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公开(公告)号：US07629137B2
公开(公告)日：2009-12-08
申请号：US11416998
申请日：2006-05-02
IPC分类号： C12Q1/00 , C12Q1/70 , G01N33/53 , G01N33/553 , G01N33/554 , G01N33/566 , G01N33/569 , G01N27/00 , B32B27/00 , B32B27/12
CPC分类号： G01N33/54313 , B01L3/502761 , B01L2200/0647 , B01L2300/0681 , B01L2300/1822 , B01L2400/043 , B01L2400/0487 , B82Y15/00 , B82Y30/00 , G01N29/022 , G01N29/036 , G01N29/4418 , G01N33/56911 , G01N2291/0256 , G01N2291/02836 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , G01N2800/324 , Y02A50/52 , Y02A50/57
摘要： Methods for detecting bacteria are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for the bacteria, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.
摘要翻译： 提供了检测细菌的方法。 将具有对细菌具有亲和力的捕获剂涂覆的多个颗粒与样品组合以形成多个分析物 - 颗粒复合物。 该系统还包括用于将样品输送到传感器表面的输送装置，以及可选地构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。 谐振传感器产生对应于结合到传感器表面的分析物 - 颗粒复合物的量的信号。
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公开(公告)号：US07632638B2
公开(公告)日：2009-12-15
申请号：US11416997
申请日：2006-05-02
IPC分类号： C12Q1/00 , C12Q1/70 , G01N33/543 , G01N33/553 , B32B27/00 , B32B27/12
CPC分类号： G01N33/54313 , B01L3/502761 , B01L2200/0647 , B01L2300/0681 , B01L2300/1822 , B01L2400/043 , B01L2400/0487 , B82Y15/00 , B82Y30/00 , G01N29/022 , G01N29/036 , G01N29/4418 , G01N33/56911 , G01N2291/0256 , G01N2291/02836 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , G01N2800/324 , Y02A50/52 , Y02A50/57
摘要： Methods for detecting viruses are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for the virus, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.
摘要翻译： 提供了检测病毒的方法。 将多个颗粒（其中每一个都涂覆有对病毒具有亲和力的捕获剂）与样品组合以形成多个分析物 - 颗粒复合物。 该系统还包括用于将样品传送到传感器表面的输送装置，以及可选地构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。 谐振传感器产生对应于结合到传感器表面的分析物 - 颗粒复合物的量的信号。
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公开(公告)号：US08227261B2
公开(公告)日：2012-07-24
申请号：US11416999
申请日：2006-05-02
IPC分类号： G01N33/553
CPC分类号： G01N33/54373 , B82Y15/00 , B82Y30/00 , G01N29/022 , G01N29/036 , G01N29/30 , G01N29/4436 , G01N2291/0255 , G01N2291/0256 , G01N2291/02836 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , Y10T436/2575
摘要： Methods and apparatuses for performing assays involving binding material elements with a plurality of bonds over a substantial area of a surface of a resonant device establishing a normalized exposure. The methods and apparatuses also involve controlling an external influence applied to the material elements over a first period of time and measuring a signal during a second period of time that is indicative of the change in the amount of material elements bound to the surface relative to the normalized exposure. In some cases, the measured signals are integrated with respect to time to determine the time averaged amount of material elements bound to the surface.
摘要翻译： 用于进行测定的方法和装置，其涉及在谐振装置的表面的实质区域上结合具有多个键的材料元件，从而建立归一化曝光。 所述方法和装置还涉及控制在第一时间段内施加到材料元件的外部影响，并且在第二时间段内测量指示与表面相关的材料元素量相对于 归一化曝光 在一些情况下，测量的信号相对于时间被积分，以确定与表面结合的材料元素的时间平均量。
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