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    SYSTEM AND METHOD FOR MONITORING DIASTOLIC FUNCTION USING AN IMPLANTABLE MEDICAL DEVICE
    1.
    发明申请
    SYSTEM AND METHOD FOR MONITORING DIASTOLIC FUNCTION USING AN IMPLANTABLE MEDICAL DEVICE 有权
    使用可植入医疗装置监测脱脂功能的系统和方法

    公开(公告)号：US20120330371A1

    公开(公告)日：2012-12-27

    申请号：US13601569

    申请日：2012-08-31

    申请人： Allen Keel ,  Steve Koh ,  Taraneh Ghaffari Farazi

    发明人： Allen Keel ,  Steve Koh ,  Taraneh Ghaffari Farazi

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3702 ,  A61N1/3627 ,  A61N1/36507 ,  A61N1/368 ,  A61N1/3712

    摘要： Diastolic function is monitored within a patient using a pacemaker or other implantable medical device. In one example, the implantable device uses morphological parameters derived from the T-wave evoked response waveform as proxies for ventricular relaxation rate and ventricular compliance. In particular, the magnitude of the peak of the T-wave evoked response is employed as a proxy for ventricular compliance. The maximum slew rate of the T-wave evoked response following its peak is employed as a proxy for ventricular relaxation. A metric is derived from these proxy values to represent diastolic function. The metric is tracked over time to evaluate changes in diastolic function. In other examples, specific values for ventricular compliance and ventricular relaxation are derived for the patient based on the T-wave evoked response parameters.

    摘要翻译： 使用起搏器或其他可植入医疗器械在患者体内监测舒张功能。 在一个示例中，可植入装置使用从T波诱发反应波形导出的形态参数作为心室松弛率和心室顺应性的代理。 特别地，T波诱发反应的峰值的大小被用作心室顺应性的代表。 其峰值后的T波诱发反应的最大压摆率被用作心室松弛的代用品。 来自这些代理值的度量来表示舒张功能。 随着时间的推移跟踪度量以评估舒张功能的变化。 在其他实例中，基于T波诱发反应参数为患者导出心室顺应性和心室松弛的具体值。

    System and method for monitoring diastolic function using an implantable medical device
    2.
    发明授权
    System and method for monitoring diastolic function using an implantable medical device 有权
    使用可植入医疗装置监测舒张功能的系统和方法

    公开(公告)号：US08280523B2

    公开(公告)日：2012-10-02

    申请号：US12341355

    申请日：2008-12-22

    申请人： Allen Keel ,  Steve Koh ,  Taraneh Ghaffari Farazi

    发明人： Allen Keel ,  Steve Koh ,  Taraneh Ghaffari Farazi

    IPC分类号： A61N1/36 ,  A61N1/378

    CPC分类号： A61N1/3702 ,  A61N1/3627 ,  A61N1/36507 ,  A61N1/368 ,  A61N1/3712

    摘要： Diastolic function is monitored within a patient using a pacemaker or other implantable medical device. In one example, the implantable device uses morphological parameters derived from the T-wave evoked response waveform as proxies for ventricular relaxation rate and ventricular compliance. In particular, the magnitude of the peak of the T-wave evoked response is employed as a proxy for ventricular compliance. The maximum slew rate of the T-wave evoked response following its peak is employed as a proxy for ventricular relaxation. A metric is derived from these proxy values to represent diastolic function. The metric is tracked over time to evaluate changes in diastolic function. In other examples, specific values for ventricular compliance and ventricular relaxation are derived for the patient based on the T-wave evoked response parameters.

    摘要翻译： 使用起搏器或其他可植入医疗器械在患者体内监测舒张功能。 在一个示例中，可植入装置使用从T波诱发反应波形导出的形态参数作为心室松弛率和心室顺应性的代理。 特别地，T波诱发反应的峰值的大小被用作心室顺应性的代表。 其峰值后的T波诱发反应的最大压摆率被用作心室松弛的代用品。 来自这些代理值的度量来表示舒张功能。 随着时间的推移跟踪度量以评估舒张功能的变化。 在其他实例中，基于T波诱发反应参数为患者导出心室顺应性和心室松弛的具体值。

    System and method for monitoring diastolic function using an implantable medical device
    3.
    发明授权
    System and method for monitoring diastolic function using an implantable medical device 有权
    使用可植入医疗装置监测舒张功能的系统和方法

    公开(公告)号：US08874213B2

    公开(公告)日：2014-10-28

    申请号：US13601569

    申请日：2012-08-31

    申请人： Allen Keel ,  Steve Koh ,  Taraneh Ghaffari Farazi

    发明人： Allen Keel ,  Steve Koh ,  Taraneh Ghaffari Farazi

    IPC分类号： A61N1/362 ,  A61N1/37 ,  A61N1/368 ,  A61N1/365

    CPC分类号： A61N1/3702 ,  A61N1/3627 ,  A61N1/36507 ,  A61N1/368 ,  A61N1/3712

    摘要： Diastolic function is monitored within a patient using a pacemaker or other implantable medical device. In one example, the implantable device uses morphological parameters derived from the T-wave evoked response waveform as proxies for ventricular relaxation rate and ventricular compliance. In particular, the magnitude of the peak of the T-wave evoked response is employed as a proxy for ventricular compliance. The maximum slew rate of the T-wave evoked response following its peak is employed as a proxy for ventricular relaxation. A metric is derived from these proxy values to represent diastolic function. The metric is tracked over time to evaluate changes in diastolic function. In other examples, specific values for ventricular compliance and ventricular relaxation are derived for the patient based on the T-wave evoked response parameters.

