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    Neuromodulatory methods for treating pulmonary disorders
    4.
    发明授权
    Neuromodulatory methods for treating pulmonary disorders 有权
    用于治疗肺部疾病的神经调节方法

    公开(公告)号：US08155744B2

    公开(公告)日：2012-04-10

    申请号：US12333162

    申请日：2008-12-11

    申请人： Ali R. Rezai

    发明人： Ali R. Rezai

    IPC分类号： A61N1/18

    CPC分类号： A61F2/82 ,  A61F2250/0001 ,  A61N1/3601 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3787

    摘要： A method for treating a pulmonary disorder in a subject includes inserting a therapy delivery device into a vessel of the subject, advancing the therapy delivery device to a point adjacent an intraluminal target site of the autonomic nervous system, and activating the therapy delivery device to delivery a therapy signal to the intraluminal target site to treat the pulmonary disorder. The intraluminal target site is in electrical communication with nervous tissue selected from the group consisting of a spinal nerve, a postganglionic fiber of a spinal nerve, a sympathetic chain ganglion, a thoracic sympathetic chain ganglion, a cervical ganglion, a lower cervical ganglion, an inferior cervical ganglion, an intramural ganglion, a splanchnic nerve, an esophageal plexus, a cardiac plexus, a pulmonary plexus, an anterior pulmonary plexus, a posterior pulmonary plexus, a celiac plexus, a hypogastric plexus, an inferior mesenteric ganglion, a celiac ganglion, and a superior mesenteric ganglion.

    摘要翻译： 用于治疗受试者的肺部疾病的方法包括将治疗递送装置插入受试者的血管，将治疗递送装置推进到与自主神经系统的腔内靶位点相邻的点，以及将治疗递送装置激活到递送 治疗信号到腔内靶位点治疗肺部疾病。 管腔内靶点与神经组织电连通，神经组织选自脊髓神经，神经节神经节纤维，交感神经节神经节，胸交感神经节神经节，子宫颈神经节，下宫颈神经节， 下宫颈神经节，壁内神经节，内脏神经，食管丛，心丛，肺丛，前肺丛，后肺丛，腹腔神经丛，下腹神经丛，肠系膜下神经节，腹腔神经节 和肠系膜上神经节。

    METHOD FOR TREATING ERECTILE DYSFUNCTION
    5.
    发明申请
    METHOD FOR TREATING ERECTILE DYSFUNCTION 有权
    治疗溃疡性功能障碍的方法

    公开(公告)号：US20110077458A1

    公开(公告)日：2011-03-31

    申请号：US12934930

    申请日：2008-05-30

    申请人： Ali R. Rezai ,  Roy K. Greenberg ,  Milind Deogaonkar

    发明人： Ali R. Rezai ,  Roy K. Greenberg ,  Milind Deogaonkar

    IPC分类号： A61F5/41

    CPC分类号： A61N1/3787 ,  A61F2/26 ,  A61F2/82 ,  A61F2250/0001 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/3605 ,  A61N1/36107 ,  A61N1/37205

    摘要： A method for treating erectile dysfunction in a subject includes providing an expandable support member for engaging a wall of a blood vessel. The expandable support member includes at least one electrode connected with the expandable support member and arranged to selectively deliver electric current to modulate the autonomic nervous system (ANS). The expandable support member includes and an insulative material attached to at least a portion of the expandable support member for isolating blood flowing through the vessel from the electric current delivered by the at least one electrode. The expandable support member is implanted intravascularly so that at least a portion of the expandable support member is positioned substantially adjacent a desired location where modulation of the ANS is effective to improve erectile function. After implanting the expandable support member, electric current is delivered to the at least one electrode to effect a change in the ANS.

