公开(公告)号：US20060034935A1

公开(公告)日：2006-02-16

申请号：US11187337

申请日：2005-07-22

申请人： Allan Pronovost ,  Henry Eisenson

发明人： Allan Pronovost ,  Henry Eisenson

IPC分类号： A61K9/14 ,  A61K33/00 ,  A61K38/46

CPC分类号： A61L26/0004 ,  A61K9/7015 ,  A61K31/695 ,  A61K33/00 ,  A61K38/4833 ,  A61K45/06 ,  A61K47/02 ,  A61L2400/12 ,  A61K2300/00

摘要： The inventive material is a unique family of externally used wound sealants based upon a binding agent of reactive submicron silica particles that, when hydrated, agglomerate in the form of a supramolecular cross-linked network serving as the structural framework facilitating clot formation. A thrombolytic cascade accelerant can be provided, optionally with additional clotting factors, to further accelerate the clotting process.

摘要翻译： 本发明的材料是基于反应性亚微米二氧化硅颗粒的粘合剂的独特的外部使用的伤口密封剂系列，当水合时，作为促进凝块形成的结构骨架的超分子交联网络的形式聚集。 可以提供溶栓级联加速剂，任选地具有另外的凝血因子，以进一步加速凝血过程。

公开(公告)号：US20070179373A1

公开(公告)日：2007-08-02

申请号：US11644496

申请日：2006-12-22

申请人： Allan Pronovost

发明人： Allan Pronovost

IPC分类号： A61B5/00 ,  G01N21/00 ,  G01N31/22

CPC分类号： A61B5/1486 ,  A61B5/6833 ,  A61B2560/0412 ,  B01L3/5023 ,  B01L2300/0681 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/084 ,  G01N21/01 ,  G01N21/78 ,  G01N31/22

摘要： Methods and apparatus for collecting a fluid sample using an integrated collection device are disclosed. The integrated collection device includes an analyte detector and a gradient means to actively and rapidly drive the transport of a sample fluid from the point of contact to the point of detection and reading. The analyte detector can include a visually-read colorimetric detector using a chemical or enzymatic detection process. The gradient means can include physical and/or chemical processes as described in more detail herein. In some embodiments, the device is provided as an occlusive patch. Preferably, the test device provides a reading immediately upon fluid contact with the analyte detector. Consequently, the time-to-result is sample volume and transport time dependent. By providing immediate or nearly immediate reading of results, the device is particularly useful in those applications in which immediate results are advantageous.

摘要翻译： 公开了使用集成收集装置收集流体样品的方法和装置。 集成收集装置包括分析物检测器和梯度装置，用于主动且快速地驱动样品流体从接触点到检测点和读取点的输送。 分析物检测器可以包括使用化学或酶检测过程的视觉读取的比色检测器。 梯度装置可以包括如本文更详细描述的物理和/或化学过程。 在一些实施例中，该装置被提供为闭塞补片。 优选地，测试装置在与分析物检测器流体接触时立即提供读数。 因此，时间到结果是样品体积和运输时间依赖。 通过立即或几乎立即读取结果，该设备在即时结果有利的那些应用中特别有用。

公开(公告)号：US06924153B1

公开(公告)日：2005-08-02

申请号：US08812616

申请日：1997-03-06

申请人： Hans Boehringer ,  Gerald Rowley ,  Allan Pronovost

发明人： Hans Boehringer ,  Gerald Rowley ,  Allan Pronovost

IPC分类号： G01N33/558 ,  G01N33/68 ,  G01N33/76

CPC分类号： G01N33/689 ,  G01N33/558 ,  G01N33/76 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/973 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/808 ,  Y10S436/81

摘要： This invention provides solid phase specific binding lateral flow assay methods, devices and kits for quantitating high and low molecular weight analytes. The methods and devices of the invention employ labelled reagents which are either analyte analogs or complementary specific binding pair members for the analyte and a novel arrangement of capture zones comprising immobilized specific binding substances for either the analyte or the labelled reagent to effect bound from unbound labelled reagent as a function of analyte concentration. The capture zones are disposed on a non-bibulous matrix defining a flow path from a sample receiving zone to the capture zone. The devices of this invention also include multilane flow paths and multiple capture zones to quantitate analyte.

公开(公告)号：US20070243630A1

公开(公告)日：2007-10-18

申请号：US11595777

申请日：2006-11-08

申请人： Hans Boehringer ,  Gerald Rowley ,  Allan Pronovost

发明人： Hans Boehringer ,  Gerald Rowley ,  Allan Pronovost

IPC分类号： G01N33/566

CPC分类号： G01N33/689 ,  G01N33/558 ,  G01N33/76 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/973 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/808 ,  Y10S436/81

摘要： This invention provides solid phase specific binding lateral flow assay methods, devices and kits for quantitating high and low molecular weight analytes. The methods and devices of the invention employ labelled reagents which are either analyte analogs or complementary specific binding pair members for the analyte and a novel arrangement of capture zones comprising immobilized specific binding substances for either the analyte or the labelled reagent to effect bound from unbound labelled reagent as a function of analyte concentration. The capture zones are disposed on a non-bibulous matrix defining a flow path from a sample receiving zone to the capture zone. The devices of this invention also include multilane flow paths and multiple capture zones to quantitate analyte.

