公开(公告)号：US10182800B2

公开(公告)日：2019-01-22

申请号：US13354278

申请日：2012-01-19

申请人： Andy H. Uchida ,  Anthony P. Spizuoco ,  Kevin To ,  Florencia Lim ,  Scott R. Sershen

发明人： Andy H. Uchida ,  Anthony P. Spizuoco ,  Kevin To ,  Florencia Lim ,  Scott R. Sershen

IPC分类号： A61B17/00 ,  A61L24/02 ,  C08L71/02 ,  A61B17/22 ,  A61B90/90

摘要： A sealant is provided for sealing a puncture through tissue that includes an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section fused to and extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The second section may be formed from a solid mass of non-freeze-dried, non-crosslinked hydrogel precursors, the precursors remaining in an unreactive state until exposed to an aqueous physiological, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.

公开(公告)号：US09386968B2

公开(公告)日：2016-07-12

申请号：US13105822

申请日：2011-05-11

申请人： Andy H. Uchida ,  Kevin To ,  Brandon Fell ,  Peter A. Swenson

发明人： Andy H. Uchida ,  Kevin To ,  Brandon Fell ,  Peter A. Swenson

IPC分类号： A61B17/00

CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/0065 ,  A61B2017/00654 ,  A61B2017/00778 ,  A61B2017/00898 ,  A61M39/06

摘要： An apparatus for sealing a puncture through tissue having an introducer sheath therein includes an elongate positioning member including a housing on a proximal end and an expandable member on a distal end, and a cartridge advanceable along the positioning member from a proximal position to a distal position. The cartridge includes a tubular member including a sealant and an advancer member disposed within lumen of the tubular member. A sleeve is slidably disposed over the tubular member distal end such that, when the tubular member is advanced over the positioning member, the tubular member distal end enters the introducer sheath while the sleeve is stopped and slides over the tubular member to expose the tubular member distal end within the introducer sheath. The introducer sheath and cartridge are then withdrawn, exposing the sealant within the puncture.

摘要翻译： 一种用于密封通过其中具有引导器护套的组织穿刺的装置，其中包括细长定位构件，其包括在近端上的壳体和在远端上的可扩张构件，以及可沿着定位构件从近侧位置向远侧位置可前进的盒 。 所述筒包括管状构件，所述管状构件包括密封剂和设置在所述管状构件的内腔内的推进构件。 套管可滑动地设置在管状构件远端上方，使得当管状构件推进到定位构件上时，管状构件远端在套管停止时进入导引器护套，并在管状构件上滑动以暴露管状构件 引导器鞘内的远端。 然后引导器护套和药筒被抽出，使穿刺中的密封剂暴露。

公开(公告)号：US20120290001A1

公开(公告)日：2012-11-15

申请号：US13105822

申请日：2011-05-11

申请人： Andy H. Uchida ,  Kevin To ,  Brandon Fell ,  Peter A. Swenson

发明人： Andy H. Uchida ,  Kevin To ,  Brandon Fell ,  Peter A. Swenson

IPC分类号： A61B17/03

CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/0065 ,  A61B2017/00654 ,  A61B2017/00778 ,  A61B2017/00898 ,  A61M39/06

摘要： An apparatus for sealing a puncture through tissue having an introducer sheath therein includes an elongate positioning member including a housing on a proximal end and an expandable member on a distal end, and a cartridge advanceable along the positioning member from a proximal position to a distal position. The cartridge includes a tubular member including a sealant and an advancer member disposed within lumen of the tubular member. A sleeve is slidably disposed over the tubular member distal end such that, when the tubular member is advanced over the positioning member, the tubular member distal end enters the introducer sheath while the sleeve is stopped and slides over the tubular member to expose the tubular member distal end within the introducer sheath. The introducer sheath and cartridge are then withdrawn, exposing the sealant within the puncture.