    摘要翻译： 用于治疗受试者勃起功能障碍的方法包括提供用于接合血管壁的可扩张支撑构件。 可扩展支撑构件包括至少一个电极，其与可扩张支撑构件连接并且布置成选择性地输送电流以调制自主神经系统（ANS）。 可膨胀支撑构件包括附接到可膨胀支撑构件的至少一部分的绝缘材料，用于将流过容器的血液与由至少一个电极输送的电流隔离。 可膨胀支撑构件植入血管内，使得可扩展支撑构件的至少一部分基本上邻近于ANS的调节有效改善勃起功能的期望位置。 在植入可扩展支撑构件之后，将电流输送到至少一个电极以实现ANS的改变。

    Methods of treating medical conditions by neuromodulation of the cerebellar pathways
    6.
    发明授权
    Methods of treating medical conditions by neuromodulation of the cerebellar pathways 有权
    通过神经调节小脑途径治疗病情的方法

    公开(公告)号：US07640063B2

    公开(公告)日：2009-12-29

    申请号：US11121005

    申请日：2005-05-04

    申请人： Ali R. Rezai ,  Andre Machado

    发明人： Ali R. Rezai ,  Andre Machado

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36082 ,  A61N1/36017 ,  A61N1/36025

    摘要： Methods of treating various medical conditions by neuromodulation of target sites of a cerebello-thalamo-cortical pathway and/or a cortical-ponto-cerebellar pathway. Such medical conditions include unilateral motor deficits, movement disorders, psychiatric disorders, epilepsy, speech or cognitive deficits associated with hemispheric lesions, visual deficits associated with hemispheric lesions, learning disorders associated with hemispheric lesions, vertigo and/or dizziness, gait disturbances, hereditary/genetic disorders, congenital malformations, infectious disease, degenerative disorders, autoimmune disorders, and metabolic disorders. A method of enhancing memory, learning and/or cognitive capacity in a normal individual by stimulating a target site of a cerebello-thalamo-cortical pathway and/or a cortical-ponto-cerebellar pathway is also provided.

    摘要翻译： 通过神经调节大脑 - 皮质 - 皮层途径和/或皮层 - 脑 - 小脑通路的靶位点治疗各种医学病症的方法。 这种医疗状况包括单侧运动障碍，运动障碍，精神障碍，癫痫，与半球病变相关的言语或认知缺陷，与半球病变相关的视力缺陷，与半球病变相关的学习障碍，眩晕和/或头晕，步态障碍，遗传性/ 遗传性疾病，先天性畸形，感染性疾病，退行性疾病，自身免疫性疾病和代谢性疾病。 还提供了通过刺激小脑 - 皮层 - 皮层途径的靶位点和/或皮层 - 小脑 - 小脑途径来增强正常个体的记忆，学习和/或认知能力的方法。

    METHOD AND APPARATUS FOR RENAL NEUROMODULATION
    7.
    发明申请
    METHOD AND APPARATUS FOR RENAL NEUROMODULATION 有权
    方法和装置用于肾神经修复

    公开(公告)号：US20090024195A1

    公开(公告)日：2009-01-22

    申请号：US12101452

    申请日：2008-04-11

    申请人： Ali R. Rezai ,  Roy K. Greenberg ,  Milind Deogaonkar

    发明人： Ali R. Rezai ,  Roy K. Greenberg ,  Milind Deogaonkar

    IPC分类号： A61N1/05

    CPC分类号： A61N1/36007 ,  A61N1/0558

    摘要： An apparatus for renal neuromodulation includes an expandable support member having a main body portion for engaging a wall of a blood vessel proximate a renal vasculature and at least one electrode connected with the main body portion. The at least one electrode is arranged to selectively deliver electric current to a desired location where modulation of the sympathetic nervous system is effective to alter renal function. The apparatus further includes an insulative material attached to at least a portion of the main body portion for isolating blood flow through the vessel from the electric current delivered by the at least one electrode.

    摘要翻译： 用于肾神经调节的装置包括可扩张支撑构件，其具有用于接合靠近肾血管系统的血管壁和与主体部分连接的至少一个电极的主体部分。 所述至少一个电极布置成选择性地将电流输送到期望的位置，其中交感神经系统的调节有效地改变肾功能。 该装置还包括附接到主体部分的至少一部分的绝缘材料，用于将通过该容器的血流与由至少一个电极传送的电流隔离。

    APPARATUS AND METHOD FOR TREATING PULMONARY CONDITIONS
    8.
    发明申请
    APPARATUS AND METHOD FOR TREATING PULMONARY CONDITIONS 有权
    用于治疗脉搏条件的装置和方法

