公开(公告)号：US07178378B2

公开(公告)日：2007-02-20

申请号：US10651338

申请日：2003-08-28

Applicant: Ed Crawley ,  Mark Lundstrom ,  Brett Masters ,  Alok Srivastava ,  Martin Schmidt ,  Michael Miller

Inventor： Ed Crawley ,  Mark Lundstrom ,  Brett Masters ,  Alok Srivastava ,  Martin Schmidt ,  Michael Miller

IPC: G01N23/036

CPC classification number: G01N29/036 ,  B81B3/0089 ,  B81B2201/0214 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  G01L1/10 ,  G01N2291/0257 ,  G01N2291/0427

Abstract: The disclosed sensor chip includes a substrate and a moving member coupled to the substrate and disposed for movement relative to the substrate. The moving member moves relative to the substrate in a first direction and in a second direction in response to movement of the substrate. The first direction is different than the second direction. The moving member includes a plurality of receptors. The receptors are configured for selectively binding to a first measurand.

Abstract translation: 所公开的传感器芯片包括衬底和耦合到衬底并被设置为相对于衬底移动的移动构件。 移动构件响应于衬底的移动而在第一方向和第二方向上相对于衬底移动。 第一方向与第二方向不同。 移动构件包括多个受体。 受体被配置为选择性地结合第一被测量。

公开(公告)号：US20060286685A1

公开(公告)日：2006-12-21

申请号：US11183484

申请日：2005-07-18

Applicant: Michael Miller ,  Brett Masters ,  Mark Lundstrom ,  Eric Fitch

Inventor： Michael Miller ,  Brett Masters ,  Mark Lundstrom ,  Eric Fitch

IPC: G01N33/553 ,  C12M1/34

CPC classification number: G01N33/54313 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0681 ,  B01L2300/1822 ,  B01L2400/043 ,  B01L2400/0487 ,  B82Y15/00 ,  B82Y30/00 ,  G01N29/022 ,  G01N29/036 ,  G01N29/4418 ,  G01N33/56911 ,  G01N2291/0256 ,  G01N2291/02836 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427 ,  G01N2800/324 ,  Y02A50/52 ,  Y02A50/57

Abstract: A system for detecting an analyte in a sample includes a resonant sensor that has a sensor surface coated with the capture agent. A plurality of magnetic particles, each of which is coated with a capture agent having an affinity for the analyte, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.

Abstract translation: 用于检测样品中的分析物的系统包括具有涂覆有捕获剂的传感器表面的共振传感器。 将多个磁性颗粒（其中每一个都涂覆有对分析物具有亲和力的捕获剂）与样品组合以形成多个分析物 - 颗粒复合物。 该系统还包括用于将样品传送到传感器表面的传送装置，以及构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。 谐振传感器产生对应于结合到传感器表面的分析物 - 颗粒复合物的量的信号。

公开(公告)号：US20130200421A1

公开(公告)日：2013-08-08

申请号：US13368000

申请日：2012-02-07

Applicant: Changwook Jeong ,  Mark Lundstrom ,  Muhammad Ashraful Alam

Inventor： Changwook Jeong ,  Mark Lundstrom ,  Muhammad Ashraful Alam

IPC: H01L33/62 ,  H01B1/04 ,  H01L31/0224 ,  H01B1/00 ,  B82Y30/00

CPC classification number: H01B1/04 ,  B32B3/12 ,  B32B9/007 ,  B32B15/04 ,  B32B2262/103 ,  B32B2307/202 ,  B32B2307/704 ,  B32B2311/08 ,  B32B2313/04 ,  B82Y30/00 ,  H01B1/02 ,  H01L31/022466

Abstract: Illustrative embodiments of hybrid transparent conducting materials and applications thereof are disclosed. In one illustrative embodiment, a hybrid transparent conducting material may include a polycrystalline film and a plurality of conductive nanostructures randomly dispersed in the polycrystalline film. In another illustrative embodiment, a photovoltaic cell may include a transparent electrode comprising polycrystalline graphene that is percolation doped with metallic nanowires, where the metallic nanowires do not form a percolation network for charge carriers across the transparent electrode.

Abstract translation: 公开了混合透明导电材料的说明性实施例及其应用。 在一个说明性实施例中，混合透明导电材料可以包括多晶膜和随机分散在多晶膜中的多个导电纳米结构。 在另一个说明性实施例中，光伏电池可以包括透明电极，其包括渗透掺杂有金属纳米线的多晶石墨烯，其中金属纳米线不形成穿过透明电极的电荷载体的渗透网络。

公开(公告)号：US09524806B2

公开(公告)日：2016-12-20

申请号：US13368000

申请日：2012-02-07

Applicant: Changwook Jeong ,  Mark Lundstrom ,  Muhammad Ashraful Alam

Inventor： Changwook Jeong ,  Mark Lundstrom ,  Muhammad Ashraful Alam

IPC: H01B1/04 ,  B32B9/00 ,  B32B3/12 ,  B32B15/04 ,  H01L31/0224 ,  H01B1/02 ,  B82Y30/00

CPC classification number: H01B1/04 ,  B32B3/12 ,  B32B9/007 ,  B32B15/04 ,  B32B2262/103 ,  B32B2307/202 ,  B32B2307/704 ,  B32B2311/08 ,  B32B2313/04 ,  B82Y30/00 ,  H01B1/02 ,  H01L31/022466

