公开(公告)号：US20100049491A1

公开(公告)日：2010-02-25

申请号：US12330079

申请日：2008-12-08

申请人： Alessandro SETTE ,  Robert Chestnut ,  Brian D. Livingston ,  Denise Marie Baker ,  Mark J. Newman ,  David H. Brown

发明人： Alessandro SETTE ,  Robert Chestnut ,  Brian D. Livingston ,  Denise Marie Baker ,  Mark J. Newman ,  David H. Brown

IPC分类号： G06F17/50 ,  G06F19/00

CPC分类号： A61K39/29 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K39/292 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2039/70 ,  C07K14/005 ,  C07K2319/00 ,  C12N15/86 ,  C12N2730/10122 ,  C12N2730/10134 ,  C12N2740/16022 ,  C12N2740/16034 ,  G16B15/00 ,  G16B20/00 ,  G16B30/00 ,  G16B40/00

摘要： The invention relates to the field of biology. In particular, the invention relates to a method and system for designing optimized multi-epitope vaccines having selected combinations of amino acid insertions at the junctions of the multi-epitope constructs so as to minimize the number of junctional epitopes and provide vaccines with increased immunogenicity.

摘要翻译： 本发明涉及生物学领域。 特别地，本发明涉及一种用于设计优化的多表位疫苗的方法和系统，其具有在多表位构建体的连接处具有氨基酸插入的选择的组合，以便最小化连接表位的数目并提供具有增加的免疫原性的疫苗。

公开(公告)号：US08172516B2

公开(公告)日：2012-05-08

申请号：US11999875

申请日：2007-12-07

申请人： John Frederick Parker ,  David Luck ,  David H. Brown

发明人： John Frederick Parker ,  David Luck ,  David H. Brown

IPC分类号： F01D17/14

CPC分类号： F01D17/143 ,  F01D17/167 ,  F05D2220/40

摘要： A variable geometry turbine comprises a turbine wheel (9) supported in a housing (1) for rotation about an axis. A nozzle ring (5) is moveably mounted within a cavity (19) provided within the housing for adjustment of the width of an annular inlet passageway (4) extending radially inwards towards the turbine wheel (9). An array of inlet guide vanes (8) extends between a radial face of the nozzle ring (5) and an opposing wall of the inlet (4) defining a radial vane passage. A first circumferential array of apertures (25) is provided through the radial face, each of which lies substantially within the vane passage. A second circumferential array of apertures (24) is also provided in said radial face, each of lies substantially upstream or downstream of the first array (25) of apertures. The inlet (4) and cavity (19) are in fluid communication via both the first and second sets of apertures (25,24).

摘要翻译： 可变几何涡轮机包括支撑在壳体（1）中以围绕轴线旋转的涡轮机叶轮（9）。 喷嘴环（5）可移动地安装在设置在壳体内的空腔（19）内，用于调节径向向内朝向涡轮机叶轮（9）延伸的环形入口通道（4）的宽度。 入口导向叶片（8）的阵列在喷嘴环（5）的径向面和入口（4）的相对的壁之间延伸，限定出径向叶片通道。 第一圆周阵列的孔（25）设置穿过径向面，每个基本上位于叶片通道内。 第二圆周阵列的孔（24）也设置在所述径向面中，每个位于基本上在第一阵列（25）孔的上游或下游。 入口（4）和空腔（19）经由第一和第二组孔（25,24）流体连通。

公开(公告)号：US08571971B1

公开(公告)日：2013-10-29

申请号：US10126013

申请日：2002-04-19

申请人： David H. Brown ,  Shelley I. Stadler ,  Donald E. Wratislaw ,  Joy M. Wyche

发明人： David H. Brown ,  Shelley I. Stadler ,  Donald E. Wratislaw ,  Joy M. Wyche

IPC分类号： G06Q40/00

CPC分类号： G06Q40/025

摘要： A management system and method for a credit decision-making process. The system and method provide access to an automatically generated and updated status report providing information about conditions required for final credit approval. The status report is available via computer systems used by parties to the credit decision-making process, such as the potential borrower, the creditor, and a business partner working with the potential borrower and creditor. Notifications of changes to the status report and/or updated status reports are automatically provided to the parties via the computer systems. In some embodiments, a request for the current status report can be requested in response to the notification.The system and method also include the capability to access dates scheduled for fulfilling the conditions for final credit approval and to allow requests for changes to the scheduled dates. Notifications of requests for date changes can be automatically provided to all parties needing the information.