    公开(公告)号：US20080306570A1

    公开(公告)日：2008-12-11

    申请号：US12129734

    申请日：2008-05-30

    申请人： Ali R. Rezai ,  Milind Deogaonkar

    发明人： Ali R. Rezai ,  Milind Deogaonkar

    IPC分类号： A61N1/36

    CPC分类号： A61N1/0553 ,  A61N1/0519 ,  A61N1/0556 ,  A61N1/3611 ,  A61N1/36114

    摘要： An apparatus for positioning at a target site and for treating a pulmonary condition in a subject includes a fluid exchange catheter for insertion into a tracheo-bronchial tree and an inflatable balloon coupled to the fluid exchange catheter. At least a portion of the inflatable balloon is for engaging a luminal wall of the tracheo-bronchial tree at the target site. The apparatus further includes an energy delivery mechanism operably coupled to the inflatable balloon. The energy delivery mechanism includes at least one energy delivery member for delivering electrical energy to the target site.

    摘要翻译： 用于定位在目标部位并用于治疗受试者的肺部病症的装置包括用于插入气管支气管树的树脂和用于与流体交换导管联接的可充气气囊的流体交换导管。 可充气气囊的至少一部分用于在目标位置处接合气管支气管树的腔壁。 该装置还包括可操作地联接到可膨胀气囊的能量传递机构。 能量输送机构包括用于将电能传递到目标部位的至少一个能量传递部件。

    Method of treating palmar hyperhydrosis by electrical stimulation of the sympathetic nervous chain
    9.
    发明授权
    Method of treating palmar hyperhydrosis by electrical stimulation of the sympathetic nervous chain 有权
    通过电刺激交感神经链治疗手掌超氧化的方法

    公开(公告)号：US06356786B1

    公开(公告)日：2002-03-12

    申请号：US09488999

    申请日：2000-01-20

    申请人： Ali R. Rezai ,  Martin Zonenshayn

    发明人： Ali R. Rezai ,  Martin Zonenshayn

    IPC分类号： A61N105

    CPC分类号： A61N1/05 ,  A61N1/32

    摘要： A method for treating hyperhidrosis by applying an oscillating electric field to the stellate ganglion. The method includes the steps of inserting an electrode into the vacinity of the sympathetic ganglion, for example the stellate ganglion, such that the necessary electric field may be applied to the ganglion. The necessary field oscillation frequency and strength, as well as other characteristics of the signal are determined individually for each patient. Continued driving of the pathological activity of the ganglion into the normal function is the long-term, reversible palatative remedy for the condition.

    摘要翻译： 一种通过向星状神经节施加振荡电场来治疗多汗症的方法。 该方法包括以下步骤：将电极插入交感神经节的空位，例如星状神经节，使得必要的电场可以应用于神经节。 对于每个患者单独确定必要的场振荡频率和强度以及信号的其它特征。 继续驱动神经节的病理活动进入正常功能，是对病情的长期，可逆的适口补救。

    Apparatus and method for treating pulmonary conditions
    10.
    发明授权
    Apparatus and method for treating pulmonary conditions 有权
    用于治疗肺部疾病的装置和方法

    公开(公告)号：US08983609B2

    公开(公告)日：2015-03-17

    申请号：US12129734

    申请日：2008-05-30

    申请人： Ali R. Rezai ,  Milind Deogaonkar

    发明人： Ali R. Rezai ,  Milind Deogaonkar

    IPC分类号： A61N1/36 ,  A61N1/05

    CPC分类号： A61N1/0553 ,  A61N1/0519 ,  A61N1/0556 ,  A61N1/3611 ,  A61N1/36114

    摘要： An apparatus for positioning at a target site and for treating a pulmonary condition in a subject includes a fluid exchange catheter for insertion into a tracheo-bronchial tree and an inflatable balloon coupled to the fluid exchange catheter. At least a portion of the inflatable balloon is for engaging a luminal wall of the tracheo-bronchial tree at the target site. The apparatus further includes an energy delivery mechanism operably coupled to the inflatable balloon. The energy delivery mechanism includes at least one energy delivery member for delivering electrical energy to the target site.

    摘要翻译： 用于定位在目标部位并用于治疗受试者的肺部病症的装置包括用于插入气管支气管树的树脂和用于与流体交换导管联接的可充气气囊的流体交换导管。 可充气气囊的至少一部分用于在目标位置处接合气管支气管树的腔壁。 该装置还包括可操作地联接到可膨胀气囊的能量传递机构。 能量输送机构包括用于将电能传递到目标部位的至少一个能量传递部件。