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公开(公告)号：US06514495B1
公开(公告)日：2003-02-04
申请号：US09273871
申请日：1999-03-22
申请人： Allan Svendsen , Søren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehmann , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
发明人： Allan Svendsen , Søren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehmann , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
IPC分类号： A61K3846
CPC分类号： C12N15/8257 , A23K10/14 , A23K20/189 , C12N9/16 , C12N15/8242 , C12N15/8243 , Y10S435/911 , Y10S435/916
摘要： Phytase variants, their preparation and uses, which phytase variants, when aligned according to FIG. 1, are amended as compared to a model phytase in at least one of a number of positions. Preferred model phytases are basidiomycete and ascomycete phytases, such as Peniophora phytase and Aspergillus phytases. Preferred phytase variants exhibits amended activity characteristics, such as improved specific activity and/or improved thermostability.
摘要翻译： 植酸酶变体，它们的制备和用途，当植酸酶变体根据图1对齐时， 与在多个位置中的至少一个中的模型植酸酶相比，修改了1。 优选的植酸酶类型是担子菌和子囊菌植酸酶，如Peniophora植酸酶和曲霉属植酸酶。 优选的植酸酶变体表现出修正的活性特征，例如提高的比活性和/或改善的热稳定性。
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公开(公告)号：US06689358B2
公开(公告)日：2004-02-10
申请号：US10083452
申请日：2002-02-26
申请人： Allan Svendsen , Søren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehmann , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
发明人： Allan Svendsen , Søren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehmann , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
IPC分类号： A61K3846
CPC分类号： C12N15/8257 , A23K10/14 , A23K20/189 , C12N9/16 , C12N15/8242 , C12N15/8243 , Y10S435/911 , Y10S435/916
摘要： The present invention relates to phytase variants, their preparation and uses, which phytase variants, when aligned according to FIG. 1, are amended as compared to a model phytase in at least one of a number of positions. Preferred model phytases are basidiomycete and ascomycete phytases, such as Peniophora phytase and Aspergillus phytases. Preferred phytase variants exhibits amended activity characteristics, such as improved specific activity and/or improved thermostability.
摘要翻译： 本发明涉及植酸酶变体，其制备和用途，当植酸酶变体在根据图1对齐时。 与在多个位置中的至少一个中的模型植酸酶相比，修改了1。 优选的植酸酶类型是担子菌和子囊菌植酸酶，如Peniophora植酸酶和曲霉属植酸酶。 优选的植酸酶变体表现出修正的活性特征，例如提高的比活性和/或改善的热稳定性。
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公开(公告)号：US20080219965A1
公开(公告)日：2008-09-11
申请号：US11942220
申请日：2007-11-19
申请人： Allan Svendsen , Soren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehmann , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
发明人： Allan Svendsen , Soren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehmann , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
CPC分类号： C12N15/8257 , A23K10/14 , A23K20/189 , C12N9/16 , C12N15/8242 , C12N15/8243 , Y10S435/911 , Y10S435/916
摘要： The present invention relates to phytase variants, their preparation and uses, which phytase variants, when aligned according to FIG. 1, are amended as compared to a model phytase in at least one of a number of positions. Preferred model phytases are basidiomycete and ascomycete phytases, such as Peniophora phytase and Aspergillus phytases. Preferred phytase variants exhibits amended activity characteristics, such as improved specific activity and/or improved thermostability.
摘要翻译： 本发明涉及植酸酶变体，其制备和用途，当植酸酶变体在根据图1对齐时。 与在多个位置中的至少一个中的模型植酸酶相比，修改了1。 优选的植酸酶类型是担子菌和子囊菌植酸酶，如Peniophora植酸酶和曲霉属植酸酶。 优选的植酸酶变体表现出修正的活性特征，例如提高的比活性和/或改善的热稳定性。
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公开(公告)号：US20080220118A1
公开(公告)日：2008-09-11
申请号：US11942242
申请日：2007-11-19
申请人： Allan Svendsen , Soren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehman , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
发明人： Allan Svendsen , Soren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehman , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
CPC分类号： C12N15/8257 , A23K10/14 , A23K20/189 , C12N9/16 , C12N15/8242 , C12N15/8243 , Y10S435/911 , Y10S435/916
摘要： The present invention relates to phytase variants, their preparation and uses, which phytase variants, when aligned according to FIG. 1, are amended as compared to a model phytase in at least one of a number of positions. Preferred model phytases are basidiomycete and ascomycete phytases, such as Peniophora phytase and Aspergillus phytases. Preferred phytase variants exhibits amended activity characteristics, such as improved specific activity and/or improved thermostability.
