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公开(公告)号：US5284660A
公开(公告)日：1994-02-08
申请号：US933423
申请日：1992-08-21
申请人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
发明人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
CPC分类号： A61K9/7084 , A61K9/7069 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir, which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.
摘要翻译： 描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。 在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。 合适的方法包括设置在释放表面和药剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初不能渗透到试剂中，然后变得可渗透。 可以提供由一种或多种这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。 延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。
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公开(公告)号：US5071656A
公开(公告)日：1991-12-10
申请号：US271207
申请日：1988-11-14
CPC分类号： A61K9/7069 , A61K31/21 , A61K9/7084 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in a predetermined temporal pattern at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.
摘要翻译： 描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。 在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。 合适的方法包括设置在释放表面和试剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初对试剂不渗透，然后变为可渗透的。 可以提供由一个或多个这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。 延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。
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公开(公告)号：US4564364A
公开(公告)日：1986-01-14
申请号：US498381
申请日：1983-05-26
CPC分类号： A61K9/7023 , A61K9/2086 , A61M31/002 , A61F2013/0296
摘要： The release pattern of a dispersion type active agent dispenser can be improved by forming the device from a depleted zone containing the agent at a concentration no greater than the saturation and a non-depleted zone containing the agent dispersed in the matrix at a uniform concentration greater than saturation. The depleted zone is disposed between the surface through which the agent is to be dispensed and at least a substantial portion of the non-depleted zone with the interface therebetween disposed at a non-uniform distance from the releasing surface. Certain embodiments are particularly useful for the transdermal administration of drugs.
摘要翻译： 分散型活性剂分配器的释放模式可以通过从不含饱和度的含有试剂的贫化区形成装置，并且以均匀的浓度将含有分散在基质中的试剂的非贫化区形成， 比饱和度。 耗尽区设置在待分配试剂的表面和至少大部分的非耗尽区之间，其间的界面设置在与释放表面不均匀的距离处。 某些实施方案对于透皮给药药物特别有用。
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4.发明授权Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings 失效液体填充的明胶胶囊通过多个涂层转化为控制释放系统公开(公告)号：US06929803B2
公开(公告)日：2005-08-16
申请号：US10117359
申请日：2002-04-04
申请人： Patrick S. L. Wong , Liang C. Dong , Jiansheng Wan
发明人： Patrick S. L. Wong , Liang C. Dong , Jiansheng Wan
CPC分类号： A61K9/0004
摘要： A dosage form comprising a gelatin capsule formed with a composite wall and containing a liquid, active agent formulation where the wall comprises a barrier layer formed over the external surface of the gelatin capsule, an expandable layer formed over the barrier layer and a semipermeable layer formed over the expandable layer is described. The dosage forms and methods provide for the conversion of standard gelatin, liquid formulation capsules into controlled, release dosage forms that permit the controlled release of the active agent into the environment of use over time.
摘要翻译： 一种剂型，其包含形成有复合壁并且含有液体活性剂制剂的明胶胶囊，其中所述壁包含形成在所述明胶胶囊的外表面上的阻挡层，形成在阻挡层上的可膨胀层和形成的半透膜 描述在可膨胀层之上。 剂型和方法提供将标准明胶，液体制剂胶囊转化成受控释放剂型，其允许活性剂随时间的控制释放到使用环境中。
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公开(公告)号：US06572582B1
公开(公告)日：2003-06-03
申请号：US09447655
申请日：1999-11-23
IPC分类号： A61M3700
CPC分类号： A61J1/2093 , A61J7/0038
摘要： The present invention is directed to a mixing system for an active agent delivery device. The device comprises an elongate tubular member having first and second ends and a mixing system. The mixing system enables the entire dose of active agent to be entrained in a liquid. In use, liquid is drawn into the first end of the device, the mixing system mixes the liquid and active agent within the device and the active agent entrained in the liquid is drawn out of the second end of the member and into the patient's mouth.
摘要翻译： 本发明涉及一种用于活性剂输送装置的混合系统。 该装置包括具有第一端和第二端的细长管状构件和混合系统。 混合系统使整个剂量的活性剂被夹带在液体中。 在使用中，液体被吸入装置的第一端，混合系统将液体和活性剂混合在装置内，并且夹带在液体中的活性剂从该构件的第二端引出并进入患者的口中。
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公开(公告)号：US06440457B1
公开(公告)日：2002-08-27
申请号：US08068480
申请日：1993-05-27
IPC分类号： A61K922
CPC分类号： A61K31/135 , A61K9/0004 , Y10S514/96 , Y10S514/964
摘要： The invention pertains to a dosage form 10 and to administering an antidepressant medicament 16 for an extended period of time in a rate-known dose.
摘要翻译： 本发明涉及一种剂型10，并以剂量已知的剂量给予抗抑郁药物16延长一段时间。
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公开(公告)号：US06174547B1
公开(公告)日：2001-01-16
申请号：US09353702
申请日：1999-07-14
IPC分类号： A61K948
CPC分类号： A61K9/4858 , A61K9/0004 , A61K9/1075 , A61K9/4866
摘要： A dosage form is disclosed comprising a drug formulation that self-emulsifies in said dosage form.
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公开(公告)号：US6120803A
公开(公告)日：2000-09-19
申请号：US131923
申请日：1998-08-10
申请人： Patrick S. L. Wong , Liang-Chang Dong , David E. Edgren , Felix Theeuwes , Phyllis I. Gardner , Francisco Jao , Jason J. Wan
发明人： Patrick S. L. Wong , Liang-Chang Dong , David E. Edgren , Felix Theeuwes , Phyllis I. Gardner , Francisco Jao , Jason J. Wan
IPC分类号： A61K47/22 , A61K9/00 , A61K9/20 , A61K9/22 , A61K9/26 , A61K31/341 , A61K31/522 , A61K45/00 , A61P31/12
CPC分类号： A61K9/0065 , A61K9/2072
摘要： The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix is surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.
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公开(公告)号：US6096339A
公开(公告)日：2000-08-01
申请号：US826642
申请日：1997-04-04
CPC分类号： A61K9/0004
摘要： The invention disclosed pertains to a dosage form comprising an agent formulation comprising drug and pharmaceutical carrier of cooperating particle size and means for dispensing the agent formulation from the dosage form.
摘要翻译： 所公开的本发明涉及包含药物制剂的剂型，其包含具有协调粒径的药物和药物载体以及用于从剂型分配药剂制剂的装置。
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公开(公告)号：US5512299A
公开(公告)日：1996-04-30
申请号：US092024
申请日：1993-07-14
CPC分类号： A61K31/573 , A61K9/0004 , A61K9/006
摘要： A method of treating inflammatory disease of the mouth by locally delivering beclomethasone dipropionate and related compounds to the oral cavity of a patient over an extended period of time is disclosed. In one embodiment, beclomethasone dipropionate is delivered by an osmotic device (10), in another embodiment, it is delivered by an erosion controlled device (110) and in yet another embodiment, it is delivered by a diffusion controlled device (310).
摘要翻译： 公开了一种通过在长时间内将二丙酸倍氯米松和相关化合物局部递送到患者的口腔来治疗口腔炎症的方法。 在一个实施方案中，二丙酸倍氯米松通过渗透装置（10）递送，在另一个实施方案中，其由侵蚀受控装置（110）递送，并且在另一个实施方案中，其由扩散控制装置（310）递送。
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