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1.发明授权公开(公告)号：US09957304B2
公开(公告)日：2018-05-01
申请号：US12130705
申请日：2008-05-30
申请人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Yonghua Zhu
发明人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Yonghua Zhu
IPC分类号： C07K14/21 , C07K14/705 , A61K38/16 , C07K14/195 , C07K7/08
CPC分类号： C07K14/21 , A61K38/164 , A61K38/168 , C07K14/195 , C07K14/705
摘要： The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system in mammalian cells. Specifically, the invention relates to compositions and methods that use cupredoxins, such as azurin, rusticyanin and plastocyanin, and variants, derivatives and structural equivalents thereof to treat cancer in mammals.
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公开(公告)号：US07691383B2
公开(公告)日：2010-04-06
申请号：US11244105
申请日：2005-10-06
CPC分类号： C07K14/28 , A61K35/13 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/164 , A61K45/06 , A61K49/00 , A61K49/04 , A61K49/14 , A61K49/221 , C07K14/195 , C07K14/21 , C07K14/22 , C07K14/235 , C07K2319/02
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer.
摘要翻译： 本发明公开了将货物化合物输送到癌细胞中的方法和材料。 货物化合物的交付是通过使用来自铜氧还蛋白的蛋白质转导结构域完成的。 本发明还公开了治疗癌症和诊断癌症的方法。
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公开(公告)号：US08530635B2
公开(公告)日：2013-09-10
申请号：US13531832
申请日：2012-06-25
CPC分类号： C07K14/28 , A61K35/13 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/164 , A61K45/06 , A61K49/00 , A61K49/04 , A61K49/14 , A61K49/221 , C07K14/195 , C07K14/21 , C07K14/22 , C07K14/235 , C07K2319/02
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer.
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4.发明授权Compositions and methods for treating HIV infection with cupredoxin and cytochrome c 有权用氧还蛋白和细胞色素c治疗HIV感染的组合物和方法公开(公告)号：US07795410B2
公开(公告)日：2010-09-14
申请号：US12398708
申请日：2009-03-05
申请人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
发明人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
CPC分类号： C12Q1/18 , A61K38/00 , C12N9/0004 , G01N2333/16 , G01N2500/10 , Y02A50/386 , Y02A50/466
摘要： The present invention relates to cupredoxin, specifically Pseudomonas aeruginosa azurin, and/or Pseudomonas aeruginosa cytochrome c551 and their use in inhibiting of viral infection, and in particular infection of mammalian cells by the Human Immunodeficiency Virus (HIV). The invention also relates to variants and derivatives of cupredoxin and cytochrome c that retain the ability to inhibit viral infection, and in particular infection by the Human Immunodeficiency Virus (HIV). The invention also relates to research methods for studying viral and bacterial infection in mammalian cells.
摘要翻译： 本发明涉及铜绿假单胞菌，特别是铜绿假单胞菌azurin和/或铜绿假单胞菌细胞色素c551及其在抑制病毒感染中的用途，特别是人类免疫缺陷病毒（HIV）感染哺乳动物细胞。 本发明还涉及保留抑制病毒感染的能力，特别是人类免疫缺陷病毒（HIV）的感染的铜氧还蛋白和细胞色素C的变体和衍生物。 本发明还涉及用于研究哺乳动物细胞中病毒和细菌感染的研究方法。
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5.发明申请COMPOSITIONS AND METHODS FOR TREATING HIV INFECTION WITH CUPREDOXIN AND CYTOCHROME C 有权用丙泊酚和细胞色素C治疗艾滋病毒感染的组合物和方法C公开(公告)号：US20080131873A1
公开(公告)日：2008-06-05
申请号：US11943034
申请日：2007-11-20
申请人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
发明人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
IPC分类号： C12Q1/70
CPC分类号： C12Q1/18 , A61K38/00 , C12N9/0004 , G01N2333/16 , G01N2500/10 , Y02A50/386 , Y02A50/466
摘要： The present invention relates to cupredoxin, specifically Pseudomonas aeruginosa azurin, and/or Pseudomonas aeruginosa cytochrome c551 and their use in inhibiting of viral infection, and in particular infection of mammalian cells by the Human Immunodeficiency Virus (HIV). The invention also relates to variants and derivatives of cupredoxin and cytochrome c that retain the ability to inhibit viral infection, and in particular infection by the Human Immunodeficiency Virus (HIV). The invention also relates to research methods for studying viral and bacterial infection in mammalian cells.
