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公开(公告)号：US10182800B2
公开(公告)日：2019-01-22
申请号：US13354278
申请日：2012-01-19
摘要： A sealant is provided for sealing a puncture through tissue that includes an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section fused to and extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The second section may be formed from a solid mass of non-freeze-dried, non-crosslinked hydrogel precursors, the precursors remaining in an unreactive state until exposed to an aqueous physiological, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.
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公开(公告)号：US20120209323A1
公开(公告)日：2012-08-16
申请号：US13354278
申请日：2012-01-19
CPC分类号： A61B17/0057 , A61B90/90 , A61B2017/00495 , A61B2017/00526 , A61B2017/00561 , A61B2017/0065 , A61B2017/00871 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/00898 , A61B2017/00951 , A61B2017/22067 , A61B2017/22069 , A61L24/02 , C08L71/02
摘要： A sealant is provided for sealing a puncture through tissue that includes an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section fused to and extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The second section may be formed from a solid mass of non-freeze-dried, non-crosslinked hydrogel precursors, the precursors remaining in an unreactive state until exposed to an aqueous physiological, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.
摘要翻译： 提供密封剂用于密封通过组织的穿刺，所述组织包括细长的第一部分，所述细长的第一部分包括近端，远端以及尺寸适于通过组织输送穿刺的横截面，以及与所述远端 第一部分结束。 第一部分可以由冻干的水凝胶形成，当暴露于穿刺内的生理流体时，该水凝胶膨胀。 第二部分可以由固体物质的非冷冻干燥的非交联水凝胶前体形成，前体保持在非活性状态直到暴露于水性生理学，于是前体彼此原位交联以提供 粘合到第一部分的粘合剂层。 还提供了用于将密封剂输送穿过组织穿刺的装置和方法。
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