摘要翻译： 一种用于密封通过其中具有引导器护套的组织穿刺的装置，其中包括细长定位构件，其包括在近端上的壳体和在远端上的可扩张构件，以及可沿着定位构件从近侧位置向远侧位置可前进的盒 。 所述筒包括管状构件，其包括密封剂和设置在所述管状构件的内腔内的推进器构件。 套管可滑动地设置在管状构件远端上方，使得当管状构件推进到定位构件上时，管状构件远端在套管停止时进入导引器护套，并在管状构件上滑动以暴露管状构件 引导器鞘内的远端。 然后引导器护套和药筒被抽出，使穿刺中的密封剂暴露。

公开(公告)号：US06726685B2

公开(公告)日：2004-04-27

申请号：US09876833

申请日：2001-06-06

申请人： Kevin To ,  Le T. Le ,  Andy Uchida ,  Hugh Sharkey ,  John Ashley

发明人： Kevin To ,  Le T. Le ,  Andy Uchida ,  Hugh Sharkey ,  John Ashley

IPC分类号： H61B1818

CPC分类号： A61B18/1492 ,  A61B2017/00261 ,  A61B2017/003 ,  A61B2018/0044 ,  A61B2018/1407

摘要： An intervertebral disc device is provided comprising a probe capable of being extended from a distal end of an introducer that is percutaneously delivered into an interior of an intervertebral disc, the probe forming a loop when extended from the distal end of the introducer, the loop having first and second proximal ends external to the introducer which are brought together adjacent the introducer distal end to form the loop by the proximal ends being either attached to or entering the distal end of the introducer; and a proximal handle for externally causing the probe to be extended from the distal end of the introducer and externally guiding the probe within an intervertebral disc.

公开(公告)号：US20120209323A1

公开(公告)日：2012-08-16

申请号：US13354278

申请日：2012-01-19

申请人： Andy H. Uchida ,  Anthony P. Spizuoco ,  Kevin To ,  Florencia Lim ,  Scott R. Sershen

发明人： Andy H. Uchida ,  Anthony P. Spizuoco ,  Kevin To ,  Florencia Lim ,  Scott R. Sershen

IPC分类号： A61B17/08 ,  B32B9/00 ,  A61B17/10

CPC分类号： A61B17/0057 ,  A61B90/90 ,  A61B2017/00495 ,  A61B2017/00526 ,  A61B2017/00561 ,  A61B2017/0065 ,  A61B2017/00871 ,  A61B2017/00884 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61B2017/00898 ,  A61B2017/00951 ,  A61B2017/22067 ,  A61B2017/22069 ,  A61L24/02 ,  C08L71/02

摘要： A sealant is provided for sealing a puncture through tissue that includes an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section fused to and extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The second section may be formed from a solid mass of non-freeze-dried, non-crosslinked hydrogel precursors, the precursors remaining in an unreactive state until exposed to an aqueous physiological, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.

摘要翻译： 提供密封剂用于密封通过组织的穿刺，所述组织包括细长的第一部分，所述细长的第一部分包括近端，远端以及尺寸适于通过组织输送穿刺的横截面，以及与所述远端 第一部分结束。 第一部分可以由冻干的水凝胶形成，当暴露于穿刺内的生理流体时，该水凝胶膨胀。 第二部分可以由固体物质的非冷冻干燥的非交联水凝胶前体形成，前体保持在非活性状态直到暴露于水性生理学，于是前体彼此原位交联以提供 粘合到第一部分的粘合剂层。 还提供了用于将密封剂输送穿过组织穿刺的装置和方法。

公开(公告)号：US07256811B2

公开(公告)日：2007-08-14

申请号：US10688901

申请日：2003-10-21

申请人： Derrick Kevin To ,  Calvin D. Cummings ,  Roland Wescott Montague ,  Remy Dawson ,  Guy Sirton

发明人： Derrick Kevin To ,  Calvin D. Cummings ,  Roland Wescott Montague ,  Remy Dawson ,  Guy Sirton

IPC分类号： B41J2/435

CPC分类号： G03F7/24 ,  G03F7/2055

摘要： An imaging system is equipped with two or more exposure heads that are each able to image either a separate media sheet or a portion of a single media sheet loaded on a media carrier. The imaging time for any combination of media sheets is minimized by providing for the adjustment of the spacing between the dual exposure heads whenever the media configuration changes. In imaging a unitary image using two exposure heads to each image a sub-image, any discontinuity between the end of the first sub-image and the start of the next sub-image is reduced by changing the traversing speed of one of the exposure heads by a fractional amount.