    摘要翻译： 使用起搏器或其他可植入医疗器械在患者体内监测舒张功能。 在一个示例中，可植入装置使用从T波诱发反应波形导出的形态参数作为心室松弛率和心室顺应性的代理。 特别地，T波诱发反应的峰值的大小被用作心室顺应性的代表。 其峰值后的T波诱发反应的最大压摆率被用作心室松弛的代用品。 来自这些代理值的度量来表示舒张功能。 随着时间的推移跟踪度量以评估舒张功能的变化。 在其他实例中，基于T波诱发反应参数为患者导出心室顺应性和心室松弛的具体值。

    SYSTEM AND METHOD FOR MONITORING DIASTOLIC FUNCTION USING AN IMPLANTABLE MEDICAL DEVICE
    4.
    发明申请
    SYSTEM AND METHOD FOR MONITORING DIASTOLIC FUNCTION USING AN IMPLANTABLE MEDICAL DEVICE 有权
    使用可植入医疗装置监测脱脂功能的系统和方法

    公开(公告)号：US20100161006A1

    公开(公告)日：2010-06-24

    申请号：US12341355

    申请日：2008-12-22

    申请人： Allen Keel ,  Steve Koh ,  Taraneh Ghaffari Farazi

    发明人： Allen Keel ,  Steve Koh ,  Taraneh Ghaffari Farazi

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3702 ,  A61N1/3627 ,  A61N1/36507 ,  A61N1/368 ,  A61N1/3712

    摘要： Diastolic function is monitored within a patient using a pacemaker or other implantable medical device. In one example, the implantable device uses morphological parameters derived from the T-wave evoked response waveform as proxies for ventricular relaxation rate and ventricular compliance. In particular, the magnitude of the peak of the T-wave evoked response is employed as a proxy for ventricular compliance. The maximum slew rate of the T-wave evoked response following its peak is employed as a proxy for ventricular relaxation. A metric is derived from these proxy values to represent diastolic function. The metric is tracked over time to evaluate changes in diastolic function. In other examples, specific values for ventricular compliance and ventricular relaxation are derived for the patient based on the T-wave evoked response parameters.

    摘要翻译： 使用起搏器或其他可植入医疗器械在患者体内监测舒张功能。 在一个示例中，可植入装置使用从T波诱发反应波形导出的形态参数作为心室松弛率和心室顺应性的代理。 特别地，T波诱发反应的峰值的大小被用作心室顺应性的代表。 其峰值后的T波诱发反应的最大压摆率被用作心室松弛的代用品。 来自这些代理值的度量来表示舒张功能。 随着时间的推移跟踪度量以评估舒张功能的变化。 在其他实例中，基于T波诱发反应参数为患者导出心室顺应性和心室松弛的具体值。

    IMPLANTABLE SYSTEMS AND METHODS FOR MONITORING BNP LEVELS, HF AND MI
    5.
    发明申请
    IMPLANTABLE SYSTEMS AND METHODS FOR MONITORING BNP LEVELS, HF AND MI 有权
    用于监测BNP水平，HF和MI的可植入系统和方法

    公开(公告)号：US20100160993A1

    公开(公告)日：2010-06-24

    申请号：US12341074

    申请日：2008-12-22

    申请人： Allen Keel ,  Steve Koh ,  Taraneh Ghaffari Farazi

    发明人： Allen Keel ,  Steve Koh ,  Taraneh Ghaffari Farazi

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/0464 ,  A61B5/053 ,  A61B5/145 ,  A61N1/36557 ,  A61N1/36585 ,  A61N1/37258

    摘要： Methods for monitoring a patient's level of B-type natriuretic peptide (BNP), and implantable cardiac systems capable of performing such methods, are provided. A ventricle is paced for a period of time to provoke a ventricular evoked response, and a ventricular intracardiac electrogram (IEGM) indicative of the ventricular evoked response is obtained. Based on the ventricular IEGM, there is a determination of at least one ventricular evoked response metric (e.g., ventricular evoked response peak-to-peak amplitude, ventricular evoked response area and/or ventricular evoked response maximum slope), and the patient's level of BNP is monitored based on determined ventricular evoked response metric(s). Based on the monitored level's of BNP, the patients heart failure (HF) condition and/or risks and/or occurrences of certain events (e.g., an acute HF exacerbation and/or an acute myocardial infarction) can be monitored.

