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    Immunostimulatory oligoribonucleotides
    1.
    发明授权
    Immunostimulatory oligoribonucleotides 有权
    免疫刺激寡核糖核苷酸

    公开(公告)号：US08354522B2

    公开(公告)日：2013-01-15

    申请号：US13046871

    申请日：2011-03-14

    申请人： Alexandra Forsbach ,  Jorg Vollmer ,  Grayson B. Lipford

    发明人： Alexandra Forsbach ,  Jorg Vollmer ,  Grayson B. Lipford

    IPC分类号： C07H21/04 ,  C07H21/02 ,  A61K39/00 ,  A61K48/00

    CPC分类号： A61K39/39 ,  A61K31/7105 ,  A61K2039/55561 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315

    摘要： The invention provides immunostimulatory compositions and use of those compounds in the preparation of medicaments for the treatment of disease as well as in vitro uses. In particular, the compositions of the invention include immunostimulatory oligoribonucleotides that incorporate a sequence-dependent immunostimulatory sequence motif. Specific modifications involving phosphate linkages, nucleotide analogs, adducts, and combinations thereof are provided. Compositions of the invention, which optionally can include an antigen, can be used alone or together with other treatments to stimulate or enhance an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an allergic condition, asthma, airway remodeling, or immunodeficiency. Immunostimulatory oligoribonucleotides of the invention are believed to stimulate Toll-like receptor 8 (TLR8).

    摘要翻译： 本发明提供免疫刺激组合物和这些化合物在制备用于治疗疾病和体外用途的药物中的用途。 特别地，本发明的组合物包括掺入序列依赖性免疫刺激序列基序的免疫刺激性寡核糖核苷酸。 提供涉及磷酸键，核苷酸类似物，加合物及其组合的具体修饰。 任选地可以包括抗原的本发明的组合物可以单独使用或与其它治疗一起使用以刺激或增强免疫应答。 还提供了可用于治疗患有感染，癌症，过敏性疾病，哮喘，气道重塑或免疫缺陷的受试者的组合物和方法。 认为本发明的免疫刺激性寡核糖核苷酸可刺激Toll样受体8（TLR8）。

    Immunostimulatory oligoribonucleotides
    2.
    发明申请
    Immunostimulatory oligoribonucleotides 有权
    免疫刺激寡核糖核苷酸

    公开(公告)号：US20070142315A1

    公开(公告)日：2007-06-21

    申请号：US11603978

    申请日：2006-11-22

    申请人： Alexandra Forsbach ,  Jorg Vollmer ,  Grayson Lipford

    发明人： Alexandra Forsbach ,  Jorg Vollmer ,  Grayson Lipford

    IPC分类号： A61K48/00 ,  A61K9/14 ,  C07H21/02

    CPC分类号： A61K39/39 ,  A61K31/7105 ,  A61K2039/55561 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315

    摘要： The invention provides immunostimulatory compositions and use of those compounds in the preparation of medicaments for the treatment of disease as well as in vitro uses. In particular, the compositions of the invention include immunostimulatory oligoribonucleotides that incorporate a sequence-dependent immunostimulatory sequence motif. Specific modifications involving phosphate linkages, nucleotide analogs, adducts, and combinations thereof are provided. Compositions of the invention, which optionally can include an antigen, can be used alone or together with other treatments to stimulate or enhance an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an allergic condition, asthma, airway remodeling, or immunodeficiency. Immunostimulatory oligoribonucleotides of the invention are believed to stimulate Toll-like receptor 8 (TLR8).