摘要翻译： 本发明涉及铜绿假单胞菌，特别是铜绿假单胞菌azurin，和/或绿脓假单胞菌细胞色素c551及其在抑制病毒感染中的用途，特别是人免疫缺陷病毒（HIV）感染哺乳动物细胞 ）。 本发明还涉及保留抑制病毒感染的能力，特别是人类免疫缺陷病毒（HIV）的感染的铜氧还蛋白和细胞色素C的变体和衍生物。 本发明还涉及用于研究哺乳动物细胞中病毒和细菌感染的研究方法。
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公开(公告)号：US20100209355A1
公开(公告)日：2010-08-19
申请号：US12754197
申请日：2010-04-05
IPC分类号： A61K49/14 , A61K49/00 , A61K49/04 , A61K49/22 , C12N5/00 , A61K38/16 , C07K9/00 , A61P35/04 , C07K14/21 , C07K7/08 , C07K7/06 , C07K14/195 , C07H21/04
CPC分类号： C07K14/28 , A61K35/13 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/164 , A61K45/06 , A61K49/00 , A61K49/04 , A61K49/14 , A61K49/221 , C07K14/195 , C07K14/21 , C07K14/22 , C07K14/235 , C07K2319/02
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer.
摘要翻译： 本发明公开了将货物化合物输送到癌细胞中的方法和材料。 货物化合物的交付是通过使用来自铜氧还蛋白的蛋白质转导结构域完成的。 本发明还公开了治疗癌症和诊断癌症的方法。
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7.发明申请COMPOSITIONS AND METHODS FOR TREATING HIV INFECTION WITH CUPREDOXIN AND CYTOCHROME C 有权用丙泊酚和细胞色素C治疗艾滋病毒感染的组合物和方法C公开(公告)号：US20090191623A1
公开(公告)日：2009-07-30
申请号：US12398708
申请日：2009-03-05
申请人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
发明人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
IPC分类号： C12N15/63
CPC分类号： C12Q1/18 , A61K38/00 , C12N9/0004 , G01N2333/16 , G01N2500/10 , Y02A50/386 , Y02A50/466
摘要： The present invention relates to cupredoxin, specifically Pseudomonas aeruginosa azurin, and/or Pseudomonas aeruginosa cytochrome c551 and their use in inhibiting of viral infection, and in particular infection of mammalian cells by the Human Immunodeficiency Virus (HIV). The invention also relates to variants and derivatives of cupredoxin and cytochrome c that retain the ability to inhibit viral infection, and in particular infection by the Human Immunodeficiency Virus (HIV). The invention also relates to research methods for studying viral and bacterial infection in mammalian cells.
摘要翻译： 本发明涉及铜绿假单胞菌，特别是铜绿假单胞菌azurin和/或铜绿假单胞菌细胞色素c551及其在抑制病毒感染中的用途，特别是人类免疫缺陷病毒（HIV）感染哺乳动物细胞。 本发明还涉及保留抑制病毒感染的能力，特别是人类免疫缺陷病毒（HIV）的感染的铜氧还蛋白和细胞色素C的变体和衍生物。 本发明还涉及用于研究哺乳动物细胞中病毒和细菌感染的研究方法。
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8.发明授权Compositions and methods for treating HIV infection with cupredoxin and cytochrome c 有权用氧还蛋白和细胞色素c治疗HIV感染的组合物和方法公开(公告)号：US07511117B2
公开(公告)日：2009-03-31
申请号：US11943034
申请日：2007-11-20
申请人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
发明人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
IPC分类号： C07K5/00
CPC分类号： C12Q1/18 , A61K38/00 , C12N9/0004 , G01N2333/16 , G01N2500/10 , Y02A50/386 , Y02A50/466
摘要： The present invention relates to cupredoxin, specifically Pseudomonas aeruginosa azurin, and/or Pseudomonas aeruginosa cytochrome c551 and their use in inhibiting of viral infection, and in particular infection of mammalian cells by the Human Immunodeficiency Virus (HIV). The invention also relates to variants and derivatives of cupredoxin and cytochrome c that retain the ability to inhibit viral infection, and in particular infection by the Human Immunodeficiency Virus (HIV). The invention also relates to research methods for studying viral and bacterial infection in mammalian cells.
