺乳动物宿主细胞中的瞬时表达来克隆来自哺乳动物表达文库的cDNA（包括CD27（SEQ ID NO：28））的简单且高效的方法。 公开了能够高效构建哺乳动物cDNA文库的新型表达载体。 用于克隆人淋巴细胞表面抗原基因的本发明的克隆方法在基因克隆中具有一般应用。 已经纯化了根据本发明克隆的细胞表面抗原，并确定了核苷酸和氨基酸序列。 这些抗原在哺乳动物（包括人）的免疫介导感染中具有诊断和治疗效用。
-
-
-
-
-
-
-
-
-
搜索结果
15 条记录 (耗时 0.023 秒)