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公开(公告)号：US07326554B2
公开(公告)日：2008-02-05
申请号：US10734510
申请日：2003-12-12
申请人： Allan Svendsen , Soren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehman , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
发明人： Allan Svendsen , Soren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehman , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
IPC分类号： C12N9/16
CPC分类号： C12N15/8257 , A23K10/14 , A23K20/189 , C12N9/16 , C12N15/8242 , C12N15/8243 , Y10S435/911 , Y10S435/916
摘要： The present invention relates to phytase variants, their preparation and uses, which phytase variants, when aligned according to FIG. 1, are amended as compared to a model phytase in at least one of a number of positions. Preferred model phytases are basidiomycete and ascomycete phytases, such as Peniophora phytase and Aspergillus phytases. Preferred phytase variants exhibits amended activity characteristics, such as improved specific activity and/or improved thermostability.
摘要翻译： 本发明涉及植酸酶变体，其制备和用途，当植酸酶变体在根据图1对齐时。 与在多个位置中的至少一个中的模型植酸酶相比，修改了1。 优选的植酸酶类型是担子菌和子囊菌植酸酶，如Peniophora植酸酶和曲霉属植酸酶。 优选的植酸酶变体表现出修正的活性特征，例如提高的比活性和/或改善的热稳定性。
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6.发明授权Cleaning composition comprising amylase variants with high stability in the presence of a chelating agent 有权包含在螯合剂存在下具有高稳定性的淀粉酶变体的清洁组合物公开(公告)号：US09493730B2
公开(公告)日：2016-11-15
申请号：US13024637
申请日：2011-02-10
申请人： Michelle Meek , Philip Frank Souter , Lindsay Suzanne Bewick , Allan Svendsen , Annette Helle Johansen , Mads Eskelund Bjoernvad , Frank Winther Rasmussen , Michael Skjoet , Signe Eskildsen Larsen , Jens Oebro , Svend Kaasgaard , Lars Beier
发明人： Michelle Meek , Philip Frank Souter , Lindsay Suzanne Bewick , Allan Svendsen , Annette Helle Johansen , Mads Eskelund Bjoernvad , Frank Winther Rasmussen , Michael Skjoet , Signe Eskildsen Larsen , Jens Oebro , Svend Kaasgaard , Lars Beier
CPC分类号： C11D3/386 , C11D3/33 , C11D3/361 , C12N9/2417 , C12Y302/01001
摘要： The present invention relates to cleaning compositions comprising variants of an alpha-amylase having improved stability to chelating agents relative to its parent enzyme and cleaning processes comprising such compositions.
摘要翻译： 本发明涉及清洁组合物，其包含相对于其母体酶具有改善的螯合剂稳定性的α-淀粉酶的变体和包含该组合物的清洁方法。
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7.发明授权Cleaning compositions comprising amylase variants reference to a sequence listing 有权包含淀粉酶变体的清洁组合物参考序列表公开(公告)号：US09284544B2
公开(公告)日：2016-03-15
申请号：US13537606
申请日：2012-06-29
申请人： Michelle Jackson , Philip Frank Souter , Lindsay Suzanne Bewick , Svend Kaasgaard , Jens Oebro , Signe Eskildsen Larsen , Allan Svendsen , Annette Helle Johansen , Michael Skjoet , Carsten Andersen , Lars Beier , Esben Peter Friis , Miguel Duarte Guilherme Pereira Toscano , Mads Bjoernvad , Frank Winther Rasmussen , Liv Spaangner Christiansen
发明人： Michelle Jackson , Philip Frank Souter , Lindsay Suzanne Bewick , Svend Kaasgaard , Jens Oebro , Signe Eskildsen Larsen , Allan Svendsen , Annette Helle Johansen , Michael Skjoet , Carsten Andersen , Lars Beier , Esben Peter Friis , Miguel Duarte Guilherme Pereira Toscano , Mads Bjoernvad , Frank Winther Rasmussen , Liv Spaangner Christiansen
CPC分类号： C11D3/386 , C11D3/38681 , C12N9/2417 , C12Y302/01001
摘要： The present invention relates to cleaning compositions comprising variants of an alpha-amylase and methods of treating surfaces such as textiles with aqueous liquor comprising such compositions, especially at low temperatures.