Abstract: Illustrative embodiments of hybrid transparent conducting materials and applications thereof are disclosed. In one illustrative embodiment, a hybrid transparent conducting material may include a polycrystalline film and a plurality of conductive nanostructures randomly dispersed in the polycrystalline film. In another illustrative embodiment, a photovoltaic cell may include a transparent electrode comprising polycrystalline graphene that is percolation doped with metallic nanowires, where the metallic nanowires do not form a percolation network for charge carriers across the transparent electrode.

Abstract translation: 公开了混合透明导电材料的说明性实施例及其应用。 在一个说明性实施例中，混合透明导电材料可以包括多晶膜和随机分散在多晶膜中的多个导电纳米结构。 在另一个说明性实施例中，光伏电池可以包括透明电极，其包括渗透掺杂有金属纳米线的多晶石墨烯，其中金属纳米线不形成穿过透明电极的电荷载体的渗透网络。

公开(公告)号：US07632638B2

公开(公告)日：2009-12-15

申请号：US11416997

申请日：2006-05-02

Applicant: Alexis F. Sauer-Budge ,  Brett P. Masters ,  Michael Miller ,  Mark Lundstrom

Inventor： Alexis F. Sauer-Budge ,  Brett P. Masters ,  Michael Miller ,  Mark Lundstrom

IPC: C12Q1/00 ,  C12Q1/70 ,  G01N33/543 ,  G01N33/553 ,  B32B27/00 ,  B32B27/12

CPC classification number: G01N33/54313 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0681 ,  B01L2300/1822 ,  B01L2400/043 ,  B01L2400/0487 ,  B82Y15/00 ,  B82Y30/00 ,  G01N29/022 ,  G01N29/036 ,  G01N29/4418 ,  G01N33/56911 ,  G01N2291/0256 ,  G01N2291/02836 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427 ,  G01N2800/324 ,  Y02A50/52 ,  Y02A50/57

Abstract: Methods for detecting viruses are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for the virus, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.

Abstract translation: 提供了检测病毒的方法。 将多个颗粒（其中每一个都涂覆有对病毒具有亲和力的捕获剂）与样品组合以形成多个分析物 - 颗粒复合物。 该系统还包括用于将样品传送到传感器表面的输送装置，以及可选地构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。 谐振传感器产生对应于结合到传感器表面的分析物 - 颗粒复合物的量的信号。

公开(公告)号：US20090148856A1

公开(公告)日：2009-06-11

申请号：US11416624

申请日：2006-05-02

Applicant: Michael Miller ,  Brett P. Masters ,  Mark Lundstrom ,  Alok Srivastava ,  Wayne U. Wang

Inventor： Michael Miller ,  Brett P. Masters ,  Mark Lundstrom ,  Alok Srivastava ,  Wayne U. Wang

IPC: G01N33/53

CPC classification number: G01N29/4418 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0681 ,  B01L2300/1822 ,  B01L2400/043 ,  B01L2400/0487 ,  B82Y15/00 ,  B82Y30/00 ,  G01N29/022 ,  G01N29/036 ,  G01N33/54313 ,  G01N33/9493 ,  G01N2291/0256 ,  G01N2291/02836 ,  G01N2291/0427 ,  G01N2800/324

Abstract: Methods for therapeutic drug monitoring are provided. A plurality of particles, each of which is coated with a capture agent capable of binding a therapeutic drug of choice is combined with the sample to form a plurality of therapeutic drug-particle complexes. The system also includes a transport arrangement for transporting the sample and/or particles to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of therapeutic drug-particle complexes that are bound to the sensor surface.

Abstract translation: 提供治疗药物监测的方法。 将能够结合选择的治疗药物的捕获剂的多个颗粒与样品组合以形成多个治疗药物 - 颗粒复合物。 该系统还包括用于将样品和/或颗粒传送到传感器表面的输送装置，以及可选地构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。 谐振传感器产生对应于结合到传感器表面的治疗药物 - 颗粒复合物的量的信号。

公开(公告)号：US20070281371A1

公开(公告)日：2007-12-06

申请号：US11709068

申请日：2007-02-21

Applicant: Michael Miller ,  Brett Masters ,  Mark Lundstrom ,  Eric Fitch

Inventor： Michael Miller ,  Brett Masters ,  Mark Lundstrom ,  Eric Fitch

IPC: G01N33/553

CPC classification number: G01N33/54313 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0681 ,  B01L2300/1822 ,  B01L2400/043 ,  B01L2400/0487 ,  B82Y15/00 ,  B82Y30/00 ,  G01N29/022 ,  G01N29/036 ,  G01N29/4418 ,  G01N33/56911 ,  G01N2291/0256 ,  G01N2291/02836 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427 ,  G01N2800/324 ,  Y02A50/52 ,  Y02A50/57

Abstract: A system for detecting an analyte in a sample includes a resonant sensor that has a sensor surface coated with the capture agent. A plurality of magnetic particles, each of which is coated with a capture agent having an affinity for the analyte, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.