摘要翻译： 信用决策过程的管理制度和方法。 系统和方法提供访问自动生成和更新的状态报告，提供有关最终信用审批所需条件的信息。 状态报告可通过信用决策过程各方使用的计算机系统获得，例如潜在的借款人，债权人和与潜在借款人和债权人合作的业务伙伴。 状态报告和/或更新的状态报告的更改通知将通过计算机系统自动提供给各方。 在一些实施例中，响应于该通知可以请求对当前状态报告的请求。 该系统和方法还包括访问计划完成最终信用审批条件的日期的能力，并允许更改预定日期的请求。 有关日期更改请求的通知可以自动提供给需要信息的所有各方。

公开(公告)号：US06562885B1

公开(公告)日：2003-05-13

申请号：US09270636

申请日：1999-03-17

申请人： John S. Moorehead ,  Lynnette D. Blaney ,  David H. Brown ,  Pierre J. Messier ,  Norbert G. Laderoute

发明人： John S. Moorehead ,  Lynnette D. Blaney ,  David H. Brown ,  Pierre J. Messier ,  Norbert G. Laderoute

IPC分类号： C08K300

CPC分类号： A01N59/12 ,  A62D3/30 ,  A62D3/38 ,  A62D2101/02 ,  C09D5/14 ,  C09D7/65 ,  C09D7/68 ,  C09D7/69

摘要： A substance capable of devitalizing hazardous biological agents and deactivating hazardous chemical agents comprising an activated anion exchange resin having a particle size substantially in the range of about 0.1-300 microns, which resin particles have been iodinated by exposure to a sufficient amount of an iodine-substance absorbable by the anion exchange resin such that the resin particles absorb the iodine-substance so as to convert the resin particles into activated resin particles. The iodine-substance may be selected from the group consisting of I2 (i.e., diatomic iodine), and polyiodide ions having a valence of −1. The activated resin particles may be placed into contact with the biological or chemical agent as a dry aerosol, by dust coating, or by admixing the particles with a carrier to form a coating.

摘要翻译： 能够使有害生物制剂失活的物质和灭活有害化学试剂的物质，其包含基本上在约0.1-300微米范围内的粒度的活化阴离子交换树脂，该树脂颗粒通过暴露于足够量的碘 - 通过阴离子交换树脂可吸收的物质，使得树脂颗粒吸收碘物质，以将树脂颗粒转化为活性树脂颗粒。 碘物质可以选自I2（即双原子碘）和化合价为-1的多碘离子。 可以将活化的树脂颗粒与生物或化学试剂接触，作为干燥气溶胶，通过粉尘涂覆，或通过将颗粒与载体混合以形成涂层。

公开(公告)号：US06279434B1

公开(公告)日：2001-08-28

申请号：US09612936

申请日：2000-07-10

申请人： David H. Brown

发明人： David H. Brown

IPC分类号： B25B2300

CPC分类号： B25G1/085 ,  A63C17/0006 ,  B25B13/48 ,  B25B13/56

摘要： The present invention is directed to a tool for use on a skateboard and easily carried in a pants pocket of a user. The tool has a body is in the general shape of a “T” having a crossbar bisected by a stem and provides for three sockets of differing sizes, one of each being mounted at each end of the crossbar and the free end of the stem. Provision is also made for carrying a combination Allen key and Phillips head screwdriver and is in the general form of a standard Allen wrench having a long arm and a short arm normal to the long arm. This provision constitutes a cylindrical cavity with an opening at the intersection of the crossbar and stem and extending into the stem for distance adequate to accommodate the long arm of the combination Allen key and Phillips head screwdriver, which preferably is the Phillips head portion. This provision also provides a groove extending along the surface of the crossbar of such size and shape to accommodate the short arm of the combination Allen key and Phillips head screwdriver, which preferably is the Allen key portion. An “O” ring is positioned within the cylindrical cavity to provide a friction fit with the Phillips head screwdriver portion of the combination Allen key and Phillips head screwdriver. An “O” ring may be positioned circumferentially on the Allen key portion so as to provide an improved fit within the corresponding groove as an alternative or in conjunction with the cylindrical cavity “O” ring.

摘要翻译： 本发明涉及一种在滑板上使用并易于携带在用户口袋中的工具。 该工具具有“T”的一般形状的主体，其具有由杆平分的横杆，并提供不同尺寸的三个插座，每个插座中的一个安装在横杆的每一端和杆的自由端。 另外还配备了内六角螺丝刀和十字头螺丝刀，并具有长臂和短臂垂直于长臂的标准内六角扳手的一般形式。 该配置构成一个圆柱形腔体，在横杆和阀杆的交点处具有一个开口，并延伸到阀杆上，距离足以容纳组合内六角螺丝刀和十字头螺丝刀的长臂，这最好是菲利普头部。 该设备还提供了一个沿着这种尺寸和形状的横杆的表面延伸的凹槽，以容纳组合内六角扳手和十字头螺丝刀的短臂，其优选地是内六角扳手部分。 一个“O”形环位于圆柱形腔内，以提供与内六角螺丝刀和十字头螺丝刀组合的十字头螺丝刀部分的摩擦配合。 “O”形环可以周向地定位在内六角扳手部分上，以便在相应的凹槽内提供改进的配合，作为替代或者与圆柱形腔“O”环结合使用。