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公开(公告)号：US20160264610A1
公开(公告)日：2016-09-15
申请号：US15161821
申请日：2016-05-23
IPC分类号： C07H19/06 , C07H19/056 , C07H19/20 , C07H19/16 , C07H19/10
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , A61K45/06 , C07H19/056 , C07H19/067 , C07H19/073 , C07H19/09 , C07H19/10 , C07H19/11 , C07H19/16 , C07H19/167 , C07H19/19 , C07H19/20 , A61K2300/00
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.
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公开(公告)号：US20150183819A1
公开(公告)日：2015-07-02
申请号：US14531552
申请日：2014-11-03
IPC分类号： C07H19/20 , C07H19/056 , C07H19/06 , C07H19/10 , C07H19/16
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , A61K45/06 , C07H19/056 , C07H19/067 , C07H19/073 , C07H19/09 , C07H19/10 , C07H19/11 , C07H19/16 , C07H19/167 , C07H19/19 , C07H19/20 , A61K2300/00
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.
摘要翻译： 本文公开了核苷，核苷酸及其类似物，包括核苷，核苷酸及其类似物中的一种或多种的药物组合物及其合成方法。 本文还公开了改善和/或治疗疾病和/或病症（包括副粘病毒和/或正粘病毒的感染）与其核苷，核苷酸和类似物的方法。 病毒感染的实例包括呼吸道合胞病毒（RSV）和流感感染。
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公开(公告)号：US09932363B2
公开(公告)日：2018-04-03
申请号：US15215434
申请日：2016-07-20
IPC分类号： A01N43/04 , A61K31/70 , C07H19/06 , C07H19/20 , C07H19/16 , C07H19/10 , A61K31/7072 , A61K31/7068 , A61K31/708 , A61K45/06 , A61K31/7076
CPC分类号： C07H19/06 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/10 , C07H19/16 , C07H19/20 , A61K2300/00
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.
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公开(公告)号：US20160318967A1
公开(公告)日：2016-11-03
申请号：US15215434
申请日：2016-07-20
IPC分类号： C07H19/06 , A61K31/7072 , A61K31/7068 , C07H19/20 , C07H19/16 , A61K31/708 , A61K31/7076 , A61K45/06 , C07H19/10
CPC分类号： C07H19/06 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/10 , C07H19/16 , C07H19/20 , A61K2300/00
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.
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公开(公告)号：US09365605B2
公开(公告)日：2016-06-14
申请号：US14312179
申请日：2014-06-23
IPC分类号： C07H17/02 , A61K31/14 , A61K31/513 , A61K31/52 , A61K45/06 , C07H19/11 , C07H19/213
CPC分类号： C07H19/20 , A61K31/14 , A61K31/513 , A61K31/52 , A61K31/685 , A61K31/7072 , A61K31/7076 , A61K45/06 , C07F9/65744 , C07H17/02 , C07H19/10 , C07H19/11 , C07H19/213 , Y02A50/414 , Y02A50/465 , A61K2300/00
摘要： Disclosed herein are cyclic nucleotide analogs, methods of synthesizing cyclic nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with cyclic nucleotide analogs.
摘要翻译： 本文公开了环状核苷酸类似物，合成环状核苷酸类似物的方法和用环状核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。
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公开(公告)号：US20170002037A1
公开(公告)日：2017-01-05
申请号：US15180999
申请日：2016-06-13
IPC分类号： C07H19/20 , A61K45/06 , A61K31/7072 , A61K31/685 , C07H19/10 , A61K31/7076 , C07F9/6574
CPC分类号： C07H19/20 , A61K31/14 , A61K31/513 , A61K31/52 , A61K31/685 , A61K31/7072 , A61K31/7076 , A61K45/06 , C07F9/65744 , C07H17/02 , C07H19/10 , C07H19/11 , C07H19/213 , Y02A50/414 , Y02A50/465 , A61K2300/00
摘要： Disclosed herein are cyclic nucleotide analogs, methods of synthesizing cyclic nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with cyclic nucleotide analogs.
摘要翻译： 本文公开了环状核苷酸类似物，合成环状核苷酸类似物的方法和用环状核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。
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公开(公告)号：US09422322B2
公开(公告)日：2016-08-23
申请号：US14312990
申请日：2014-06-24
IPC分类号： A01N43/04 , A61K31/70 , C07H19/20 , C07H19/06 , C07H19/16 , C07H19/10 , A61K31/7072 , A61K31/7068 , A61K31/708 , A61K45/06
CPC分类号： C07H19/06 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/10 , C07H19/16 , C07H19/20 , A61K2300/00
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.
摘要翻译： 本文公开了核苷，核苷酸及其类似物，包括核苷，核苷酸及其类似物中的一种或多种的药物组合物及其合成方法。 本文还公开了用核苷，核苷酸和类似物改善和/或治疗副粘病毒病毒感染的方法。
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公开(公告)号：US20150005251A1
公开(公告)日：2015-01-01
申请号：US14312990
申请日：2014-06-24
IPC分类号： C07H19/20 , C07H19/16 , A61K45/06 , A61K31/7072 , A61K31/7068 , A61K31/708 , C07H19/06 , C07H19/10
CPC分类号： C07H19/06 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/10 , C07H19/16 , C07H19/20 , A61K2300/00
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.
摘要翻译： 本文公开了核苷，核苷酸及其类似物，包括核苷，核苷酸及其类似物中的一种或多种的药物组合物及其合成方法。 本文还公开了用核苷，核苷酸和类似物改善和/或治疗副粘病毒病毒感染的方法。
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公开(公告)号：US20140303108A1
公开(公告)日：2014-10-09
申请号：US14312179
申请日：2014-06-23
IPC分类号： C07H17/02
CPC分类号： C07H19/20 , A61K31/14 , A61K31/513 , A61K31/52 , A61K31/685 , A61K31/7072 , A61K31/7076 , A61K45/06 , C07F9/65744 , C07H17/02 , C07H19/10 , C07H19/11 , C07H19/213 , Y02A50/414 , Y02A50/465 , A61K2300/00
摘要： Disclosed herein are cyclic nucleotide analogs, methods of synthesizing cyclic nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with cyclic nucleotide analogs.
摘要翻译： 本文公开了环状核苷酸类似物，合成环状核苷酸类似物的方法和用环状核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。
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公开(公告)号：US20180194793A1
公开(公告)日：2018-07-12
申请号：US15895872
申请日：2018-02-13
IPC分类号： C07H19/06 , A61K31/708 , C07H19/20 , C07H19/16 , C07H19/10 , A61K45/06 , A61K31/7076 , A61K31/7068 , A61K31/7072
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.
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