公开(公告)号：US20070042441A1

公开(公告)日：2007-02-22

申请号：US11417000

申请日：2006-05-02

Applicant: Brett Masters ,  Michael Miller ,  Vishal Gulati ,  Mark Lundstrom ,  Alok Srivastava ,  Wayne Wang

Inventor： Brett Masters ,  Michael Miller ,  Vishal Gulati ,  Mark Lundstrom ,  Alok Srivastava ,  Wayne Wang

IPC: G01N33/551 ,  G01N33/53 ,  C12M3/00

CPC classification number: G01N33/54313 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0681 ,  B01L2300/1822 ,  B01L2400/043 ,  B01L2400/0487 ,  B82Y15/00 ,  B82Y30/00 ,  G01N29/022 ,  G01N29/036 ,  G01N29/4418 ,  G01N33/56911 ,  G01N2291/0256 ,  G01N2291/02836 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427 ,  G01N2800/324 ,  Y02A50/52 ,  Y02A50/57

Abstract: Methods for detecting estradiol and metabolites thereof in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for estradiol, is combined with the sample to form a plurality of estradiol-particle complexes. The system also includes a transport arrangement for transporting the sample and/or particles to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of estradiol-particle complexes that are bound to the sensor surface.

Abstract translation: 提供了检测样品中雌二醇及其代谢物的方法。 将多个颗粒，每个颗粒涂覆有对雌二醇具有亲和性的捕获剂，与样品组合以形成多个雌二醇 - 颗粒复合物。 该系统还包括用于将样品和/或颗粒传送到传感器表面的输送装置，以及可选地构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。 谐振传感器产生对应于结合到传感器表面的雌二醇 - 颗粒复合物的量的信号。

公开(公告)号：US20070037142A1

公开(公告)日：2007-02-15

申请号：US11416997

申请日：2006-05-02

Applicant: Alexis Sauer-Budge ,  Brett Masters ,  Michael Miller ,  Mark Lundstrom

Inventor： Alexis Sauer-Budge ,  Brett Masters ,  Michael Miller ,  Mark Lundstrom

IPC: C12Q1/70

CPC classification number: G01N33/54313 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0681 ,  B01L2300/1822 ,  B01L2400/043 ,  B01L2400/0487 ,  B82Y15/00 ,  B82Y30/00 ,  G01N29/022 ,  G01N29/036 ,  G01N29/4418 ,  G01N33/56911 ,  G01N2291/0256 ,  G01N2291/02836 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427 ,  G01N2800/324 ,  Y02A50/52 ,  Y02A50/57

Abstract: Methods for detecting viruses are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for the virus, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.

Abstract translation: 提供了检测病毒的方法。 将多个颗粒（其中每一个都涂覆有对病毒具有亲和力的捕获剂）与样品组合以形成多个分析物 - 颗粒复合物。 该系统还包括用于将样品输送到传感器表面的输送装置，以及可选地构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。 谐振传感器产生对应于结合到传感器表面的分析物 - 颗粒复合物的量的信号。

公开(公告)号：US07615381B2

公开(公告)日：2009-11-10

申请号：US11417000

申请日：2006-05-02

Applicant: Brett P. Masters ,  Michael Miller ,  Vishal K. Gulati ,  Mark Lundstrom ,  Alok Srivastava ,  Wayne U. Wang

Inventor： Brett P. Masters ,  Michael Miller ,  Vishal K. Gulati ,  Mark Lundstrom ,  Alok Srivastava ,  Wayne U. Wang

IPC: G01N33/553 ,  B32B27/00 ,  B32B27/12

CPC classification number: G01N33/54313 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0681 ,  B01L2300/1822 ,  B01L2400/043 ,  B01L2400/0487 ,  B82Y15/00 ,  B82Y30/00 ,  G01N29/022 ,  G01N29/036 ,  G01N29/4418 ,  G01N33/56911 ,  G01N2291/0256 ,  G01N2291/02836 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427 ,  G01N2800/324 ,  Y02A50/52 ,  Y02A50/57

Abstract: Methods for detecting estradiol and metabolites thereof in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for estradiol, is combined with the sample to form a plurality of estradiol-particle complexes. The system also includes a transport arrangement for transporting the sample and/or particles to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of estradiol-particle complexes that are bound to the sensor surface.

Abstract translation: 提供了检测样品中雌二醇及其代谢物的方法。 将多个颗粒，每个颗粒涂覆有对雌二醇具有亲和性的捕获剂，与样品组合以形成多个雌二醇 - 颗粒复合物。 该系统还包括用于将样品和/或颗粒传送到传感器表面的输送装置，以及可选地构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。 谐振传感器产生对应于结合到传感器表面的雌二醇 - 颗粒复合物的量的信号。