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    Isolated proteins having retinol dehydrogenase activity, and which associate with retinol binding receptors
    2.
    发明授权
    Isolated proteins having retinol dehydrogenase activity, and which associate with retinol binding receptors 失效
    分离的蛋白质具有视黄醇脱氢酶活性，并与视黄醇结合受体相关

    公开(公告)号：US06399344B1

    公开(公告)日：2002-06-04

    申请号：US08937993

    申请日：1997-09-26

    申请人： Ulf Eriksson ,  Andras Simon ,  Anna Romert

    发明人： Ulf Eriksson ,  Andras Simon ,  Anna Romert

    IPC分类号： C12N904

    CPC分类号： C12N9/0006

    摘要： Isolated membrane associated proteins which have a molecular weight of from about 30 kD to about 36 kilodaltons as determined by SDS-PAGE, are disclosed. The proteins have cis retinol dehydrogenase activity, such as 9, 11 or 13 cis retinol dehydrogenase activity, or cis activity at more than one position. Other trans-retinol dehydrogenases are also disclosed. Nucleic acid molecules which code for the proteins are also disclosed.

    摘要翻译： 公开了通过SDS-PAGE测定的具有约30kD至约36千道尔顿的分离膜相关蛋白。 蛋白质具有顺式视黄醇脱氢酶活性，例如9,11或13顺式视黄醇脱氢酶活性，或多于一个位置的顺式活性。 还公开了其他反式视黄醇脱氢酶。 还公开了编码蛋白质的核酸分子。

    Isolated nucleic acid molecule which codes for a 32 KDA protein having 11-CIS retinol dehydrogenase activity, and which associates with P63, a portion of a retinol binding protein receptor
    3.
    发明授权
    Isolated nucleic acid molecule which codes for a 32 KDA protein having 11-CIS retinol dehydrogenase activity, and which associates with P63, a portion of a retinol binding protein receptor 失效
    编码具有11-CIS视黄醇脱氢酶活性的32KDA蛋白的分离的核酸分子，其与P63相结合，视黄醇结合蛋白受体的一部分

    公开(公告)号：US06280997B1

    公开(公告)日：2001-08-28

    申请号：US08729594

    申请日：1996-10-11

    申请人： Ulf Eriksson ,  Andras Simon ,  Anna Romert

    发明人： Ulf Eriksson ,  Andras Simon ,  Anna Romert

    IPC分类号： C12N1512

    CPC分类号： C12N9/0006

    摘要： In accordance with this invention, an RPE cell membrane associated protein which has a molecular weight of about 32 kd, as determined by SDS-PAGE, has been discovered. This protein, referred to an “p32,” forms an oligomeric protein complex with the previously characterized p63 protein, a component of the membrane receptor for RBP. A nucleic acid molecule which codes for the p32 protein has also been isolated and sequence analysis shows that the p32 protein belongs to the family of short chain alcohol dehydrogenases, and exhibits 11-cis retinol dehydrogenase activity, the enzyme which catalyzes conversion of 11-cis-retinol into 11-cis retinaldehyde.

    摘要翻译： 根据本发明，已经发现通过SDS-PAGE测定的具有约32kd分子量的RPE细胞膜相关蛋白。 这种称为“p32”的蛋白质与先前表征的p63蛋白形成寡聚蛋白复合物，后者是RBP膜受体的一个成分。 编码p32蛋白的核酸分子也已经被分离，序列分析显示p32蛋白属于短链醇脱氢酶家族，并且表现出11-顺式视黄醇脱氢酶活性，该酶催化11-顺式 - 维甲酸变为11-顺式视黄醛。

    Pre-Heater For An Apparatus For The Production Of Carbon Black
    7.
    发明申请
    Pre-Heater For An Apparatus For The Production Of Carbon Black 审中-公开
    用于生产炭黑的设备的预热器