摘要翻译： 本发明提供固相特异性结合侧流测定方法，用于定量高分子量和低分子量分析物的装置和试剂盒。 本发明的方法和装置使用标记试剂，其为分析物的分析物类似物或互补特异性结合对成员，以及包含用于分析物或标记试剂的固定化特异性结合物质的俘获区的新布置，以实现未结合的标记 试剂作为分析物浓度的函数。 捕获区域设置在非吸收性矩阵上，其限定从样品接收区到捕获区的流动路径。 本发明的装置还包括多通道流动路径和多个捕获区域以定量分析物。

公开(公告)号：US5939331A

公开(公告)日：1999-08-17

申请号：US66410

申请日：1993-05-21

申请人： John Burd ,  Steven Miller ,  Gerald Rowley ,  Allan Pronovost

发明人： John Burd ,  Steven Miller ,  Gerald Rowley ,  Allan Pronovost

IPC分类号： G01N33/48 ,  G01N33/543 ,  G01N33/556 ,  G01N33/558 ,  G01N33/563 ,  G01N33/80 ,  G01N37/00 ,  G01N33/53

CPC分类号： G01N33/558 ,  G01N33/54366 ,  G01N33/556 ,  G01N33/563 ,  G01N33/80 ,  Y10S435/962 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S436/825

摘要： A method and device for detecting the presence, absence or amount of an analyte in a whole blood sample is disclosed. The device comprises four zones, a sample receiving zone, a labeling zone, a capture zone and an absorbent zone. The sample receiving zone contains an irreversibly immobilized reagent that allows for removal of substantially all red blood cells from the whole blood sample. Flow through the device is via capillary migration and all of the dissolved or dispersed components in the sample flow at substantially equal rates and with relatively unimpaired flow through the device. The method involves the use of the device for detection of analyte in a whole blood sample.

摘要翻译： 公开了一种用于检测全血样品中分析物的存在，不存在或量的方法和装置。 该装置包括四个区域，样品接收区域，标记区域，捕获区域和吸收区域。 样品接收区包含不可逆固定的试剂，其允许从全血样品中去除基本上所有的红细胞。 通过该装置的流动是通过毛细管迁移，并且样品中的所有溶解或分散的组分以基本相同的速率流动并且流过装置的相对不受限制的流动。 该方法涉及使用该装置来检测全血样品中的分析物。

公开(公告)号：US20080020477A1

公开(公告)日：2008-01-24

申请号：US11574952

申请日：2005-09-12

申请人： Allan Pronovost

发明人： Allan Pronovost

IPC分类号： G01N33/00 ,  C12M1/00

CPC分类号： A61B5/411 ,  A61B5/14532 ,  A61B10/0051 ,  Y10T436/144444

摘要： The present invention relates to the measurement of carbohydrate in a fluid and uses thereof. Specifically, the invention is directed to the field of glucose measurement in the saliva of a subject. The invention provides devices and mathematical algorithms for the measurement of glucose in a subject.

摘要翻译： 本发明涉及流体中碳水化合物的测量及其用途。 具体地，本发明涉及在受试者的唾液中的葡萄糖测量领域。 本发明提供了用于测量受试者中的葡萄糖的装置和数学算法。

公开(公告)号：US20050170527A1

公开(公告)日：2005-08-04

申请号：US11016550

申请日：2004-12-17

申请人： Hans Boehringer ,  Gerald Rowley ,  Allan Pronovost

发明人： Hans Boehringer ,  Gerald Rowley ,  Allan Pronovost

IPC分类号： G01N33/558 ,  G01N33/68 ,  G01N33/76 ,  G01N33/53

CPC分类号： G01N33/689 ,  G01N33/558 ,  G01N33/76 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/973 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/808 ,  Y10S436/81

摘要： This invention provides solid phase specific binding lateral flow assay methods, devices and kits for quantitating high and low molecular weight analytes. The methods and devices of the invention employ labelled reagents which are either analyte analogs or complementary specific binding pair members for the analyte and a novel arrangement of capture zones comprising immobilized specific binding substances for either the analyte or the labelled reagent to effect bound from unbound labelled reagent as a function of analyte concentration. The capture zones are disposed on a non-bibulous matrix defining a flow path from a sample receiving zone to the capture zone. The devices of this invention also include multilane flow paths and multiple capture zones to quantitate analyte.

摘要翻译： 本发明提供固相特异性结合侧流测定方法，用于定量高分子量和低分子量分析物的装置和试剂盒。 本发明的方法和装置使用标记试剂，其为分析物的分析物类似物或互补特异性结合对成员，以及包含用于分析物或标记试剂的固定化特异性结合物质的俘获区的新布置，以实现未结合的标记 试剂作为分析物浓度的函数。 捕获区域设置在非吸收性矩阵上，其限定从样品接收区到捕获区的流动路径。 本发明的装置还包括多通道流动路径和多个捕获区域以定量分析物。