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    Process for the preparation of medications in the form of pearls
    4.
    发明授权
    Process for the preparation of medications in the form of pearls 失效
    在PEARLS形式中制备药物的方法

    公开(公告)号：US5188838A

    公开(公告)日：1993-02-23

    申请号：US642947

    申请日：1991-01-18

    Applicant: Michel Deleuil ,  Pierre Labourt-Ibarre ,  Robert Rona ,  Eraclis Statiotis

    Inventor： Michel Deleuil ,  Pierre Labourt-Ibarre ,  Robert Rona ,  Eraclis Statiotis

    IPC: A61J3/06 ,  A61K9/16

    CPC classification number: A61K9/1617 ,  A61K9/1694 ,  Y10S514/87

    Abstract: Process for the preparation of pearls based on a pharmaceutical active substance exhibiting an indefinite crystallization point. The said active substance is mixed in molten form which a pharmaceutical excipient promoting the solidification of the active substance, the melt is forced to pass through a nozzle which is subjected to a vibration, the pearls formed are allowed to fall in a tower countercurrentwise to a gas, and the pearls formed are collected in the bottom of the tower.

    Abstract translation: 基于表现出无限结晶点的药物活性物质制备珍珠的方法。 所述活性物质以熔融形式混合，药物赋形剂促进活性物质的固化，使熔体被迫通过经受振动的喷嘴，所形成的珍珠被允许以与 气体，形成的珍珠收集在塔的底部。

    Process for obtaining cristallized pearls exhibiting the phenomenon of supercooling
    6.
    发明授权
    Process for obtaining cristallized pearls exhibiting the phenomenon of supercooling 失效
    获得呈现过冷现象的珍珠珍珠的方法

    公开(公告)号：US5766521A

    公开(公告)日：1998-06-16

    申请号：US629859

    申请日：1996-04-09

    Applicant: Jean-Claude Le Thiesse ,  Eraclis Statiotis

    Inventor： Jean-Claude Le Thiesse ,  Eraclis Statiotis

    IPC: B01J2/02 ,  A61K9/16 ,  B01J2/04 ,  C07B61/00 ,  C07C41/40 ,  C07C43/23 ,  C07C51/43 ,  C07C53/134 ,  C30B1/02 ,  C30B29/54 ,  B29B9/10 ,  B29C35/02

    CPC classification number: B01J2/04 ,  A61K9/1688

    Abstract: The present invention relates to a novel presentation of a product exhibiting the phenomenon of supercooling. More precisely, the subject of the invention is cristallized pearls of a product exhibiting strong supercooling. The invention also relates to the preparation of the said pearls. The characteristic feature of the process of the invention is to melt, if necessary, the product to be shaped; to break up the molten mass into droplets; to cool the droplets to a temperature below the glass transition temperature of the product, so that these droplets harden by vitrification; to maintain the pearls thus vitrified at a temperature below the glass transition temperature and to place them in contact with crystallization seeds; to crystallize the pearls by raising the temperature above the glass transition temperature and then to recover the crystallized pearls.

    Abstract translation: 本发明涉及一种表现出过冷现象的产品的新颖表现。 更确切地说，本发明的主题是显示出强烈过冷的产品的重要珍珠。 本发明还涉及所述珍珠的制备。 本发明方法的特征在于，如果需要，可熔化待成型的产品; 将熔融物质分解成液滴; 以将液滴冷却到低于产品的玻璃化转变温度的温度，使得这些液滴通过玻璃化而硬化; 以在低于玻璃化转变温度的温度下保持珍珠如此玻璃化并使其与结晶种子接触; 通过将温度升高到高于玻璃化转变温度而使珍珠结晶，然后回收结晶的珍珠。

    Coumarin spherules/beads having unique morphology
    7.
    发明授权
    Coumarin spherules/beads having unique morphology 失效
    香豆素球/珠具有独特的形态

    公开(公告)号：US5693342A

    公开(公告)日：1997-12-02

    申请号：US405232

    申请日：1995-03-16

    Applicant: Eric Cervos ,  Pierre Labourt-Ibarre ,  Eraclis Statiotis

    Inventor： Eric Cervos ,  Pierre Labourt-Ibarre ,  Eraclis Statiotis

    IPC: C07D311/08 ,  C07D311/10 ,  C07D311/12 ,  C07D311/14 ,  A61K9/14

    CPC classification number: C07D311/08

    Abstract: Free-flowing, non-agglomerating and attrition resistant, substantially spherical solid beads/spherules of a coumarin compound, advantageously having a particle size ranging from 100 .mu.m to 2,000 .mu.m, a loose bulk density ranging from 0.25 to 0.8 and a compressive strength ranging from 500 to 10,000 N/m.sup.2, dissolve rapidly in ethanol and are conveniently prepared by prilling/fragmenting a melt of the coumarin compound into a stream of a cooling gas.

    Abstract translation: 香豆素化合物的自由流动，非附聚和耐磨损，基本上球形的固体珠/小球，有利地具有100μm至2,000μm的粒度，0.25至0.8的松散堆积密度和0.25至0.8的压缩强度 范围在500至10,000N / m 2之间，迅速溶解在乙醇中，通过将香豆素化合物的熔体造粒/碎裂成冷却气体流方便地制备。

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