摘要翻译： 成像系统配备有两个或更多个曝光头，每个曝光头都可以对单独的介质片或加载在介质载体上的单个介质片的一部分进行成像。 只要媒体配置发生改变，通过提供双曝光头之间的间距调整，可以最大程度地减少媒体片的任何组合的成像时间。 在使用两个曝光头将每个图像的单一图像成像为子图像时，通过改变其中一个曝光头的移动速度来减小第一子图像的结束与下一个子图像的开始之间的任何不连续性 分数。

公开(公告)号：US20130046376A1

公开(公告)日：2013-02-21

申请号：US13531227

申请日：2012-06-22

申请人： Ali Hassan ,  Kevin To ,  Andy Uchida ,  Jose Garcia ,  Yi Yang

发明人： Ali Hassan ,  Kevin To ,  Andy Uchida ,  Jose Garcia ,  Yi Yang

IPC分类号： A61M25/09 ,  A61M25/098 ,  A61F2/24 ,  A61M25/10

CPC分类号： A61M25/09 ,  A61M25/002 ,  A61M25/10185 ,  A61M2025/09008 ,  A61M2025/09083 ,  A61M2025/09125 ,  A61M2025/09175

摘要： A method of reducing the risk of clinical sequelae to catheter induced vascular injuries may include introducing a guide wire into a vascular sheath residing in a blood vessel, proximally retracting the vascular sheath while leaving the wire in place, and observing indicia of the presence or absence of a vascular injury caused to the blood vessel by the vascular sheath or a procedural catheter previously advanced through the vascular sheath. If indicia of a vascular injury are observed, the method may further involve proximally retracting the guide wire to position the inflatable balloon adjacent the injury and inflating the balloon to reduce blood flow past the injury, while leaving the guide wire in place to provide subsequent access to the injury.

摘要翻译： 减少导管引起的血管损伤的临床后遗症的风险的方法可包括将引导线引入位于血管中的血管鞘中，使血管鞘向近端缩回，同时留下线的存在或不存在 通过血管鞘引起血管的血管损伤或先前通过血管鞘的手术导管。 如果观察到血管损伤的标记，则该方法可进一步包括向近端缩回导丝以将可膨胀气囊定位在伤害附近并使气囊膨胀以减少血液流过损伤，同时将引导线放置在适当位置以提供随后的进入 受伤。

公开(公告)号：US20100268029A1

公开(公告)日：2010-10-21

申请号：US12757421

申请日：2010-04-09

申请人： Hoang Phan ,  John Lunsford ,  Fiona Sander ,  Kevin To ,  Michael Allen

发明人： Hoang Phan ,  John Lunsford ,  Fiona Sander ,  Kevin To ,  Michael Allen

IPC分类号： A61B1/01

CPC分类号： A61B1/018 ,  A61B1/00082 ,  A61B5/6882 ,  A61B17/320016 ,  A61B17/3209 ,  A61B2017/00278 ,  A61B2017/22042 ,  A61B2017/22044 ,  A61B2017/22047 ,  A61B2017/22048 ,  A61B2017/3484 ,  A61M25/09 ,  A61M2025/09008 ,  A61M2025/09125 ,  A61M2025/09183

摘要： A guidewire has a guidewire body with a distal end and a proximal end. A balloon or other tissue anchor is disposed at or near the distal end of the guidewire, and the guidewire may be used to draw two layers of tissue into apposition by placing the guidewire through a tissue penetration, deploying the tissue anchor, and drawing proximally on the guidewire body. Optionally, the guidewire may include deployable blades for enlarging a tissue penetration as the guidewire is advanced therethrough.

摘要翻译： 导丝具有带有远端和近端的导丝体。 气球或其他组织锚固件设置在导丝的远端处或附近，并且导丝可以用于通过将导丝穿过组织穿透，展开组织锚固件并向近侧拉伸而将两层组织拉平 导丝体。 可选地，导丝可以包括可展开的刀片，用于当导丝从其穿过时扩大组织穿透。

公开(公告)号：US07719556B2

公开(公告)日：2010-05-18

申请号：US11755204

申请日：2007-05-30

申请人： Derrick Kevin To ,  Calvin D. Cummings ,  Roland Wescott Montague ,  Remy Dawson ,  Guy Sirton

发明人： Derrick Kevin To ,  Calvin D. Cummings ,  Roland Wescott Montague ,  Remy Dawson ,  Guy Sirton

IPC分类号： B41J2/435

CPC分类号： G03F7/24 ,  G03F7/2055

摘要： An imaging system is equipped with two or more exposure heads that are each able to image either a separate media sheet or a portion of a single media sheet loaded on a media carrier. The imaging time for any combination of media sheets is minimized by providing for the adjustment of the spacing between the dual exposure heads whenever the media configuration changes. In imaging a unitary image using two exposure heads to each image a sub-image, any discontinuity between the end of the first sub-image and the start of the next sub-image is reduced by changing the traversing speed of one of the exposure heads by a fractional amount.

