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    Superabsorbent, freeze dried hydrogels for medical applications
    1.
    发明授权
    Superabsorbent, freeze dried hydrogels for medical applications 有权
    超吸收剂，用于医疗应用的冷冻干燥水凝胶

    公开(公告)号：US08795709B2

    公开(公告)日：2014-08-05

    申请号：US11465791

    申请日：2006-08-18

    申请人： Amarpreet S. Sawhney ,  Steven L. Bennett ,  Suresh S. Pai ,  Scott R. Sershen ,  Fred H. Co

    发明人： Amarpreet S. Sawhney ,  Steven L. Bennett ,  Suresh S. Pai ,  Scott R. Sershen ,  Fred H. Co

    IPC分类号： A61F2/00

    CPC分类号： A61L24/0031 ,  A61B2017/0065 ,  A61L24/046 ,  A61L24/10 ,  C08L71/02

    摘要： Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue.

    摘要翻译： 提供了用于制备冻干的水凝胶和其结构的方法，其可以被引入患者体内用于医疗应用。 组合前体组分以引发交联。 将组合的前体组分置于冷藏的托盘中，并在放置在托盘上之前和/或之后使其交联至所需水平的完全交联。 将部分交联的水凝胶冷冻并冷冻干燥。 冷冻干燥后，将水凝胶调节至基本上完全交联，并形成一种或多种结构，例如塞子，止血剂或其他医疗装置。 例如，水凝胶可以被切割，机加工，滚压，折叠，压缩和/或加工成可以被加载到可被引入到体内的输送装置中以将结构植入或以其他方式将结构输送到体内，例如 密封穿刺或穿过组织的其他通道。

    SUPERABSORBENT, FREEZE DRIED HYDROGELS FOR MEDICAL APPLICATIONS
    2.
    发明申请
    SUPERABSORBENT, FREEZE DRIED HYDROGELS FOR MEDICAL APPLICATIONS 有权
    用于医疗应用的冷冻干燥水凝胶

    公开(公告)号：US20070231366A1

    公开(公告)日：2007-10-04

    申请号：US11465791

    申请日：2006-08-18

    申请人： Amarpreet S. SAWHNEY ,  Steven L. Bennett ,  Suresh S. Pai ,  Scott R. Sershen ,  Fred H. Co

    发明人： Amarpreet S. SAWHNEY ,  Steven L. Bennett ,  Suresh S. Pai ,  Scott R. Sershen ,  Fred H. Co

    IPC分类号： A61K36/17 ,  A61K38/17

    CPC分类号： A61L24/0031 ,  A61B2017/0065 ,  A61L24/046 ,  A61L24/10 ,  C08L71/02

    摘要： Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue.

    摘要翻译： 提供了用于制备冻干的水凝胶和其结构的方法，其可以被引入患者体内用于医疗应用。 组合前体组分以引发交联。 将组合的前体组分置于冷藏的托盘中，并在放置在托盘上之前和/或之后使其交联至所需水平的完全交联。 将部分交联的水凝胶冷冻并冷冻干燥。 冷冻干燥后，将水凝胶调节至基本上完全交联，并形成一种或多种结构，例如塞子，止血剂或其他医疗装置。 例如，水凝胶可以被切割，机加工，滚压，折叠，压缩和/或加工成可以被加载到可被引入到体内的输送装置中以将结构植入或以其他方式将结构输送到体内，例如 密封穿刺或穿过组织的其他通道。

    Apparatus and methods for sealing a vascular puncture
    7.
    发明授权
    Apparatus and methods for sealing a vascular puncture 有权
    用于密封血管穿刺的装置和方法

    公开(公告)号：US08617204B2

    公开(公告)日：2013-12-31

    申请号：US11854534

    申请日：2007-09-12

    申请人： Farhad Khosravi ,  Suresh S. Pai ,  Celso J. Bagaoisan ,  Scott R. Sershen ,  Marlon Moreno ,  Juan Domingo

    发明人： Farhad Khosravi ,  Suresh S. Pai ,  Celso J. Bagaoisan ,  Scott R. Sershen ,  Marlon Moreno ,  Juan Domingo

    IPC分类号： A61B17/08

    CPC分类号： A61B17/0057 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00654

    摘要： An apparatus for sealing a puncture through tissue to a vessel includes an elongate occlusion member including an expandable member, a cartridge carried on the occlusion member, and a sealant carried within the cartridge. The cartridge includes an outer member and a pusher member within the outer member. The sealant is disposed within the outer member adjacent the expandable member distal to the pusher member. During use, the occlusion member is introduced into a puncture until the expandable member and the sealant extend from the puncture into the vessel. The expandable member is expanded, and withdrawn until the expanded expandable member contacts the vessel wall, thereby withdrawing the sealant back into the puncture. The outer member is withdrawn to expose the sealant within the puncture, while the pusher member prevents removal of the sealant, and then the cartridge, occlusion member, and pusher member are successively removed.

    摘要翻译： 用于将通过组织的穿刺密封到容器的装置包括包括可扩张构件的细长阻塞构件，承载在闭塞构件上的药筒和在药筒内承载的密封剂。 该盒在外部构件内包括外部构件和推动构件。 密封剂设置在外部构件中，邻近可推动构件远离推动构件。 在使用期间，将阻塞构件引入穿刺中，直到可膨胀构件和密封剂从穿刺件延伸到容器中。 可膨胀构件被膨胀并且被抽出直到膨胀的可膨胀构件接触血管壁，从而将密封剂抽回到穿刺中。 取出外部构件以在穿刺中露出密封剂，同时推动器构件防止密封剂的移除，然后连续地移除盒，遮挡构件和推动构件。