摘要翻译： 本发明涉及铜绿假单胞菌，特别是铜绿假单胞菌azurin和/或铜绿假单胞菌细胞色素c551及其在抑制病毒感染中的用途，特别是人类免疫缺陷病毒（HIV）感染哺乳动物细胞。 本发明还涉及保留抑制病毒感染的能力，特别是人类免疫缺陷病毒（HIV）的感染的铜氧还蛋白和细胞色素C的变体和衍生物。 本发明还涉及用于研究哺乳动物细胞中病毒和细菌感染的研究方法。
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9.发明授权Compositions and methods for treating HIV infection with cupredoxin and cytochrome c 有权用氧还蛋白和细胞色素c治疗HIV感染的组合物和方法公开(公告)号：US07301010B2
公开(公告)日：2007-11-27
申请号：US11436591
申请日：2006-05-19
申请人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
发明人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
CPC分类号： C12Q1/18 , A61K38/00 , C12N9/0004 , G01N2333/16 , G01N2500/10 , Y02A50/386 , Y02A50/466
摘要： The present invention relates to cupredoxin, specifically Pseudomonas aeruginosa azurin, and/or Pseudomonas aeruginosa cytochrome C551 and their use in inhibiting of viral infection, and in particular infection of mammalian cells by the Human Immunodeficiency Virus (HIV). The invention also relates to variants and derivatives of cupredoxin and cytochrome c that retain the ability to inhibit viral infection, and in particular infection by the Human Immunodeficiency Virus (HIV). The invention also relates to research methods for studying viral and bacterial infection in mammalian cells.
摘要翻译： 本发明涉及铜绿假单胞菌，特别是铜绿假单胞菌azurin，和/或铜绿假单胞菌细胞色素C551及其在抑制病毒感染中的用途，特别是人类免疫缺陷病毒（HIV）感染哺乳动物细胞 ）。 本发明还涉及保留抑制病毒感染的能力，特别是人类免疫缺陷病毒（HIV）的感染的铜氧还蛋白和细胞色素C的变体和衍生物。 本发明还涉及用于研究哺乳动物细胞中病毒和细菌感染的研究方法。
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10.发明授权Compositions and methods for treating conditions related to ephrin signaling with cupredoxins and mutants thereof 有权用于氧化还原蛋白及其突变体治疗与ephrin信号传导相关的病症的组合物和方法公开(公告)号：US09096663B2
公开(公告)日：2015-08-04
申请号：US12013122
申请日：2008-01-11
申请人： Anita Chaudhari , Ananda Chakrabarty , Tapas Das Gupta , Arsenio Fialho , Tohru Yamada , Yonghua Zhu
发明人： Anita Chaudhari , Ananda Chakrabarty , Tapas Das Gupta , Arsenio Fialho , Tohru Yamada , Yonghua Zhu
CPC分类号： A61K38/164 , A61K38/00 , C07K14/21 , C07K14/52 , C07K14/705
摘要： The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system in mammalian cells. Specifically, the invention relates to compositions and methods that use cupredoxins, such as azurin, rusticyanin and plastocyanin, and variants, derivatives and structural equivalents thereof, to treat cancer in mammals. The invention specifically includes mutants with altered Eph binding constants and selectivities.
摘要翻译： 本发明涉及使用铜氧还蛋白的组合物和方法，以及干扰哺乳动物细胞中ephrin信号系统的铜氧还蛋白的变体，衍生物和结构等同物。 具体地说，本发明涉及使用铜氧还蛋白，例如azurin，铁氰菊酯和质体蛋白及其变体，衍生物和结构等价物来治疗哺乳动物癌症的组合物和方法。 本发明具体包括具有改变的Eph结合常数和选择性的突变体。
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