    公开(公告)号：US20090107660A1

    公开(公告)日：2009-04-30

    申请号：US11791614

    申请日：2005-10-12

    申请人： Ulf Eriksson ,  Fredrik Dahlstedt

    发明人： Ulf Eriksson ,  Fredrik Dahlstedt

    IPC分类号： F28D7/00

    CPC分类号： C09C1/48 ,  F28D7/16 ,  F28F9/007 ,  F28F2265/26

    摘要： A pre-heater for an apparatus for the production of carbon black, is adapted to pre-heat air by heat exchange to a temperature of at least 800° C., comprises an elongated jacket arranged substantially and having a top end and a bottom end, said jacket defining a space, a plurality of tubings arranged inside said space, said tubings having a diameter of 85 to 90 mm, said jacket being provided with an air inlet and an air outlet, for allowing said air to enter and exit said space, a smoke inlet chamber and a smoke collection chamber for allowing smoke to enter and exit said tubing. Said jacket is supported by a suspension means between said top and bottom ends excluding at the top end as such, such that the jacket is allowed to expand upwards above and downwards below said suspension means.

    摘要翻译： 用于生产炭黑的设备的预热器适于通过热交换将空气预热至至少800℃的温度，包括基本上设置有顶端和底端的细长护套 所述护套限定空间，多个管道布置在所述空间内，所述管道具有85至90mm的直径，所述护套设置有空气入口和空气出口，用于允许所述空气进入和离开所述空间 烟雾入口室和烟雾收集室，用于允许烟雾进入和离开所述管道。 所述护套由顶部和底部端部之间的顶端和底端之间的悬挂装置支撑，从而允许外套在所述悬挂装置下方向上和向下扩展。

    Antibodies to PDGF-D
    8.
    发明申请
    Antibodies to PDGF-D 审中-公开

    公开(公告)号：US20080261888A1

    公开(公告)日：2008-10-23

    申请号：US12148656

    申请日：2008-04-21

    申请人： Marko Uutela ,  Ulf Eriksson ,  Kari Alitalo

    发明人： Marko Uutela ,  Ulf Eriksson ,  Kari Alitalo

    IPC分类号： A61K38/00 ,  C12N5/06 ,  A61P43/00

    CPC分类号： C07K14/49 ,  A61K38/00 ,  C07K16/22 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.

    Soluble neuropilin/growth factor receptor fusion proteins
    9.
    发明授权
    Soluble neuropilin/growth factor receptor fusion proteins 失效
    可溶性神经蛋白/生长因子受体融合蛋白

    公开(公告)号：US07420042B2

    公开(公告)日：2008-09-02

    申请号：US10303786

    申请日：2002-11-26

    申请人： Kari Alitalo ,  Ulf Eriksson ,  Brigitta Olofsson ,  Taija Makinen

    发明人： Kari Alitalo ,  Ulf Eriksson ,  Brigitta Olofsson ,  Taija Makinen

    IPC分类号： C12P21/08 ,  C07K14/71

    CPC分类号： C07K14/71 ,  C07K14/52 ,  C07K2319/00

    摘要： Complexes of a protein selected from the group consisting of VEGF-B167, VEGF-C, VEGF-D and processed VEGF-B186 and analogs thereof and the neuropilin-1 (NP-1) receptor, the extracellular domain or a ligand-binding fragment or analogue thereof; the use of such complexes in assays for growth factor proteins having substantially the same binding affinity for a cell surface receptor as VEGF-B167, VEGF-C, VEGF-D or processed VEGF-B186 and/or in promoting or antagonizing a cellular response mediated by VEGF-B167, VEGF-C, VEGF-D and/or processed VEGF-B186; and specific binding partners, e.g. antibodies, for such complexes.

    摘要翻译： 选自VEGF-B 167，VEGF-C，VEGF-D和加工的VEGF-B 186和其类似物的蛋白质的复合物和神经毡蛋白-1 （NP-1）受体，细胞外结构域或其配体结合片段或其类似物; 对于对VEGF-B 167，VEGF-C，VEGF-D或加工的VEGF-B细胞表面受体具有基本上相同的结合亲和力的生长因子蛋白的测定中使用这种复合物 186和/或促进或拮抗由VEGF-B 167，VEGF-C，VEGF-D和/或经加工的VEGF-B 186介导的细胞应答; 和特异性结合配偶体，例如 抗体。