    摘要翻译： 本发明提供免疫刺激组合物和这些化合物在制备用于治疗疾病和体外用途的药物中的用途。 特别地，本发明的组合物包括掺入序列依赖性免疫刺激序列基序的免疫刺激性寡核糖核苷酸。 提供涉及磷酸键，核苷酸类似物，加合物及其组合的具体修饰。 任选地可以包括抗原的本发明的组合物可以单独使用或与其它治疗一起使用以刺激或增强免疫应答。 还提供了可用于治疗患有感染，癌症，过敏性疾病，哮喘，气道重塑或免疫缺陷的受试者的组合物和方法。 认为本发明的免疫刺激性寡核糖核苷酸可刺激Toll样受体8（TLR8）。

    Immunostimulatory nucleic acids
    4.
    发明申请
    Immunostimulatory nucleic acids 审中-公开
    免疫刺激核酸

    公开(公告)号：US20070066554A1

    公开(公告)日：2007-03-22

    申请号：US11507079

    申请日：2006-08-18

    申请人： Arthur Krieg ,  Christian Schetter ,  Jorg Vollmer

    发明人： Arthur Krieg ,  Christian Schetter ,  Jorg Vollmer

    IPC分类号： A61K48/00 ,  C12Q1/68

    CPC分类号： A61K31/7105 ,  A61K31/7088 ,  A61K31/7125 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/55561

    摘要： The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25% T nucleotide residues. The TG nucleic acids have TG dinucleotides. The C-rich nucleic acids have at least one poly-C region and/ore greater than 50% c nucleotides. These immunostimulatory nucleic acids function in a similar manner to nucleic acids containing CpG motifs. The invention also encompasses preferred CpG nucleic acids.

    摘要翻译： 本发明涉及免疫刺激性核酸组合物和使用该组合物的方法。 富含T的核酸含有多T序列和/或具有大于25％的T核苷酸残基。 TG核酸具有TG二核苷酸。 富含C的核酸具有至少一个多C区和/或大于50％c核苷酸。 这些免疫刺激性核酸以与含有CpG基序的核酸类似的方式起作用。 本发明还包括优选的CpG核酸。

    CPG-like nucleic acids and methods of use thereof
    9.
    发明申请
    CPG-like nucleic acids and methods of use thereof 审中-公开
    CPG样核酸及其使用方法

    公开(公告)号：US20080226649A1

    公开(公告)日：2008-09-18

    申请号：US11725339

    申请日：2007-03-19

    申请人： Christian Schetter ,  Jorg Vollmer

    发明人： Christian Schetter ,  Jorg Vollmer

    IPC分类号： A61K39/395 ,  A61K31/711 ,  A61P37/00 ,  A61K39/00

    CPC分类号： C07H21/00 ,  A61K31/7115 ,  A61K39/39 ,  A61K2039/55561 ,  C12N15/111 ,  C12N15/117 ,  C12N2310/17 ,  C12N2320/31

    摘要： Immunostimulatory compositions described as CpG-like nucleic acids are provided, including nucleic acids having immunostimulatory characteristics of CpG nucleic acid, despite certain substitutions of C, G, or C and G of the CpG dinucleotide. The substitutions can include, among others, exchange of methylated C for C, inosine for G, and ZpY for CpG, where Z is cytosine or dSpacer and Y is inosine, 2-aminopurine, nebularine, or dSpacer. Also provided are methods for inducing an immune response in a subject using the CpG-like nucleic acids. The methods are useful in the treatment of a subject that has or is at risk of developing an infectious disease, allergy, asthma, cancer, anemia, thrombocytopenia, or neutropenia.

    摘要翻译： 提供描述为CpG样核酸的免疫刺激组合物，包括具有CpG核酸的免疫刺激特性的核酸，尽管CpG二核苷酸的C，G或C和G的某些取代。 取代可以包括C的甲基化C，G的肌苷和CpG的ZpY，其中Z是胞嘧啶或dSpacer，Y是肌苷，2-氨基嘌呤，星云素或dSpacer。 还提供了使用CpG样核酸在受试者中诱导免疫应答的方法。 该方法在治疗感染性疾病，过敏症，哮喘，癌症，贫血，血小板减少症或中性粒细胞减少症风险的受试者中是有用的。