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1.发明申请Inducing cellar immune responses to hepatitis C virus using peptide and nucleic acid compositions 审中-公开使用肽和核酸组合物诱导丙型肝炎病毒的地窖免疫应答公开(公告)号：US20090304746A1
公开(公告)日：2009-12-10
申请号：US11980348
申请日：2007-10-31
申请人： Alessandro Sette , John Sidney , Scott Southwood , Brian D. Livingston , Robert Chesnut , Denise Marie Baker , Esteban Celis , Ralph T. Kubo , Howard M. Grey
发明人： Alessandro Sette , John Sidney , Scott Southwood , Brian D. Livingston , Robert Chesnut , Denise Marie Baker , Esteban Celis , Ralph T. Kubo , Howard M. Grey
IPC分类号： A61K39/29 , C07K7/06 , C07K7/08 , A61K38/08 , A61K38/10 , A61K31/7052 , C07K14/00 , G01N33/53 , A61K38/16 , A61P31/12
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/70 , C07K2319/00 , C12N2770/24222
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare HCV epitopes, and to develop epitope-based vaccines directed towards HCV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HCV infection.
摘要翻译： 本发明使用我们对抗原被T细胞识别和制备HCV表位的机制的知识，并开发针对HCV的基于表位的疫苗。 更具体地说，本申请将我们发现的药物组合物和使用方法用于预防和治疗HCV感染。
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2.发明授权公开(公告)号：US07462354B2
公开(公告)日：2008-12-09
申请号：US09894018
申请日：2001-06-27
CPC分类号： A61K39/29 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/292 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , A61K2039/70 , C07K14/005 , C07K2319/00 , C12N15/86 , C12N2730/10122 , C12N2730/10134 , C12N2740/16022 , C12N2740/16034 , G06F19/16 , G06F19/18 , G06F19/22 , G06F19/24
摘要： The invention relates to the field of biology. In particular, the invention relates to a method and system for designing optimized multi-epitope vaccines having selected combinations of amino acid insertions at the junctions of the multi-epitope constructs so as to minimize the number of junctional epitopes and provide vaccines with increased immunogenicity.
摘要翻译： 本发明涉及生物学领域。 特别地，本发明涉及一种用于设计优化的多表位疫苗的方法和系统，其具有在多表位构建体的连接处具有氨基酸插入的选择的组合，以便最小化连接表位的数目并提供具有增加的免疫原性的疫苗。
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3.发明授权Inducing cellular immune responses to Plasmodium falciparum using peptide and nucleic acid compositions 有权使用肽和核酸组合物诱导恶性疟原虫的细胞免疫应答公开(公告)号：US09266930B1
公开(公告)日：2016-02-23
申请号：US09390061
申请日：1999-09-03
申请人： Alessandro Sette , John Sidney , Scott Southwood , Brian D. Livingston , Robert Chestnut , Denise Marie Baker , Esteban Celis , Ralph T. Kubo , Howard M. Grey
发明人： Alessandro Sette , John Sidney , Scott Southwood , Brian D. Livingston , Robert Chestnut , Denise Marie Baker , Esteban Celis , Ralph T. Kubo , Howard M. Grey
IPC分类号： A61K39/002 , A61K39/015 , C07K14/44 , C07K14/445 , A61K39/00
CPC分类号： A61K39/015 , A61K39/0011 , A61K39/002 , A61K2039/5154 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/605 , C07K7/08 , C07K14/005 , C07K14/445 , C07K14/70539 , C07K2319/00 , C07K2319/01 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , Y02A50/412
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare Plasmodium falciparum epitopes, and to develop epitope-based vaccines directed towards malaria. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of malaria. In particular, this application discloses isolated peptides comprising oligopeptides, for example the oligopeptide GVSENIFLK, or isolated peptides conjugated with T helper peptides that are used as antigens in epitope-based vaccines to prevent and/or treat malaria.
摘要翻译： 本发明使用我们对抗原被T细胞识别和制备恶性疟原虫表位的机制的知识，并开发针对疟疾的基于表位的疫苗。 更具体地说，本申请将我们发现的药物组合物和使用方法用于预防和治疗疟疾。 特别地，本申请公开了分离的肽，其包含寡肽，例如寡肽GVSENIFLK，或与T辅助肽缀合的分离肽，其用作基于表位的疫苗中的抗原以预防和/或治疗疟疾。
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4.发明申请公开(公告)号：US20100049491A1
公开(公告)日：2010-02-25
申请号：US12330079
申请日：2008-12-08
申请人： Alessandro SETTE , Robert Chestnut , Brian D. Livingston , Denise Marie Baker , Mark J. Newman , David H. Brown
发明人： Alessandro SETTE , Robert Chestnut , Brian D. Livingston , Denise Marie Baker , Mark J. Newman , David H. Brown
CPC分类号： A61K39/29 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/292 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , A61K2039/70 , C07K14/005 , C07K2319/00 , C12N15/86 , C12N2730/10122 , C12N2730/10134 , C12N2740/16022 , C12N2740/16034 , G16B15/00 , G16B20/00 , G16B30/00 , G16B40/00
摘要： The invention relates to the field of biology. In particular, the invention relates to a method and system for designing optimized multi-epitope vaccines having selected combinations of amino acid insertions at the junctions of the multi-epitope constructs so as to minimize the number of junctional epitopes and provide vaccines with increased immunogenicity.
摘要翻译： 本发明涉及生物学领域。 特别地，本发明涉及一种用于设计优化的多表位疫苗的方法和系统，其具有在多表位构建体的连接处具有氨基酸插入的选择的组合，以便最小化连接表位的数目并提供具有增加的免疫原性的疫苗。
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