摘要翻译： 本发明涉及包含α-淀粉酶的变体的清洁组合物和包含这种组合物的含水液体的表面如纺织品的处理方法，特别是在低温下。
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公开(公告)号：US09029115B2
公开(公告)日：2015-05-12
申请号：US13587043
申请日：2012-08-16
申请人： Allan Svendsen , Michael Skjoet , Deborah Yaver , Lars Lehmann Hylling Christensen , Signe Eskildsen Larsen , Nina Lundin , Michael Lamsa , Peter Colin Gregory
发明人： Allan Svendsen , Michael Skjoet , Deborah Yaver , Lars Lehmann Hylling Christensen , Signe Eskildsen Larsen , Nina Lundin , Michael Lamsa , Peter Colin Gregory
CPC分类号： A61K38/465 , A61K38/47 , A61K38/48 , C12N9/20
摘要： The pharmaceutical use of lipases related to the Thermomyces lanuginosus (Humicola lanuginosa) lipase comprising amino acids 1-269 of SEQ ID NO: 2, optionally in combination with a protease and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II. The lipases of the invention have, e.g., an improved digestion performance in vitro, an improved activity at a pH in the neutral range, an improved stability at low pH, and are stable against protease-degradation, and/or are stable in the presence of pepsin and bile salts. The invention also relates to methods of determining digestion performance in vitro of lipases, as well as to certain novel variants of the lipase of T. lanuginosus.
摘要翻译： 与包含SEQ ID NO：2的氨基酸1-269的Thermomyces lanuginosus（Humicola lanuginosa）脂肪酶相关的脂肪酶的药物用途，任选地与蛋白酶和/或淀粉酶组合。 医学适应症的例子有：消化系统疾病，胰腺外分泌功能不全（PEI），胰腺炎，囊性纤维化，I型糖尿病和/或II型糖尿病的治疗。 本发明的脂肪酶例如在体外具有改善的消化性能，在中性范围内的pH值改善的活性，在低pH下的改进的稳定性，并且对蛋白酶降解是稳定的，和/或在存在下是稳定的 的胃蛋白酶和胆汁盐。 本发明还涉及确定脂肪酶的体外消化性能的方法以及T.lanuginosus的脂肪酶的某些新颖变体。
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公开(公告)号：US20140206026A1
公开(公告)日：2014-07-24
申请号：US14127781
申请日：2012-06-29
申请人： Svend Kaasgaard , Signe Eskildsen Larsen , Jens Oebro , Lars Beier , Connie Pontoppidan , Iben Damager , Carsten Andersen , Allan Svendsen
发明人： Svend Kaasgaard , Signe Eskildsen Larsen , Jens Oebro , Lars Beier , Connie Pontoppidan , Iben Damager , Carsten Andersen , Allan Svendsen
摘要： The present invention relates to variants of a parent alpha-amylase. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
摘要翻译： 本发明涉及母体α-淀粉酶的变体。 本发明还涉及编码这些变体的多核苷酸; 核酸构建体，载体和包含多核苷酸的宿主细胞; 以及使用这些变体的方法。
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公开(公告)号：US08617837B2
公开(公告)日：2013-12-31
申请号：US13455905
申请日：2012-04-25
CPC分类号： C12N9/2417 , C11D3/386 , C11D3/38618 , C12P7/06 , C12P7/14 , C12P19/14 , C12Y302/01001 , Y02E50/17
摘要： The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.
摘要翻译： 本发明涉及亲本Termamyl样α-淀粉酶的变体（突变体），该变体具有α-淀粉酶活性并且相对于母体α-淀粉酶具有改变的性质。
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