    摘要翻译： 提供了用于监测患者B型利钠肽（BNP）水平的方法，以及能够执行这些方法的可植入心脏系统。 心室起搏一段时间以引发心室诱发反应，并获得指示心室诱发反应的心室心内电图（IEGM）。 基于心室IEGM，确定至少一个心室诱发反应度量（例如，心室诱发反应峰 - 峰幅度，心室诱发反应面积和/或心室诱发反应最大斜率）和患者的水平 基于确定的心室诱发反应度量监测BNP。 基于监测的BNP水平，可以监测患者的心力衰竭（HF）状况和/或某些事件的风险和/或发生（例如急性HF急性发作和/或急性心肌梗塞）。

    Implantable systems and methods for monitoring BNP levels, HF and MI
    6.
    发明授权
    Implantable systems and methods for monitoring BNP levels, HF and MI 有权
    用于监测BNP水平，HF和MI的植入式系统和方法

    公开(公告)号：US08326422B2

    公开(公告)日：2012-12-04

    申请号：US12341074

    申请日：2008-12-22

    申请人： Allen Keel ,  Steve Koh ,  Taraneh Ghaffari Farazi

    发明人： Allen Keel ,  Steve Koh ,  Taraneh Ghaffari Farazi

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3627 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/0464 ,  A61B5/053 ,  A61B5/145 ,  A61N1/36557 ,  A61N1/36585 ,  A61N1/37258

    摘要： Methods for monitoring a patient's level of B-type natriuretic peptide (BNP), and implantable cardiac systems capable of performing such methods, are provided. A ventricle is paced for a period of time to provoke a ventricular evoked response, and a ventricular intracardiac electrogram (IEGM) indicative of the ventricular evoked response is obtained. Based on the ventricular IEGM, there is a determination of at least one ventricular evoked response metric (e.g., ventricular evoked response peak-to-peak amplitude, ventricular evoked response area and/or ventricular evoked response maximum slope), and the patient's level of BNP is monitored based on determined ventricular evoked response metric(s). Based on the monitored level's of BNP, the patients heart failure (HF) condition and/or risks and/or occurrences of certain events (e.g., an acute HF exacerbation and/or an acute myocardial infarction) can be monitored.

    摘要翻译： 提供了用于监测患者B型利钠肽（BNP）水平的方法，以及能够执行这些方法的可植入心脏系统。 心室起搏一段时间以引发心室诱发反应，并获得指示心室诱发反应的心室心内电图（IEGM）。 基于心室IEGM，确定至少一个心室诱发反应度量（例如，心室诱发反应峰 - 峰幅度，心室诱发反应面积和/或心室诱发反应最大斜率）和患者的水平 基于确定的心室诱发反应度量监测BNP。 基于监测的BNP水平，可以监测患者的心力衰竭（HF）状况和/或某些事件的风险和/或发生（例如急性HF急性发作和/或急性心肌梗塞）。

    Cardiac Resynchronization Therapy Optimization Using Vector Measurements Obtained from Realtime Electrode Position Tracking
    10.
    发明申请
    Cardiac Resynchronization Therapy Optimization Using Vector Measurements Obtained from Realtime Electrode Position Tracking 有权
    使用从实时电极位置跟踪获得的矢量测量的心脏再同步治疗优化

    公开(公告)号：US20100152801A1

    公开(公告)日：2010-06-17

    申请号：US12621373

    申请日：2009-11-18

    申请人： Steve Koh ,  Stuart Rosenberg ,  Kyungmoo Ryu ,  Allen Keel ,  Michael Yang

    发明人： Steve Koh ,  Stuart Rosenberg ,  Kyungmoo Ryu ,  Allen Keel ,  Michael Yang

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3627 ,  A61B5/0422 ,  A61B5/0452 ,  A61N1/36585 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3686

    摘要： An exemplary method includes selecting multiple electrodes located in a patient; acquiring position information during one or more cardiac cycles for the multiple electrodes where the acquiring includes using each of the electrodes for measuring one or more electrical potentials in an electrical localization field established in the patient; calculating one or more vector metrics based on the acquired position information for one or more vectors, each vector defined by two of the multiple electrodes; and analyzing the one or more vector metrics to assess cardiac performance during the one or more cardiac cycles. Various other methods, devices, systems, etc., are also disclosed.

    摘要翻译： 一种示例性方法包括选择位于患者体内的多个电极; 在所述多个电极的一个或多个心动周期期间获取位置信息，其中所述获取包括使用每个所述电极来测量在所述患者中建立的电定位场中的一个或多个电位; 基于所获取的一个或多个向量的位置信息来计算一个或多个矢量度量，每个矢量由所述多个电极中的两个限定; 以及分析所述一个或多个矢量度量以评估所述一个或多个心动周期期间的心脏性能。 还公开了各种其它方法，装置，系统等。