摘要翻译： 成像系统配备有两个或更多个曝光头，每个曝光头都可以对单独的介质片或加载在介质载体上的单个介质片的一部分进行成像。 只要媒体配置发生改变，通过提供双曝光头之间的间距调整，可以最大程度地减少媒体片的任何组合的成像时间。 在使用两个曝光头将每个图像的单一图像成像为子图像时，通过改变其中一个曝光头的移动速度来减小第一子图像的结束与下一个子图像的开始之间的任何不连续性 分数。

公开(公告)号：US07449019B2

公开(公告)日：2008-11-11

申请号：US10650928

申请日：2003-08-29

申请人： Andy H. Uchida ,  Kevin To

发明人： Andy H. Uchida ,  Kevin To

IPC分类号： A61B18/04

CPC分类号： A61B18/082 ,  A61B10/02 ,  A61B17/00491 ,  A61B17/1671 ,  A61B17/29 ,  A61B17/320016 ,  A61B17/3203 ,  A61B17/3421 ,  A61B17/3496 ,  A61B17/7061 ,  A61B17/8836 ,  A61B18/00 ,  A61B18/14 ,  A61B18/148 ,  A61B18/1482 ,  A61B18/1485 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/24 ,  A61B34/20 ,  A61B2017/00022 ,  A61B2017/00084 ,  A61B2017/0011 ,  A61B2017/00119 ,  A61B2017/00261 ,  A61B2017/00274 ,  A61B2017/003 ,  A61B2017/00336 ,  A61B2017/00455 ,  A61B2017/00867 ,  A61B2017/22044 ,  A61B2017/22049 ,  A61B2017/22082 ,  A61B2017/22087 ,  A61B2017/2905 ,  A61B2017/2927 ,  A61B2017/320008 ,  A61B2017/320044 ,  A61B2017/3445 ,  A61B2017/3488 ,  A61B2018/00011 ,  A61B2018/00267 ,  A61B2018/00434 ,  A61B2018/0044 ,  A61B2018/00547 ,  A61B2018/00625 ,  A61B2018/00654 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/046 ,  A61B2018/1266 ,  A61B2018/1405 ,  A61B2018/1407 ,  A61B2018/1425 ,  A61B2018/1435 ,  A61B2018/1472 ,  A61B2018/1807 ,  A61B2090/0454 ,  A61B2090/061 ,  A61B2090/064 ,  A61B2090/3937 ,  A61B2217/005 ,  A61B2218/002 ,  A61B2218/007 ,  A61F2/442 ,  A61F2002/30677 ,  A61F2007/0298 ,  A61M25/0084 ,  A61M25/0133 ,  A61M25/0144 ,  A61M25/0147 ,  A61M25/0155 ,  A61M25/0158 ,  A61M25/09 ,  A61N1/06 ,  A61N1/40

摘要： A method of delivering energy to an intervertebral disc includes positioning an energy delivery device adjacent an inner wall of the disc, and shrinking the nucleus pulposus. An energy delivery element of the device is positioned adjacent a bulge in the intervertebral disc. Energy delivery is controlled based on monitored temperature. A device for delivering energy includes a catheter with a distal portion configured to be inserted into a patient and to follow a natural boundary of a patient tissue, and an energy delivery element located at the distal portion for treating tissue. The distal portion includes a braided polymeric material. The catheter has a proximal portion including a tube for transmitted torque to the distal portion. The energy delivery element is a resistive heating coil having a length, e.g., of about 1.5 cm.

摘要翻译： 向椎间盘递送能量的方法包括将能量递送装置定位成邻近盘的内壁并收缩髓核。 装置的能量输送元件邻近椎间盘中的凸起定位。 基于监测温度控制能量输送。 用于递送能量的装置包括导管，其具有被构造成插入到患者体内并且跟随患者组织的自然边界的远端部分，以及位于远端部分处的用于治疗组织的能量输送元件。 远端部分包括编织的聚合材料。 导管具有近端部分，其包括用于向远端部分传递扭矩的管。 能量输送元件是具有例如约1.5cm长度的电阻加热线圈。