Coumarin spherules/beads having unique morphology
    3.
    发明授权
    Coumarin spherules/beads having unique morphology 失效
    香豆素球/珠具有独特的形态

    公开(公告)号:US5693342A

    公开(公告)日:1997-12-02

    申请号:US405232

    申请日:1995-03-16

    CPC分类号: C07D311/08

    摘要: Free-flowing, non-agglomerating and attrition resistant, substantially spherical solid beads/spherules of a coumarin compound, advantageously having a particle size ranging from 100 .mu.m to 2,000 .mu.m, a loose bulk density ranging from 0.25 to 0.8 and a compressive strength ranging from 500 to 10,000 N/m.sup.2, dissolve rapidly in ethanol and are conveniently prepared by prilling/fragmenting a melt of the coumarin compound into a stream of a cooling gas.

    摘要翻译: 香豆素化合物的自由流动,非附聚和耐磨损,基本上球形的固体珠/小球,有利地具有100μm至2,000μm的粒度,0.25至0.8的松散堆积密度和0.25至0.8的压缩强度 范围在500至10,000N / m 2之间,迅速溶解在乙醇中,通过将香豆素化合物的熔体造粒/碎裂成冷却气体流方便地制备。

    Process for the preparation of medications in the form of pearls
    5.
    发明授权
    Process for the preparation of medications in the form of pearls 失效
    在PEARLS形式中制备药物的方法

    公开(公告)号:US5188838A

    公开(公告)日:1993-02-23

    申请号:US642947

    申请日:1991-01-18

    IPC分类号: A61J3/06 A61K9/16

    摘要: Process for the preparation of pearls based on a pharmaceutical active substance exhibiting an indefinite crystallization point. The said active substance is mixed in molten form which a pharmaceutical excipient promoting the solidification of the active substance, the melt is forced to pass through a nozzle which is subjected to a vibration, the pearls formed are allowed to fall in a tower countercurrentwise to a gas, and the pearls formed are collected in the bottom of the tower.

    摘要翻译: 基于表现出无限结晶点的药物活性物质制备珍珠的方法。 所述活性物质以熔融形式混合,药物赋形剂促进活性物质的固化,使熔体被迫通过经受振动的喷嘴,所形成的珍珠被允许以与 气体,形成的珍珠收集在塔的底部。